ClinicalTrials.gov record
A Study of Daily Oral Orforglipron (LY3502970) Compared With Insulin Glargine in Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk
ClinicalTrials.gov ID: NCT05803421
Public ClinicalTrials.gov record NCT05803421. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Open-Label Study of Once Daily LY3502970 Compared With Insulin Glargine in Adult Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The main purpose of this study is to determine safety and efficacy of orforglipron compared with insulin glargine in participants with type 2 diabetes and obesity or overweight at increased cardiovascular risk. The study will last approximately 2 years may include up to 27 visits.
Study identification
- NCT ID
- NCT05803421
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 2,749 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 3, 2023 (Actual)
- Primary completion
- Mar 16, 2026 (Actual)
- Completion
- Mar 16, 2026 (Actual)
- Last update posted
- Apr 17, 2026
2023 – 2026
United States locations
- U.S. sites
- 173
- U.S. states
- 38
- U.S. cities
- 152
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alliance for Multispecialty Research, LLC | Daphne | Alabama | 36526 | — |
| Alliance for Multispecialty Research, LLC | Mobile | Alabama | 36608 | — |
| Cahaba Research - Pelham | Pelham | Alabama | 35124 | — |
| Syed Research Consultants Llc | Sheffield | Alabama | 35660 | — |
| The Institute for Liver Health | Chandler | Arizona | 85224 | — |
| Aventiv Research | Mesa | Arizona | 85206 | — |
| Arizona Liver Health - Peoria | Peoria | Arizona | 85381 | — |
| Elite Clinical Studies, LLC | Phoenix | Arizona | 85018 | — |
| Absolute Clinical Research | Phoenix | Arizona | 85051 | — |
| Clinical Research Institute of Arizona (CRI) - Sun City West | Sun City West | Arizona | 85375 | — |
| Alliance for Multispecialty Research, LLC | Tempe | Arizona | 85281 | — |
| Orange Grove Family Practice | Tucson | Arizona | 85741 | — |
| KLR Business Group, Inc. dba Arkansas Clinical Research | Little Rock | Arkansas | 72205 | — |
| Hope Clinical Research, Inc. | Canoga Park | California | 91303 | — |
| Valley Clinical Trials, Inc. | Covina | California | 91723 | — |
| Neighborhood Healthcare Institute of Health | Escondido | California | 92025 | — |
| Valley Research | Fresno | California | 93720 | — |
| Orange County Research Center | Lake Forest | California | 92630 | — |
| Ark Clinical Research | Long Beach | California | 90815 | — |
| Pacific Clinical Studies | Los Alamitos | California | 90720 | — |
| Velocity Clinical Research, Los Angeles | Los Angeles | California | 90017 | — |
| Infinity Clinical Research - Norco | Norco | California | 92860 | — |
| Velocity Clinical Research, North Hollywood | North Hollywood | California | 91606 | — |
| Valley Clinical Trials, Inc. | Northridge | California | 91325 | — |
| Rancho Cucamonga Clinical Research | Rancho Cucamonga | California | 91730 | — |
| LCGK Research | San Carlos | California | 94070 | — |
| Norcal Endocrinology & Internal Medicine | San Ramon | California | 94583 | — |
| Velocity Clinical Research, Coastal Heart Medical Group | Santa Ana | California | 92704 | — |
| Diablo Clinical Research, Inc. | Walnut Creek | California | 94598 | — |
| Millennium Clinical Trials | Westlake Village | California | 91361 | — |
| Rocky Mountain Regional VA Medical Center | Aurora | Colorado | 80045 | — |
| University of Colorado Anschutz Medical Campus | Aurora | Colorado | 80045 | — |
| Legacy Clinical Trials | Colorado Springs | Colorado | 80909 | — |
| CMR of Greater New Haven, LLC | Hamden | Connecticut | 06517 | — |
| Orlando Heart & Vascular Institute | Altamonte Springs | Florida | 32714 | — |
| JEM Research Institute | Atlantis | Florida | 33462 | — |
| Excel Medical Clinical Trials | Boca Raton | Florida | 33434 | — |
| Velocity Clinical Research, New Smyrna Beach | Edgewater | Florida | 32132 | — |
| Alliance for Multispecialty Research, LLC | Fort Myers | Florida | 33912 | — |
| Indago Research & Health Center, Inc | Hialeah | Florida | 33012 | — |
| Nature Coast Clinical Research - Inverness | Inverness | Florida | 34452 | — |
| Northeast Research Institute - Downtown Office | Jacksonville | Florida | 32204 | — |
| Clinical Research of Central Florida | Lakeland | Florida | 33805 | — |
| Clinical Site Partners Leesburg | Leesburg | Florida | 34748 | — |
| L&C Professional Medical Research Institute | Miami | Florida | 33144 | — |
| Panax Clinical Research | Miami Lakes | Florida | 33014 | — |
| Adult Medicine of Lake County | Mt. Dora | Florida | 32757 | — |
| Renstar Medical Research | Ocala | Florida | 34470 | — |
| West Orange Endocrinology | Ocoee | Florida | 34761 | — |
| Better Life Clinical Research | Tampa | Florida | 33607 | — |
| Precision Research Center | Tampa | Florida | 33614 | — |
| Care Access - Tampa | Tampa | Florida | 33625 | — |
| Metabolic Research Institute, Inc. | West Palm Beach | Florida | 33401 | — |
| Encore Medical Research - Weston | Weston | Florida | 33331 | — |
| Conquest Research | Winter Park | Florida | 32789 | — |
| Balanced Life Health Care Solutions/SKYCRNG | Lawrenceville | Georgia | 30046 | — |
| The Jones Center Clinical Research | Macon | Georgia | 31210 | — |
| Clinical Research Atlanta | Stockbridge | Georgia | 30281 | — |
| Rophe Adult and Pediatric Medicine/SKYCRNG | Union City | Georgia | 30291 | — |
| North Georgia Clinical Research | Woodstock | Georgia | 30189 | — |
| Elite Clinical Trials | Blackfoot | Idaho | 83221 | — |
| Saltzer Health | Nampa | Idaho | 83686 | — |
| Elite Clinical Trials | Rexburg | Idaho | 83440 | — |
| Great Lakes Clinical Trials - Ravenswood | Chicago | Illinois | 60640 | — |
| Midwest CRC | Crystal Lake | Illinois | 60012 | — |
| AMR Clinical | Oak Brook | Illinois | 60523 | — |
| NorthShore University Health System | Skokie | Illinois | 60077 | — |
| American Health Network of Indiana, LLC - Avon | Avon | Indiana | 46123 | — |
| Investigators Research Group | Brownsburg | Indiana | 46112 | — |
| Qualmedica Research, LLC | Evansville | Indiana | 47715 | — |
| American Health Network of Indiana, LLC - Franklin | Franklin | Indiana | 46131 | — |
| American Health Network of Indiana, LLC - Greenfield | Greenfield | Indiana | 46140 | — |
| American Health Network of Indiana, LLC - Muncie | Muncie | Indiana | 47304 | — |
| University of Iowa | Iowa City | Iowa | 52242 | — |
| Iowa Diabetes and Endocrinology Research Center | West Des Moines | Iowa | 50265 | — |
| Alliance for Multispecialty Research, LLC | Newton | Kansas | 67114 | — |
| Cotton O'Neil Diabetes & Endocrinology | Topeka | Kansas | 66606 | — |
| Cotton O'Neil Mulvane | Topeka | Kansas | 66606 | — |
| Qualmedica Research | Bowling Green | Kentucky | 42101 | — |
| L-MARC Research Center | Louisville | Kentucky | 40213 | — |
| Louisiana Heart Center - Convington | Covington | Louisiana | 70433 | — |
| Care Access - Lake Charles (Bayou Pines) | Lake Charles | Louisiana | 70601 | — |
| Alliance for Multispecialty Research, LLC | New Orleans | Louisiana | 70119 | — |
| Maryland Cardiovascular Specialists | Baltimore | Maryland | 21229 | — |
| Endocrine and Metabolic Consultants | Rockville | Maryland | 20852 | — |
| ActivMed Practices and Research | Methuen | Massachusetts | 01844 | — |
| Revival Research Institute | Dearborn | Michigan | 48126 | — |
| Arcturus Healthcare , PLC, Troy Internal Medicine Research Division | Troy | Michigan | 48098 | — |
| SKY Clinical Research Network Group - Hall | Fayette | Mississippi | 39069 | — |
| SKY Integrative Medical Center/SKYCRNG | Ridgeland | Mississippi | 39157 | — |
| Clinical Research Professionals | Chesterfield | Missouri | 63005 | — |
| Diabetes and Endocrinology Specialists | Chesterfield | Missouri | 63017 | — |
| StudyMetrix Research | City of Saint Peters | Missouri | 63303 | — |
| Clinvest Research LLC | Springfield | Missouri | 65807 | — |
| Logan Health Research | Kalispell | Montana | 59901 | — |
| Montana Medical Research | Missoula | Montana | 59808 | — |
| Sierra Clinical Research | Las Vegas | Nevada | 89106 | — |
| Las Vegas Medical Research | Las Vegas | Nevada | 89128 | — |
| Palm Research Center Tenaya | Las Vegas | Nevada | 89128 | — |
| Palm Research Center Sunset | Las Vegas | Nevada | 89148 | — |
| Northern Nevada Endocrinology | Reno | Nevada | 89511 | — |
| Renown South Meadows Medical Center | Reno | Nevada | 89521 | — |
| UniMed Center | East Brunswick | New Jersey | 08816 | — |
| IMA Clinical Research | Albuquerque | New Mexico | 87109 | — |
| Albany Stratton VA Medical Center | Albany | New York | 12208 | — |
| Meridian Clinical Research, LLC | Binghamton | New York | 13905 | — |
| SUNY Downstate Health Sciences University | Brooklyn | New York | 11203 | — |
| Velocity Clinical Research, Syracuse | East Syracuse | New York | 13057 | — |
| IMA Clinical Research Westchester | Hartsdale | New York | 10530 | — |
| NYC Research INC | Long Island City | New York | 11106 | — |
| Mid Hudson Medical Research | New Windsor | New York | 12553 | — |
| IMA Clinical Research Manhattan | New York | New York | 10036 | — |
| University of North Carolina Medical Center | Chapel Hill | North Carolina | 27514 | — |
| Care Access - Fayetteville | Fayetteville | North Carolina | 28314 | — |
| PharmQuest Life Sciences, LLC | Greensboro | North Carolina | 27408 | — |
| Lucas Research, Inc | Morehead City | North Carolina | 28557 | — |
| Carolina Research Center | Shelby | North Carolina | 28150 | — |
| Accellacare - Piedmont | Statesville | North Carolina | 28625 | — |
| Accellacare - Wilmington - 1917 Tradd Court | Wilmington | North Carolina | 28401 | — |
| Lillestol Research | Fargo | North Dakota | 58104 | — |
| Centricity Research Columbus Ohio Multispecialty | Columbus | Ohio | 43213 | — |
| Remington-Davis, Inc | Columbus | Ohio | 43215 | — |
| Tekton Research, Inc | Moore | Oklahoma | 73160 | — |
| Central States Research | Tulsa | Oklahoma | 74136 | — |
| Northwest Research Center | Portland | Oregon | 97202 | — |
| Heritage Valley Medical Group, Inc. | Beaver | Pennsylvania | 15009 | — |
| Capital Area Research - Newport | Newport | Pennsylvania | 17074 | — |
| Clinical Research of Philadelphia | Philadelphia | Pennsylvania | 19114 | — |
| Preferred Primary Care Physicians, Preferred Clinical Research-St. Clair | Pittsburgh | Pennsylvania | 15243 | — |
| Preferred Primary Care Physicians | Uniontown | Pennsylvania | 15401 | — |
| The Research Center of The Upstate | Greenville | South Carolina | 29607 | — |
| Care Access - Mauldin | Mauldin | South Carolina | 29662 | — |
| Alliance for Multispecialty Research, LLC | Knoxville | Tennessee | 37909 | — |
| New Phase Research and Development | Knoxville | Tennessee | 37909 | — |
| Tennessee Center for Clinical Trials | Tullahoma | Tennessee | 37388 | — |
| Texas Diabetes & Endocrinology, P.A. | Austin | Texas | 78749 | — |
| South Texas Clinical Research | Corpus Christi | Texas | 78404 | — |
| Thyroid, Endocrinology, and Diabetes | Dallas | Texas | 75208 | — |
| Velocity Clinical Research, Dallas | Dallas | Texas | 75230 | — |
| Cardio Voyage | Denison | Texas | 75020 | — |
| Soma Clinical Trials | Denison | Texas | 75020 | — |
| Care United Research | Forney | Texas | 75126 | — |
| Diabetes and Thyroid Center of Ft. Worth | Fort Worth | Texas | 76132 | — |
| Valley Institute of Research - Fort Worth | Fort Worth | Texas | 76164 | — |
| Victorium Clinical Research - Houston | Houston | Texas | 77024 | — |
| Juno Research | Houston | Texas | 77040 | — |
| Biopharma Informatic, LLC | Houston | Texas | 77043 | — |
| Endocrine Ips, Pllc | Houston | Texas | 77079 | — |
| Research Physicians Network, LLC | Houston | Texas | 77089 | — |
| Biopharma Informatic, LLC | McAllen | Texas | 78503 | — |
| Southern Endocrinology Associates | Mesquite | Texas | 75149 | — |
| Texas Diabetes & Endocrinology, P.A. | Round Rock | Texas | 78681 | — |
| Audie L Murphy VA Hospital | San Antonio | Texas | 78229 | — |
| Clinical Trials of Texas, LLC | San Antonio | Texas | 78229 | — |
| VIP Trials | San Antonio | Texas | 78230 | — |
| Consano Clinical Research, LLC | Shavano Park | Texas | 78231 | — |
| Sherman Clinical Research | Sherman | Texas | 75090 | — |
| Northwest Houston Heart Center | Tomball | Texas | 77375 | — |
| Texas Valley Clinical Research | Weslaco | Texas | 78596 | — |
| Soma Clinical Trials | Wylie | Texas | 75098 | — |
| Wasatch Clinical Research, LLC | Salt Lake City | Utah | 84107 | — |
| Chrysalis Clinical Research | St. George | Utah | 84790 | — |
| Velocity Clinical Research, Salt Lake City | West Jordan | Utah | 84088 | — |
| Kalo Clinical Research | West Valley City | Utah | 84120 | — |
| Manassas Clinical Research Center | Manassas | Virginia | 20110 | — |
| Virginia Research Center | Midlothian | Virginia | 23114 | — |
| Eastern Virginia Medical School (EVMS) Strelitz Diabetes Research Center | Norfolk | Virginia | 23510 | — |
| Centricity Research Suffolk Family Medicine | Suffolk | Virginia | 23435 | — |
| Eastside Research Associates | Redmond | Washington | 98052 | — |
| MultiCare Rockwood Clinic- Main | Spokane | Washington | 99202 | — |
| Universal Research Group | Tacoma | Washington | 98405 | — |
| St. Vincent Hospital d/b/a Prevea Health | Green Bay | Wisconsin | 54303 | — |
| Clinical Investigation Specialists | Kenosha | Wisconsin | 53144 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 185 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05803421, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 17, 2026 · Synced Oct 24, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05803421 live on ClinicalTrials.gov.