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Showing 25–46 of 22 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Adverse Childhood Experience Clear all
Completed Not applicable Interventional Accepts healthy volunteers

The Building Resilience Program: Examining Self-Regulation, Behavior, and Resilience in Under-Resourced Preschoolers With ACEs

NCT07170605
View directory record Official record
Conditions
Preschool Age Children, Preschool Education, Adverse Childhood Experience, Mental Health, Resilience, Minority Groups
Interventions
Mental health, positive coping strategies promoting self-regulation and adaptive skills, Standard care/School Readiness Condition
Behavioral · Other
Lead sponsor
Cleveland State University
Other
Eligibility
24 Months to 66 Months
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 11, 2025 · Synced Jul 22, 2026, 3:58 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Relationship of Adverse Childhood Experiences to Overweight and Obesity

NCT00632346
View directory record Official record
Conditions
Overweight, Obesity
Interventions
Not listed
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years to 23 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 9, 2008 · Synced Jul 22, 2026, 3:58 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

ACE, Resilience, and Substance Use Disorder: Maternal and Baby Outcomes in the First Year of Life

NCT05731557
View directory record Official record
Conditions
Adverse Childhood Experiences
Interventions
Not listed
Lead sponsor
The Cooper Health System
Other
Eligibility
18 Years and older · Female only
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
Camden, New Jersey
Source: ClinicalTrials.gov public record
Updated Oct 14, 2024 · Synced Jul 22, 2026, 3:58 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Impact of an Adapted Version of the Strengthening Families Program on IPV Among Caregivers and ACEs Among Children

NCT05129501
View directory record Official record
Conditions
Adverse Childhood Experiences, Domestic Violence
Interventions
Experimental
Behavioral
Lead sponsor
University of Nebraska Lincoln
Other
Eligibility
10 Years and older
Enrollment
318 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Rapid City, South Dakota
Source: ClinicalTrials.gov public record
Updated Feb 4, 2025 · Synced Jul 22, 2026, 3:58 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The THRIVE Study: Teaching Healthy Regulation in Individuals & Vulnerable Environments

NCT06821035
View directory record Official record
Conditions
Adverse Childhood Experiences, Family Functioning
Interventions
Garnering Resilience in Traumatized youth and families (GRIT), Digital Citizenship Curriculum (DCC)
Behavioral
Lead sponsor
University of California, Irvine
Other
Eligibility
11 Years to 14 Years
Enrollment
210 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Jul 22, 2026, 3:58 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Childhood Trauma, Exercise, and Cognition

NCT05972265
View directory record Official record
Conditions
Adverse Childhood Experiences
Interventions
Moderate Intensity Exercise (one day), Placebo - Light Intensity Exercise (one day), Moderate Intensity Exercise (9 wks), Day 1 Assessments, Symptom Measures and Neuropsychological Tests, Day 36 Assessments, Day 57 Assessments, Day 78 Assessments
Behavioral · Other
Lead sponsor
University of Texas at Austin
Other
Eligibility
40 Years to 60 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Jul 22, 2026, 3:58 PM EDT
Not listed Phase 2 Interventional Accepts healthy volunteers

Evaluation of the Building Healthy Life Skills Program

NCT05611060
View directory record Official record
Conditions
Adverse Childhood Experiences, Housing Problems, Emotion Regulation
Interventions
Building Healthy Life Skills Program
Behavioral
Lead sponsor
University of California, Merced
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Merced, California
Source: ClinicalTrials.gov public record
Updated Nov 8, 2022 · Synced Jul 22, 2026, 3:58 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

ACEs, SIRT1, and Premature Vascular Aging in Humans

NCT07073352
View directory record Official record
Conditions
Adverse Childhood Experiences, Endothelial Dysfunction
Interventions
Nicotinamide Riboside, Placebo
Dietary Supplement
Lead sponsor
Nathaniel Jenkins
Other
Eligibility
18 Years to 30 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 17, 2025 · Synced Jul 22, 2026, 3:58 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Probing the Role of Mitochondrial Oxidative Stress in Impaired Vascular Function Among Young Adults With Early Life Adversity

NCT07244809
View directory record Official record
Conditions
Adverse Childhood Experience, Endothelial Function (FMD), Endothelial Injury, Mitochondrial Function, Oxidative Stress, Psychosocial Influence on Cardiovascular Disease
Interventions
Mitoquinone mesylate (MitoQ), Placebo
Dietary Supplement
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 29 Years
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Nov 23, 2025 · Synced Jul 22, 2026, 3:58 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Resilience Clinic Evaluation

NCT05690256
View directory record Official record
Conditions
Early Life Adversity, Caregiver Stress
Interventions
Resilience Clinic, Enhanced primary care
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
2 Years to 5 Years
Enrollment
87 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
4
States / cities
Oakland, California • San Leandro, California
Source: ClinicalTrials.gov public record
Updated Jul 9, 2025 · Synced Jul 22, 2026, 3:58 PM EDT
Completed Not applicable Interventional

Brief Intervention for Chronic Pain and History of Stressful Experiences

NCT06983327
View directory record Official record
Conditions
Chronic Pain, Trauma, Adverse Childhood Experiences
Interventions
Trauma Focused Emotional Awareness and Expression Therapy (EAET)
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
21 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Chestnut Hill, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Jul 22, 2026, 3:58 PM EDT
Active, not recruiting Not applicable Interventional

Playing Playfully to Overcome Adversity

NCT06985017
View directory record Official record
Conditions
Adverse Childhood Experiences
Interventions
Playing Playfully to Overcome Adversity
Behavioral
Lead sponsor
Sacred Heart University
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Fairfield, Connecticut
Source: ClinicalTrials.gov public record
Updated May 21, 2025 · Synced Jul 22, 2026, 3:58 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Iowa ACEs and Sleep Cohort and Manipulating Sleep in Young Adults With ACEs Studies

NCT06454344
View directory record Official record
Conditions
Adverse Childhood Experiences, Vascular Dilatation, Sleep, Sleep Disturbance, Psychosocial Stressor, Psychological Trauma, Endothelial Dysfunction, Inflammation, Oxidative Stress
Interventions
Cognitive Behavioral Therapy for Insomnia (CBT-i)
Behavioral
Lead sponsor
Nathaniel Jenkins
Other
Eligibility
18 Years to 29 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Dec 10, 2025 · Synced Jul 22, 2026, 3:58 PM EDT
Completed Not applicable Interventional

Life Experiences in Adolescents and the Development of Skills

NCT04719897
View directory record Official record
Conditions
Depression in Adolescence, Adverse Childhood Experiences
Interventions
FIRST: Repairing Thoughts
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
12 Years to 15 Years
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 12, 2025 · Synced Jul 22, 2026, 3:58 PM EDT
Completed Not applicable Interventional

Caregiver Adverse Childhood Experiences (ACEs) in Pediatric Primary Care

NCT05013138
View directory record Official record
Conditions
Child Development
Interventions
Training for ACEs and study procedures, Training on study procedures
Behavioral
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
181 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Chamblee, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 13, 2025 · Synced Jul 22, 2026, 3:58 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Building Resilient Families

NCT05388864
View directory record Official record
Conditions
Adverse Childhood Experiences
Interventions
Three-Tier Model
Behavioral
Lead sponsor
Loma Linda University
Other
Eligibility
3 Years to 11 Years
Enrollment
340 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2028
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Jul 22, 2026, 3:58 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Today Not Tomorrow Pregnancy and Infant Support Program (TNT- PISP)

NCT04100577
View directory record Official record
Conditions
Infant Mortality, Infant Death, Racial Bias, Prenatal Stress, Prenatal Care, Maternal Child Health, Health Problems in Pregnancy, Adverse Childhood Experiences, Mental Health, Support Groups, Minority Health, Healthcare Disparities, Maternal-child Health Services, Social Determinants of Health, Trust, Physician-Patient Relations, Quality of Care
Interventions
Today Not Tomorrrow Pregnancy and Infant Support Program
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 99 Years · Female only
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Sep 13, 2022 · Synced Jul 22, 2026, 3:58 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Adverse Childhood Experiences in Urogynecologic Patients

NCT03480477
View directory record Official record
Conditions
Pelvic Floor Disorders, Interstitial Cystitis, Urinary Incontinence
Interventions
ACE questionnaire
Other
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older · Female only
Enrollment
356 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Feb 8, 2024 · Synced Jul 22, 2026, 3:58 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Testing a Scalable Model For ACEs-Related Care Navigation

NCT05567250
View directory record Official record
Conditions
Adverse Childhood Experiences, Child Development
Interventions
Behavioral: Telephone-based ACEs care coordination
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
Up to 11 Years
Enrollment
102 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 13, 2024 · Synced Jul 22, 2026, 3:58 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

BLOOM: Boldly Living outdOOrs for Mental Health

NCT05973123
View directory record Official record
Conditions
Anxiety, Stress Disorder, Posttraumatic, Loneliness, Adverse Childhood Experiences
Interventions
Group Nature Outings, Family Outings
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
9 Years to 12 Years
Enrollment
126 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Oakland, California
Source: ClinicalTrials.gov public record
Updated Aug 27, 2023 · Synced Jul 22, 2026, 3:58 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Building Wealth and Health Network: A Microfinance/TANF Demonstration Project

NCT02577705
View directory record Official record
Conditions
Hunger, Child Development, Social Isolation
Interventions
Self Empowerment Groups, Financial Empowerment, Matched Savings
Behavioral
Lead sponsor
Center for Hunger-Free Communities
Other
Eligibility
18 Years and older
Enrollment
145 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 31, 2017 · Synced Jul 22, 2026, 3:58 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Examine the Effects of Meditation on Daily Psychological Stress Responses in Woman With a History of Child Adversity

NCT04606199
View directory record Official record
Conditions
Stress, Psychological Stress, Child Maltreatment, Depressive Symptoms, Signs and Symptoms, Psychological Distress, Psychological
Interventions
Mindfulness-based intervention, up to 5 minutes 0-3 times/day
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
30 Years to 60 Years · Female only
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 3, 2025 · Synced Jul 22, 2026, 3:58 PM EDT