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Showing 1–24 of 122 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Affective Symptoms Clear all
Terminated Phase 2 Interventional Results available

Double-Blind Placebo-Controlled Trial of Riluzole in Pediatric Bipolar Disorder

NCT00805493
View directory record Official record
Conditions
Bipolar Disorder, Anxiety Disorders, Bipolar Affective Disorder, Bipolar Depression
Interventions
Riluzole
Drug
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
9 Years to 17 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 14, 2017 · Synced Jul 22, 2026, 12:50 AM EDT
Completed Phase 4 Interventional Results available

Tachyphylaxis, Tolerance, & Withdrawal Post Treatment With Igalmi for Agitation in Schizophrenia or Bipolar Disorder

NCT06041646
View directory record Official record
Conditions
Bipolar Disorder, Schizophrenia, Agitation,Psychomotor, Schizo Affective Disorder, Schizophreniform Disorders
Interventions
Sublingual film containing Igalmi
Drug
Lead sponsor
BioXcel Therapeutics Inc
Industry
Eligibility
18 Years to 65 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
2
States / cities
Little Rock, Arkansas • Rogers, Arkansas
Source: ClinicalTrials.gov public record
Updated Jan 1, 2026 · Synced Jul 22, 2026, 12:50 AM EDT
Recruiting Not applicable Interventional

Clinical Trial Comparing the Efficacy of Two Teletherapy Programs at Improving Psychological Health in People With Brain Injury

NCT07436754
View directory record Official record
Conditions
Mild Traumatic Brain Injury, Alexithymia
Interventions
Program 1, Program 2
Behavioral
Lead sponsor
Hackensack Meridian Health
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
3
States / cities
Indianapolis, Indiana • Bethesda, Maryland • Edison, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Jul 22, 2026, 12:50 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

The Menopause Transition: Estrogen Variability, Stress Reactivity and Mood

NCT03003949
View directory record Official record
Conditions
Perimenopausal Disorder, Stress, Emotional
Interventions
Estradiol Patch, 0.1 Mg/24 Hours Weekly Transdermal Film, Extended Release, Placebo Patch, Progesterone Capsule, Placebo Oral Capsule
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
45 Years to 60 Years · Female only
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
2
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 25, 2021 · Synced Jul 22, 2026, 12:50 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Reducing Caregiver Stress and Sleep Disturbances in Patients With Progressive Dementia

NCT00178568
View directory record Official record
Conditions
Sleep Disorders
Interventions
Stress Management and Healthy Sleep Practices
Behavioral
Lead sponsor
Kathy Kennedy
Other
Eligibility
60 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2009
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 27, 2015 · Synced Jul 22, 2026, 12:50 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Systematic Efficacy Replication Study of Conjoint Behavioral Consultation in Elementary Schools

NCT05466214
View directory record Official record
Conditions
Emotional Disturbances
Interventions
Conjoint Behavioral Consultation (CBC)
Behavioral
Lead sponsor
American Institutes for Research
Other
Eligibility
4 Years to 10 Years
Enrollment
720 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 8, 2023 · Synced Jul 22, 2026, 12:50 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Effect of Sleep Deprivation and Recovery Sleep on Emotional Memory and Affective Reactivity

NCT03767426
View directory record Official record
Conditions
Sleep Deprivation, Sleep
Interventions
Sleep Deprivation, Daytime nap
Behavioral
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years to 35 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 5, 2024 · Synced Jul 22, 2026, 12:50 AM EDT
Recruiting Phase 4 Interventional

Examining the Effects of Estradiol on Neural and Molecular Response to Reward

NCT05282277
View directory record Official record
Conditions
Depression, Psychosis, Anhedonia
Interventions
Transdermal Estradiol, Micronized Progesterone, Matching Placebo Patch, Raclopride C11
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
45 Years to 55 Years · Female only
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Jul 22, 2026, 12:50 AM EDT
Completed Phase 1 Interventional

Mindfulness-Oriented Recovery Enhancement for Chronic Pain Patients Receiving Opioid Therapy

NCT01505101
View directory record Official record
Conditions
Chronic Pain, Opioid Abuse, Unspecified Use
Interventions
Mindfulness-Oriented Recovery Enhancement, Conventional Support Group (SG)
Behavioral
Lead sponsor
Florida State University
Other
Eligibility
18 Years and older
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Aug 5, 2014 · Synced Jul 22, 2026, 12:50 AM EDT
Withdrawn Phase 2 Interventional Accepts healthy volunteers

Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder

NCT00327756
View directory record Official record
Conditions
Bipolar Affective Disorder, Depression
Interventions
Coenzyme Q10
Drug
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 65 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2006
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 22, 2011 · Synced Jul 22, 2026, 12:50 AM EDT
Completed Not applicable Interventional

Transdiagnostic Group Intervention for Children With Behavior Problems

NCT02794051
View directory record Official record
Conditions
Behavioral Symptoms, Emotional Disturbances
Interventions
Group Therapy
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
8 Years to 12 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 28, 2016 · Synced Jul 22, 2026, 12:50 AM EDT
Terminated Phase 4 Interventional

Use of Risperidone in ECT for Treatment Resistant Depression

NCT00203723
View directory record Official record
Conditions
Major Depression
Interventions
Risperidone
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 89 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 17, 2006 · Synced Jul 22, 2026, 12:50 AM EDT
Completed Phase 2 Interventional

An Investigation of the Antidepressant Efficacy of the 5-HT2A Antagonist, M100907, in Combination With Citalopram in Treatment Resistant Depression

NCT00070694
View directory record Official record
Conditions
Depressive Disorder
Interventions
MDL100.907
Drug
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
Not listed
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2004
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Jul 22, 2026, 12:50 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

eMOTION: Examining Implicit Attitudes in Physical Activity Engagement

NCT07044570
View directory record Official record
Conditions
Physical Activity, Overweight or Obesity, Cancer
Interventions
Physical Activity Goals mHealth Intervention, TYPE/CONTEXT enhancement, SAVOR enhancement
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Nov 2, 2025 · Synced Jul 22, 2026, 12:50 AM EDT
Completed Not applicable Interventional

Testing an Alternative Therapy for Bulimia Nervosa

NCT00773617
View directory record Official record
Conditions
Eating Disorders
Interventions
ICAT, CBT
Behavioral
Lead sponsor
Neuropsychiatric Research Institute, Fargo, North Dakota
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
2
States / cities
Minneapolis, Minnesota • Fargo, North Dakota
Source: ClinicalTrials.gov public record
Updated Mar 28, 2018 · Synced Jul 22, 2026, 12:50 AM EDT
Completed Not applicable Interventional

Integrative Cognitive-Affective Therapy for Adolescent Eating Disorders

NCT03324724
View directory record Official record
Conditions
Eating Disorder, Emotional Disorder
Interventions
Integrative cognitive-affective therapy for adolescents (ICAT-A)
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
14 Years to 20 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 5, 2022 · Synced Jul 22, 2026, 12:50 AM EDT
Terminated Not applicable Interventional Results available

Ceftriaxone in the Management of Bipolar Depression

NCT00566111
View directory record Official record
Conditions
Bipolar Depression
Interventions
ceftriaxone, Saline solution
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 30, 2020 · Synced Jul 22, 2026, 12:50 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Perimenopausal Effects of Estradiol on Reward Responsiveness

NCT02255175
View directory record Official record
Conditions
Perimenopausal Depression
Interventions
Estradiol, Progesterone
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
44 Years to 55 Years · Female only
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 11, 2019 · Synced Jul 22, 2026, 12:50 AM EDT
Completed Not applicable Interventional

Affect Treatment for Depression and Anxiety (TAD Pilot)

NCT06488859
View directory record Official record
Conditions
Depression, Anxiety
Interventions
Positive Affect Treatment, Positive Affect Treatment and Negative Affect Treatment
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
2
States / cities
Los Angeles, California • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated May 10, 2025 · Synced Jul 22, 2026, 12:50 AM EDT
Completed Not applicable Interventional

Building Emotional Self-Awareness Teletherapy (BEST)

NCT05623046
View directory record Official record
Conditions
Concussion, Mild, Concussion, Brain, Concussion, Severe, Concussion, Intermediate, Concussion; Syndrome, Concussion Injury of Cerebrum, Concussion with Brief Loss of Consciousness, Alexithymia
Interventions
Treatment
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 31, 2025 · Synced Jul 22, 2026, 12:50 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Neural and Psychological Mechanisms of Pain Perception

NCT02446262
View directory record Official record
Conditions
Pain, Normal Physiology, Healthy Volunteers
Interventions
Instructions, Attention, Thermal Pain, Placebo instructions
Behavioral
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
18 Years to 50 Years
Enrollment
550 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2027
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Jul 22, 2026, 12:50 AM EDT
Completed Not applicable Interventional Results available

Targeting Auditory Hallucinations With Alternating Current Stimulation

NCT03221270
View directory record Official record
Conditions
Schizophrenia, Schizo Affective Disorder
Interventions
tACS treatment week, tACS sham week, Maintenance tACS, Maintenance Sham tACS
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 70 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 15, 2022 · Synced Jul 22, 2026, 12:50 AM EDT
Completed Not applicable Interventional

Training to Reconnect With Emotional Awareness Therapy

NCT03414463
View directory record Official record
Conditions
Traumatic Brain Injury, Alexithymia
Interventions
TREAT
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated May 19, 2024 · Synced Jul 22, 2026, 12:50 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Neurophysiology, Estrogen, and Stress Exposure in the Emergence of Depression in Adolescent Girls

NCT03450135
View directory record Official record
Conditions
Adolescent Development, Stress, Emotional Disturbances
Interventions
Trier Social Stress Test, Emotional go/no-go task
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
11 Years to 14 Years · Female only
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 23, 2020 · Synced Jul 22, 2026, 12:50 AM EDT