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ClinicalTrials.gov public records Last synced Oct 2, 2026, 7:52 PM EDT

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Showing 25–48 of 988 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Alcohol or Other Drugs Use Clear all
Completed Not applicable Interventional

Promoting Caregiver-child Attachment and Recovery Through Early Intervention (pCARE): A Pilot Randomized Control Trial

NCT04675099
View directory record Official record
Conditions
Opioid-use Disorder, Substance Use Disorders, Parenting
Interventions
pCARE, Standard Early Intervention services
Behavioral · Other
Lead sponsor
Baystate Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Springfield, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 6, 2024 · Synced Oct 2, 2026, 7:52 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

First Years Away From Home: Letting Go and Staying Connected

NCT03227809
View directory record Official record
Conditions
Substance Abuse, Risk Reduction, RIsky Sexual Behavior
Interventions
Handbook condition, Handbook plus condition
Behavioral
Lead sponsor
Washington State University
Other
Eligibility
17 Years to 22 Years
Enrollment
910 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Pullman, Washington
Source: ClinicalTrials.gov public record
Updated May 19, 2020 · Synced Oct 2, 2026, 7:52 PM EDT
Recruiting Not applicable Interventional

EXPANDED SCOPE for Parent Grant Entitled, "Peer Recovery Support Services for Individuals in Recovery Residences on MOUD"

NCT06696157
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
PRSS intervention for MOUD initiation
Behavioral
Lead sponsor
Potomac Health Foundations
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 4, 2025 · Synced Oct 2, 2026, 7:52 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

A Trial of Connecting to Promote Foster Teen Well-Being

NCT03157895
View directory record Official record
Conditions
Relationship, Family (Foster), Substance Use Prevention
Interventions
Connecting
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
11 Years to 15 Years
Enrollment
220 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jul 31, 2019 · Synced Oct 2, 2026, 7:52 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Connecting Loved Ones to Support and Empowering Recovery

NCT07740395
View directory record Official record
Conditions
Substance Use Disorder (SUD), mHealth
Interventions
KulaMind-Recovery
Behavioral
Lead sponsor
Rhode Island Hospital
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Oct 2, 2026, 7:52 PM EDT
Completed Not applicable Interventional

RETAIN: Retaining Opioid Users Entering Medication Assisted Treatment and Encouraging HCV/HIV Testing

NCT03411265
View directory record Official record
Conditions
Opioid-Related Disorders, Opioid-use Disorder, Drug Addiction, Substance Use Disorders
Interventions
self-administered, e-health application
Other
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 10, 2019 · Synced Oct 2, 2026, 7:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

NOLA GEM: Feasibility and Acceptability of an MHealth Intervention for Violence-affected PLWH

NCT05784714
View directory record Official record
Conditions
HIV, Mental Health, Substance Use
Interventions
NOLA GEM
Behavioral
Lead sponsor
Tulane University
Other
Eligibility
18 Years to 65 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
4
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Dec 17, 2024 · Synced Oct 2, 2026, 7:52 PM EDT
Not listed Phase 4 Interventional

Buprenorphine and Integrated HIV Care Evaluation

NCT00124358
View directory record Official record
Conditions
Opioid-Related Disorders, HIV Infections, AIDS
Interventions
Buprenorphine, Integrated HIV care and office-based opioid dependence treatment
Drug · Behavioral
Lead sponsor
The New York Academy of Medicine
Other
Eligibility
18 Years and older
Enrollment
1,350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
10
States / cities
Tucson, Arizona • Oakland, California • San Francisco, California + 7 more
Source: ClinicalTrials.gov public record
Updated Mar 27, 2007 · Synced Oct 2, 2026, 7:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Increasing Linkage to Family Planning Care for Individuals With Substance Use Disorder

NCT04162184
View directory record Official record
Conditions
Family Planning Services, Substance-Related Disorders, Opiate Substitution Treatment, Sexual Health
Interventions
Sexual Health Initiative for Navigation and Education (SHINE) Health Educator Intervention
Behavioral
Lead sponsor
Denver Health and Hospital Authority
Other
Eligibility
18 Years to 44 Years
Enrollment
199 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 12, 2024 · Synced Oct 2, 2026, 7:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Adaptation Processes in School-based Substance Abuse Prevention

NCT02715206
View directory record Official record
Conditions
Substance Abuse Problem
Interventions
keepin' it REAL classic, keepin' it REAL rural, control
Behavioral
Lead sponsor
Penn State University
Other
Eligibility
11 Years to 15 Years
Enrollment
2,827 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2015
U.S. locations
2
States / cities
Columbus, Ohio • University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 20, 2017 · Synced Oct 2, 2026, 7:52 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

The STop UNhealthy Substance Use Now Trial

NCT06524232
View directory record Official record
Conditions
Risky Health Behavior, Substance Use Disorders, Substance Abuse, Alcohol Use Disorder, Drinking, Alcohol, Substance Use
Interventions
Practice Facilitation (PF), Learning Collaborative (LC), Performance Incentives (PI)
Other
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
144 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
3
States / cities
Cincinnati, Ohio • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 25, 2026 · Synced Oct 2, 2026, 7:52 PM EDT
Active, not recruiting Not applicable Interventional Results available

Addressing Barriers to Care for Substance Use Disorder Pilot Study

NCT06317987
View directory record Official record
Conditions
Drug Use Disorders, Illicit Drug Use, Alcohol-Related Disorders
Interventions
Care Navigation
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jul 31, 2026 · Synced Oct 2, 2026, 7:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Drug Abuse Prevention Among Girls Through a Mother-Daughter Intervention

NCT01236248
View directory record Official record
Conditions
Substance Use
Interventions
Prevention
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
11 Years to 13 Years · Female only
Enrollment
916 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 18, 2017 · Synced Oct 2, 2026, 7:52 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Train Your Brain 2.0 - Improving Memory and Decision Making Among Youth

NCT06242704
View directory record Official record
Conditions
Behavior, Health
Interventions
Working Memory Training, Working Memory
Behavioral
Lead sponsor
Wayne State University
Other
Eligibility
11 Years and older
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
2
States / cities
Flint, Michigan • Highland Park, Michigan
Source: ClinicalTrials.gov public record
Updated May 25, 2025 · Synced Oct 2, 2026, 7:52 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Prazosin and Naltrexone (PaN) Study for Veterans With Alcohol Use Disorders

NCT02322047
View directory record Official record
Conditions
Alcohol Use Disorder, Posttraumatic Stress Disorder (PTSD)
Interventions
Prazosin, Naltrexone, Placebo (Prazosin), Placebo (Naltrexone)
Drug
Lead sponsor
Seattle Institute for Biomedical and Clinical Research
Other
Eligibility
18 Years to 80 Years
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Dec 29, 2020 · Synced Oct 2, 2026, 7:52 PM EDT
Completed Not applicable Interventional

Trial of a Novel Cognitive-Behavioral Treatment for Posttraumatic Stress and Substance Dependence

NCT02461732
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Substance Dependence
Interventions
Treatment for Integrated Posttraumatic Stress and Substance Use (TIPSS), Cognitive-Behavioral Therapy for Substance Dependence
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 10, 2017 · Synced Oct 2, 2026, 7:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Remotely Delivered Programs Targeting COVID-19 Stress-Related Depression and Substance Use

NCT04595084
View directory record Official record
Conditions
Depression, Anxiety, Substance Use, Stress, Psychological, Stress, Emotional, Alcohol Use, Unspecified, Drug Use, Covid19
Interventions
Mindfulness Based Cognitive Therapy for Resilience During COVID-19 plus CHAMindWell, Internet Cognitive Behavioral Therapy plus CHAMindWell, CHAMindWell
Behavioral
Lead sponsor
Cambridge Health Alliance
Other
Eligibility
18 Years to 70 Years
Enrollment
113 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Oct 2, 2026, 7:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Tobacco, Alcohol, Prescription Medication and Other Substances Tool

NCT02110693
View directory record Official record
Conditions
Substance Use Disorder
Interventions
Interviewer and tablet administration of the TAPS Tool
Other
Lead sponsor
Friends Research Institute, Inc.
Other
Eligibility
18 Years and older
Enrollment
2,057 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
4
States / cities
Baltimore, Maryland • New York, New York • Kannapolis, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 26, 2018 · Synced Oct 2, 2026, 7:52 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Entolimod, an Adjuvant for Vaccine Augmentation

NCT03063736
View directory record Official record
Conditions
Substance Use Disorders
Interventions
Entolimod, Td Vaccine
Drug · Biological
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 40 Years · Male only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 1, 2020 · Synced Oct 2, 2026, 7:52 PM EDT
Active, not recruiting Not applicable Interventional

Recovery Finance: Financial Health and Mental Health After Incarceration

NCT06914856
View directory record Official record
Conditions
Financial Hardship, Mental Health Issue, Substance Use
Interventions
Financial Capability Support with Peer Support Services
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
238 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Oct 2, 2026, 7:52 PM EDT
Completed Phase 2 Interventional Results available

UH3 Varenicline for Cannabis Use Disorder

NCT03980561
View directory record Official record
Conditions
Cannabis Use Disorder
Interventions
Varenicline, Placebo
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
174 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
2
States / cities
Charleston, South Carolina • Pickens, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 18, 2024 · Synced Oct 2, 2026, 7:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Community Reinforcement and Family Training for Early Psychosis (CRAFT-EP) and Substance Use: A Pilot Study

NCT05380583
View directory record Official record
Conditions
Psychosis, Substance Use, Substance Use Disorders, Family, Cannabis, Marijuana, Alcohol, Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Mental Disorder
Interventions
CRAFT-EP, TAU
Behavioral
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
65 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 27, 2026 · Synced Oct 2, 2026, 7:52 PM EDT
Recruiting Not applicable Interventional

A Randomized Clinical Trial of a Novel Drug Education and Diversion Program (iDECIDE) for Middle and High School Students

NCT06115746
View directory record Official record
Conditions
Substance Use, Harm Reduction, Adolescent Behavior
Interventions
iDECIDE
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
9 Years to 22 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 30, 2025 · Synced Oct 2, 2026, 7:52 PM EDT
Completed Not applicable Interventional

OPTIONS: A Patient-Centered HIV Prevention Decision Aid for PrEP Uptake for Women With Substance Use in Treatment Settings

NCT03651453
View directory record Official record
Conditions
HIV Infections, Substance Abuse
Interventions
Decision aid, Standard care
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older · Female only
Enrollment
164 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 28, 2021 · Synced Oct 2, 2026, 7:52 PM EDT