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ClinicalTrials.gov public records Last synced Oct 21, 2026, 8:25 AM EDT

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Showing 1–24 of 75 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Altitude Clear all
Completed Phase 4 Interventional Accepts healthy volunteers

Effects of Naltrexone on Nocturnal Breathing Patterns at Altitude

NCT05037032
View directory record Official record
Conditions
Altitude, Sleep Apnea, Central
Interventions
Naltrexone Pill, Placebo
Drug
Lead sponsor
VA Loma Linda Health Care System
Federal
Eligibility
18 Years to 35 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Apr 26, 2023 · Synced Oct 21, 2026, 8:25 AM EDT
Recruiting Phase 1Phase 2 Interventional Accepts healthy volunteers

Advair HFA in Healthy and HAPE Predisposed Subjects

NCT06040268
View directory record Official record
Conditions
Altitude Edema
Interventions
Advair HFA, Placebo
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 50 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 22, 2025 · Synced Oct 21, 2026, 8:25 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Sickness Evaluation at Altitude With Acetazolamide at Relative Doses

NCT03828474
View directory record Official record
Conditions
Acute Mountain Sickness
Interventions
Acetazolamide Pill
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 75 Years
Enrollment
108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Bishop, California
Source: ClinicalTrials.gov public record
Updated Oct 22, 2019 · Synced Oct 21, 2026, 8:25 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Melatonin on Sleep, Ventilatory Control and Cognition at Altitude

NCT03588676
View directory record Official record
Conditions
Intermittent Hypoxia
Interventions
Melatonin, Placebo
Other
Lead sponsor
Robert L. Owens
Other
Eligibility
18 Years to 65 Years
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Aug 14, 2019 · Synced Oct 21, 2026, 8:25 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Protocol for the Evaluation of Dario™ BGMS Performance at Elevated Altitude

NCT02352298
View directory record Official record
Conditions
Diabetes
Interventions
Dario Blood Glucose Monitoring System, YSI Analyzer
Device
Lead sponsor
LabStyle Innovations Ltd.
Industry
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 9, 2017 · Synced Oct 21, 2026, 8:25 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Prevention of Altitude Illness With Non-steroidal Anti-inflammatory Study (PAINS)

NCT01171794
View directory record Official record
Conditions
Altitude Sickness
Interventions
Ibuprofen, Placebo
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 65 Years
Enrollment
89 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Dec 13, 2018 · Synced Oct 21, 2026, 8:25 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

The Effect of a Multi-strain Probiotic on Acclimatization to High Altitude

NCT06552806
View directory record Official record
Conditions
Probiotics
Interventions
SLAB51
Dietary Supplement
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 65 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
2
States / cities
Bishop, California • La Jolla, California
Source: ClinicalTrials.gov public record
Updated Aug 14, 2024 · Synced Oct 21, 2026, 8:25 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effects of Continuous Positive Airway Pressure on Peripheral Oxygen Saturation, Work of Breathing, and Exercise Tolerance at Altitude

NCT05971290
View directory record Official record
Conditions
Hypoxemia, Altitude Hypoxia
Interventions
Continuous positive airway pressure, Ambient air
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 70 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 2, 2023 · Synced Oct 21, 2026, 8:25 AM EDT
Active, not recruiting Phase 4 Interventional Accepts healthy volunteers

Pharmacological Countermeasures for High Altitude

NCT05300477
View directory record Official record
Conditions
Hypobaric Hypoxia
Interventions
Acetazolamide, Erythropoietin
Drug
Lead sponsor
United States Army Research Institute of Environmental Medicine
Federal
Eligibility
18 Years to 40 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Natick, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 26, 2025 · Synced Oct 21, 2026, 8:25 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Effect of Bosentan on Exercise Capacity at High Altitude

NCT00432978
View directory record Official record
Conditions
Altitude, Pulmonary Hypertension
Interventions
Bosentan administration
Drug
Lead sponsor
VA Loma Linda Health Care System
Federal
Eligibility
18 Years to 55 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Apr 18, 2007 · Synced Oct 21, 2026, 8:25 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Effect of Acetazolamide on Subclinical High-Altitude Pulmonary Edema Detected by Lung Ultrasonography

NCT03490916
View directory record Official record
Conditions
High Altitude Pulmonary Edema
Interventions
Acetazolamide, Placebo
Drug
Lead sponsor
Vincent Kan
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 10, 2019 · Synced Oct 21, 2026, 8:25 AM EDT
Active, not recruiting Early Phase 1 Interventional Accepts healthy volunteers

The Role of Acetazolamide in Mitigating Inflammation and Innate Immune Activation at High Altitude

NCT07517068
View directory record Official record
Conditions
Hypoxemia, Acute Mountain Sickness (AMS), Inflammation, Immune Response
Interventions
ACETAZOLAMIDE oral capsule, Placebo Arm
Drug · Device
Lead sponsor
University of California, Riverside
Other
Eligibility
18 Years to 65 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Riverside, California
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Oct 21, 2026, 8:25 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Breathing Training to Improve Human Performance at High Altitude

NCT03530163
View directory record Official record
Conditions
Mountain Sickness Acute
Interventions
Respiratory Muscle Training, Sham Breathing Training
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 45 Years · Male only
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 19, 2022 · Synced Oct 21, 2026, 8:25 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Breathing Training and Nitrate on Exercise at Simulated Altitude

NCT07216755
View directory record Official record
Conditions
Healthy Adults, Mechanical Ventilation Dependence, Hypoxia, Exercise Training, Exercise Intolerance, Dietary Supplement, Nitrate Supplementation, Inspiratory Muscle Training
Interventions
Respiratory Muscle Training (RMT), Sham Respiratory Muscle Training, Dietary Supplement: Beetroot Juice Concentrate, placebo beverage
Device · Dietary Supplement
Lead sponsor
Embry-Riddle Aeronautical University
Other
Eligibility
18 Years to 40 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Daytona Beach, Florida
Source: ClinicalTrials.gov public record
Updated Oct 15, 2025 · Synced Oct 21, 2026, 8:25 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Safety and Efficacy of T89 in Prevention and Treatment of Adults With Acute Mountain Sickness (AMS)

NCT03552263
View directory record Official record
Conditions
Acute Mountain Sickness (AMS)
Interventions
T89 capsule, Placebo capsule
Drug
Lead sponsor
Tasly Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 55 Years
Enrollment
132 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Nov 13, 2019 · Synced Oct 21, 2026, 8:25 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating the Utility of Continuous Positive Airway Pressure in the Treatment of High Altitude Pulmonary Edema

NCT04186598
View directory record Official record
Conditions
Continuous Positive Airway Pressure, High Altitude Pulmonary Edema
Interventions
CPAP mask system, Nifedipine 30 MG, CPAP mask system without PEEP
Device · Drug
Lead sponsor
CommonSpirit Health
Other
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Breckenridge, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 7, 2024 · Synced Oct 21, 2026, 8:25 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Altitude Sickness Prevention and Efficacy of Comparative Treatments

NCT02604173
View directory record Official record
Conditions
Acute Mountain Sickness
Interventions
Budesonide, Acetazolamide, Placebo
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 65 Years
Enrollment
103 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Bishop, California
Source: ClinicalTrials.gov public record
Updated Dec 12, 2018 · Synced Oct 21, 2026, 8:25 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Acetazolamide and Exercise Performance at Altitude

NCT03525561
View directory record Official record
Conditions
Hypoxia, Exercise Performance, Cognitive Function, Dexterity
Interventions
Acetazolamide Pill, Placebo pill
Drug
Lead sponsor
United States Army Research Institute of Environmental Medicine
Federal
Eligibility
18 Years to 45 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Natick, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 5, 2019 · Synced Oct 21, 2026, 8:25 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Creatine Supplementation At Simulated Altitude

NCT06489587
View directory record Official record
Conditions
Exercise Performance
Interventions
Placebo, Creatine
Dietary Supplement
Lead sponsor
California Polytechnic State University-San Luis Obispo
Other
Eligibility
18 Years to 40 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
San Luis Obispo, California
Source: ClinicalTrials.gov public record
Updated Jul 8, 2024 · Synced Oct 21, 2026, 8:25 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

High Altitude and Exogenous Carbohydrate Oxidation

NCT03851744
View directory record Official record
Conditions
Glucose Metabolism, High Altitude
Interventions
Sea Level, High Altitude
Other
Lead sponsor
United States Army Research Institute of Environmental Medicine
Federal
Eligibility
18 Years to 39 Years · Male only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Natick, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 2, 2021 · Synced Oct 21, 2026, 8:25 AM EDT
Recruiting Phase 1Phase 2 Interventional

A Study of Dara-RVd and Teclistamab-RVd in People With Multiple Myeloma

NCT07099391
View directory record Official record
Conditions
Multiple Myeloma
Interventions
Dara-RVd, Tec-RVd
Drug
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
7
States / cities
Basking Ridge, New Jersey • Middletown, New Jersey • Montvale, New Jersey + 4 more
Source: ClinicalTrials.gov public record
Updated Jul 28, 2026 · Synced Oct 21, 2026, 8:25 AM EDT
Completed Not applicable Interventional Results available

Use of NIRS in Preterm Population Born at Altitude

NCT04639583
View directory record Official record
Conditions
Prematurity; Extreme
Interventions
Near-infrared spectroscopy (NIRS) utilization
Device
Lead sponsor
University of New Mexico
Other
Eligibility
0 Hours to 24 Hours
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated May 29, 2024 · Synced Oct 21, 2026, 8:25 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Drug Combination on Exercise Performance at High Altitude

NCT01902758
View directory record Official record
Conditions
Acute Mountain Sickness
Interventions
ambrisentan and theophylline, placebo
Drug
Lead sponsor
University of Montana
Other
Eligibility
18 Years to 45 Years · Male only
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Missoula, Montana
Source: ClinicalTrials.gov public record
Updated Feb 26, 2016 · Synced Oct 21, 2026, 8:25 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Safety and Efficacy of T89 in the Prevention and Treatment of Adults With Acute Mountain Sickness (AMS)

NCT04993729
View directory record Official record
Conditions
Acute Mountain Sickness (AMS)
Interventions
T89 capsule, Placebo capsule
Drug
Lead sponsor
Tasly Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 55 Years
Enrollment
853 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 13, 2024 · Synced Oct 21, 2026, 8:25 AM EDT