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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Amputation of Knee Clear all
Completed Not applicable Interventional

The Effect of Ischemic Conditioning on Strength and Ambulation in Subjects with PAD

NCT04937179
View directory record Official record
Conditions
Peripheral Arterial Disease, Peripheral Vascular Disease, Amputation, Lower Limb Amputation Knee, Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Below Knee (Injury)
Interventions
Ischemic Conditioning Low - Sham Comparator, Ischemic Conditioning High - Active Comparator
Procedure
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 26, 2025 · Synced Jul 23, 2026, 10:54 AM EDT
Completed Not applicable Interventional Results available

An Investigation of Functional Improvements in the RHEO KNEE Compared to Hydraulic Microprocessor Controlled Knees (MPKs)

NCT04023578
View directory record Official record
Conditions
Prosthesis User, Amputation
Interventions
RHEO KNEE XC
Device
Lead sponsor
Össur Iceland ehf
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
4
States / cities
Orlando, Florida • Flowood, Mississippi • Fort Worth, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 5, 2020 · Synced Jul 23, 2026, 10:54 AM EDT
Recruiting Not applicable Interventional

Effects of Microprocessor-controlled Prosthetic Knees on Fall-related Health Outcomes in Limited Community Ambulators

NCT06937242
View directory record Official record
Conditions
Amputation, Prosthesis User, Amputation; Traumatic, Leg: Thigh, Between Hip and Knee, Limb; Absence, Congenital, Lower, Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Above Knee
Interventions
Ottobock C-Leg 4 Microprocessor Knee, Ottobock Kenevo
Device
Lead sponsor
Hanger Institute for Clinical Research and Education, LLC
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced Jul 23, 2026, 10:54 AM EDT
Not listed No phase listed Observational

Evaluation of High-Performance, Customized, Rapidly-Manufacturable Prosthetic Feet That Provide Improved Mobility

NCT05265403
View directory record Official record
Conditions
Amputation of Lower Limb Below Knee
Interventions
Commercially-available energy storage and return prosthetic foot, MIT-Lower Leg Trajectory Error (LLTE) customized prosthetic feet
Drug · Device
Lead sponsor
Massachusetts Institute of Technology
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 11, 2022 · Synced Jul 23, 2026, 10:54 AM EDT
Recruiting Not applicable Interventional

Restoration of Normative Postural Control

NCT06452186
View directory record Official record
Conditions
Lower Limb Amputation Below Knee (Injury)
Interventions
direct EMG controlled prosthetic ankle, PT guided prosthetic training
Device · Behavioral
Lead sponsor
North Carolina State University
Other
Eligibility
18 Years to 99 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Jul 23, 2026, 10:54 AM EDT
Recruiting Not applicable Interventional

Randomized Clinical Trial for Ewing Amputation in the VA

NCT05437562
View directory record Official record
Conditions
Peripheral Arterial Disease
Interventions
Ewing Below Knee Amputation, Standard Below Knee Amputation
Procedure
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
3
States / cities
Decatur, Georgia • Nashville, Tennessee • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 8, 2026 · Synced Jul 23, 2026, 10:54 AM EDT
Completed Not applicable Interventional Results available

Auto Control of Volume Management for Limb Loss

NCT03550118
View directory record Official record
Conditions
Lower Limb Amputation Below Knee (Injury)
Interventions
Adjustable socket
Device
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2022
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 2, 2023 · Synced Jul 23, 2026, 10:54 AM EDT
Active, not recruiting No phase listed Observational

C-STAR Movement Database

NCT05471375
View directory record Official record
Conditions
Stroke, Parkinson Disease, Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Below Knee (Injury)
Interventions
Database Entry
Other
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
Up to 99 Years
Enrollment
250 participants
Timeline
2022 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Jul 23, 2026, 10:54 AM EDT
Withdrawn No phase listed Observational

Comparing the Ultrasound Appearance of the Sciatic Nerve With Its Appearance Under a Microscope

NCT02384447
View directory record Official record
Conditions
Diabetes
Interventions
Not listed
Lead sponsor
University of Toledo Health Science Campus
Other
Eligibility
18 Years to 90 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Toledo, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 9, 2015 · Synced Jul 23, 2026, 10:54 AM EDT
Completed Not applicable Interventional Results available

Adherence and Perspiration While Wearing Lower Limb Prostheses

NCT03900845
View directory record Official record
Conditions
Lower Extremity Amputation
Interventions
Dynamic Air Exchange - Rising Edge Design (DAE-RED), Perforated elastomeric liner, As-prescribed prosthesis
Device
Lead sponsor
Seattle Institute for Biomedical and Clinical Research
Other
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Jul 23, 2026, 10:54 AM EDT
Completed Not applicable Interventional Results available

An Investigation on Function and Performance of a New Microprocessor Controlled Prosthetic Knee

NCT05523349
View directory record Official record
Conditions
Prosthesis User, Amputation
Interventions
NAVii
Device
Lead sponsor
Össur Iceland ehf
Industry
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
3
States / cities
Merrillville, Indiana • Bay City, Michigan • Perrysburg, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 1, 2026 · Synced Jul 23, 2026, 10:54 AM EDT
Completed Phase 1 Interventional

Effect of Socket Wall Height With Vacuum Suspension for Above Knee Amputees

NCT01559909
View directory record Official record
Conditions
Amputation
Interventions
Vacuum assisted socket technology (Harmony System, Otto Bock Healthcare)
Device
Lead sponsor
Stony Brook University
Other
Eligibility
21 Years to 75 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
2
States / cities
Stony Brook, New York • West Babylon, New York
Source: ClinicalTrials.gov public record
Updated May 11, 2014 · Synced Jul 23, 2026, 10:54 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Comparison of Prosthetic Knee Performance During Sitting and Standing

NCT00421356
View directory record Official record
Conditions
Amputation
Interventions
Not listed
Lead sponsor
University of South Florida
Other
Eligibility
21 Years to 65 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2010
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Dec 13, 2023 · Synced Jul 23, 2026, 10:54 AM EDT
Completed No phase listed Observational

Pilot Study to Assess the Use of Spy Elite for Assessment of Amputation Healing

NCT02440295
View directory record Official record
Conditions
Wound Healing, Lower Extremity Amputation, Above Knee Amputation, Below Knee Amputation
Interventions
Lower Extremity Amputation, SPY Elite Imaging System, Indocyaine Green
Procedure · Device · Drug
Lead sponsor
Corewell Health West
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Grand Rapids, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 27, 2023 · Synced Jul 23, 2026, 10:54 AM EDT
Terminated Phase 4 Interventional Results available

Liposomal Bupivacaine vs Continuous Nerve Catheters for Below the Knee Amputations

NCT05140499
View directory record Official record
Conditions
Pain, Postoperative, Amputation
Interventions
Liposomal bupivacaine, Bupivacaine Hydrochloride 0.5 % Injectable Solution
Drug
Lead sponsor
Aurora Quaye
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Portland, Maine
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Jul 23, 2026, 10:54 AM EDT
Recruiting Phase 1 Interventional

Influence of Prosthetic Foot Stiffness on Transtibial Osseointegrated Bone-Anchored Limb Outcomes

NCT07263945
View directory record Official record
Conditions
Amputation, Transtibial Amputation - Unilateral, Bone Anchored Devices, Osseointegration
Interventions
As-prescribed prosthetic foot stiffness, A prosthetic foot that is two prosthetic foot stiffness categories stiffer than the stiffness of the as-prescribed prosthetic foot, A prosthetic foot that is two prosthetic foot stiffness categories softer than the stiffness of the as-prescribed prosthetic foot
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 20, 2026 · Synced Jul 23, 2026, 10:54 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparative Outcomes Assessment of the C-Leg With a New Knee Prosthesis

NCT01473992
View directory record Official record
Conditions
Other and Unspecified Complications of Amputation Stump
Interventions
Otto Bock C-Leg, Otto Bock Genium
Device
Lead sponsor
Jason Highsmith
Other
Eligibility
18 Years to 85 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Dec 11, 2023 · Synced Jul 23, 2026, 10:54 AM EDT
Not yet recruiting Not applicable Interventional

Effect of a Microprocessor-controlled Prosthetic Knee Joint on K2 Level Ambulators

NCT07103798
View directory record Official record
Conditions
Transfemoral Amputation, Limb Loss, Limb Absence
Interventions
College Park ICON, Conventional NMPK
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
45 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
2
States / cities
Chicago, Illinois • Hines, Illinois
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Jul 23, 2026, 10:54 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Evaluation of Ultrasonic Neuroma Size With Residual Limb Pain in Above-Knee Amputees

NCT00686764
View directory record Official record
Conditions
Neuroma Amputation
Interventions
Observational
Other
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 99 Years
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Dec 13, 2015 · Synced Jul 23, 2026, 10:54 AM EDT
Active, not recruiting Not applicable Interventional

VR to Evaluate Phantom Limb Pain

NCT05915065
View directory record Official record
Conditions
Phantom Limb Pain, Phantom Pain, Phantom Sensation, Phantom Limb Syndrome With Pain, Phantom Pain Following Amputation of Lower Limb, Phantom Pain Following Amputation of Upper Limb, Amputation, Upper Limb Amputation at the Hand, Upper Limb Amputation at the Wrist, Upper Limb Amputation Below Elbow (Injury), Upper Limb Amputation Above Elbow (Injury), Lower Limb Amputation Knee, Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Below Knee (Injury), Lower Limb Amputation at Ankle (Injury)
Interventions
Coapt Phantom Limb Pain Management System
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 13, 2025 · Synced Jul 23, 2026, 10:54 AM EDT
Completed Not applicable Interventional Results available

Assist-Knee: Energy-Harvesting Knee Prosthesis

NCT04023045
View directory record Official record
Conditions
Transfemoral Amputation, Artificial Limbs
Interventions
Assist-Knee, Habitual Prosthesis
Device
Lead sponsor
Orthocare Innovations, LLC
Industry
Eligibility
21 Years to 80 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Edmonds, Washington
Source: ClinicalTrials.gov public record
Updated Oct 17, 2023 · Synced Jul 23, 2026, 10:54 AM EDT
Completed Not applicable Interventional Results available

Clinical Investigation (Beta) of Power Knee Mainstream - Dynamic

NCT04787627
View directory record Official record
Conditions
Prosthesis User, Amputation
Interventions
Power Knee
Device
Lead sponsor
Össur Iceland ehf
Industry
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
2
States / cities
Silver Spring, Maryland • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 21, 2025 · Synced Jul 23, 2026, 10:54 AM EDT
Completed Early Phase 1 Interventional Results available

N-Acetyl-Cysteine (NAC) for Healing of Amputation Stumps in the Setting of Diabetes

NCT03253328
View directory record Official record
Conditions
Diabetes Mellitus, Critical Limb Ischemia, Lower Limb Amputation Knee, Peripheral Arterial Disease
Interventions
Active Arm N-acetyl cysteine (NAC), Placebo Arm
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
30 Years to 90 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 15, 2024 · Synced Jul 23, 2026, 10:54 AM EDT
Active, not recruiting Not applicable Interventional

Assessing Outcomes With Microprocessor Knee Utilization in a K2 Population

NCT04784429
View directory record Official record
Conditions
Lower Limb Amputation Above Knee (Injury), Congenital Amputation of Lower Limb, Lower Limb Amputation Knee
Interventions
Kenevo or C-Leg 4, Non microprocessor controlled knee (NMPK)
Device
Lead sponsor
Otto Bock Healthcare Products GmbH
Industry
Eligibility
65 Years and older
Enrollment
107 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
90
States / cities
Dothan, Alabama • Gilbert, Arizona • Phoenix, Arizona + 85 more
Source: ClinicalTrials.gov public record
Updated Feb 8, 2024 · Synced Jul 23, 2026, 10:54 AM EDT