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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Anhedonia Clear all
Recruiting Phase 4 Interventional

Ovarian Hormone Withdrawal, Anhedonia, and Reward Sensitivity in Women With Premenstrual Exacerbations of Depression

NCT06610305
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Transdermal estradiol, Progesterone, Transdermal placebo patch, placebo capsule
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 28, 2025 · Synced Sep 24, 2026, 9:32 AM EDT
Completed Phase 2 Interventional

PD, PK, and Safety of ALTO-203 in Patients With MDD

NCT06391593
View directory record Official record
Conditions
Major Depressive Disorder, Anhedonia
Interventions
ALTO-203 25 μg, ALTO-203 75 μg, Placebo
Drug
Lead sponsor
Alto Neuroscience
Industry
Eligibility
25 Years to 64 Years
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
15
States / cities
Tucson, Arizona • Oceanside, California • Torrance, California + 12 more
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Sep 24, 2026, 9:32 AM EDT
Terminated Not applicable Interventional

Transcranial Direct Current Stimulation (tDCS) in Chronic Post-Stroke Apathy

NCT02915484
View directory record Official record
Conditions
Apathy, Stroke
Interventions
Transcranial Direct Current Stimulation
Device
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Oct 2, 2017 · Synced Sep 24, 2026, 9:32 AM EDT
Completed Phase 1 Interventional

Virtual Reality-Reward Training for Anhedonia

NCT05342077
View directory record Official record
Conditions
Positive Affect, Depression
Interventions
Virtual Reality-Reward Training (VR-RT), Virtual Reality-Memory Training (VR-MT)
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 3, 2025 · Synced Sep 24, 2026, 9:32 AM EDT
Recruiting Not applicable Interventional

A Just-in-time Adaptive Intervention for Suicide Safety Planning in Adolescents

NCT07348666
View directory record Official record
Conditions
Suicide, Mental Health Disorder, Anhedonia
Interventions
ViraSafe: Treatment pushes, BRITE
Behavioral
Lead sponsor
Ksana Health
Industry
Eligibility
13 Years to 24 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
3
States / cities
Eugene, Oregon • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Sep 24, 2026, 9:32 AM EDT
Completed No phase listed Observational

Stanford RAD-AT Study (Research on Anxiety and Depression - Anhedonia Treatment)

NCT02220309
View directory record Official record
Conditions
Anxiety, Depression
Interventions
Pramipexole Oral Tablet
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 65 Years
Enrollment
167 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2025
U.S. locations
3
States / cities
Los Altos, California • Palo Alto, California • Stanford, California
Source: ClinicalTrials.gov public record
Updated Jan 4, 2026 · Synced Sep 24, 2026, 9:32 AM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Neural Circuit Effects of Ketamine in Depression

NCT06213324
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Ketamine, Placebo
Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 2, 2025 · Synced Sep 24, 2026, 9:32 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Sleep and Healthy Aging Research on Depression for Younger Women

NCT03848715
View directory record Official record
Conditions
Anhedonia, Depression
Interventions
Endotoxin, Placebo
Biological
Lead sponsor
University of California, Los Angeles
Other
Eligibility
25 Years to 44 Years · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Sep 24, 2026, 9:32 AM EDT
Enrolling by invitation Not applicable Interventional

Causal Role of Rostromedial Prefrontal Cortex for Positive Savoring in Depression

NCT07467473
View directory record Official record
Conditions
Left Rostromedial Prefrontal Cortex - Accelerated Intermittent Theta Burst, Left Dorsolateral Prefrontal Cortex - Accelerated Intermittent Theta Burst, Left Primary Somatosensory Cortex - Accelerated Intermittent Theta Burst
Interventions
Accelerated Intermittent Theta Burst Transcranial Magnetic Stimulation
Device
Lead sponsor
Florida State University
Other
Eligibility
18 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced Sep 24, 2026, 9:32 AM EDT
Withdrawn Phase 1 Interventional Accepts healthy volunteers

FASTMAS (Fast-Fail Trials in Mood and Anxiety Spectrum Disorders) Kappa Opioid Receptor Phase 1 Study

NCT02218775
View directory record Official record
Conditions
Anxiety Disorders
Interventions
LY2456302
Drug
Lead sponsor
Andrew Krystal
Other
Eligibility
21 Years to 65 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 27, 2015 · Synced Sep 24, 2026, 9:32 AM EDT
Completed Phase 2 Interventional Results available

Study to Evaluate the Efficacy and Safety of Once-Weekly Oral NBI-1065846 in the Treatment of Anhedonia in MDD

NCT05165394
View directory record Official record
Conditions
Anhedonia, Major Depressive Disorder
Interventions
Placebo, NBI-1065846
Drug
Lead sponsor
Neurocrine Biosciences
Industry
Eligibility
18 Years to 65 Years
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
22
States / cities
Birmingham, Alabama • Garden Grove, California • Lemon Grove, California + 19 more
Source: ClinicalTrials.gov public record
Updated Jul 30, 2024 · Synced Sep 24, 2026, 9:32 AM EDT
Completed Not applicable Interventional Results available

Investigating the Causal Role of Prefrontal Control in Decision-making in Patients With Anhedonia

NCT05084924
View directory record Official record
Conditions
Major Depressive Disorder, Anhedonia
Interventions
Cross-frequency transcranial alternating current stimulation via the NeuroConn Direct Current Stimulator Plus
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 65 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 24, 2024 · Synced Sep 24, 2026, 9:32 AM EDT
Recruiting Not applicable Interventional

Reward Processing and Exposure Therapy for Social Anxiety Disorder

NCT06776991
View directory record Official record
Conditions
Social Anxiety Disorder (Social Phobia), Public Speaking Anxiety, Anhedonia, ANXIETY DISORDERS (or Anxiety and Phobic Neuroses), Phobic Disorders
Interventions
Positive Affect Treatment - Behavioral (PAT-B), Relaxation Treatment, Exposure Therapy
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 60 Years
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Sep 24, 2026, 9:32 AM EDT
Recruiting Not applicable Interventional

A Digitally Assisted Risk Reduction Platform for Youth at High Risk for Suicide

NCT05920252
View directory record Official record
Conditions
Suicide, Mental Health Disorder, Anhedonia
Interventions
Vira, Treatment as Usual (TAU)
Behavioral
Lead sponsor
Ksana Health
Industry
Eligibility
13 Years to 18 Years
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 3, 2026 · Synced Sep 24, 2026, 9:32 AM EDT
Recruiting Phase 1 Interventional

Psilocybin as a Novel Therapy for Residual Anhedonia

NCT07607938
View directory record Official record
Conditions
Anhedonia, Emotional Blunting
Interventions
Psilocybin, Placebo
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 65 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Sep 24, 2026, 9:32 AM EDT
Completed Phase 2 Interventional

Psilocybin for Treatment-Resistant Depression

NCT06230757
View directory record Official record
Conditions
Major Depressive Disorder, Anhedonia, Treatment Resistant Depression
Interventions
Psilocybin 25mg, Placebo (active placebo)
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
21 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Sep 24, 2026, 9:32 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Geolocation Positional System (GPS) Experience

NCT05991713
View directory record Official record
Conditions
Emotions, Anhedonia, Depression
Interventions
Modifying Exploration
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 50 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Sep 24, 2026, 9:32 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Behavioral Activation Plus Savoring for University Students

NCT05234476
View directory record Official record
Conditions
Mood, Anhedonia, Depression
Interventions
Behavioral Activation plus Savoring, Empathic Listening
Behavioral
Lead sponsor
Southern Methodist University
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Feb 15, 2022 · Synced Sep 24, 2026, 9:32 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Understanding Brain Reward Responses in Individuals With Major Depressive Disorder

NCT00183755
View directory record Official record
Conditions
Depression
Interventions
Not listed
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 64 Years
Enrollment
87 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2009
U.S. locations
3
States / cities
Boston, Massachusetts • Cambridge, Massachusetts • Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 20, 2014 · Synced Sep 24, 2026, 9:32 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Translational Model of Anhedonia

NCT03856177
View directory record Official record
Conditions
Anhedonia
Interventions
Emotion Induction
Behavioral
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years to 55 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Mar 28, 2024 · Synced Sep 24, 2026, 9:32 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Sex, Hormones and Gamma-Aminobutyric Acid (GABA) in Stress Induced Anhedonia in Depression

NCT03031665
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Not listed
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 25 Years
Enrollment
251 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 12, 2024 · Synced Sep 24, 2026, 9:32 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Dissociating Components of Anhedonia: A Pilot fMRI Study

NCT02569034
View directory record Official record
Conditions
Anhedonia
Interventions
Functional Magnetic Resonance Imaging, Effort-Expenditure for Rewards Task
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 80 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Nov 12, 2018 · Synced Sep 24, 2026, 9:32 AM EDT
Not listed Phase 2 Interventional Accepts healthy volunteers

Proof of Mechanism Study for the Treatment of Social Anhedonia in ASD

NCT03243552
View directory record Official record
Conditions
ASD
Interventions
L-DOPA versus Placebo, Social Skills Training
Drug · Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
13 Years to 30 Years
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 27, 2023 · Synced Sep 24, 2026, 9:32 AM EDT
Withdrawn Phase 2 Interventional

PET Synaptogenesis After Psilocybin In DEpression Recovery

NCT05601648
View directory record Official record
Conditions
Major Depressive Disorder, Anhedonia
Interventions
Psilocybin
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 29, 2023 · Synced Sep 24, 2026, 9:32 AM EDT