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Showing 1–24 of 425 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Ankle Clear all
Completed Not applicable Interventional Results available

Ultrasound-Guided Percutaneous Peripheral Nerve Stimulation: A Department of Defense Funded Multicenter Pilot Study

NCT03481725
View directory record Official record
Conditions
Rotator Cuff Repair, Anterior Cruciate Ligament Reconstruction, Ankle Arthrodesis or Arthroplasty, Hallux Valgus Correction
Interventions
ACTIVE peripheral nerve stimulation with a percutaneously inserted lead and wearable stimulator (SPR Therapeutics, Cleveland, Ohio), SHAM peripheral nerve stimulation with a percutaneously inserted lead and wearable SHAM stimulator (SPR Therapeutics, Cleveland, Ohio)
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
6
States / cities
San Diego, California • Bethesda, Maryland • Fort Bragg, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 17, 2021 · Synced Jul 21, 2026, 5:27 PM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Study to Evaluate the REMEDY SPECTRUM GV IM Spacer Nail in the Treatment of Ankle-Related Infections

NCT06428448
View directory record Official record
Conditions
Periprosthetic Joint Infection
Interventions
REMEDY Spectrum IM Spacer Nail
Combination Product
Lead sponsor
OsteoRemedies, LLC
Industry
Eligibility
21 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
3
States / cities
Lansing, Michigan • Charlotte, North Carolina • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Jul 21, 2026, 5:27 PM EDT
Completed No phase listed Observational

Insole Sensor to Determine Optimal Limb Loading in the Rehabilitation of Ankle Fractures

NCT02334618
View directory record Official record
Conditions
Ankle Fracture
Interventions
Not listed
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 90 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Oct 25, 2017 · Synced Jul 21, 2026, 5:27 PM EDT
Completed Not applicable Interventional

Effects of Proximal and Distal Tibiofibular Joint Manipulation on Lower Extremity Muscle Activation, Ankle Range of Motion, and Functional Outcome Scores in Individuals With Chronic Ankle Instability

NCT00601471
View directory record Official record
Conditions
Ankle Sprain, Ankle Injuries, Sprain
Interventions
proximal tibiofibular manipulation, distal tibiofibular manipulation, no intervention
Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 50 Years
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 23, 2010 · Synced Jul 21, 2026, 5:27 PM EDT
Suspended Not applicable Interventional Accepts healthy volunteers

Enovis High Ankle Sprain Brace Testing

NCT06719609
View directory record Official record
Conditions
Athletes in Cutting Sports
Interventions
Ankle tape, Standard lace-up ankle brace, Standard high ankle-sprain (HAS) brace, Low-profile HAS brace, No ankle brace or tape
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 40 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Jul 21, 2026, 5:27 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Impact of Physical Therapy Intervention on Foot and Ankle Function

NCT04930406
View directory record Official record
Conditions
Neoplasms, Physical Therapy Modalities, Survivorship
Interventions
Physical therapy
Other
Lead sponsor
Children's Hospitals and Clinics of Minnesota
Other
Eligibility
7 Years to 30 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2024
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 19, 2024 · Synced Jul 21, 2026, 5:27 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Chronic Ankle Instability and Proprioception

NCT00494403
View directory record Official record
Conditions
Chronic Ankle Sprains
Interventions
Not listed
Lead sponsor
Logan College of Chiropractic
Other
Eligibility
20 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated May 2, 2013 · Synced Jul 21, 2026, 5:27 PM EDT
Recruiting Not applicable Interventional

AFO Prescription to Optimize Post-Stroke Function

NCT06692686
View directory record Official record
Conditions
Ankle Foot Orthosis (AFO), Stroke Patients, Post-Stroke Hemiparesis
Interventions
Pre-fabricated (PF) ankle-foot orthosis (AFO), Carbon-strut (CS) ankle-foot orthosis (AFO), Multifunctional articulating (MA) ankle-foot orthosis (AFO)
Device
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
4
States / cities
Downey, California • Jacksonville, Florida • Charleston, South Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 20, 2025 · Synced Jul 21, 2026, 5:27 PM EDT
Enrolling by invitation Phase 4 Interventional

Periarticular Injection Versus Popliteal Block

NCT04575688
View directory record Official record
Conditions
Foot Surgery, Ankle Surgery
Interventions
Exparel, Bupivicaine
Drug
Lead sponsor
Campbell Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Germantown, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Jul 21, 2026, 5:27 PM EDT
Completed Phase 3 Interventional

HKT-500 in the Treatment of Adult Patients With Ankle Sprain

NCT00927641
View directory record Official record
Conditions
Ankle Sprain
Interventions
Ketoprofen Patch, Placebo Patch
Drug · Other
Lead sponsor
Hisamitsu Pharmaceutical Co., Inc.
Industry
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
25
States / cities
Birmingham, Alabama • Phoenix, Arizona • Tucson, Arizona + 21 more
Source: ClinicalTrials.gov public record
Updated Jun 3, 2015 · Synced Jul 21, 2026, 5:27 PM EDT
Terminated Not applicable Interventional

Ankle Equinus Contracture Treated With Dynamic Splinting

NCT01238484
View directory record Official record
Conditions
Ankle Equinus, Ankle Contracture, Diabetes Mellitus
Interventions
Standard of care, Dynasplint
Other · Device
Lead sponsor
Dynasplint Systems, Inc.
Industry
Eligibility
18 Years to 90 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
2
States / cities
Jonesboro, Georgia • Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Jul 10, 2013 · Synced Jul 21, 2026, 5:27 PM EDT
Withdrawn Not applicable Interventional

Waterproof Casting Versus Standard Casting for Short Leg Walking Casts

NCT04961957
View directory record Official record
Conditions
Ankle Fractures, Foot Fracture, Ankle Sprains, Foot Sprain, Toe-walking, Tendonitis of Foot, Apophysitis; Juvenile
Interventions
Waterproof padding, Non-waterproof padding
Device
Lead sponsor
West Virginia University
Other
Eligibility
5 Years to 18 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Sep 7, 2025 · Synced Jul 21, 2026, 5:27 PM EDT
Completed No phase listed Observational Results available

Treatment Outcomes for Ankle Arthritis

NCT00391365
View directory record Official record
Conditions
Osteoarthritis
Interventions
Gait analysis
Procedure
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 89 Years
Enrollment
368 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 25, 2026 · Synced Jul 21, 2026, 5:27 PM EDT
Not yet recruiting Phase 1 Interventional

Enhancing Wound Perfusion in High-Risk Lower Extremity Orthopaedic Surgery: A Study on Nitropaste Using Intraoperative SPY Imaging.

NCT07004764
View directory record Official record
Conditions
Achilles Tendon Repairs/Reconstructions, Pilon Fracture of Tibia, Tibial Plateau Fracture, Ankle Fracture (Bimalleolar Equivalent, Bimalleolar, or Trimalleolar), Calcaneus Fractures, Talus Fracture, Wound Infection Deep, Wound Infection Post-Traumatic, Wound Dehiscence, Surgical
Interventions
Nitroglycerin Ointment 2%
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced Jul 21, 2026, 5:27 PM EDT
Completed Not applicable Interventional Results available

Iterative Design of Custom Dynamic Orthoses

NCT04800510
View directory record Official record
Conditions
Adult ALL, Healthy
Interventions
Carbon Fiber Custom Dynamic Orthosis (CDO)
Device
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 50 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Jul 21, 2026, 5:27 PM EDT
Completed Not applicable Interventional Results available

AMPLEX Ankle Fusion and Hindfoot

NCT03028415
View directory record Official record
Conditions
Arthrodesis Surgery Involving the Hindfoot or Ankle
Interventions
AMPLEX, Autogenous Bone Graft (ABG)
Device · Procedure
Lead sponsor
Ferring Pharmaceuticals
Industry
Eligibility
18 Years to 74 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
28
States / cities
Gilbert, Arizona • Phoenix, Arizona • San Francisco, California + 23 more
Source: ClinicalTrials.gov public record
Updated Mar 10, 2021 · Synced Jul 21, 2026, 5:27 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Low-Molecular-Weight Heparin (LMWH) for Deep Venous Thrombosis (DVT) Prophylaxis

NCT01029821
View directory record Official record
Conditions
Deep Venous Thrombosis
Interventions
Low-Molecular-Weight Heparin
Drug
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years to 85 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
1
States / cities
Chattanooga, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 15, 2011 · Synced Jul 21, 2026, 5:27 PM EDT
Completed Phase 2 Interventional

Sensory-Targeted Ankle Rehabilitation Strategies (STARS)

NCT01541657
View directory record Official record
Conditions
Chronic Ankle Instability
Interventions
Ankle Joint Mobilization, Foot Massage, Calf Stretching
Other
Lead sponsor
Joel Thompson
Other
Eligibility
18 Years to 45 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
2
States / cities
Ithaca, New York • Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 25, 2018 · Synced Jul 21, 2026, 5:27 PM EDT
Not listed Not applicable Interventional

Nerve Block for Pain Control After Fracture Surgery

NCT05391464
View directory record Official record
Conditions
Ankle Fractures, Distal Radius Fracture
Interventions
Peripheral Nerve Block
Procedure
Lead sponsor
MaineGeneral Health
Other
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Augusta, Maine
Source: ClinicalTrials.gov public record
Updated May 25, 2022 · Synced Jul 21, 2026, 5:27 PM EDT
Recruiting Not applicable Interventional

The Effects of Heel Distraction Height on Foot Loading With Carbon Fiber Custom Dynamic Orthoses

NCT06127316
View directory record Official record
Conditions
Traumatic Lower Limb Injury
Interventions
Carbon Fiber Custom Dynamic Orthosis (CDO)
Device
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Jul 21, 2026, 5:27 PM EDT
Completed Early Phase 1 Interventional

Bedside Ultrasound in the Diagnosis of Ankle Fractures in Children

NCT01341015
View directory record Official record
Conditions
Ankle Fracture
Interventions
Ultrasound
Other
Lead sponsor
Rhode Island Hospital
Other
Eligibility
2 Years to 18 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Dec 4, 2012 · Synced Jul 21, 2026, 5:27 PM EDT
Completed Phase 1 Interventional Results available

Development of a Robotic Ankle Assist Device

NCT04516343
View directory record Official record
Conditions
Cerebral Palsy
Interventions
Robotic Ankle Assist Device (RAAD)
Device
Lead sponsor
BiOMOTUM, Inc.
Industry
Eligibility
8 Years to 21 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Flagstaff, Arizona
Source: ClinicalTrials.gov public record
Updated Apr 3, 2025 · Synced Jul 21, 2026, 5:27 PM EDT
Active, not recruiting No phase listed Observational

JuggerKnot With Broadband PMCF Study

NCT05762588
View directory record Official record
Conditions
Shoulder Injuries, Hip Injuries, Foot Injury, Ankle Injuries, Knee Injuries
Interventions
Juggerknot with Broadband tape
Device
Lead sponsor
Riverpoint Medical
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Hyattsville, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 16, 2025 · Synced Jul 21, 2026, 5:27 PM EDT
Recruiting Not applicable Interventional

Outcomes of Low-Impact Exercise Program for People With Ankle, Knee, and/or Hip Pain

NCT03711773
View directory record Official record
Conditions
Osteoarthritis, Osteoarthritis, Knee, Osteoarthritis, Hip, Osteoarthritis Ankle
Interventions
Group Physical Therapy Classes
Other
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
10,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2030
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 1, 2026 · Synced Jul 21, 2026, 5:27 PM EDT