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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Ankle Clear all
Completed No phase listed Observational Accepts healthy volunteers

Effect of Ankle-foot Orthoses Trim Line Modifications on Ankle and Knee Motion and Force.

NCT01865682
View directory record Official record
Conditions
Lower Extremity Biomechanics
Interventions
Not listed
Lead sponsor
Southern California Institute for Research and Education
Other
Eligibility
18 Years to 40 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2017
U.S. locations
1
States / cities
Long Beach, California
Source: ClinicalTrials.gov public record
Updated Oct 5, 2017 · Synced Sep 14, 2026, 2:10 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Using Near-Infrared Light to Better Understand Peripheral Artery Disease

NCT07313410
View directory record Official record
Conditions
Peripheral Artery Disease (PAD)
Interventions
Not listed
Lead sponsor
The University of Texas at Arlington
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
2
States / cities
Arlington, Texas
Source: ClinicalTrials.gov public record
Updated Jan 1, 2026 · Synced Sep 14, 2026, 2:10 PM EDT
Active, not recruiting Not applicable Interventional

Ankle Exosuit Training in the Clinic to Community Community

NCT04251091
View directory record Official record
Conditions
Stroke
Interventions
Treadmill walking, Overground Walking
Other
Lead sponsor
Arun Jayaraman, PT, PhD
Other
Eligibility
18 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 31, 2025 · Synced Sep 14, 2026, 2:10 PM EDT
Completed Early Phase 1 Interventional Results available

Testing an Adjustable Ankle Orthosis During Walking in Cerebral Palsy

NCT06262191
View directory record Official record
Conditions
Cerebral Palsy
Interventions
Differential and adjustable stiffness AFO (DAS-AFO)
Device
Lead sponsor
Northern Arizona University
Other
Eligibility
8 Years to 35 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Flagstaff, Arizona
Source: ClinicalTrials.gov public record
Updated May 24, 2025 · Synced Sep 14, 2026, 2:10 PM EDT
Not listed Not applicable Interventional

Lateral Ankle Ligament Reconstruction With InternalBrace™ Augmentation

NCT04770818
View directory record Official record
Conditions
Lateral Ankle Instability
Interventions
Modified Brostrum procedure with Internal Brace Augmentation, Modified Brostrum procedure
Device
Lead sponsor
Arthrex, Inc.
Industry
Eligibility
18 Years and older
Enrollment
154 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
3
States / cities
Chicago, Illinois • Las Vegas, Nevada • Logan, Utah
Source: ClinicalTrials.gov public record
Updated Mar 15, 2021 · Synced Sep 14, 2026, 2:10 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Sensor Ankle Brace for Special Operations Rehabilitation

NCT07776223
View directory record Official record
Conditions
Gait, Balance, Biomechanical Data, Postural Control, Locomotion
Interventions
Sensor-enabled Athletic X Ankle Brace (sXAB)
Device
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 40 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Sep 14, 2026, 2:10 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers Results available

Wright Foot & Ankle Post-Market Observational Study

NCT04118894
View directory record Official record
Conditions
Arthritis, Rheumatoid Arthritis, Fracture, Trauma Injury, Fusion of Joint
Interventions
Foot and Ankle Devices
Device
Lead sponsor
Stryker Trauma and Extremities
Industry
Eligibility
18 Years and older
Enrollment
119 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
2
States / cities
Hamilton, New Jersey • Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 13, 2025 · Synced Sep 14, 2026, 2:10 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Progressing Ankle Brace Restriction on Walking and Running Gait Characteristics in Healthy Individuals

NCT03641066
View directory record Official record
Conditions
Ankle Sprains
Interventions
Ankle Brace
Device
Lead sponsor
Sport and Spine Rehab Clinical Research Foundation
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Rockville, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 24, 2019 · Synced Sep 14, 2026, 2:10 PM EDT
Completed Phase 2Phase 3 Interventional

Study of How An Ankle Strap Changes Effects of Insole Treatment for Knee Osteoarthritis

NCT00331110
View directory record Official record
Conditions
Medial Compartment Knee Osteoarthritis
Interventions
Laterally-Wedged Insole with Ankle Strapping, Laterally-Weged Insole
Device
Lead sponsor
University of Iowa
Other
Eligibility
45 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jan 2, 2008 · Synced Sep 14, 2026, 2:10 PM EDT
Recruiting Not applicable Interventional

Neurocognitive Ankle Training for Instability to Optimize Neuromusculoskeletal Outcomes (NATION)

NCT06527287
View directory record Official record
Conditions
Chronic Ankle Instability
Interventions
Neurocognitive Ankle Training for Instablity to Optimize Neuromusculoskeletal outcomes (NATION), Evidence-Based
Other
Lead sponsor
Womack Army Medical Center
Federal
Eligibility
18 Years to 44 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
Lexington, Kentucky • Fort Bragg, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Sep 14, 2026, 2:10 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Effect of Manipulation of the Ankle Joint on Gait

NCT01787721
View directory record Official record
Conditions
Gait
Interventions
Ankle manipulation, Sham manipulation
Procedure · Other
Lead sponsor
University of Bridgeport
Other
Eligibility
18 Years to 65 Years
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Bridgeport, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 22, 2014 · Synced Sep 14, 2026, 2:10 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Reliability of Force Measurement Within the Carbon Fiber Orthosis Proximal Cuff

NCT06127264
View directory record Official record
Conditions
Healthy, Ankle Foot Orthosis (AFO), Peripheral Neuropathy
Interventions
Carbon Fiber Custom Dynamic Orthosis (CDO)
Device
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 90 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Dec 30, 2025 · Synced Sep 14, 2026, 2:10 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Wearing a Powered Ankle-Foot Prosthesis on Amputee Walking

NCT00869947
View directory record Official record
Conditions
Traumatic Amputation of Lower Extremity
Interventions
Powered ankle-foot prosthesis, No device
Device · Other
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 60 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2013
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Feb 24, 2014 · Synced Sep 14, 2026, 2:10 PM EDT
Recruiting Not applicable Interventional

A Prospective, Randomized, Single-blind, Controlled, Multi-center Study to Assess the Safety and Performance of MagnetOsTM Compared to Autogenous Bone Graft in Patients Undergoing Hindfoot or Ankle Fusions.

NCT07225751
View directory record Official record
Conditions
Ankle Arthrodesis or Arthroplasty, Hindfoot Fusion, Ankle Deformity, Ankle Disease, Hindfoot Arthrodesis, Hindfoot Pathologies
Interventions
MagnetOs, Autograft
Device · Other
Lead sponsor
Kuros Biosurgery AG
Industry
Eligibility
18 Years to 75 Years
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
7
States / cities
Sacramento, California • Vail, Colorado • Columbus, Georgia + 4 more
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Sep 14, 2026, 2:10 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Software Generated Customized Foot Orthoses

NCT05462912
View directory record Official record
Conditions
Arthropathy of Ankle or Foot
Interventions
custom foot orthotic
Device
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jul 31, 2025 · Synced Sep 14, 2026, 2:10 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Postoperative Aspirin and Ankle Fracture Healing

NCT03765619
View directory record Official record
Conditions
Ankle Fractures
Interventions
Aspirin
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 110 Years
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 12, 2025 · Synced Sep 14, 2026, 2:10 PM EDT
Completed Not applicable Interventional Results available

WalkAide Compared to Ankle-Foot Orthosis (AFO) in Stroke Patients

NCT01087957
View directory record Official record
Conditions
Stroke
Interventions
WalkAide, Ankle-Foot Orthosis (AFO)
Device · Other
Lead sponsor
Innovative Neurotronics
Industry
Eligibility
18 Years and older
Enrollment
495 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
29
States / cities
Loma Linda, California • Los Angeles, California • Pomona, California + 25 more
Source: ClinicalTrials.gov public record
Updated May 12, 2014 · Synced Sep 14, 2026, 2:10 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Platelet Rich Plasma for Musculoskeletal Conditions

NCT07231471
View directory record Official record
Conditions
Osteoarthritis (OA), Osteoarthritis (OA) of the Knee, Osteoarthritis (OA) of the Hip, Osteoarthritis (OA) of the Shoulder, Osteoarthritis Ankle, Elbow Osteoarthritis, Epicondylitis of the Elbow, Plantar Fasciitis of Both Feet, Tendinopathy
Interventions
Platelet Rich Plasma Injection, Platelet Rich Plasma Preparation
Biological · Device
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
10,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2035
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Sep 14, 2026, 2:10 PM EDT
Completed Phase 3 Interventional

Efficacy and Safety of SST 0225, a Topical Ibuprofen Cream, in the Treatment of Pain Associated With Acute Ankle Sprain

NCT01874626
View directory record Official record
Conditions
Acute Ankle Sprain
Interventions
Placebo, SST-0225 Topical Ibuprofen Cream
Drug
Lead sponsor
Strategic Science & Technologies, LLC
Industry
Eligibility
16 Years and older
Enrollment
305 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Guilford, Connecticut
Source: ClinicalTrials.gov public record
Updated May 20, 2021 · Synced Sep 14, 2026, 2:10 PM EDT
Completed No phase listed Observational

Pilon Fracture Reduction and Functional Outcome

NCT01316289
View directory record Official record
Conditions
Pilon Fracture of Tibia
Interventions
Not listed
Lead sponsor
AO Clinical Investigation and Publishing Documentation
Other
Eligibility
18 Years and older
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
4
States / cities
Indianapolis, Indiana • Saint Paul, Minnesota • Jackson, Mississippi + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 12, 2020 · Synced Sep 14, 2026, 2:10 PM EDT
Active, not recruiting Not applicable Interventional

Electromagnetic Transduction Therapy on Osteoarthritis in the Foot and Ankle

NCT06696118
View directory record Official record
Conditions
Osteoarthritis Ankle, Osteoarthritis Foot
Interventions
Electromagnetic Transduction Therapy (EMTT)
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 27, 2026 · Synced Sep 14, 2026, 2:10 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Fibulink Syndesmosis Repair System With Early Full-Weight Bearing

NCT06085586
View directory record Official record
Conditions
Ankle Fractures, Bimalleolar Fractures, Syndesmotic Injuries, Bimalleolar Equivalent Fracture, Maisonneuve Fracture, Trimalleolar Fractures, Ankle Dislocation
Interventions
Early Weight Bearing, Normal Weight Bearing
Other
Lead sponsor
Maimonides Medical Center
Other
Eligibility
22 Years and older
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Mar 19, 2026 · Synced Sep 14, 2026, 2:10 PM EDT
Enrolling by invitation Phase 4 Interventional

Mepivacaine Versus Bupivacaine Onset Time in Ultrasound-guided Ankle Blocks

NCT05425979
View directory record Official record
Conditions
Ankle Block, Foot Surgery
Interventions
Mepivacaine, Bupivacaine
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 10, 2025 · Synced Sep 14, 2026, 2:10 PM EDT
Completed Not applicable Interventional Results available

Cortical and Biomechanical Dynamics of Ankle Robotics Training in Stroke

NCT01072032
View directory record Official record
Conditions
Cerebral Stroke
Interventions
Anklebot (Ankle Robot)
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
21 Years to 85 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 29, 2016 · Synced Sep 14, 2026, 2:10 PM EDT