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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Ankle Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Excess Opioid Disposal Following Orthopedic Foot and Ankle Surgery

NCT03285061
View directory record Official record
Conditions
Medication Disposal, Behavior
Interventions
Deterra Drug Deactivation System
Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 5, 2021 · Synced Jul 21, 2026, 10:10 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Clinical Evaluation of the Treatment of Spider Veins on the Ankles

NCT02754479
View directory record Official record
Conditions
Spider Veins
Interventions
Nd:YAG laser
Device
Lead sponsor
Cutera Inc.
Industry
Eligibility
20 Years to 75 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Naperville, Illinois
Source: ClinicalTrials.gov public record
Updated May 8, 2023 · Synced Jul 21, 2026, 10:10 PM EDT
Recruiting Not applicable Interventional

Correlation Between Intraoperative Tourniquet Use and Limb pH, Functional Measures and Patient-reported Outcomes After Ankle Fracture Surgery

NCT05445960
View directory record Official record
Conditions
Ankle Fractures, Ankle Fracture - Lateral Malleolus, Ankle Fracture, Bimalleolar, Ankle Fracture, Trimalleolar, Ankle Fracture - Medial Malleolus, Maisonneuve's Fracture, Syndesmotic Injuries, Fibula Fracture
Interventions
Tourniquet
Procedure
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 89 Years
Enrollment
390 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Mar 23, 2025 · Synced Jul 21, 2026, 10:10 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

An Evaluation Of Healthy Ankle Motion And Morphology

NCT03619382
View directory record Official record
Conditions
Healthy Ankle
Interventions
Cone Beam Computed Tomography, Radiographs
Radiation
Lead sponsor
Paragon 28
Industry
Eligibility
18 Years to 65 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Atlantis, Florida
Source: ClinicalTrials.gov public record
Updated Jun 17, 2021 · Synced Jul 21, 2026, 10:10 PM EDT
Recruiting Not applicable Interventional

BioBrace® in Arthroscopic Brostrom Lateral Ankle Ligament Repair

NCT07401095
View directory record Official record
Conditions
ATFL, Lateral Ankle Instability, Anterior Talofibular Ligament, Anterior Talofibular Ligament Injury, Brostrom Procedure, Brostrom, Ankle
Interventions
Brostrom repair with augmentation, Brostrom repair without augmentation
Device · Other
Lead sponsor
Hancock Orthopedics
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Greenfield, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 11, 2026 · Synced Jul 21, 2026, 10:10 PM EDT
Completed No phase listed Observational

Outcomes Following Severe Distal Tibia, Ankle and/or Foot Trauma: Comparison of Limb Salvage Versus Transtibial Amputation Protocol

NCT01606501
View directory record Official record
Conditions
Severe Distal Tibia Injury, Severe Ankle Injury, Severe Foot Injury, Major Soft Tissue Loss, Major Bone Articular Surface Loss, Major Ankle Articular Surface Loss
Interventions
Not listed
Lead sponsor
Major Extremity Trauma Research Consortium
Other
Eligibility
18 Years to 60 Years
Enrollment
664 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2019
U.S. locations
33
States / cities
Birmingham, Alabama • San Diego, California • San Francisco, California + 26 more
Source: ClinicalTrials.gov public record
Updated Mar 23, 2021 · Synced Jul 21, 2026, 10:10 PM EDT
Completed Not applicable Interventional Results available

Use of Platelet-Rich Plasma (PRP) and Platelet-Poor Plasma (PPP) to Prevent Infection and Delayed Wound Healing

NCT01639144
View directory record Official record
Conditions
Elective Foot and Ankle Surgery.
Interventions
PRP and PPP
Biological
Lead sponsor
Gary M. Kiebzak, Ph.D.
Other
Eligibility
18 Years to 80 Years
Enrollment
515 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated May 21, 2015 · Synced Jul 21, 2026, 10:10 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Orthotic Dose Response Study

NCT02629731
View directory record Official record
Conditions
Ankle Osteoarthritis, Flat Foot or Pes Planus
Interventions
custom orthoses with varying degrees of hindfoot posting
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 80 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2023
U.S. locations
2
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 20, 2024 · Synced Jul 21, 2026, 10:10 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Dry Needling the Calf Muscles on Biomechanics and Muscle Function in Individuals With Restricted Dorsiflexion

NCT07474948
View directory record Official record
Conditions
Ankle Stiffness
Interventions
Dry needling
Procedure
Lead sponsor
University of Dayton
Other
Eligibility
18 Years to 40 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Dayton, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 15, 2026 · Synced Jul 21, 2026, 10:10 PM EDT
Terminated Not applicable Interventional

Weight Change With Controlled Ankle Movement (CAM) Walker Boot Use

NCT02643524
View directory record Official record
Conditions
Foot Injury, Ankle Injury
Interventions
Nutrition and Exercise Counseling, Control
Behavioral
Lead sponsor
Nell Blake, DPM
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 27, 2019 · Synced Jul 21, 2026, 10:10 PM EDT
Completed Not applicable Interventional Results available

Clinical Trial Comparing C-Brace to Knee Ankle Foot Orthosis (KAFO)/Stance Control Orthosis (SCO)

NCT03906656
View directory record Official record
Conditions
Pareses, Lower Extremity
Interventions
C-Brace, KAFO/SCO
Device
Lead sponsor
Otto Bock Healthcare Products GmbH
Industry
Eligibility
18 Years and older
Enrollment
149 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
4
States / cities
Sarasota, Florida • Chicago, Illinois • Houston, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Jul 21, 2026, 10:10 PM EDT
Not listed Phase 1 Interventional

NMES and Chronic Ankle Instability

NCT04322409
View directory record Official record
Conditions
Chronic Ankle Instability
Interventions
Neuromuscular Electrical Stimulation, Transcutaneous Electrical Nerve Stimulation
Device
Lead sponsor
Appalachian State University
Other
Eligibility
18 Years to 35 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Boone, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 25, 2020 · Synced Jul 21, 2026, 10:10 PM EDT
Withdrawn Not applicable Interventional

Custom Dynamic Orthoses to Reduce Articular Contact Stress

NCT05209347
View directory record Official record
Conditions
Ankle Fractures, Post-traumatic Osteoarthritis, Osteoarthritis Ankle
Interventions
Carbon Fiber Custom Dynamic Orthosis (CDO)
Device
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Jul 21, 2026, 10:10 PM EDT
Completed No phase listed Observational Results available

Post- Surgery Recovery: Nerve Blocks w/ Sedation vs. Nerve Block w/ Either Sedation/Gen. Anesthesia

NCT02602080
View directory record Official record
Conditions
Nausea, Emesis
Interventions
Not listed
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 99 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 1, 2019 · Synced Jul 21, 2026, 10:10 PM EDT
Completed Not applicable Interventional Results available

Orthotics in Ambulatory Cerebral Palsy

NCT01527162
View directory record Official record
Conditions
Cerebral Palsy
Interventions
SAFO worn, SAFO not worn
Device · Other
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
2 Years to 9 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 15, 2021 · Synced Jul 21, 2026, 10:10 PM EDT
Completed No phase listed Observational

Ankle Fracture vs Ankle Fracture-Dislocation

NCT02198768
View directory record Official record
Conditions
Ankle Fractures
Interventions
Not listed
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 24, 2022 · Synced Jul 21, 2026, 10:10 PM EDT
Recruiting Not applicable Interventional

Neuromuscular Electrical Stimulation in Foot and Ankle Surgery

NCT06370325
View directory record Official record
Conditions
Ankle Fractures
Interventions
VPOD Wireless Tens Unit, Physical Therapy, Biodex
Procedure · Device
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 26, 2026 · Synced Jul 21, 2026, 10:10 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Effect of Manipulation of the Ankle Joint on Gait

NCT01787721
View directory record Official record
Conditions
Gait
Interventions
Ankle manipulation, Sham manipulation
Procedure · Other
Lead sponsor
University of Bridgeport
Other
Eligibility
18 Years to 65 Years
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Bridgeport, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 22, 2014 · Synced Jul 21, 2026, 10:10 PM EDT
Recruiting Phase 4 Interventional

Buprenorphine as a Post-operative Analgesic in Opioid-Naive Patients After Ankle Fracture Surgery

NCT06949826
View directory record Official record
Conditions
Pain, Postoperative, Ankle Fracture Surgery, Opioid Use Disorder, Opioid Dependence, Opioid Analgesia
Interventions
Buprenorphine Transdermal System, Placebo Patch
Drug
Lead sponsor
Jenna-Leigh Wilson
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 5, 2026 · Synced Jul 21, 2026, 10:10 PM EDT
Completed No phase listed Observational

Ankle Joint Replacement Outcomes Study

NCT00503438
View directory record Official record
Conditions
Osteoarthritis, Rheumatoid Arthritis, Post-Traumatic Arthritis, Septic Arthritis, Prior Ankle Fusion
Interventions
Salto Talaris Ankle
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2023
U.S. locations
2
States / cities
San Antonio, Texas • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jan 23, 2024 · Synced Jul 21, 2026, 10:10 PM EDT
Completed Not applicable Interventional

Effects of Balance Training on Corticospinal Excitability in People With Chronic Ankle Instability

NCT05655143
View directory record Official record
Conditions
Ankle Injuries
Interventions
Balance training
Behavioral
Lead sponsor
Old Dominion University
Other
Eligibility
18 Years to 40 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated May 6, 2024 · Synced Jul 21, 2026, 10:10 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Triage-Based Application of OFAR on the Number of Radiographs Ordered

NCT01779804
View directory record Official record
Conditions
Ankle Injuries, Foot Injuries
Interventions
OFAR
Procedure
Lead sponsor
Lehigh Valley Hospital
Other
Eligibility
16 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Allentown, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 7, 2016 · Synced Jul 21, 2026, 10:10 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Stories to Educate Patients With Ankle, Foot, and Knee Injuries

NCT01810523
View directory record Official record
Conditions
Injury
Interventions
Narrative, Control
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2013
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 21, 2016 · Synced Jul 21, 2026, 10:10 PM EDT
Completed Phase 3 Interventional Results available

Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of EXPAREL, EXPAREL Admixed With Bupivacaine HCl vs. Bupivacaine HCl Administered as Combined Sciatic and Saphenous Nerve Blocks for Postsurgical Analgesia in Subjects Undergoing Lower Extremity Surgeries

NCT04518462
View directory record Official record
Conditions
Lower Extremity Surgery, Bunion, Metatarsophalangeal Fushion, Midfoot Fusion, Hindfoot Fushion, Total Ankle Arthroplasty
Interventions
Exparel, Bupivacaine Hydrochloride
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
121 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
5
States / cities
Phoenix, Arizona • Pasadena, California • Boston, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 17, 2022 · Synced Jul 21, 2026, 10:10 PM EDT