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ClinicalTrials.gov public records Last synced Nov 15, 2026, 12:13 AM EST

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Showing 1–24 of 85 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Ankle Pathology Clear all

Conditions: Peripheral Artery Disease
Interventions: AFO to improve outcomes; Device
Lead sponsor: University of Minnesota; Other
Eligibility: 40 Years and older
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Missoula, Montana

Conditions: Pain
Interventions: Pain Coping Information, Mindfulness Practice (alone), Mindfulness Introduction + Mindfulness Practice, Pain Introduction + Mindfulness Introduction + Mindfulness Practice; Behavioral
Lead sponsor: University of Utah; Other
Eligibility: 18 Years and older
Enrollment: 28 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Post-Traumatic Osteoarthritis of Ankle, Ankle Osteoarthritis, Ankle Injuries
Interventions: Osteochondral allograft ankle; Procedure
Lead sponsor: University of Missouri-Columbia; Other
Eligibility: 18 Years to 55 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Columbia, Missouri

Conditions: Nerve Block, General Anesthesia, Spinal Anesthesia, Pain, Postoperative Nausea and Vomiting
Interventions: 25 mL of 0.25% bupivacaine plus 2 mg preservative-free (PF) dexamethasone / 30 ml for popliteal nerve block, 10 mL of 0.25% bupivacaine plus 2 mg preservative-free (PF) dexamethasone / 30 ml for adductor canal nerve block, Midazolam, 2-5 mg IV + Glycopyrrolate, 0.1 mg IV + Ketamine, 10-20 mg + propofol as needed, 45-60 mg of 1.5% mepivacaine for spinal anesthesia, LMA insertion + titrated propofol infusion + sevoflurane + ketamine 10 mg/hr for general anesthesia; Procedure · Drug
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 18 Years to 75 Years
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017
U.S. locations: 1
States / cities: New York, New York

Conditions: Ankle Fracture
Interventions: Tourniquet, No Tourniquet; Device · Other
Lead sponsor: Alex Demers; Other
Eligibility: 18 Years to 65 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Ankle Fractures
Interventions: Regional anesthesia group, Local multimodal analgesia group; Drug
Lead sponsor: University of Utah; Other
Eligibility: 18 Years to 80 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2028
U.S. locations: 2
States / cities: Salt Lake City, Utah

Conditions: Pain, Postoperative, Ankle Fracture Surgery, Opioid Use Disorder, Opioid Dependence, Opioid Analgesia
Interventions: Buprenorphine Transdermal System, Placebo Patch; Drug
Lead sponsor: Jenna-Leigh Wilson; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Foot Injuries and Disorders
Interventions: Structure Sensor, Caliper; Device
Lead sponsor: University of Iowa; Other
Eligibility: 18 Years to 75 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Gait, Hemiplegic
Interventions: Ankle Orthotic; Device
Lead sponsor: University of Delaware; Other
Eligibility: Not listed
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2023
U.S. locations: 1
States / cities: Newark, Delaware

Conditions: Stroke, CVA, Hemiplegia, Hemiparesis, Foot Drop
Interventions: Posterior Leaf spring AFO, Double adjustable AFO; Device
Lead sponsor: Texas Woman's University; Other
Eligibility: 18 Years and older
Enrollment: 23 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Frisco, Texas

Conditions: Osteoarthritis, Osteoarthritis, Knee, Osteoarthritis, Hip, Osteoarthritis Ankle
Interventions: Group Physical Therapy Classes; Other
Lead sponsor: University of Missouri-Columbia; Other
Eligibility: 18 Years and older
Enrollment: 10,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2030
U.S. locations: 1
States / cities: Columbia, Missouri

Conditions: Phantom Limb Pain, Phantom Pain, Phantom Sensation, Phantom Limb Syndrome With Pain, Phantom Pain Following Amputation of Lower Limb, Phantom Pain Following Amputation of Upper Limb, Amputation, Upper Limb Amputation at the Hand, Upper Limb Amputation at the Wrist, Upper Limb Amputation Below Elbow (Injury), Upper Limb Amputation Above Elbow (Injury), Lower Limb Amputation Knee, Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Below Knee (Injury), Lower Limb Amputation at Ankle (Injury)
Interventions: Coapt Phantom Limb Pain Management System; Device
Lead sponsor: Shirley Ryan AbilityLab; Other
Eligibility: 18 Years and older
Enrollment: 48 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2025
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Total Ankle Arthroplasty, Postsurgical Analgesia
Interventions: EXPAREL, 0.25% bupivacaine (HCl): 50 ml, 0.25% bupivacaine (HCl): 30 ml; Drug
Lead sponsor: Emory University; Other
Eligibility: 18 Years and older
Enrollment: 104 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Degenerative and Traumatic Pathology of the Knee, Degenerative and Traumatic Pathology of the Shoulder and Elbow, Degenerative and Traumatic Pathology of the Foot and Ankle, Degenerative and Traumatic Pathology of the Hand and Wrist, Degenerative and Traumatic Pathology of the Hip
Interventions: Not listed
Lead sponsor: Arthrex, Inc.; Industry
Eligibility: 12 Years and older
Enrollment: 12,500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2023
U.S. locations: 220
States / cities: Birmingham, Alabama • Montgomery, Alabama • Anchorage, Alaska + 171 more

Conditions: Popliteal Nerve Block, Foot Surgery, Ankle Surgery, Popliteal Bifurcation
Interventions: Catheter Placed At Bifurcation, Catheter Placed 5cm Above Bifurcation; Procedure
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2015
U.S. locations: 1
States / cities: San Diego, California

Conditions: Intraoperative Bleeding
Interventions: Epinephrine, Normal Saline irrigation fluid; Drug · Procedure
Lead sponsor: The Guthrie Clinic; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Sayre, Pennsylvania

Conditions: Pain, Ankle Sprain
Interventions: PENNSAID, Diclofenac hydroxyethylpyrrolidine; Drug
Lead sponsor: University of Utah; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Postoperative Infection, Postoperative Complications
Interventions: Soak and Scrub, Clorhexadine scrub; Procedure
Lead sponsor: Rush University Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 242 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Pain, Postoperative, Fracture, Ankle, Pilon Fracture of Tibia, Foot Fracture
Interventions: Auricular acupuncture; Device
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 18 Years to 64 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Sprain, Strain
Interventions: Ketoprofen Topical Patch 20%; Drug
Lead sponsor: Alkemira SA; Industry
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2007
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Foot and Ankle Surgeries, Bunion
Interventions: Tranexamic Acid, Normal saline; Drug
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 18 Years to 75 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018
U.S. locations: 2
States / cities: New York, New York

Conditions: Foot and Ankle Procedures
Interventions: Dexamethasone, Saline; Drug
Lead sponsor: Cedars-Sinai Medical Center; Other
Eligibility: 18 Years to 90 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Hemiplegia, Spastic
Interventions: Not listed
Lead sponsor: Kessler Foundation; Other
Eligibility: 18 Years to 75 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2008
U.S. locations: 1
States / cities: West Orange, New Jersey

Conditions: Pain, Ankle Injuries
Interventions: Not listed
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Boston, Massachusetts

Search by objective public record fields.

Ankle-foot Orthoses for Peripheral Artery Disease

Brief Mindfulness for Foot and Ankle Pain

Indications for Osteochondral Allograft Transplantation

Spinal Versus General Anesthesia With Popliteal and Adductor Canal Blocks for Ambulatory Foot and Ankle Surgery.

Ankle Fracture Tourniquet Utilization

Local Multimodal Injection Versus Regional Anesthesia in Controlling Pain for Treating Rotational Ankle Fractures

Buprenorphine as a Post-operative Analgesic in Opioid-Naive Patients After Ankle Fracture Surgery

SCANREP: Reliability of 3D Lower Limb Scanning

Understanding the Effects of Quantitatively-Prescribing Passive-Dynamic Ankle-Foot Orthosis Bending Stiffness for Individuals Post-Stroke

Effects of Two Different Types of Ankle Foot Orthoses on Gait Outcomes in Patients With Subacute Stroke.

Outcomes of Low-Impact Exercise Program for People With Ankle, Knee, and/or Hip Pain

VR to Evaluate Phantom Limb Pain

Efficacy of EXPAREL vs. Bupivacaine

Web Based Orthopaedic Sports Medicine Registry

Continuous Popliteal Nerve Blocks: Effect of Perineural Catheter Tip Location Relative to the Sciatic Nerve Bifurcation on Postoperative Analgesia

Epinephrine in Irrigation Fluid for Visualization During Ankle Surgery

Efficacy of PENNSAID® for Pain Management in the Emergency Department

Dilute Betadine Soak and Scrub for Foot and Ankle Surgery

Auricular Acupuncture as Part of Multimodal Analgesia After Lower Leg Fracture

Efficacy and Safety of Ketoprofen Topical Patch 20% in the Treatment of Pain Associated With Ankle Sprain or Strain

Efficacy of Tranexamic Acid in Foot and Ankle Surgeries

Efficacy of Popliteal Nerve Blocks With and Without Dexamethasone on the Duration of Analgesia for Foot & Ankle Surgery

Evaluation of the Effect of an Ankle Foot Orthoses for Ambulatory Function

Associated Joint Pain With Controlled Ankle Movement (CAM) Walker Boot Wear