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ClinicalTrials.gov public records Last synced Oct 5, 2026, 5:22 AM EDT

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Showing 25–48 of 104 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Anxiety and Distress Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Community Discussions and Social Participation

NCT07013357
View directory record Official record
Conditions
Social Connectedness, Community Engagement, Physical Wellbeing
Interventions
Virtual Community Intervention, Control
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
185 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Oct 5, 2026, 5:22 AM EDT
Completed Not applicable Interventional Results available

Acceptance and Commitment Therapy (ACT) for OEF/OIF Veterans

NCT01253044
View directory record Official record
Conditions
Distress, Anxiety, Depression, Postconcussive Symptoms
Interventions
Acceptance and Commitment Therapy, Present Centered Therapy
Behavioral
Lead sponsor
Veterans Medical Research Foundation
Other
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
6
States / cities
La Jolla, California • Washington D.C., District of Columbia • Augusta, Maine + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 19, 2015 · Synced Oct 5, 2026, 5:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mobilized Psychoeducation and Skills Based Intervention (Pep-Pal) for Caregivers of Patients With Advanced Illness

NCT03002896
View directory record Official record
Conditions
Distress, Anxiety, Depression
Interventions
Pep-Pal, Treatment as Usual
Behavioral · Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 85 Years
Enrollment
69 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 4, 2020 · Synced Oct 5, 2026, 5:22 AM EDT
Completed Not applicable Interventional Results available

Effect of Guided Imagery for Radiotherapy-Related Distress in Patients With Head and Neck Cancer

NCT03662698
View directory record Official record
Conditions
Head and Neck Cancer
Interventions
Guided Imagery, Treatment as Usual
Behavioral · Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 100 Years
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 13, 2025 · Synced Oct 5, 2026, 5:22 AM EDT
Completed Not applicable Interventional

A Guided Online ACT Intervention Combined With Psychoeducation for People With Spinal Cord Injury

NCT04670406
View directory record Official record
Conditions
Spinal Cord Injuries, Psychological Distress
Interventions
acceptance and commitment therapy (ACT) combined with psychoeducation
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Sep 8, 2021 · Synced Oct 5, 2026, 5:22 AM EDT
Completed Not applicable Interventional

Precision Psychiatry Continuity Clinic Project

NCT03260985
View directory record Official record
Conditions
Depressive Disorders, Depressive Symptoms, Anxiety Disorders and Symptoms, Psychological Distress, Mood Disorders
Interventions
Feedback Report
Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Feb 7, 2020 · Synced Oct 5, 2026, 5:22 AM EDT
Completed Phase 1 Interventional

Acupuncture to Reduce Symptoms of Advanced Colorectal Cancer

NCT00034034
View directory record Official record
Conditions
Colorectal Neoplasms
Interventions
Acupuncture
Procedure
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
18 Years and older
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2006
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 5, 2007 · Synced Oct 5, 2026, 5:22 AM EDT
Terminated Not applicable Interventional

ACT for HIV-Positive Men

NCT06625437
View directory record Official record
Conditions
Stress, Anxiety, Mental Disorder, Distress-based Psychopathology
Interventions
Acceptance and commitment therapy
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older · Male only
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Apr 20, 2026 · Synced Oct 5, 2026, 5:22 AM EDT
Completed Not applicable Interventional

Psychotherapy Treatment of Deployment-Related PTSD in Primary Care Settings

NCT00974402
View directory record Official record
Conditions
Post-Traumatic Stress Disorders, Stress Disorders, Combat Disorders
Interventions
Cognitive Behavioral Therapy
Behavioral
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
3
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Sep 18, 2014 · Synced Oct 5, 2026, 5:22 AM EDT
Completed Not applicable Interventional Results available

Mobile Coping Skills Training to Improve Cardiorespiratory Failure Survivors' Psychological Distress

NCT04329702
View directory record Official record
Conditions
Cardiorespiratory Failure
Interventions
Coping skills training mobile app with call from CST therapist, Coping skills training mobile app only
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 3, 2023 · Synced Oct 5, 2026, 5:22 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Project EMPOWER-OCD

NCT07158801
View directory record Official record
Conditions
Obsessive-Compulsive Disorder
Interventions
Project EMPOWER-OCD, Project CARE
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Oct 5, 2026, 5:22 AM EDT
Withdrawn No phase listed Observational

A Prospective Study of Body Image, Social Avoidance and Distress and Psychological Functioning in Burn Patients

NCT01136070
View directory record Official record
Conditions
Depression, Anxiety, Body Image
Interventions
Not listed
Lead sponsor
Saint Elizabeth Regional Medical Center
Other
Eligibility
19 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Oct 13, 2016 · Synced Oct 5, 2026, 5:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Reducing Tobacco Smoking: a Transcranial Direct Current Stimulation (TDCS) Telehealth Study

NCT05460676
View directory record Official record
Conditions
Smoking Cessation
Interventions
Transcranial Direct Current Stimulation (tDCS), Mindfulness, Sham - Transcranial Direct Current Stimulation (tDCS)
Device · Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
21 Years to 75 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated May 29, 2026 · Synced Oct 5, 2026, 5:22 AM EDT
Completed Not applicable Interventional Results available

Mental Health Among Patients, Providers, and Staff During the COVID-19 Era

NCT04700137
View directory record Official record
Conditions
Covid19, Mental Health
Interventions
Caring Contacts Plus Introductory Phone Call (CC+), Caring Contacts without an introductory phone call (CC)
Other
Lead sponsor
St. Luke's Health System, Boise, Idaho
Other
Eligibility
12 Years and older
Enrollment
666 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Boise, Idaho
Source: ClinicalTrials.gov public record
Updated Jan 25, 2024 · Synced Oct 5, 2026, 5:22 AM EDT
Completed Not applicable Interventional

Impact of Music Therapy on Anxiety in Patients With Cancer Undergoing Simulation for Radiation Therapy

NCT02150395
View directory record Official record
Conditions
Anxiety and Distress
Interventions
music therapy
Other
Lead sponsor
Beth Israel Medical Center
Other
Eligibility
18 Years and older
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 29, 2014 · Synced Oct 5, 2026, 5:22 AM EDT
Enrolling by invitation Phase 2 Interventional

An Open-Label Extension Study to Evaluate the Safety and Tolerability of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 OLE Study)

NCT07161700
View directory record Official record
Conditions
Major Depressive Disorder (MDD), Major Depressive Disorder With Anxious Distress
Interventions
SPT-300
Drug
Lead sponsor
Seaport Therapeutics
Industry
Eligibility
18 Years to 66 Years
Enrollment
360 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
19
States / cities
Chino, California • Garden Grove, California • Glendale, California + 16 more
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Oct 5, 2026, 5:22 AM EDT
Recruiting Not applicable Interventional

Brief Interventions for Coping with Distress

NCT05779761
View directory record Official record
Conditions
Distress, Emotional, Emotional Dysfunction, Anxiety, Depression
Interventions
Online, Self-Directed Attention Skills Training with Coaching Support, Online, Self-Directed Attention & Reflective Thought Skills Training with Coaching Support, Online, Self-Directed Health & Wellness Education Training with Coaching Support
Behavioral
Lead sponsor
Teachers College, Columbia University
Other
Eligibility
18 Years to 65 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 21, 2024 · Synced Oct 5, 2026, 5:22 AM EDT
Completed No phase listed Observational

Impact of Dental Desensitization Facilitated by a Child Life Specialist Distress and Cooperation

NCT06620289
View directory record Official record
Conditions
Desensitization, Dental Anxiety, Dental Care, Distress, Emotional, Cooperation, Patient
Interventions
Dental Desensitization Clinic
Behavioral
Lead sponsor
Children's Hospital Colorado
Other
Eligibility
2 Years to 25 Years
Enrollment
60 participants
Timeline
2024 – 2026
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Oct 5, 2026, 5:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Healthy Lifestyle Intervention for High-Risk Minority Pregnant Women

NCT03416010
View directory record Official record
Conditions
Emotional Disturbances, Depression, Pregnancy Late, Post-Partum Depression, Anxiety, Nutritional Deficiency
Interventions
COPE-P
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
299 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
3
States / cities
The Bronx, New York • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 18, 2025 · Synced Oct 5, 2026, 5:22 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Impact of Physician Contact on Patient Anxiety During the Waiting Period After Embryo Transfer

NCT04190732
View directory record Official record
Conditions
Infertility
Interventions
Physician phone call
Behavioral
Lead sponsor
Boston IVF
Other
Eligibility
18 Years to 43 Years · Female only
Enrollment
231 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Waltham, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 11, 2022 · Synced Oct 5, 2026, 5:22 AM EDT
Not listed Not applicable Interventional

Peer Intervention to Improve Access Among Rural Women Veterans With Psychological Distress and Unmet Social Needs

NCT05477706
View directory record Official record
Conditions
Psychological Distress, Depression, PTSD, Anxiety
Interventions
Personalized Support for Progress (PSP), Tailored Referral (TR)
Other
Lead sponsor
Syracuse VA Medical Center
Federal
Eligibility
18 Years and older · Female only
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
2
States / cities
Syracuse, New York • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 28, 2022 · Synced Oct 5, 2026, 5:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mindful Moms: Mechanisms of Mindfulness-based Cognitive Therapy During Pregnancy and Postpartum

NCT05137925
View directory record Official record
Conditions
Psychological Distress, Pregnancy Related, Postpartum Blues, Postpartum Depression, Postpartum Anxiety, Postpartum Sadness
Interventions
Mindfulness-Based Cognitive Therapy (MBCT), Treatment as Usual (TAU)
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older · Female only
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 4, 2026 · Synced Oct 5, 2026, 5:22 AM EDT
Completed Not applicable Interventional Results available

Mobile Mindfulness to Improve Psychological Distress After Critical Illness

NCT02701361
View directory record Official record
Conditions
Psychological Distress, Depression, Anxiety, Post-traumatic Stress Disorder, Informal Caregivers, Family Members
Interventions
mobile mindfulness, standard mindfulness, education
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
2
States / cities
Durham, North Carolina • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 7, 2018 · Synced Oct 5, 2026, 5:22 AM EDT
Completed Phase 2 Interventional

Yoga to Reduce Cancer Fatigue

NCT00583739
View directory record Official record
Conditions
Breast Neoplasm
Interventions
Yoga
Behavioral
Lead sponsor
University of Iowa
Other
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Dec 4, 2008 · Synced Oct 5, 2026, 5:22 AM EDT