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Showing 1–24 of 414 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Aortic Valve Disease Clear all
Completed Phase 1 Interventional

Natural History and Results of Dual Chamber (DDD) Pacemaker Therapy of Children With Obstructive Hypertrophic Cardiomyop...

NCT00001396
View directory record Official record
Conditions
Hypertrophic Cardiomyopathy
Interventions
Paragon Pacemaker
Device
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
5 Years to 20 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1993 – 2008
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Sep 25, 2026, 6:52 AM EDT
Completed No phase listed Observational

Hypertrophic Cardiomyopathy Pilot Study

NCT02806479
View directory record Official record
Conditions
Hypertrophic Cardiomyopathy, Coronary Artery Disease
Interventions
Observational: Arrhythmogenic Substrate
Other
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 99 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Sep 15, 2020 · Synced Sep 25, 2026, 6:52 AM EDT
Terminated Not applicable Interventional

Effect of Personalized Accelerated Pacing in Symptomatic Patients With Non-Obstructive Hypertrophic Cardiomyopathy

NCT06775886
View directory record Official record
Conditions
Non-obstructive Hypertrophic Cardiomyopathy, Hypertrophic Cardiomyopathy
Interventions
myPACE+ algorithm
Other
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Feb 10, 2026 · Synced Sep 25, 2026, 6:52 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Treatment of Preclinical Hypertrophic Cardiomyopathy With Diltiazem

NCT00319982
View directory record Official record
Conditions
Hypertrophic Cardiomyopathy
Interventions
Diltiazem, Placebo
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
5 Years to 39 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2013
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 6, 2015 · Synced Sep 25, 2026, 6:52 AM EDT
Active, not recruiting Not applicable Interventional Results available

PERIGON Pivotal Trial

NCT02088554
View directory record Official record
Conditions
Aortic Stenosis
Interventions
Model 400 aortic valve bioprosthesis
Device
Lead sponsor
Medtronic Cardiac Surgery
Industry
Eligibility
18 Years and older
Enrollment
1,312 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2035
U.S. locations
20
States / cities
Los Angeles, California • Aurora, Colorado • Hartford, Connecticut + 16 more
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Sep 25, 2026, 6:52 AM EDT
Completed Phase 4 Interventional Results available

Ranolazine for the Treatment of Chest Pain in HCM Patients

NCT01721967
View directory record Official record
Conditions
Hypertrophic Cardiomyopathy
Interventions
Ranolazine
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 2, 2017 · Synced Sep 25, 2026, 6:52 AM EDT
Active, not recruiting Not applicable Interventional Results available

Portico Next Generation Approval Study

NCT04011722
View directory record Official record
Conditions
Symptomatic Severe Aortic Stenosis
Interventions
Portico™ NG (Navitor) Valve and FlexNav™ Delivery System, Navitor Titan Valve (35mm) Valve and Large FlexNav™ Delivery System
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years to 100 Years
Enrollment
333 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2033
U.S. locations
21
States / cities
Los Angeles, California • Thousand Oaks, California • Washington D.C., District of Columbia + 17 more
Source: ClinicalTrials.gov public record
Updated Jul 20, 2026 · Synced Sep 25, 2026, 6:52 AM EDT
Recruiting No phase listed Observational

Valved Graft PMCF Study

NCT04754217
View directory record Official record
Conditions
Aortic Valve Disease, Ascending Aorta Abnormality, Aortic Dissection
Interventions
VAVGJ, CAVGJ
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
260 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2029
U.S. locations
5
States / cities
Birmingham, Alabama • Ann Arbor, Michigan • Asheville, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Sep 25, 2026, 6:52 AM EDT
Recruiting Not applicable Interventional

ARTIST: Aortic Regurgitation Trial Investigating Surgery Versus Trilogy™

NCT06608823
View directory record Official record
Conditions
Aortic Regurgitation, Aortic Valve Insufficiency, Aortic Insufficiency
Interventions
Transcatheter Aortic Valve Replacement (TAVR) using Trilogy THV System, SAVR
Device
Lead sponsor
JenaValve Technology, Inc.
Industry
Eligibility
Not listed
Enrollment
1,016 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2036
U.S. locations
34
States / cities
Burlingame, California • La Jolla, California • Los Angeles, California + 29 more
Source: ClinicalTrials.gov public record
Updated Sep 16, 2026 · Synced Sep 25, 2026, 6:52 AM EDT
Completed Not applicable Interventional

Aortic Stenosis Pre-Transcatheter Aortic Valve Replacement (TAVR) Procedure CT Scan

NCT01843426
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
Low-volume, low-concentration contrast (iodixanol - Visipaque 270) CT scan
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 90 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 1, 2018 · Synced Sep 25, 2026, 6:52 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Defining the Brain Phenotype of Children With Williams Syndrome

NCT01132885
View directory record Official record
Conditions
Williams Syndrome, Duplication
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
5 Years and older
Enrollment
415 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2011
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Sep 25, 2026, 6:52 AM EDT
Completed Phase 3 Interventional Results available

Edoxaban Compared to Standard Care After Heart Valve Replacement Using a Catheter in Patients With Atrial Fibrillation (ENVISAGE-TAVI AF)

NCT02943785
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Edoxaban-based Regimen, VKA-based Regimen
Drug
Lead sponsor
Daiichi Sankyo
Industry
Eligibility
18 Years and older
Enrollment
1,426 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
66
States / cities
Birmingham, Alabama • Tucson, Arizona • Little Rock, Arkansas + 60 more
Source: ClinicalTrials.gov public record
Updated Mar 23, 2022 · Synced Sep 25, 2026, 6:52 AM EDT
Recruiting Not applicable Interventional

Staged Complete Revascularization for Coronary Artery Disease vs Medical Management Alone in Patients With AS Undergoing Transcatheter Aortic Valve Replacement

NCT04634240
View directory record Official record
Conditions
Aortic Stenosis, Coronary Artery Disease, Coronary Stenosis
Interventions
Percutaneous Coronary Intervention (PCI)
Procedure
Lead sponsor
University of British Columbia
Other
Eligibility
Not listed
Enrollment
4,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
55
States / cities
Huntsville, Alabama • Phoenix, Arizona • Palo Alto, California + 49 more
Source: ClinicalTrials.gov public record
Updated Jul 23, 2025 · Synced Sep 25, 2026, 6:52 AM EDT
Not listed No phase listed Observational

Hypertrophic Cardiomyopathy Federated Learning Implementation Platform

NCT06461468
View directory record Official record
Conditions
Hypertrophic Cardiomyopathy
Interventions
Not listed
Lead sponsor
American Heart Association
Other
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
6
States / cities
Fairhope, Alabama • Kankakee, Illinois • Baltimore, Maryland + 3 more
Source: ClinicalTrials.gov public record
Updated Aug 5, 2024 · Synced Sep 25, 2026, 6:52 AM EDT
Active, not recruiting Not applicable Interventional

J-Valve TF Early Feasibility Study

NCT06034028
View directory record Official record
Conditions
Aortic Valve Disease, Aortic Valve Insufficiency, Aortic Regurgitation
Interventions
J-Valve TF System
Device
Lead sponsor
JC Medical, Inc., an affiliate of Edwards Lifesciences LLC
Industry
Eligibility
Not listed
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
9
States / cities
Scottsdale, Arizona • Washington D.C., District of Columbia • Oak Lawn, Illinois + 6 more
Source: ClinicalTrials.gov public record
Updated Jul 10, 2025 · Synced Sep 25, 2026, 6:52 AM EDT
Completed No phase listed Observational

Podocan and Wnt Pathway in Left Ventricular Remodeling of Aortic Stenosis

NCT02624934
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
Not listed
Lead sponsor
Bassett Healthcare
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Cooperstown, New York
Source: ClinicalTrials.gov public record
Updated Jul 8, 2020 · Synced Sep 25, 2026, 6:52 AM EDT
Completed Phase 4 Interventional Results available

Inflammation and Thrombosis in Patients With Severe Aortic Stenosis After Transcatheter Aortic Valve Replacement (TAVR)

NCT02486367
View directory record Official record
Conditions
Aortic Stenosis, Inflammation, Thrombosis
Interventions
Clopidogrel, Ticagrelor
Drug
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 19, 2022 · Synced Sep 25, 2026, 6:52 AM EDT
Withdrawn Phase 2 Interventional

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of MEK162 in Noonan Syndrome Hypertrophic Cardiomyopathy

NCT01556568
View directory record Official record
Conditions
Cardiomegaly
Interventions
MEK162
Drug
Lead sponsor
Array Biopharma, now a wholly owned subsidiary of Pfizer
Industry
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 5, 2020 · Synced Sep 25, 2026, 6:52 AM EDT
Terminated Not applicable Interventional Results available

On-X Heart Valve - 17mm Aortic and 23mm Mitral

NCT01812174
View directory record Official record
Conditions
Heart Valve Disease
Interventions
17mm aortic valve (On-X ), 23mm mitral valve (On-X)
Device
Lead sponsor
On-X Life Technologies, Inc.
Industry
Eligibility
Not listed
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2018
U.S. locations
7
States / cities
Little Rock, Arkansas • Portland, Maine • Las Vegas, Nevada + 4 more
Source: ClinicalTrials.gov public record
Updated Mar 5, 2024 · Synced Sep 25, 2026, 6:52 AM EDT
Completed Phase 4 Interventional Results available

Buspirone Treatment of Anxiety in Williams Syndrome

NCT04807517
View directory record Official record
Conditions
Williams Syndrome, Anxiety
Interventions
Buspirone
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
5 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Lexington, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 2, 2024 · Synced Sep 25, 2026, 6:52 AM EDT
Active, not recruiting Phase 3 Interventional

A Study to Evaluate Mavacamten in Adolescents With Symptomatic Obstructive Hypertrophic Cardiomyopathy

NCT06253221
View directory record Official record
Conditions
Cardiomyopathy, Hypertrophic
Interventions
Mavacamten, Placebo
Drug
Lead sponsor
Bristol-Myers Squibb
Industry
Eligibility
12 Years to 17 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2031
U.S. locations
31
States / cities
Birmingham, Alabama • Phoenix, Arizona • Los Angeles, California + 26 more
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Sep 25, 2026, 6:52 AM EDT
Not listed No phase listed Observational

Transcatheter Aortic Valve Replacement (TAVR) Double Balloon Valvuloplasty

NCT05189886
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
Double Balloon Valvuloplasty in TAVR
Procedure
Lead sponsor
Community Memorial Health System
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Ventura, California
Source: ClinicalTrials.gov public record
Updated Jan 12, 2022 · Synced Sep 25, 2026, 6:52 AM EDT
Completed Not applicable Interventional Results available

Trifecta™ GT Post Market Clinical Follow-up

NCT03016169
View directory record Official record
Conditions
Aortic Valve Disease, Aortic Valve Disorder
Interventions
Trifecta GT (Glide Technology) Valve
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
358 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
5
States / cities
Rochester, Minnesota • Asheville, North Carolina • Wynnewood, Pennsylvania + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 10, 2025 · Synced Sep 25, 2026, 6:52 AM EDT
Completed Not applicable Interventional

A pragmatiC sTrategy to Promote actIVity and Enhance Quality of Life AFTER Transcatheter Aortic Valve Replacement

NCT03270124
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
Daily Activity Goal, Resistance Exercises, Daily Activity Recording
Behavioral
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
5
States / cities
Boston, Massachusetts • Lebanon, New Hampshire • Morristown, New Jersey + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 31, 2021 · Synced Sep 25, 2026, 6:52 AM EDT