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ClinicalTrials.gov public records Last synced Nov 15, 2026, 2:22 PM EST

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Showing 433–456 of 1,804 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Arthritis, Degenerative Clear all
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Weight Loss and Exercise on Knee Osteoarthritis

NCT00061490
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Behavioral weight control and lifestyle exercise
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
19 Years and older
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2006
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 26, 2017 · Synced Nov 15, 2026, 2:22 PM EST
Terminated No phase listed Observational

INBONE Total Ankle Arthroplasty(TAA)Using Calcaneal Stem Fixation

NCT01366989
View directory record Official record
Conditions
Arthrodesis, Degenerative Arthritis, Rheumatoid Arthritis, Complications; Arthroplasty, Mechanical
Interventions
Radiographic evaluation of previously implanted patients
Device
Lead sponsor
Stryker Trauma and Extremities
Industry
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 17, 2017 · Synced Nov 15, 2026, 2:22 PM EST
Active, not recruiting Not applicable Interventional

Prospective Randomized Study of Cementless vs Cemented UKA

NCT05377450
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Engage Partial Knee
Device
Lead sponsor
JIS Research Institute
Other
Eligibility
21 Years to 80 Years
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
New Albany, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 26, 2025 · Synced Nov 15, 2026, 2:22 PM EST
Completed Not applicable Interventional

Using Web-based Tools to Facilitate Tailored Exercise for People With Osteoarthritis

NCT02404974
View directory record Official record
Conditions
Osteoarthritis
Interventions
exercise
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
50 Years to 85 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jan 25, 2016 · Synced Nov 15, 2026, 2:22 PM EST
Completed Phase 1 Interventional Accepts healthy volunteers

Safety Study of ECO Conversion System For Red Blood Cells.

NCT00261274
View directory record Official record
Conditions
Anemia
Interventions
A-ECO, Saline
Biological
Lead sponsor
Velico Medical
Industry
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2005
U.S. locations
6
States / cities
New Haven, Connecticut • Minneapolis, Minnesota • Albuquerque, New Mexico + 3 more
Source: ClinicalTrials.gov public record
Updated May 27, 2020 · Synced Nov 15, 2026, 2:22 PM EST
Completed Phase 1 Interventional

A Study to Assess the Effects of Naproxcinod and Naproxen on Blood Pressure Measurements in Osteoarthritis Patients With Controlled High Blood Pressure

NCT00662610
View directory record Official record
Conditions
Osteoarthritis, Hypertension
Interventions
naproxcinod 375 mg -750 mg -1125 mg bid, naproxen 250 mg - 500mg -750 mg bid
Drug
Lead sponsor
NicOx
Industry
Eligibility
40 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
29
States / cities
Mobile, Alabama • Tempe, Arizona • Tucson, Arizona + 26 more
Source: ClinicalTrials.gov public record
Updated Jun 17, 2011 · Synced Nov 15, 2026, 2:22 PM EST
Completed Not applicable Interventional Accepts healthy volunteers Results available

Efficacy of Micro-fragmented Adipose Tissue Injection for Knee Osteoarthritis.

NCT03379168
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Microfragmented Adipose Tissue (Lipogems), Corticosteroid injection, Saline
Device · Drug
Lead sponsor
Dustin L. Richter, MD
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Feb 13, 2025 · Synced Nov 15, 2026, 2:22 PM EST
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Research Study Looking at How Well Semaglutide Works in People Suffering From Obesity and Knee Osteoarthritis

NCT05064735
View directory record Official record
Conditions
Obesity
Interventions
semaglutide 2.4 mg, semaglutide 2.4 mg (placebo)
Drug
Lead sponsor
Novo Nordisk A/S
Industry
Eligibility
Not listed
Enrollment
407 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
61
States / cities
Montgomery, Alabama • Phoenix, Arizona • Anaheim, California + 52 more
Source: ClinicalTrials.gov public record
Updated Nov 17, 2025 · Synced Nov 15, 2026, 2:22 PM EST
Not listed Not applicable Interventional Accepts healthy volunteers

Does Joint Lavage Reduce Intraarticular Inflammation in High-energy Tibial Pilon Fractures?

NCT05652881
View directory record Official record
Conditions
Post-traumatic; Arthrosis, Tibial Fractures, Post-Traumatic Osteoarthritis of Ankle
Interventions
Joint Lavage
Procedure
Lead sponsor
United States Naval Medical Center, San Diego
Federal
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 6, 2024 · Synced Nov 15, 2026, 2:22 PM EST
Completed No phase listed Observational Results available

Treatment Outcomes for Ankle Arthritis

NCT00391365
View directory record Official record
Conditions
Osteoarthritis
Interventions
Gait analysis
Procedure
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 89 Years
Enrollment
368 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Nov 15, 2026, 2:22 PM EST
Enrolling by invitation Phase 1 Interventional

Oral Curcumin for the Treatment of Pain of Thumb Base Joint (CMC) Arthritis

NCT06359665
View directory record Official record
Conditions
Arthritis of Carpometacarpal Joint of Left Thumb, Arthritis of Carpometacarpal Joint of Right Thumb
Interventions
Curcumin, Placebo
Drug
Lead sponsor
Brent DeGeorge
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 19, 2025 · Synced Nov 15, 2026, 2:22 PM EST
Terminated No phase listed Observational Accepts healthy volunteers

AMS Study: Inflammatory and Biomechanical Contributors to Arthritis Development Following Arthroscopic Meniscectomy

NCT00752271
View directory record Official record
Conditions
Osteoarthritis
Interventions
Not listed
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
40 Years and older
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 18, 2009 · Synced Nov 15, 2026, 2:22 PM EST
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Duloxetine in Osteoarthritis (OA) Pain

NCT01558700
View directory record Official record
Conditions
Osteoarthritis
Interventions
Duloxetine, Sugar pill
Drug
Lead sponsor
Northwestern University
Other
Eligibility
40 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 29, 2014 · Synced Nov 15, 2026, 2:22 PM EST
Completed Phase 2 Interventional

A Study To Investigate Whether PF-04457845 Is Effective In Treating Pain, Is Safe And Tolerable In Patients With Osteoarthritis Of The Knee

NCT00981357
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
PF-04457845, Naproxen
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 75 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
5
States / cities
Miami, Florida • Overland Park, Kansas • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Sep 19, 2017 · Synced Nov 15, 2026, 2:22 PM EST
Terminated Phase 4 Interventional

Biofreeze® vs. a Placebo on Knee Osteoarthritis Walking Gait Characteristics and Pain

NCT03888807
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Biofreeze, Placebo
Drug
Lead sponsor
Sport and Spine Rehab Clinical Research Foundation
Other
Eligibility
40 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Rockville, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 2, 2024 · Synced Nov 15, 2026, 2:22 PM EST
Completed No phase listed Observational

Central Sensitization in Patients Seeking Outpatient Physical Therapy Services

NCT05467592
View directory record Official record
Conditions
Low Back Pain, Knee Osteoarthritis, Neck Pain
Interventions
Standard Physical Therapy care
Other
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years and older
Enrollment
77 participants
Timeline
2022 – 2024
U.S. locations
1
States / cities
Shawnee Mission, Kansas
Source: ClinicalTrials.gov public record
Updated May 20, 2025 · Synced Nov 15, 2026, 2:22 PM EST
Completed No phase listed Observational Results available

Precision Assessment of Platelet Rich Plasma for Joint Preservation

NCT03460236
View directory record Official record
Conditions
Osteoarthritis
Interventions
Not listed
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
30 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated May 23, 2025 · Synced Nov 15, 2026, 2:22 PM EST
Withdrawn No phase listed Observational Accepts healthy volunteers

Outcomes of Robotic Total Hip Arthroplasty

NCT01672320
View directory record Official record
Conditions
Osteoarthritis
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
20 Years to 75 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 5, 2013 · Synced Nov 15, 2026, 2:22 PM EST
Completed Phase 4 Interventional

Safety and Efficacy of Celecoxib Versus Placebo in the Treatment of Knee Osteoarthritis in Patients Who Were Unresponsive to Naproxen and Ibuprofen

NCT00638807
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Celecoxib, Placebo
Drug · Other
Lead sponsor
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Industry
Eligibility
40 Years and older
Enrollment
388 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2004
U.S. locations
33
States / cities
Birmingham, Alabama • Buena Park, California • Denver, Colorado + 28 more
Source: ClinicalTrials.gov public record
Updated Feb 2, 2021 · Synced Nov 15, 2026, 2:22 PM EST
Recruiting No phase listed Observational

AETOS Shoulder System

NCT06319911
View directory record Official record
Conditions
Shoulder Osteoarthritis, Shoulder Arthritis
Interventions
AETOS
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2030
U.S. locations
5
States / cities
San Francisco, California • Denver, Colorado • Columbus, Georgia + 2 more
Source: ClinicalTrials.gov public record
Updated May 7, 2024 · Synced Nov 15, 2026, 2:22 PM EST
Terminated No phase listed Observational Accepts healthy volunteers

TAR 2 Weeks vs 6 Weeks Post-Operative Weight-Bearing

NCT04709861
View directory record Official record
Conditions
Ankle Osteoarthritis
Interventions
Not listed
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 85 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Apr 24, 2024 · Synced Nov 15, 2026, 2:22 PM EST
Completed Phase 2 Interventional

A Study of the Safety and Effectiveness of Orally Administered CR845 in Patients With Osteoarthritis of the Hip or Knee

NCT02524197
View directory record Official record
Conditions
Osteoarthritis
Interventions
CR845 0.25 mg, CR845 0.50 mg, CR845 1 mg, CR845 5 mg
Drug
Lead sponsor
Cara Therapeutics, Inc.
Industry
Eligibility
25 Years and older
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
5
States / cities
Omaha, Nebraska • Las Vegas, Nevada • Greensboro, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 31, 2017 · Synced Nov 15, 2026, 2:22 PM EST
Completed Phase 2 Interventional Results available

Intraarticular Dextrose Prolotherapy for Symptomatic Knee Osteoarthritis

NCT05160532
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Placebo, Dextrose prolotherapy (DPT)
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
40 Years to 80 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Nov 15, 2026, 2:22 PM EST
Not listed Not applicable Interventional

Comparative Evaluation of A-CP HA Kit, Hyaluronic Acid and Placebo for the Treatment of Knee Osteoarthritis

NCT03201614
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
A-CP HA Kit, ArthroVisc 40, Placebo
Device · Drug
Lead sponsor
Regen Lab SA
Industry
Eligibility
50 Years to 80 Years
Enrollment
290 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Dec 21, 2020 · Synced Nov 15, 2026, 2:22 PM EST