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ClinicalTrials.gov public records Last synced Nov 15, 2026, 6:56 AM EST

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Showing 97–120 of 1,804 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Arthritis, Degenerative Clear all
Completed Phase 2 Interventional

Teriparatide as a Chondroregenerative Therapy in OA

NCT03072147
View directory record Official record
Conditions
Knee Osteoarthritis, Cartilage Degeneration
Interventions
Teriparatide, Placebo
Drug
Lead sponsor
Christopher Ritchlin
Other
Eligibility
40 Years to 60 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated May 12, 2023 · Synced Nov 15, 2026, 6:56 AM EST
Completed Not applicable Interventional

Exercise Plus Activity Strategy Training for Osteoarthritis

NCT00613678
View directory record Official record
Conditions
Osteoarthritis
Interventions
Activity Strategy Training, Education
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
62 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 5, 2015 · Synced Nov 15, 2026, 6:56 AM EST
Completed Not applicable Interventional Results available

Using Ultrasound to Predict Response to Intraarticular Corticosteroids in Knee Osteoarthritis

NCT00746889
View directory record Official record
Conditions
Osteoarthritis
Interventions
triamcinolone acetonide, saline
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
79 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
2
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Aug 25, 2010 · Synced Nov 15, 2026, 6:56 AM EST
Completed Phase 3 Interventional

Efficacy and Safety Study of Naproxcinod in Subjects With Osteoarthritis of the Hip

NCT00541489
View directory record Official record
Conditions
Osteoarthritis, Osteoarthritis, Hip
Interventions
Naproxcinod, Naproxen, Placebo
Drug
Lead sponsor
NicOx
Industry
Eligibility
40 Years and older
Enrollment
800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2007
U.S. locations
36
States / cities
Mobile, Alabama • Montgomery, Alabama • Tuscaloosa, Alabama + 33 more
Source: ClinicalTrials.gov public record
Updated Feb 20, 2009 · Synced Nov 15, 2026, 6:56 AM EST
Active, not recruiting Not applicable Interventional

Electromagnetic Transduction Therapy on Osteoarthritis in the Foot and Ankle

NCT06696118
View directory record Official record
Conditions
Osteoarthritis Ankle, Osteoarthritis Foot
Interventions
Electromagnetic Transduction Therapy (EMTT)
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Nov 15, 2026, 6:56 AM EST
Completed Phase 2 Interventional Results available

Study to Characterize the PK and Local Extent and Duration of Exposure From FX006 in Patients With OA of the Knee

NCT02637323
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
FX006 32 mg, TCA IR 40
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
40 Years and older
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
4
States / cities
Canoga Park, California • San Diego, California • Hialeah, Florida + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 24, 2024 · Synced Nov 15, 2026, 6:56 AM EST
Completed Phase 3 Interventional Results available

Study of Meloxicam Capsules in Subjects With Osteoarthritis of the Knee or Hip

NCT01801735
View directory record Official record
Conditions
Osteoarthritis
Interventions
Meloxicam Test Capsules
Drug
Lead sponsor
Iroko Pharmaceuticals, LLC
Industry
Eligibility
40 Years and older
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
40
States / cities
Birmingham, Alabama • Phoenix, Arizona • Carmichael, California + 32 more
Source: ClinicalTrials.gov public record
Updated May 12, 2015 · Synced Nov 15, 2026, 6:56 AM EST
Completed Phase 2 Interventional Results available

Discontinuing NSAIDs in Veterans With Knee Osteoarthritis

NCT01799213
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Meloxicam 15 mg po QD, Cognitive Behavioral Therapy
Drug · Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
20 Years and older
Enrollment
490 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
4
States / cities
West Haven, Connecticut • Gainesville, Florida • Boston, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 27, 2023 · Synced Nov 15, 2026, 6:56 AM EST
Completed Not applicable Interventional Results available

Agili-C™ Implant Performance Evaluation

NCT03299959
View directory record Official record
Conditions
Cartilage or Osteochondral Defects in the Knee, Up to Moderate Osteoarthritis
Interventions
Agili-C implant, SSOC
Device · Procedure
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
21 Years to 75 Years
Enrollment
251 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
11
States / cities
San Diego, California • New Orleans, Louisiana • Salisbury, Maryland + 7 more
Source: ClinicalTrials.gov public record
Updated Dec 5, 2025 · Synced Nov 15, 2026, 6:56 AM EST
Completed Phase 1 Interventional

A Study of Single and Repeat Dose Administration of UBX0101 in Patients With Osteoarthritis of the Knee

NCT04229225
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
UBX0101, Placebo
Drug · Other
Lead sponsor
Unity Biotechnology, Inc.
Industry
Eligibility
40 Years to 85 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
7
States / cities
The Villages, Florida • Marietta, Georgia • St Louis, Missouri + 4 more
Source: ClinicalTrials.gov public record
Updated Oct 19, 2020 · Synced Nov 15, 2026, 6:56 AM EST
Completed Not applicable Interventional Results available

Mobility Optimization Through Velocity Exercise

NCT00844558
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Gait Training, Control
Other
Lead sponsor
University of Iowa
Other
Eligibility
60 Years and older
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jun 6, 2016 · Synced Nov 15, 2026, 6:56 AM EST
Completed Phase 2Phase 3 Interventional Results available

Understanding Cognition, Oxytocin & Pain in Elders

NCT03878589
View directory record Official record
Conditions
Knee Osteoarthritis, Osteoarthritis
Interventions
Oxytocin (OT), Placebo (P)
Drug
Lead sponsor
University of Florida
Other
Eligibility
45 Years to 100 Years
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
2
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Feb 23, 2026 · Synced Nov 15, 2026, 6:56 AM EST
Not listed Not applicable Interventional

Home PT vs FORCE PT

NCT02911389
View directory record Official record
Conditions
Osteoarthritis
Interventions
Home PT via web-based platform, Home PT via paper manual, outpatient PT
Other
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2016
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 22, 2016 · Synced Nov 15, 2026, 6:56 AM EST
Completed Not applicable Interventional

A Biologic Joint Replacement Strategy for Knee Trauma and Post-Traumatic Osteoarthritis

NCT03719417
View directory record Official record
Conditions
Knee Osteoarthritis, Post-traumatic Osteoarthritis
Interventions
Unicompartmental Biologic Arthroplasty, Extensive Biologic Arthroplasty
Procedure
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 55 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Nov 2, 2022 · Synced Nov 15, 2026, 6:56 AM EST
Completed Phase 4 Interventional Results available

GI-Reasons- A Trial Of GI Safety Of Celecoxib Compared With Non-Selective Nonsteroidal Antiinflammatory Drugs (NSAIDS)

NCT00373685
View directory record Official record
Conditions
Osteoarthritis
Interventions
Celecoxib, Any commercially available NSAID with the indication for osteoarthritis
Drug
Lead sponsor
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Industry
Eligibility
55 Years to 99 Years
Enrollment
8,067 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
750
States / cities
Abbeville, Alabama • Alexander City, Alabama • Bay Minette, Alabama + 603 more
Source: ClinicalTrials.gov public record
Updated Mar 3, 2021 · Synced Nov 15, 2026, 6:56 AM EST
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Systemic Steroids for Peripheral Nerve Blocks

NCT02464176
View directory record Official record
Conditions
Osteoarthritis, Hip
Interventions
Dexamethasone, Bupivacaine, Epinephrine, Lumbar Plexus Nerve Block, Saline
Drug · Procedure
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 90 Years
Enrollment
115 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 31, 2018 · Synced Nov 15, 2026, 6:56 AM EST
Withdrawn Phase 2 Interventional

Low Level Magnetic Fields for the Treatment of Osteoarthritis of the Hip

NCT01312285
View directory record Official record
Conditions
Osteoarthritis of the Hip
Interventions
Resonator device
Device
Lead sponsor
pico-tesla Magnetic Therapies, LLC
Industry
Eligibility
18 Years to 85 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Clearwater, Florida
Source: ClinicalTrials.gov public record
Updated May 30, 2011 · Synced Nov 15, 2026, 6:56 AM EST
Recruiting Phase 4 Interventional

Knee Osteoarthritis Treatment With Zilretta vs. Kenalog in the Context of Type II Diabetes

NCT06478186
View directory record Official record
Conditions
Osteoarthritis, Knee, Diabetes Mellitus, Type 2
Interventions
triamcinolone acetonide extended-release injectable suspension; TCA-ER, Triamcinolone Acetonide- Immediate Release;TCA-IR
Drug
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
40 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Nov 15, 2026, 6:56 AM EST
Not listed Not applicable Interventional

Biomechanical Footwear as a Non-invasive Alternative and Supplement to Total Knee Replacement

NCT04732962
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
AposHealth, Total Knee Replacement (TKR)
Device · Procedure
Lead sponsor
Geisinger Clinic
Other
Eligibility
45 Years to 80 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
2
States / cities
Danville, Pennsylvania • Wilkes-Barre, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 30, 2025 · Synced Nov 15, 2026, 6:56 AM EST
Completed No phase listed Observational

Prospective, Multiconfiguration Study to Assess Functional Performance of Primary Total Knee Arthroplasty System

NCT01746524
View directory record Official record
Conditions
Osteoarthritis
Interventions
ATTUNE Primary Total Knee Arthroplasty
Device
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
22 Years to 80 Years
Enrollment
1,138 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
9
States / cities
Orange, California • San Diego, California • Fort Collins, Colorado + 6 more
Source: ClinicalTrials.gov public record
Updated Apr 11, 2019 · Synced Nov 15, 2026, 6:56 AM EST
Active, not recruiting No phase listed Observational

Evaluation of Biomarkers in Human Synovial Fluid

NCT02664870
View directory record Official record
Conditions
Osteoarthritis
Interventions
Arthroscopy, Arthroplasty
Procedure
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
149 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2028
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced Nov 15, 2026, 6:56 AM EST
Completed Not applicable Interventional

Effectiveness of BREG Flex in 12-week Peri-operative Total Knee Arthroplasty

NCT03840096
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Breg Flex
Device
Lead sponsor
The Hawkins Foundation
Other
Eligibility
55 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
2
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Sep 9, 2021 · Synced Nov 15, 2026, 6:56 AM EST
Active, not recruiting Phase 2 Interventional Accepts healthy volunteers

Platelet Rich Plasma Injections In Young And Old Human Subjects

NCT06451120
View directory record Official record
Conditions
Osteoarthritis, Articular Cartilage, Musculoskeletal Disorders
Interventions
Platelet-Rich Plasma (PRP) Injections, Centrifuge, Control saline injection
Drug · Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 70 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Nov 15, 2026, 6:56 AM EST
Completed Phase 4 Interventional

Effects of Lumiracoxib and Ibuprofen on Blood Pressure and Urinary Eicosanoid Excretion in Osteoarthritis Patients With Controlled Hypertension

NCT00419796
View directory record Official record
Conditions
Osteoarthritis With Controlled Hypertension
Interventions
Lumiracoxib
Drug
Lead sponsor
Novartis
Industry
Eligibility
50 Years and older
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
East Hanover, New Jersey
Source: ClinicalTrials.gov public record
Updated Nov 29, 2007 · Synced Nov 15, 2026, 6:56 AM EST