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ClinicalTrials.gov public records Last synced Nov 14, 2026, 10:16 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 25–48 of 102 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Articular Cartilage Clear all

Conditions: Articular Cartilage Damage
Interventions: NeoCart, microfracture; Biological · Procedure
Lead sponsor: Histogenics Corporation; Industry
Eligibility: 18 Years to 55 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2014
U.S. locations: 6
States / cities: San Francisco, California • Bloomington, Minnesota • New York, New York + 3 more

Conditions: Osteoarthritis
Interventions: Cartiva; Device
Lead sponsor: Cartiva, Inc.; Industry
Eligibility: 22 Years and older
Enrollment: 74 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2024
U.S. locations: 5
States / cities: San Diego, California • Atlanta, Georgia • Indianapolis, Indiana + 2 more

Conditions: Osteoarthritis, Knee
Interventions: Vitamin D (cholecalciferol), Placebo; Dietary Supplement
Lead sponsor: Tufts Medical Center; Other
Eligibility: 45 Years to 90 Years
Enrollment: 146 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2009
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Defect of Articular Cartilage
Interventions: Not listed
Lead sponsor: University of Missouri-Columbia; Other
Eligibility: 18 Years and older
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2018
U.S. locations: 1
States / cities: Columbia, Missouri

Conditions: Knee Injuries, Cartilage Injury, Cartilage Disease, Knee Discomfort
Interventions: Microfracture, Microfracture plus placement of Chondro-Gide® ACC; Procedure · Device
Lead sponsor: Geistlich Pharma AG; Industry
Eligibility: 18 Years to 55 Years
Enrollment: 82 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2025
U.S. locations: 3
States / cities: Phoenix, Arizona • Stamford, Connecticut • Johns Creek, Georgia

Conditions: Advanced and/or Metastatic Sarcoma
Interventions: Durvalumab, Tremelimumab; Drug
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 57 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2024
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Exercise-induced Muscle Soreness, Exercise-induced Joint Pain, Exercise-induced Joint Stiffness, Exercise-induced Cartilage Turnover
Interventions: NEM® brand eggshell membrane powder, curQ+® brand highly absorbable curcumin, EM Placebo, Curc Placebo, NEM® plus curQ+® combination; Dietary Supplement
Lead sponsor: ESM Technologies, LLC; Industry
Eligibility: 18 Years to 40 Years · Male only
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: College Station, Texas

Conditions: Osteochondral Defect, Articular Cartilage Defect
Interventions: Biologically Augmented Osteochondral Allograft Transplantation; Procedure
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Defect of Articular Cartilage, Knee Injuries
Interventions: Particulated Juvenile Articular Cartilage; Other
Lead sponsor: Zimmer Orthobiologics, Inc.; Industry
Eligibility: 18 Years to 55 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2021
U.S. locations: 16
States / cities: Los Angeles, California • San Deigo, California • Aurora, Colorado + 13 more

Conditions: Degenerative Lesion of Articular Cartilage of Knee
Interventions: ADSC Application, Microfracture; Procedure
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 18 Years to 50 Years
Enrollment: 17 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2025
U.S. locations: 3
States / cities: Redwood City, California • Santa Monica, California • Denver, Colorado

Conditions: Patellofemoral Pain Syndrome, Chondromalacia Patellae, Anterior Knee Pain Syndrome
Interventions: Lumbopelvic Manipulation, TENS- Spine, TENS- Knee; Other
Lead sponsor: Creighton University; Other
Eligibility: 15 Years to 50 Years
Enrollment: 47 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2015
U.S. locations: 1
States / cities: Omaha, Nebraska

Conditions: Obesity, Osteoarthritis, Knee Osteoarthritis
Interventions: Weight Loss; Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 45 Years
Enrollment: 88 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Meniscus Tear, Chondropathy/Degenerative Joint Disease (DJD)
Interventions: Euflexxa, Saline; Device · Other
Lead sponsor: The Hawkins Foundation; Other
Eligibility: 40 Years and older
Enrollment: 34 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: Greenville, South Carolina

Conditions: Meniscal Tears
Interventions: Nanoscopic Arthroscopy of the Knee; Procedure
Lead sponsor: Angelina Vera MD; Other
Eligibility: 18 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Las Vegas, Nevada

Conditions: Osteoarthritis of the Hip, Degenerative Joint Disease of Hip, Dysplasia; Hip
Interventions: Polymotion Hip Resurfacing (PHR) System; Device
Lead sponsor: JointMedica Inc.; Other
Eligibility: 21 Years to 65 Years
Enrollment: 238 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 8
States / cities: Tampa, Florida • Chicago, Illinois • Baltimore, Maryland + 5 more

Conditions: Articular Cartilage Disorder of Knee, Cartilage Damage, Microfractures
Interventions: microfracture surgery + HST003; Biological
Lead sponsor: Histogen; Industry
Eligibility: 18 Years to 50 Years
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 5
States / cities: Vail, Colorado • Bradenton, Florida • Bethesda, Maryland + 2 more

Conditions: Osteoarthritis
Interventions: Lateral wedge orthotic shoe inserts, Standard orthotic shoe inserts; Device
Lead sponsor: Rush University Medical Center; Other
Eligibility: 25 Years and older
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2003 – 2007
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Sprain, Strain, Acute Soft Tissue Injury
Interventions: Topical Ketoprofen 10% Cream, Topical Placebo Cream; Drug
Lead sponsor: Imprimis Pharmaceuticals, Inc.; Industry
Eligibility: 18 Years to 70 Years
Enrollment: 364 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Chondral Defect, Osteochondritis Dissecans (OCD), Articular Cartilage Defect, Articular Cartilage Disorder of Knee
Interventions: MACI, microfracture; Biological · Procedure
Lead sponsor: Vericel Corporation; Industry
Eligibility: 10 Years to 17 Years
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2030
U.S. locations: 15
States / cities: Palo Alto, California • Sacramento, California • New Orleans, Louisiana + 10 more

Conditions: Knee Osteoarthristis
Interventions: Exercise with Rest, Exercise without Rest; Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 45 Years to 79 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Degenerative Lesion of Articular Cartilage of Knee
Interventions: Episealer Knee System, Microfracture; Device · Procedure
Lead sponsor: Episurf Medical Inc.; Industry
Eligibility: 30 Years to 70 Years
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2029
U.S. locations: 8
States / cities: Tempe, Arizona • La Mesa, California • New Orleans, Louisiana + 5 more

Conditions: Articular Cartilage Defects in the Knee Joint
Interventions: GelrinC, Microfracture historical control arm; Device · Other
Lead sponsor: Regentis Biomaterials; Industry
Eligibility: 18 Years to 50 Years
Enrollment: 181 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2024
U.S. locations: 13
States / cities: La Mesa, California • Orange, California • Denver, Colorado + 10 more

Conditions: Osteoarthritis
Interventions: Synvisc; Device
Lead sponsor: Endeavor Health; Other
Eligibility: 40 Years to 80 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2009
U.S. locations: 2
States / cities: Chicago, Illinois • Evanston, Illinois

Conditions: Osteoarthritis, Knee
Interventions: Fisetin, Placebo oral capsule; Dietary Supplement · Drug
Lead sponsor: Steadman Philippon Research Institute; Other
Eligibility: 40 Years to 80 Years
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Vail, Colorado

Search by objective public record fields.

NeoCart Phase 2 Clinical Trial

Safety and Effectiveness of Cartiva Implant in the Treatment of First CMC Joint Osteoarthritis Compared to LRTI (GRIP 2)

Vitamin D to Slow Progression of Knee Osteoarthritis

Comparison of BioCartilage Versus Marrow Stimulating Procedure for Cartilage Defects of the Knee

Clinical Study of Chondro-Gide® for Large Chondral Lesions in the Knee

Multi-Arm Study to Test the Efficacy of Immunotherapeutic Agents in Multiple Sarcoma Subtypes

Effects of Eggshell Membrane and Curcumin Extract Supplementation, Separately or Combined, on Recovery From Intense Exercise

Biologic Augmentation of Osteochondral Allograft Transplantation in the Knee

DeNovo NT Natural Tissue Graft Stratified Knee Study

Microfracture Versus Adipose Derived Stem Cells for the Treatment of Articular Cartilage Defects

Changes in Quadriceps Function Following Local or Distant Interventions in Individuals With Patellofemoral Pain

Reducing Obesity and Cartilage Compression in Knees

Post-op Treatment With Hyaluronic Acid Injections

A Nanoscopic Second Look Into the Knee Joint

Evaluate the Safety and Effectiveness of the Polymotion Hip Resurfacing (PHR) System Compared to Total Hip Arthroplasty

Human ECM Implanted Within Microfracture Interstices & the Cartilage Defect in the Knee to Regenerate Hyaline Cartilage

A Study of Orthotic Shoe Inserts for Controlling Osteoarthritic Knee Pain

Ketoprofen 10% Cream for Treatment of Pain Associated With Mild to Moderate Acute Soft Tissue Injury

A Study of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee

Feasibility of Resting Intervals During Exercise Programs for Individuals With Knee Osteoarthritis

Episealer® Knee System IDE Clinical Study

Pivotal Study to Evaluate the Safety and Efficacy of GelrinC for Treatment of Cartilage Defects

Effects of Synvisc on Cartilage in Knee Osteoarthritis (OA)

Senolytic Drugs Attenuate Osteoarthritis-Related Articular Cartilage Degeneration: A Clinical Trial