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ClinicalTrials.gov public records Last synced Oct 24, 2026, 5:09 PM EDT

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Showing 457–480 of 1,190 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Back Pain Clear all
Completed No phase listed Observational

Misoprostol for Spinal Stenosis

NCT04611464
View directory record Official record
Conditions
Lumbar Spinal Stenosis, Low Back Pain
Interventions
Misoprostol
Drug
Lead sponsor
Dallas VA Medical Center
Federal
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Nov 2, 2020 · Synced Oct 24, 2026, 5:09 PM EDT
Completed Not applicable Interventional Results available

Study of Basivertebral Nerve Ablation Treatment of Chronic Low Back Pain

NCT03266107
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Intracept
Device
Lead sponsor
Relievant Medsystems, Inc.
Industry
Eligibility
25 Years to 70 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
2
States / cities
Carmel, Indiana • Austin, Texas
Source: ClinicalTrials.gov public record
Updated Dec 22, 2020 · Synced Oct 24, 2026, 5:09 PM EDT
Completed Not applicable Interventional

Feasibility and Acceptability of Group Pain Reprocessing Therapy for Veterans With Chronic Neck/Back Pain

NCT06406699
View directory record Official record
Conditions
Chronic Back Pain, Chronic Pain, Neck Pain, Back Pain
Interventions
Pain Reprocessing Therapy (PRT)
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 3, 2025 · Synced Oct 24, 2026, 5:09 PM EDT
Withdrawn Not applicable Interventional

Comparative Clinical Trial: Manual Therapy With and Without Radial Extracorporeal Shockwave Therapy to Treat Acute Low Back Pain

NCT06852898
View directory record Official record
Conditions
Acute Lower Back Pain
Interventions
Chiropractic Care, Radial Extracorporeal Shockwave Therapy (ESWT) - Radial Pulse Therapy
Other
Lead sponsor
Northeast College of Health Sciences
Other
Eligibility
18 Years to 40 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Seneca Falls, New York
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Oct 24, 2026, 5:09 PM EDT
Completed Not applicable Interventional

The Effect of AposTherapy on Pain and Function in a Non Specific Low Back Pain

NCT03167671
View directory record Official record
Conditions
Low Back Pain
Interventions
AposTherapy, Traditional Physical Therapy
Device · Other
Lead sponsor
Montefiore Medical Center
Other
Eligibility
30 Years to 85 Years
Enrollment
164 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated May 6, 2024 · Synced Oct 24, 2026, 5:09 PM EDT
Recruiting Not applicable Interventional

A Prospective Study to Evaluate the Efficacy of Iovera Lumbar Medial Branch Cryoneurolysis Versus Radiofrequency Ablation for the Treatment of Chronic Low Back Pain

NCT07214844
View directory record Official record
Conditions
Low Back Pain, Chronic
Interventions
Iovera Medial Branch Cryoneurolysis, Radiofrequency ablation (RFA)
Device · Procedure
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Oct 24, 2026, 5:09 PM EDT
Completed Not applicable Interventional Results available

Chiropractic Management of Chronic Lower Back Pain in Older Adults

NCT00475787
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Spinal Manipulation, Detuned Ultrasound
Procedure
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
65 Years and older
Enrollment
136 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
2
States / cities
Buffalo, New York • Canandaigua, New York
Source: ClinicalTrials.gov public record
Updated Dec 30, 2014 · Synced Oct 24, 2026, 5:09 PM EDT
Completed Not applicable Interventional Results available

Mixed Reality Gaming for Chronic Low Back Pain

NCT03603028
View directory record Official record
Conditions
Recurrent Low Back Pain
Interventions
Exergaming
Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 65 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 22, 2020 · Synced Oct 24, 2026, 5:09 PM EDT
Active, not recruiting Not applicable Interventional

Cryoneurolysis Versus Radiofrequency Ablation for the Treatment of Chronic Low Back Pain

NCT06804551
View directory record Official record
Conditions
Chronic Low-back Pain
Interventions
iovera system, Radiofrequency ablation alone
Device
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Oct 8, 2026 · Synced Oct 24, 2026, 5:09 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Lower Back Biomechanics in Veterans With Non-Specific Low Back Pain

NCT04249453
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Not listed
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
21 Years to 70 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Nov 1, 2024 · Synced Oct 24, 2026, 5:09 PM EDT
Terminated No phase listed Observational

Investigation of Hypermobility, Biomarkers, and Pain Generators in Chronic Pain Patients

NCT02761928
View directory record Official record
Conditions
Low Back Pain, Mechanical, Spinal Stenosis, Nerve Root Disorder, Radiculopathy, Cervical, Benign Hypermobility Syndrome
Interventions
Beighton score for hypermobility
Other
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 12, 2020 · Synced Oct 24, 2026, 5:09 PM EDT
Recruiting Early Phase 1 Interventional

Regional Nerve Blocks to Improve Analgesia and Recovery in Older Adults Undergoing Spinal Fusion

NCT05461092
View directory record Official record
Conditions
Delirium, Pain, Back, Spinal Fusion, Thoracolumbar Interfascial Plane Block
Interventions
Thoracolumbar Interfascial Plane (TLIP) Block of bupivacaine, Blood Test, 3D CAM Delirium Severity Scoring, Generalized Anxiety Disorder 7-item (GAD-7) scale, Numerical Rating Score (NRS), PROMIS-Pain Interference, Oswestry Disability Index (ODI), Saint Louis University Mental Status Examination (SLUMs), Delirium Rating Scale-Revised-98 (DRS), Telephone Interview for Cognitive Status - Modified (TICS-M), Opioid Equivalents measured by Morphine Milligram Equivalents (MME), Patient Health Questionnaire depression scale (PHQ-8), Pain Catastrophizing, Fear Avoidance Beliefs Questionnaire (FABQ), Opioid Side Effects and Likeability Questionnaire, Daily Pain Trajectory, Tampa Scale of Kinesiophobia, Quality of Recovery 15
Drug · Diagnostic Test · Other
Lead sponsor
University of Iowa
Other
Eligibility
65 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 27, 2026 · Synced Oct 24, 2026, 5:09 PM EDT
Completed Not applicable Interventional Results available

Restorative Exercise for Strength Training and Operational Resilience (RESTORE) for Chronic or Recurrent Low Back Pain

NCT02132910
View directory record Official record
Conditions
Lower Back Pain
Interventions
RESTORE Intervention
Other
Lead sponsor
Defense and Veterans Center for Integrative Pain Management
Other
Eligibility
18 Years to 68 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 25, 2019 · Synced Oct 24, 2026, 5:09 PM EDT
Completed Not applicable Interventional

Aging Successfully With Pain

NCT01405716
View directory record Official record
Conditions
Low Back Pain
Interventions
Mindfulness Meditation, Health Education
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
65 Years and older
Enrollment
282 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 3, 2017 · Synced Oct 24, 2026, 5:09 PM EDT
Completed No phase listed Observational

Accuro Versus Traditional Landmark Palpation Technique to Determine Accurate Spinal Level for Procedures

NCT02862964
View directory record Official record
Conditions
Low Back Pain
Interventions
identify L4/L5
Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 10, 2022 · Synced Oct 24, 2026, 5:09 PM EDT
Completed Not applicable Interventional

Treatment of Chronic Low Back and Lower Extremity Pain

NCT00681447
View directory record Official record
Conditions
Low Back Pain
Interventions
Lumbar Interlaminar Epidural, Lumbar Interlaminar Epidural injection
Procedure
Lead sponsor
Pain Management Center of Paducah
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
1
States / cities
Paducah, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 21, 2015 · Synced Oct 24, 2026, 5:09 PM EDT
Not listed Not applicable Interventional

Gamified Rehab vs Take-home Packet Rehab for Non-specific Low Back Pain

NCT05573932
View directory record Official record
Conditions
Non-specific Low Back Pain
Interventions
Leaderboard, Take-home packet
Other
Lead sponsor
University of Central Florida
Other
Eligibility
18 Years to 45 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Nov 28, 2023 · Synced Oct 24, 2026, 5:09 PM EDT
Completed Not applicable Interventional

Yoga, Education, and Nidra (YEN) for Chronic Low Back Pain: A Pilot Study on Pain Modulation, Well-Being, and Sleep

NCT06979713
View directory record Official record
Conditions
Low Back Pain
Interventions
yoga, pain education, yoga nidra, yoga, pain education, relaxing music
Other
Lead sponsor
University of Central Florida
Other
Eligibility
18 Years to 75 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Jul 29, 2026 · Synced Oct 24, 2026, 5:09 PM EDT
Completed Not applicable Interventional

The Use of Manual Therapy to Treat Low-Back and Hip Pain

NCT00410397
View directory record Official record
Conditions
Low Back Pain, Pain
Interventions
Osteopathic Manipulative Medicine, Sham Manipulation
Procedure
Lead sponsor
Oklahoma State University Center for Health Sciences
Other
Eligibility
18 Years to 60 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jan 15, 2008 · Synced Oct 24, 2026, 5:09 PM EDT
Completed Phase 2 Interventional Results available

A Chronic Pain Master Protocol (CPMP): A Study of LY3857210 in Participants With Chronic Low Back Pain

NCT05630196
View directory record Official record
Conditions
Chronic Low-back Pain
Interventions
LY3857210, Placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years and older
Enrollment
138 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
28
States / cities
Chandler, Arizona • Phoenix, Arizona • Riverside, California + 23 more
Source: ClinicalTrials.gov public record
Updated Aug 13, 2024 · Synced Oct 24, 2026, 5:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Osteopathic Manipulative Medicine in Pregnancy: Physiologic and Clinical Effects

NCT00426244
View directory record Official record
Conditions
Low Back Pain, Pregnancy
Interventions
Osteopathic Manipulative Treatment, Placebo Ultrasound
Other
Lead sponsor
University of North Texas Health Science Center
Other
Eligibility
18 Years to 35 Years · Female only
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2011
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Aug 21, 2018 · Synced Oct 24, 2026, 5:09 PM EDT
Terminated Phase 4 Interventional Results available

Three Way Interaction Between Gabapentin, Duloxetine, and Donepezil in Patients With Diabetic Neuropathy

NCT00619983
View directory record Official record
Conditions
Diabetic Neuropathic Pain, Chronic Low Back Pain
Interventions
donepezil, duloxetine, donepezil 2.5 mg and duloxetine 30mg, placebo, gabapentin
Drug
Lead sponsor
Wake Forest University
Other
Eligibility
18 Years to 80 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
2
States / cities
Winston-Salem, North Carolina • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 11, 2018 · Synced Oct 24, 2026, 5:09 PM EDT
Completed No phase listed Observational

Safety of Acupuncture Treatments for Chronic Low Back Pain in Older Adults

NCT03850717
View directory record Official record
Conditions
Chronic Low Back Pain, Older Adults
Interventions
acupuncture
Device
Lead sponsor
McLean Center for Complementary and Alternative Medicine, PLC
Other
Eligibility
65 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
Vienna, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 25, 2019 · Synced Oct 24, 2026, 5:09 PM EDT
Enrolling by invitation No phase listed Observational

A Prospective, Single-center, Observational Clinical Outcomes Study for Vertebral Compression Fractures Treated With the OsteoPearl Biological Allograft Implants

NCT07561489
View directory record Official record
Conditions
Kyphoplasty, Vertebroplasty, Vertebral Compression Fracture, Allograft, Back Pain
Interventions
Allograft
Biological
Lead sponsor
Lenoss Medical
Industry
Eligibility
50 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Williamsville, New York
Source: ClinicalTrials.gov public record
Updated May 1, 2026 · Synced Oct 24, 2026, 5:09 PM EDT