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Showing 1–24 of 507 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Back Pain Lower Back Chronic Clear all
Completed Phase 4 Interventional

Opiate-Induced Tolerance & Hyperalgesia in Pain Patients

NCT00246532
View directory record Official record
Conditions
Chronic Low Back Pain, Opioid-induced Hyperalgesia
Interventions
Morphine, Placebo
Drug
Lead sponsor
National Institute of General Medical Sciences (NIGMS)
NIH
Eligibility
18 Years to 70 Years
Enrollment
139 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Apr 29, 2012 · Synced Sep 3, 2026, 10:50 PM EDT
Completed Phase 3 Interventional

Efficacy and Safety of Oxymorphone Extended Release in Opioid-Experienced Patients With Chronic Non-Malignant Pain

NCT00226421
View directory record Official record
Conditions
Chronic Pain
Interventions
Oxymorphone Extended Release
Drug
Lead sponsor
Endo USA Inc., a Keenova Therapeutics Company
Industry
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
31
States / cities
Hueytown, Alabama • Phoenix, Arizona • Colorado Springs, Colorado + 26 more
Source: ClinicalTrials.gov public record
Updated Jan 1, 2024 · Synced Sep 3, 2026, 10:50 PM EDT
Not yet recruiting Not applicable Interventional

Treatment of Chronic Lower Back Pain With a Combination of Electrical Stimulation, LED, and Laser Therapy

NCT07313826
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Active Neurolumen, Inactive Neurolumen
Device
Lead sponsor
Defense and Veterans Center for Integrative Pain Management
Other
Eligibility
18 Years to 70 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Portsmouth, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Sep 3, 2026, 10:50 PM EDT
Completed No phase listed Observational Results available

Five-Plus Year Follow-Up of SMART Randomized Controlled Trial

NCT03997825
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Basivertebral Nerve (BVN) Ablation
Device
Lead sponsor
Relievant Medsystems, Inc.
Industry
Eligibility
Not listed
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
13
States / cities
Phoenix, Arizona • Daly City, California • Long Beach, California + 10 more
Source: ClinicalTrials.gov public record
Updated Jan 12, 2021 · Synced Sep 3, 2026, 10:50 PM EDT
Recruiting No phase listed Observational

Examining Racial and Socioeconomic Differences in Chronic Low Back Pain

NCT05991440
View directory record Official record
Conditions
Chronic Pain
Interventions
Not listed
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 85 Years
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Sep 3, 2026, 10:50 PM EDT
Completed Phase 2 Interventional Results available

Evaluating the Role of Neuroinflammation in Low Back Pain

NCT03106740
View directory record Official record
Conditions
Low Back Pain, Back Pain With Radiation, Back Pain Without Radiation, Back Pain Lower Back Chronic, Back Ache, Pain, Chronic
Interventions
Minocycline Hydrochloride 100mg Capsule, Magnetic Resonance-Positron Emission Tomography Imaging, Placebo Capsule
Drug · Diagnostic Test · Other
Lead sponsor
Marco Loggia
Other
Eligibility
18 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 10, 2026 · Synced Sep 3, 2026, 10:50 PM EDT
Recruiting Not applicable Interventional

Psychological Options for Wellness and Recovery (POWeR) Trial for Veterans With Chronic Back/Neck Pain

NCT07137715
View directory record Official record
Conditions
Chronic Pain, Back Pain, Back Pain Lower Back Chronic, Neck Pain
Interventions
Pain reprocessing therapy (PRT), Cognitive Behavioral Therapy for Chronic Pain (CBT-CP), Usual Care
Behavioral · Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years and older
Enrollment
360 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced Sep 3, 2026, 10:50 PM EDT
Recruiting Not applicable Interventional

Is Conditioned Pain Modulation Predictive of Clinical Improvement in Patients With Chronic Low Back Pain?

NCT06544525
View directory record Official record
Conditions
Low Back Pain
Interventions
Physical therapy
Other
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years to 64 Years
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 22, 2025 · Synced Sep 3, 2026, 10:50 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Intraosseous Basivertebral Nerve Ablation for Treatment of Chronic Low Back Pain

NCT03658018
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Intracept System Ablation
Device
Lead sponsor
Relievant Medsystems, Inc.
Industry
Eligibility
25 Years to 70 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Plano, Texas
Source: ClinicalTrials.gov public record
Updated Aug 14, 2019 · Synced Sep 3, 2026, 10:50 PM EDT
Completed Not applicable Interventional

A Mediation Analysis Investigating Dry Needling Treatment Mechanisms in a Chronic Low Back Pain Population

NCT06940492
View directory record Official record
Conditions
Chronic Low Back Pain (CLBP)
Interventions
Dry needling
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 65 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Sep 3, 2026, 10:50 PM EDT
Completed Phase 1 Interventional

Development and Evaluation of Computerized Chemosensory Based Orbitofrontal Networks Training for Treatment of Pain

NCT06218407
View directory record Official record
Conditions
Chronic Pain, Low Back Pain
Interventions
Computerized Chemosensory-Based Orbitofrontal Cortex Training (CBOT) short burst paradigm, Computerized Chemosensory-Based Orbitofrontal Cortex Training (CBOT) long burst paradigm, Computerized Chemosensory-Based Orbitofrontal Cortex Training plus beta caryophyllene (CBOT-Plus), Computerized Chemosensory-Based Orbitofrontal Cortex Training (CBOT)
Combination Product
Lead sponsor
Evon Medics LLC
Industry
Eligibility
18 Years to 85 Years
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jan 22, 2024 · Synced Sep 3, 2026, 10:50 PM EDT
Completed Not applicable Interventional Results available

Digital Care Program for Chronic Low Back Pain

NCT04808141
View directory record Official record
Conditions
Chronic Low-back Pain
Interventions
Digital program, Conventional physical therapy
Device · Other
Lead sponsor
Sword Health, SA
Industry
Eligibility
18 Years to 80 Years
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated May 15, 2025 · Synced Sep 3, 2026, 10:50 PM EDT
Recruiting Not applicable Interventional

MBM and taVNS for Low Back Pain and Depressive Symptoms

NCT07415941
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
MBM, VNSM
Behavioral · Device
Lead sponsor
Florida State University
Other
Eligibility
50 Years to 85 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Sep 3, 2026, 10:50 PM EDT
Completed Not applicable Interventional

Aging Successfully With Pain

NCT01405716
View directory record Official record
Conditions
Low Back Pain
Interventions
Mindfulness Meditation, Health Education
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
65 Years and older
Enrollment
282 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 2, 2017 · Synced Sep 3, 2026, 10:50 PM EDT
Completed Early Phase 1 Interventional

Effectiveness of Caudal Epidural Injections in Treatment of Chronic Low Back and Lower Extremity Pain

NCT00370799
View directory record Official record
Conditions
Low Back Pain
Interventions
Caudal epidural injection, Caudal Epidural Injection with generic Celestone, Caudal Epidural Injection with Celestone, Caudal Epidural Injection with DepoMedrol
Drug
Lead sponsor
Pain Management Center of Paducah
Other
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Paducah, Kentucky
Source: ClinicalTrials.gov public record
Updated Aug 15, 2013 · Synced Sep 3, 2026, 10:50 PM EDT
Active, not recruiting Phase 3 Interventional

A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back Pain

NCT07035093
View directory record Official record
Conditions
Obesity, Overweight, Chronic Low Back Pain (CLBP)
Interventions
Retatrutide, Placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years and older
Enrollment
586 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
25
States / cities
Chandler, Arizona • Tucson, Arizona • Fountain Valley, California + 22 more
Source: ClinicalTrials.gov public record
Updated Jul 22, 2026 · Synced Sep 3, 2026, 10:50 PM EDT
Active, not recruiting Phase 3 Interventional

Nonpharmacologic Pain Management in FQHC Primary Care Clinics

NCT04923334
View directory record Official record
Conditions
Low Back Pain, Chronic Pain
Interventions
Brief Pain Teleconsult, Telehealth Physical Therapy
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 80 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
2
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Sep 3, 2026, 10:50 PM EDT
Completed Not applicable Interventional

Battlefield Acupuncture for Low Back Pain

NCT03491124
View directory record Official record
Conditions
Low Back Pain, Chronic Low Back Pain
Interventions
Auricular Acupuncture, Sham Treatment
Other
Lead sponsor
The Geneva Foundation
Other
Eligibility
18 Years to 50 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Andrews Air Force Base, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 28, 2021 · Synced Sep 3, 2026, 10:50 PM EDT
Completed No phase listed Observational Results available

Pain Research: Innovative Strategies With Marijuana

NCT03522324
View directory record Official record
Conditions
Chronic Pain, Chronic Low Back Pain, Cannabis Use
Interventions
Cannabis Edible
Drug
Lead sponsor
University of Colorado, Boulder
Other
Eligibility
21 Years to 70 Years
Enrollment
268 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 26, 2025 · Synced Sep 3, 2026, 10:50 PM EDT
Completed Phase 2 Interventional

Safety and Preliminary Efficacy Study of Mesenchymal Precursor Cells (MPCs) in Subjects With Lumbar Back Pain

NCT01290367
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Single Dose MPCs Injection, Single injection of saline solution, Single injection of hyaluronic acid
Biological · Procedure
Lead sponsor
Mesoblast, Ltd.
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
13
States / cities
Scottsdale, Arizona • Sacramento, California • Santa Monica, California + 10 more
Source: ClinicalTrials.gov public record
Updated Jun 25, 2020 · Synced Sep 3, 2026, 10:50 PM EDT
Completed Not applicable Interventional Results available

Study of Opioid Use After Lumbar and Cervical Spine Surgery

NCT02674711
View directory record Official record
Conditions
Low Back Pain, Opiate Addiction, Neck Pain
Interventions
Educational Video
Behavioral
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated May 18, 2023 · Synced Sep 3, 2026, 10:50 PM EDT
Completed No phase listed Observational Results available

CLBP Single-Arm Long-Term Follow-up Study

NCT05207813
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Intracept Procedure
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
25 Years to 70 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
2
States / cities
Carmel, Indiana • Austin, Texas
Source: ClinicalTrials.gov public record
Updated May 7, 2025 · Synced Sep 3, 2026, 10:50 PM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

True Functional Restoration and Analgesia in Non-Radicular Low Back Pain

NCT05419297
View directory record Official record
Conditions
Back Pain Lower Back Chronic, Chronic Pain
Interventions
Buprenorphine Buccal Film [Belbuca], Urine Drug Screening, actigraph, PROMIS 29, sit to stand test, numerical rating scale pain score, patient global impression of function, PROMIS - sleep
Drug · Other · Device + 1 more
Lead sponsor
Carolinas Pain Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 7, 2023 · Synced Sep 3, 2026, 10:50 PM EDT
Terminated Not applicable Interventional Results available

Exercise Maintenance in Chronic Pain and PTSD

NCT03644927
View directory record Official record
Conditions
Chronic Low Back Pain, Posttraumatic Stress Disorder
Interventions
Progressive exercise training, Waitlist Control
Behavioral
Lead sponsor
Boston University
Other
Eligibility
18 Years to 65 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Jamaica Plain, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 24, 2023 · Synced Sep 3, 2026, 10:50 PM EDT