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ClinicalTrials.gov public records Last synced Nov 14, 2026, 11:53 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 385–408 of 467 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Bone Pain Clear all

Conditions: Knee Pain Chronic, Osteoarthritis, Knee, Rheumatoid Arthritis, Traumatic Arthritis, Polyarthritis, Varus Deformity, Valgus Deformity, Flexion Deformity of Knee, Avascular Necrosis
Interventions: Total Knee Arthroplasty; Device
Lead sponsor: Zimmer Biomet; Industry
Eligibility: 18 Years and older
Enrollment: 760 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2035
U.S. locations: 16
States / cities: Parker, Colorado • Tampa, Florida • Atlanta, Georgia + 13 more

Conditions: Degenerative Disc Disease Lumbar, Spinal Stenosis, Lumbar Spondylolisthesis
Interventions: Multimodal Analgesia, Patient controlled analgesia; Other
Lead sponsor: Rush University Medical Center; Other
Eligibility: Not listed
Enrollment: 42 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Breast Cancer, Hypercalcemia of Malignancy, Metastatic Cancer, Pain
Interventions: monoclonal antibody CAL, zoledronic acid; Biological · Drug
Lead sponsor: Chugai Pharmaceutical; Industry
Eligibility: 18 Years and older · Female only
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2002
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Chronic Low Back Pain, Hip Ostearthritis, Myofascial Pain Syndrome, Fibromyalgia, Depression, Maladaptive Coping, Lumbar Spinal Stenosis, Insomnia, Sacroiliac Joint Pain, Lateral Hip and Thigh Pain, Anxiety, Dementia, Recent Leg Length Discrepancy
Interventions: Patient-Centered Care, Imaging-Directed Care; Other
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 60 Years to 89 Years
Enrollment: 55 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 2
States / cities: Pittsburgh, Pennsylvania • Richmond, Virginia

Conditions: Ankle and Hindfoot Arthrodesis
Interventions: AUGMENT® Bone Graft, Standard of Care; Device · Procedure
Lead sponsor: BioMimetic Therapeutics; Industry
Eligibility: 18 Years and older
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 21
States / cities: Tucson, Arizona • Capitola, California • San Francisco, California + 18 more

Conditions: Ankle Fracture
Interventions: Ibuprofen, Acetaminophen/hydrocodone; Drug
Lead sponsor: University of California, Davis; Other
Eligibility: 18 Years to 60 Years
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015
U.S. locations: 1
States / cities: Sacramento, California

Conditions: Apical Periodontitis, Endodontically Treated Teeth, Endodontic Disease, Apical Cyst, Apical Granuloma, Periradicular Disease, Previous Endodontic Treatment
Interventions: PBM treatment, PBM sham treatment, EMS; Device
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years and older
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Pain, Stenosis, Spondylolisthesis
Interventions: Not listed
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older
Enrollment: 37 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2004 – 2009
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Spinal Fusion, Spondylolisthesis, Scoliosis, Sciatica
Interventions: Optical 3D Scanner; Device
Lead sponsor: Advanced Scanners Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 1 participant
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Hip Fractures (ICD-10 72.01-72.2), Post Operative Analgesia
Interventions: Suzetrigine (Journavx); Drug
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 79 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2028
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Ankle Fracture
Interventions: Liposomal Bupivacaine with Bupivacaine; Drug
Lead sponsor: Jamaica Hospital Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 84 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Jamaica, New York

Conditions: Post Operative Pain
Interventions: Anterior Cruciate ligament reconstruction bone patellar tendon bone autograft, Platelet Rich Plasma; Procedure · Biological
Lead sponsor: Brian Walters; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2017
U.S. locations: 1
States / cities: New York, New York

Conditions: Tibial Fractures, Leg Injuries
Interventions: Monochromatic Near-Infrared Light Energy (MIRE); Device
Lead sponsor: Samueli Institute for Information Biology; Other
Eligibility: 18 Years to 55 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2008
U.S. locations: 1
States / cities: El Paso, Texas

Conditions: Low Back Pain
Interventions: InterFuse T, Standard of Care TLIF (Stryker AVS Unilif); Device
Lead sponsor: Vertebral Technologies, Inc.; Industry
Eligibility: 18 Years to 89 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Lumbar Radiculopathy
Interventions: Lumbar Transforaminal Epidural Corticosteroid Injection, Physical Therapy, Observation; Other
Lead sponsor: Stanford University; Other
Eligibility: 18 Years to 64 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 3
States / cities: Daly City, California • Mill Valley, California • Redwood City, California

Conditions: Knee Pain, Chronic Osteoarthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus, Valgus or Flexion Deformities, Rheumatoid Arthritis
Interventions: PERSONA Total Knee, Vanguard Total Knee, NexGen Total Knee; Device
Lead sponsor: Zimmer Biomet; Industry
Eligibility: 18 Years and older
Enrollment: 181 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 5
States / cities: Vail, Colorado • Westminster, Colorado • Springfield, Illinois + 2 more

Conditions: Lumbar Radiculopathy, Lesion of Sciatic Nerve, Left Lower Limb, Lesion of Sciatic Nerve, Right Lower Limb, Lumbar Spinal Stenosis, Lumbar Spondylosis, Lumbago With Sciatica, Left Side, Lumbago With Sciatica, Right Side
Interventions: Osteopathic Manipulative Treatment (OMT); Procedure
Lead sponsor: Rowan University; Other
Eligibility: 18 Years to 84 Years
Enrollment: 146 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 3
States / cities: East Lansing, Michigan • Stratford, New Jersey • Voorhees Township, New Jersey

Conditions: Degenerative Spondylolisthesis
Interventions: ART352-L; Biological
Lead sponsor: Ankasa Regenerative Therapeutics, Inc.; Industry
Eligibility: 50 Years and older
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 3
States / cities: Los Angeles, California • Rochester, Minnesota • Columbus, Ohio

Conditions: Low Back Pain, Leg Pain, Spondylolisthesis, Lumbar Spinal Stenosis
Interventions: "TOPS System" - Total Posterior Arthroplasty Implant; Device
Lead sponsor: Impliant, Ltd.; Industry
Eligibility: 40 Years to 75 Years
Enrollment: 450 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: Started 2006
U.S. locations: 16
States / cities: Beverly Hills, California • Daly City, California • New Haven, Connecticut + 12 more

Conditions: Chronic Low Back Pain (CLBP), Intervertebral Disc Displacement
Interventions: Sustained Acoustic Medicine (SAM), Sham Device; Device
Lead sponsor: ZetrOZ, Inc.; Industry
Eligibility: 18 Years to 60 Years
Enrollment: 65 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 3
States / cities: Dryden, New York • Chapel Hill, North Carolina • Ogden, Utah

Conditions: Pain, Postoperative, Ankle Fractures
Interventions: Ropivacaine, Epinephrine, Morphine, 0.9% sodium chloride solution; Drug
Lead sponsor: University of Iowa; Other
Eligibility: 18 Years to 100 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Rib Fracture, Rib Fracture Multiple, Trauma, Trauma Chest, Trauma Injury, Trauma, Multiple
Interventions: RibFx Orthosis Belt; Device
Lead sponsor: University of Vermont Medical Center; Other
Eligibility: 18 Years to 80 Years
Enrollment: 27 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: Degenerative Disc Disease
Interventions: Active Allograft, Placebo; Other
Lead sponsor: VIVEX Biologics, Inc.; Industry
Eligibility: 18 Years to 60 Years
Enrollment: 218 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2022
U.S. locations: 13
States / cities: Santa Monica, California • Walnut Creek, California • Tampa, Florida + 10 more

Conditions: Tendonitis, Bursitis
Interventions: Ketoprofen Topical Patch 20%, Placebo; Drug · Other
Lead sponsor: Alkemira SA; Industry
Eligibility: 18 Years and older
Enrollment: 381 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2008
U.S. locations: 1
States / cities: Austin, Texas

Search by objective public record fields.

Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty)

Multimodal Analgesia Versus Routine Care Pain Management

Monoclonal Antibody Compared With Zoledronate in Treating Women With Breast Cancer and Bone Metastases

Making Better Lives: Patient-Focused Care for Low Back Pain (LBP)

Long-term Safety and Effectiveness of AUGMENT® Bone Graft Compared to Autologous Bone Graft

NSAIDS Versus Opioids in Acute SER II Ankle Fractures

Effect of Photobiomodulation on Pain and Healing of the Vertical Releasing Incision After Endodontic Microsurgery

Clinical Outcome Study of the Triad Allograft for Posterior Lumbar Fusion

Spine Registration Using 3D Scanning - Arise

Suzetrigine (Journavx) as Multimodal Therapy for Pain Management in Adults Undergoing Surgery for Hip Fracture

Liposomal Bupivacaine With Bupivacaine in Ankle Fracture Open Reduction Internal Fixation (ORIF)

The Effect of Platelet Rich Plasma (PRP) on Post Operative Pain in Anterior Cruciate Ligament Reconstruction

Light Therapy in the Treatment of Leg Pain

A Prospective Study of the InterFuse T(tm),

Lumbar Transforaminal Epidural Corticosteroid Injection(s) Versus Defined Physical Therapy

ROSA Robot Used in Total Knee Replacement Post Market Study

Cost Effectiveness of OMT for Chronic Low Back Pain

Safety Evaluation of ART352-L in Subjects Undergoing Posterolateral Spinal Fusion

Safety and Effectiveness Study of the TOPS System, a Total Posterior Arthroplasty Implant Designed to Alleviate Pain Resulting From Moderate to Severe Lumbar Stenosis

Sustained Acoustic Medicine for Chronic Low Back Pain Secondary to Herniated Nucleus Pulposus or Other Conditions

Efficacy of Multimodal Periarticular Injections in Operatively Treated Ankle Fractures

Orthosis of Acute Traumatic Rib Fractures Via RibFx Belt for Pain Alleviation and Improved Pulmonary Function

Viable Allograft Supplemented Disc Regeneration in the Treatment of Patients With Low Back Pain

Efficacy and Safety of Ketoprofen Topical Patch 20% in the Treatment of Pain Associated With Shoulder, Elbow or Knee Tendonitis or Bursitis