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ClinicalTrials.gov public records Last synced Nov 11, 2026, 5:28 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 121–144 of 467 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Bone Pain Clear all

Conditions: Rheumatoid Arthritis, Ankylosing Spondylitis, Fibromyalgia, Gout, Crohn Disease, Juvenile Idiopathic Arthritis, Lupus Erythematosus, Myositis, Osteoarthritis, Osteoporosis, Psoriasis, Psoriatic Arthritis, Scleroderma, Dermatomyositis, Inflammatory Bowel Diseases, Polymyositis, Axial Spondyloarthritis, Diffuse Idiopathic Skeletal Hyperostosis, Polymyalgia Rheumatica, Giant Cell Arteritis, Temporal Arteritis, Wegener, Relapsing Polychondritis, Undifferentiated Connective Tissue Disease, Spinal Cord Injuries, Alzheimer Disease, Amyotrophic Lateral Sclerosis, Ataxia, Bell Palsy, Brain Tumor, Cerebral Aneurysm, Epilepsy, Guillain-Barre Syndrome, Headache, Head Injury, Hydrocephalus, Lumbar Disc Disease, Meningitis, Multiple Sclerosis, Muscular Dystrophy, Neurocutaneous Syndromes, Parkinson Disease, Stroke, Cluster Headache, Tension-Type Headache, Chronic Obstructive Pulmonary Disease, Asthma, Lung Cancer, Cystic Fibrosis, Sleep Apnea, Eczema, Alopecia, Chronic Inflammation, Unstable Angina, Heart Attack, Heart Failure, Arrythmia, Valve Heart Disease, High Blood Pressure, Congenital Heart Disease, Peripheral Arterial Disease, Diabetes, Chronic Liver Disease, Obesity
Interventions: Not listed
Lead sponsor: Global Healthy Living Foundation; Other
Eligibility: 19 Years and older
Enrollment: 40,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2025
U.S. locations: 1
States / cities: Upper Nyack, New York

Conditions: Opioid Use, Spinal Diseases, Surgery--Complications, Surgery, Postoperative Pain
Interventions: Opioid Analgesic, Opioid-Free Postoperative Pain Regimen; Drug
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Humeral Fractures, Fractures, Closed
Interventions: Supraclavicular nerve block; Procedure
Lead sponsor: Ann & Robert H Lurie Children's Hospital of Chicago; Other
Eligibility: 2 Years to 10 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2012
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Low Back Pain, Leg Pain, Spondylolisthesis, Lumbar Spinal Stenosis
Interventions: "TOPS System" - Total Posterior Arthroplasty Implant; Device
Lead sponsor: Impliant, Ltd.; Industry
Eligibility: 40 Years to 75 Years
Enrollment: 450 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: Started 2006
U.S. locations: 16
States / cities: Beverly Hills, California • Daly City, California • New Haven, Connecticut + 12 more

Conditions: Breast Cancer, Hypercalcemia of Malignancy, Metastatic Cancer, Pain
Interventions: monoclonal antibody CAL, zoledronic acid; Biological · Drug
Lead sponsor: Chugai Pharmaceutical; Industry
Eligibility: 18 Years and older · Female only
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2002
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Endometriosis, Dysmenorrhea, Dyspareunia
Interventions: Norethindrone Acetate (NA), GnRH Agonist (Lupron Depot); Drug
Lead sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); NIH
Eligibility: 18 Years to 55 Years · Female only
Enrollment: 112 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2004
U.S. locations: 1
States / cities: Brooklyn, New York

Conditions: Degenerative Disc Disease, DDD, Degenerative Disc Disease Lumbar, Degenerative Disc Disease, Lumbar, Lumbar Disc Herniation, Disc Herniation, Lumbar, Bone Marrow Aspirate Concentrate, Intervertebral Disc Displacement, Low Back Pain, Chronic Low Back Pain (CLBP), CLBP - Chronic Low Back Pain
Interventions: Bone Marrow Aspirate Concentrate (BMAC); Other
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 18 Years and older
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Manhattan, New York

Conditions: Osteoarthritis, Rheumatoid Arthritis, Ankylosing Spondylitis, Other Arthritic Conditions (e.g., Psoriatic Arthritis)
Interventions: painACTION: Arthritis; Behavioral
Lead sponsor: Inflexxion, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 228 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Newton, Massachusetts

Conditions: Lumbar Disc Herniation
Interventions: SI-6603, Sham injection; Drug
Lead sponsor: Seikagaku Corporation; Industry
Eligibility: 30 Years to 70 Years
Enrollment: 352 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2023
U.S. locations: 67
States / cities: Mobile, Alabama • Fountain Valley, California • La Jolla, California + 60 more

Conditions: Fracture
Interventions: Not listed
Lead sponsor: Children's Hospitals and Clinics of Minnesota; Other
Eligibility: Up to 17 Years
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: Twin Cities, Minnesota

Conditions: Revision Spine Surgery, Fusion of Spine, Cervical Fusion, Lumbar Fusion
Interventions: Ketamine Hydrochloride; Drug
Lead sponsor: AXIS Spine Center- a division of Northwest Specialty Hospital; Other
Eligibility: 18 Years to 75 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Coeur d'Alene, Idaho

Conditions: Bunion of Unspecified Foot, Bunionette of Unspecified Foot, Hammertoe, Ankle Fractures, Achilles Tendon Surgery
Interventions: Acetominophen, Toradol, Meloxicam, Cyclobenzaprine, Lyrica; Drug
Lead sponsor: Prisma Health-Midlands; Other
Eligibility: 18 Years to 99 Years
Enrollment: 72 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Columbia, South Carolina

Conditions: Fractures
Interventions: virtual reality; Other
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Jacksonville, Florida

Conditions: Lumbar Radiculopathy
Interventions: Lumbar Transforaminal Epidural Corticosteroid Injection, Physical Therapy, Observation; Other
Lead sponsor: Stanford University; Other
Eligibility: 18 Years to 64 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 3
States / cities: Daly City, California • Mill Valley, California • Redwood City, California

Conditions: Pain, Post Operative, Quality of Life
Interventions: Ibuprofen 600 mg, Placebo, Acetaminophen; Drug
Lead sponsor: Marquette University; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Milwaukee, Wisconsin

Conditions: Lumbar Disc Herniation, Degenerative Disc Disease, Spondylolisthesis
Interventions: Morphine, Epinephrine, naropin; Drug
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Degenerative Disc Disease, Back Pain
Interventions: biologic, Osteocel Plus; Biological
Lead sponsor: NuVasive; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 104 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 13
States / cities: La Jolla, California • Hollywood, Florida • Miami Beach, Florida + 10 more

Conditions: Chronic Myeloproliferative Disorders, Kidney Cancer, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms, Neuroblastoma, Oral Complications, Ovarian Cancer, Pain, Sarcoma
Interventions: management of therapy complications, pain therapy; Procedure
Lead sponsor: Medical College of Wisconsin; Other
Eligibility: 2 Years to 18 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2002
U.S. locations: 1
States / cities: Milwaukee, Wisconsin

Conditions: Spinal Stenosis Lumbar
Interventions: coflex® Interlaminar Technology, Decompression; Device · Procedure
Lead sponsor: Companion Spine, LLC; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2026
U.S. locations: 14
States / cities: Phoenix, Arizona • Sacramento, California • San Luis Obispo, California + 11 more

Conditions: Pain, Postoperative, Ankle Fractures
Interventions: Ropivacaine, Epinephrine, Morphine, 0.9% sodium chloride solution; Drug
Lead sponsor: University of Iowa; Other
Eligibility: 18 Years to 100 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Pain, Acute, Anxiety
Interventions: Untrained Touch; Other
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 46 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Lebanon, New Hampshire

Conditions: Pain, Fracture, Sprain
Interventions: Fentanyl, Lansoprazole, Oxycodone; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 60 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Pain
Interventions: TRV130; Drug
Lead sponsor: Trevena Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Discogenic Pain
Interventions: Bone Marrow Concentrate, Placebo; Other
Lead sponsor: APM Spine and Sports Physicians; Other
Eligibility: 18 Years to 55 Years
Enrollment: 66 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2024
U.S. locations: 1
States / cities: Virginia Beach, Virginia

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PatientSpot Formerly Known as ArthritisPower

Opioid Free vs. Standard Perioperative Pain Regimen for Anterior Cervical Discectomy and Fusion (ACDF) Surgery

Pain Management in Children Undergoing Supracondylar Humerus Fracture Repair

Safety and Effectiveness Study of the TOPS System, a Total Posterior Arthroplasty Implant Designed to Alleviate Pain Resulting From Moderate to Severe Lumbar Stenosis

Monoclonal Antibody Compared With Zoledronate in Treating Women With Breast Cancer and Bone Metastases

Treatment of Endometriosis With Norethindrone Acetate ( NA) VS. Gonadotropin- Releasing Hormone (GnRH) Agonist (Lupron Depot 11.25 mg)

Biologic Injection For Adults With Lumbar Disc Herniation

Web-based Support to Manage Arthritis Pain

SI-6603 (Condoliase) Study for Lumbar Disc Herniation (Discovery 6603 Study)

Adequacy of Pain Management for Upper Extremity Fracture After Discharge From a Pediatric Emergency Depart

Pre-Operative Ketamine Infusion for Post Operative Pain Control After Revision Spinal Surgery

Opiate Free Multimodal Pain Pathway in Elective Foot and Ankle Surgery: A Prospective Study

Virtual Reality in Reducing Acute Orthopedic Pain

Lumbar Transforaminal Epidural Corticosteroid Injection(s) Versus Defined Physical Therapy

Preemptive Ibuprofen Effects on Pain Perception Following Extraction and Bone Graft

Peri-Incisional Drug Injection in Lumbar Spine Surgery

Osteocel® Plus in eXtreme Lateral Interbody Fusion (XLIF®)

Light-Emitting Diode Therapy in Preventing Mucositis in Children Receiving Chemotherapy With or Without Radiation Therapy Before Bone Marrow Transplantation

Coflex PS3 Actual Conditions for Use Study

Efficacy of Multimodal Periarticular Injections in Operatively Treated Ankle Fractures

The Effect of Touch on Pain and Anxiety During the Bone Marrow Biopsy Procedure

Fentanyl Administered Intraorally for Rapid Treatment of Orthopedic Pain

A Pilot Study of TRV130 for the Treatment of Fracture Pain

Bone Marrow Concentrate Intradiscal Injection for Chronic Discogenic Low Back Pain