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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Borderline Personality Disorder Clear all
Completed Phase 3 Interventional Accepts healthy volunteers

Quetiapine Treatment for Symptoms Associated With Borderline Personality Disorder

NCT00122070
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Quetiapine Fumarate
Drug
Lead sponsor
University of Medicine and Dentistry of New Jersey
Other
Eligibility
18 Years to 55 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2008
U.S. locations
1
States / cities
Cherry Hill, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 9, 2008 · Synced Sep 25, 2026, 12:55 AM EDT
Not yet recruiting Phase 1 Interventional

ADEPT Psilocybin-Assisted Therapy With DBT for Borderline Personality Disorder

NCT07833761
View directory record Official record
Conditions
Borderline Personality Disorder, Borderline Personality Pathology, Depressive Symptoms, Emotion Dysregulation, Suicidal Ideation
Interventions
Psilocybin, Psilocybin-Assisted Therapy With Dialectical Behavior Therapy
Drug · Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
25 Years to 65 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
2
States / cities
Minneapolis, Minnesota • Saint Louis Park, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Sep 25, 2026, 12:55 AM EDT
Completed Phase 3 Interventional

Olanzapine in Patients With Borderline Personality Disorder

NCT00091650
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Olanzapine, placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
15 Years to 65 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
9
States / cities
Atlanta, Georgia • Marietta, Georgia • Minneapolis, Minnesota + 6 more
Source: ClinicalTrials.gov public record
Updated Jul 23, 2006 · Synced Sep 25, 2026, 12:55 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

MRI Imaging in Borderline Personality Disorder

NCT00275288
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Not listed
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2007
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 1, 2010 · Synced Sep 25, 2026, 12:55 AM EDT
Completed Phase 3 Interventional

Efficacy and Safety of Olanzapine in Patients With Borderline Personality Disorder

NCT00088036
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Olanzapine
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years to 65 Years
Enrollment
450 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
7
States / cities
National City, California • New Haven, Connecticut • Indianapolis, Indiana + 4 more
Source: ClinicalTrials.gov public record
Updated Jul 23, 2006 · Synced Sep 25, 2026, 12:55 AM EDT
Completed Not applicable Interventional

Dialectical Behavior Therapy Rutgers University Research Program

NCT03123198
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Dialectical Behavior Therapy
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
145 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2023
U.S. locations
1
States / cities
Piscataway, New Jersey
Source: ClinicalTrials.gov public record
Updated Jul 29, 2024 · Synced Sep 25, 2026, 12:55 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Relationship Between Oxytocin Level, Trust, and Attachment in Individuals With Borderline Personality Disorder

NCT06045650
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
baseline serum oxytocin levels, Emotional Sensitivity test, Neuro-economical game, Childhood Trauma Questionnaire, Relationships Questionnaire, demographic questionnaire
Other
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
18 Years and older
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated May 23, 2024 · Synced Sep 25, 2026, 12:55 AM EDT
Withdrawn Not applicable Interventional

College Students Who Self-Harm

NCT02522143
View directory record Official record
Conditions
Borderline Personality Disorder, Suicide
Interventions
Informational sessions describing BPD characteristics, Condensed-DBT treatment intervention
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 27 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 19, 2017 · Synced Sep 25, 2026, 12:55 AM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

Examining Dose-Related Effects of Oxytocin on Social Cognition Across Populations

NCT02149823
View directory record Official record
Conditions
Borderline Personality Disorder, BPD, Schizotypal Personality Disorder, SPD, Autism Spectrum Disorder, Schizophrenia, Schizoaffective Disorder, Bipolar Disorder
Interventions
Syntocinon 24 Intranasal Units (IU), Syntocinon 40 Intranasal Units (IU), Intranasal Placebo
Drug
Lead sponsor
Maria de las Mercedes Perez Rodriguez
Other
Eligibility
18 Years to 65 Years
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2022
U.S. locations
2
States / cities
New York, New York • The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Oct 9, 2022 · Synced Sep 25, 2026, 12:55 AM EDT
Terminated Phase 2 Interventional Results available

Ketamine in Borderline Personality Disorder

NCT03395314
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Ketamine, Midazolam
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 60 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
2
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 25, 2023 · Synced Sep 25, 2026, 12:55 AM EDT
Completed Not applicable Interventional

Psychoeducation of Borderline Patients

NCT01719731
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Education, Non-Education
Behavioral
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 30 Years · Female only
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 24, 2015 · Synced Sep 25, 2026, 12:55 AM EDT
Recruiting Not applicable Interventional

A Precision Medicine Approach to Target Engagement for Emotion Regulation

NCT05651295
View directory record Official record
Conditions
Emotional Regulation, Depression, Anxiety, Borderline Personality Disorder, Obsessive-Compulsive Disorder, Posttraumatic Stress Disorder, Eating Disorders
Interventions
Checking the Facts, Opposite to Emotion Action, Mindfulness of Current Emotions
Behavioral
Lead sponsor
Matthew Southward, PhD
Other
Eligibility
18 Years and older
Enrollment
390 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced Sep 25, 2026, 12:55 AM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

Role Of Sensitivity to neuroEndocrine Systems in Social Decisions

NCT06018727
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Hydrocortisone, Yohimbine, Placebo
Drug · Dietary Supplement
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 45 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 4, 2024 · Synced Sep 25, 2026, 12:55 AM EDT
Completed Not applicable Interventional

Neurofeedback for Borderline Personality Disorder

NCT05398627
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Amygdala Neurofeedback
Device
Lead sponsor
Kymberly Young
Other
Eligibility
18 Years to 55 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Sep 25, 2026, 12:55 AM EDT
Completed No phase listed Observational

Tracking Response in Advance of Investigational Trials, Borderline Study

NCT05025670
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Supportive psychotherapy
Behavioral
Lead sponsor
Adams Clinical
Network
Eligibility
18 Years to 65 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Watertown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 26, 2023 · Synced Sep 25, 2026, 12:55 AM EDT
Completed Not applicable Interventional Results available

Cognitive Reappraisal Training for Borderline Personality

NCT04967222
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Cognitive Reappraisal by Distancing, Control Downregulate Condition
Behavioral
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 55 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 4, 2025 · Synced Sep 25, 2026, 12:55 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations

NCT04296604
View directory record Official record
Conditions
Traumatic Brain Injury, Major Depressive Disorder, Bipolar Disorder, Schizophrenia, Attention Deficit Hyperactivity Disorder, Borderline Personality Disorder, Substance Use Disorders
Interventions
Transcranial Direct Current Stimulation
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
600 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 9, 2025 · Synced Sep 25, 2026, 12:55 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Early Study of N-Acetylcysteine to Treat Deliberate Self-Harm in Adolescents

NCT01111734
View directory record Official record
Conditions
Deliberate Self Harm
Interventions
N-Acetylcysteine, fMRI
Dietary Supplement · Drug
Lead sponsor
University of Minnesota
Other
Eligibility
13 Years to 21 Years
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 30, 2019 · Synced Sep 25, 2026, 12:55 AM EDT
Completed Phase 2 Interventional

Psilocybin in Co-occuring Major Depressive Disorder and Borderline Personality Disorder

NCT05399498
View directory record Official record
Conditions
Borderline Personality Disorder, Major Depressive Disorder
Interventions
Psilocybin
Drug
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 65 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Sep 25, 2026, 12:55 AM EDT
Completed Not applicable Interventional

Dialectical Behavior Therapy for Adolescents at Rutgers University

NCT03861858
View directory record Official record
Conditions
Borderline Personality Disorder in Adolescence
Interventions
DBT-A
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
13 Years to 20 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Piscataway, New Jersey
Source: ClinicalTrials.gov public record
Updated Jul 29, 2024 · Synced Sep 25, 2026, 12:55 AM EDT
Completed Not applicable Interventional

Psychoeducational Videos and Digital Assessments for BPD

NCT05358925
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Psychoeducational Videos, Neuropsychological Feedback, Non-BPD-related Educational Videos
Other
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years and older
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 5, 2026 · Synced Sep 25, 2026, 12:55 AM EDT
Terminated Phase 2 Interventional Results available

Selective Serotonin Reuptake Inhibitors (SSRIs) in Borderline Personality Disorder

NCT01103180
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Escitalopram
Drug
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 40 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 13, 2019 · Synced Sep 25, 2026, 12:55 AM EDT
Not listed Not applicable Interventional

Guanfacine to Treat Borderline Personality Disorder

NCT00358969
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
guanfacine (Tenex)
Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 55 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2006
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 31, 2006 · Synced Sep 25, 2026, 12:55 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Psychodynamic Therapy For Co-occurring Borderline Personality Disorder and Alcohol Use Disorder

NCT00145678
View directory record Official record
Conditions
Borderline Personality Disorder, Alcohol Use Disorder
Interventions
Psychodynamic Therapy, Optimized Community Care
Behavioral
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
18 Years to 45 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2010
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Jan 5, 2015 · Synced Sep 25, 2026, 12:55 AM EDT