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Showing 1–24 of 52 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Cardiac; Dyspnea Clear all
Recruiting No phase listed Observational Accepts healthy volunteers

Lung and Heart Function Across Decades of Life in Health

NCT07641413
View directory record Official record
Conditions
Pollution Related Respiratory Disorder, Pollution; Exposure, Dyspnea, Cardiopulmonary
Interventions
Healthy control
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
24 Years to 68 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2030
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 13, 2026 · Synced Sep 21, 2026, 10:22 PM EDT
Completed Not applicable Interventional Results available

Family Palliative and End-of-Life Care for Advanced Heart Failure

NCT04153890
View directory record Official record
Conditions
Heart Failure NYHA Class III, Heart Failure NYHA Class IV
Interventions
FamPALcare
Behavioral
Lead sponsor
West Virginia University
Other
Eligibility
18 Years and older
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Feb 18, 2025 · Synced Sep 21, 2026, 10:22 PM EDT
Completed Phase 2Phase 3 Interventional

SHORTness of Breath In the Emergency Department (SHORTIE)

NCT00206830
View directory record Official record
Conditions
Acute Myocardial Infarction, Heart Failure, Pulmonary Embolism
Interventions
Triage Profiler S.O.B. Panel
Device
Lead sponsor
Abbott RDx Cardiometabolic
Other
Eligibility
18 Years and older
Enrollment
306 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
5
States / cities
Worcester, Massachusetts • Brooklyn, New York • Stony Brook, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 26, 2015 · Synced Sep 21, 2026, 10:22 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Emergency Department Cardiac Ultrasound

NCT02719509
View directory record Official record
Conditions
Chest Pain, Dyspnea
Interventions
Cardiac Ultrasound
Procedure
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
18 Years and older
Enrollment
380 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 25, 2016 · Synced Sep 21, 2026, 10:22 PM EDT
Withdrawn Phase 4 Interventional

Double Blind Randomized Placebo Controlled Trial of Natrecor in Acute Decompensated Heart Failure With Normal EF

NCT00505791
View directory record Official record
Conditions
Heart Failure, Congestive, Dyspnea, Pulmonary Edema
Interventions
Nesiritide
Drug
Lead sponsor
University of Medicine and Dentistry of New Jersey
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Nov 10, 2015 · Synced Sep 21, 2026, 10:22 PM EDT
Withdrawn Not applicable Interventional

Tunneled Pleural Catheters for Refractory Effusions Attributed to Congestive Heart Failure (TREAT-CHF) Trial

NCT03696524
View directory record Official record
Conditions
Pleural Effusions, Chronic, Congestive Heart Failure, Shortness of Breath
Interventions
tunneled pleural catheter
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 4, 2023 · Synced Sep 21, 2026, 10:22 PM EDT
Completed Not applicable Interventional

Diagnostic Utility of Exercise Cardiac Magnetic Resonance in the Assessment of Cardiac Dyspnea.

NCT03951779
View directory record Official record
Conditions
Shortness of Breath, Cardiac; Dyspnea
Interventions
Exercise cardiac magnetic resonance imaging
Diagnostic Test
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 6, 2022 · Synced Sep 21, 2026, 10:22 PM EDT
Completed Phase 2 Interventional

Stem Cell Mobilization to Treat Chest Pain and Shortness of Breath in Patients With Coronary Artery Disease

NCT00043628
View directory record Official record
Conditions
Coronary Artery Disease
Interventions
Stem Cell Mobilization
Procedure
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
Not listed
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2005
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Sep 21, 2026, 10:22 PM EDT
Terminated No phase listed Observational

Assessment of The Clinical Course of Dyspnea in Acute Heart Failure Patients

NCT01615926
View directory record Official record
Conditions
Acute Heart Failure, Dyspnea
Interventions
Not listed
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 30, 2013 · Synced Sep 21, 2026, 10:22 PM EDT
Completed No phase listed Observational

Biomarkers in Acute Heart Failure

NCT00537628
View directory record Official record
Conditions
Shortness of Breath, Heart Failure
Interventions
Not listed
Lead sponsor
Brahms AG
Industry
Eligibility
18 Years and older
Enrollment
1,641 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
8
States / cities
San Diego, California • San Francisco, California • Baltimore, Maryland + 4 more
Source: ClinicalTrials.gov public record
Updated Jul 31, 2008 · Synced Sep 21, 2026, 10:22 PM EDT
Completed Phase 3 Interventional Results available

Targeting Acute Congestion With Tolvaptan in Congestive Heart Failure

NCT01644331
View directory record Official record
Conditions
Heart Failure, Dyspnea
Interventions
Tolvaptan, Placebo
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
257 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
18
States / cities
Aurora, Colorado • Atlanta, Georgia • Gainesville, Georgia + 14 more
Source: ClinicalTrials.gov public record
Updated Apr 26, 2017 · Synced Sep 21, 2026, 10:22 PM EDT
Terminated No phase listed Observational

Dyspnea and Cardiotoxicity in Multiple Myeloma Patients Who Receive Carfilzomib

NCT04827563
View directory record Official record
Conditions
Multiple Myeloma, Shortness of Breath, Dyspnea, Cardiotoxicity
Interventions
EndoPAT, Blood Pressure Cuff, Echocardiogram, Quality of Life Assessment, Blood Tests
Device · Diagnostic Test · Other
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 3, 2026 · Synced Sep 21, 2026, 10:22 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Bedside Ultrasound Identifies Congestive Heart Failure

NCT00833144
View directory record Official record
Conditions
Heart Failure, Dyspnea
Interventions
Not listed
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
375 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Dec 12, 2013 · Synced Sep 21, 2026, 10:22 PM EDT
Completed No phase listed Observational

Fluid Status of Outpatients With Dyspnea

NCT02111525
View directory record Official record
Conditions
Dyspnea,, Acute Heart Failure Syndrome, Pulmonary Congestion
Interventions
Not listed
Lead sponsor
Intersection Medical, Inc.
Industry
Eligibility
45 Years and older
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
2
States / cities
Detroit, Michigan • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 13, 2015 · Synced Sep 21, 2026, 10:22 PM EDT
Terminated Not applicable Interventional Results available

Assessment of Pulmonary Congestion During Cardiac Hemodynamic Stress Testing

NCT04019613
View directory record Official record
Conditions
Dyspnea, Heart Failure With Preserved Ejection Fraction
Interventions
Lung ultrasound
Diagnostic Test
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 19, 2022 · Synced Sep 21, 2026, 10:22 PM EDT
Recruiting Not applicable Interventional

DRAIN: DRainage in Acute Decompensated Heart faIlure With Pleural effusioNs

NCT07419360
View directory record Official record
Conditions
Congestive Heart Failure(CHF), Pleural Effusion Due to Congestive Heart Failure
Interventions
Thoracentesis
Procedure
Lead sponsor
Albany Medical College
Other
Eligibility
18 Years and older
Enrollment
216 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Sep 21, 2026, 10:22 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Myocardial Ischemia Detection for Early Identification of Patients With Ischemic Chest Pain

NCT02055443
View directory record Official record
Conditions
Cardiac Ischemia, Chest Pain, Shortness of Breath
Interventions
12-lead holter monitor application
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 10, 2017 · Synced Sep 21, 2026, 10:22 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Leveraging Exercise Stress Echocardiography for Heart Failure With Preserved Ejection Fraction

NCT06927973
View directory record Official record
Conditions
Chest Pain, Shortness of Breath
Interventions
Echocardiogram
Diagnostic Test
Lead sponsor
Duke University
Other
Eligibility
50 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Sep 21, 2026, 10:22 PM EDT
Completed Phase 2 Interventional

The DIAMOND Study: Distensibility Improvement And Remodeling in Diastolic Heart Failure

NCT00043836
View directory record Official record
Conditions
Heart Failure, Congestive, Dyspnea, Pulmonary Edema
Interventions
ALT-711
Drug
Lead sponsor
Synvista Therapeutics, Inc
Industry
Eligibility
60 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2005
U.S. locations
2
States / cities
Winston-Salem, North Carolina • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Sep 1, 2009 · Synced Sep 21, 2026, 10:22 PM EDT
Enrolling by invitation Phase 1Phase 2 Interventional

Enhancing the Natriuretic Peptide System in HFpEF

NCT05279742
View directory record Official record
Conditions
Heart Failure With Preserved Ejection Fraction, Chronic Kidney Diseases
Interventions
MANP, Sacubitril/Valsartan, Oral Placebo, Injection Placebo
Drug
Lead sponsor
Horng Chen
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 8, 2025 · Synced Sep 21, 2026, 10:22 PM EDT
Completed Not applicable Interventional

Impact of Validated Diagnostic Prediction Model of Acute Heart Failure in the Emergency Department

NCT01193998
View directory record Official record
Conditions
Dyspnea, Acute Heart Failure, Shortness of Breath
Interventions
Treatment as per model probability, Treatment as per usual care
Other
Lead sponsor
Unity Health Toronto
Other
Eligibility
18 Years and older
Enrollment
186 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 15, 2014 · Synced Sep 21, 2026, 10:22 PM EDT
Terminated Early Phase 1 Interventional Results available

Post-Acute Sequelae of Coronavirus-19 (COVID-19) With Dyspnea on Exertion And Associated TaChycardia TrEatment Study

NCT05096884
View directory record Official record
Conditions
Tachycardia, Dyspnea, COVID-19
Interventions
Metoprolol Succinate
Drug
Lead sponsor
Hackensack Meridian Health
Other
Eligibility
18 Years to 40 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Hackensack, New Jersey
Source: ClinicalTrials.gov public record
Updated Dec 2, 2024 · Synced Sep 21, 2026, 10:22 PM EDT
Completed Not applicable Interventional

Improving Care of Patients With Heart Failure

NCT01461681
View directory record Official record
Conditions
Depression, Pain, Dyspnea, Quality of Life
Interventions
Symptom Management Service for Heart failure
Procedure
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 13, 2014 · Synced Sep 21, 2026, 10:22 PM EDT
Completed No phase listed Observational

Heart Failure and a Preserved Ejection Fraction

NCT00586833
View directory record Official record
Conditions
Heart Failure
Interventions
O2 consumption max bike test
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 13, 2010 · Synced Sep 21, 2026, 10:22 PM EDT