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Showing 1–24 of 47 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Cardiac Arrest, Out-Of-Hospital Clear all
Terminated Not applicable Interventional Results available

ACCESS to the Cardiac Cath Lab in Patients Without STEMI Resuscitated From Out-of-hospital VT/VF Cardiac Arrest

NCT03119571
View directory record Official record
Conditions
Cardiac Arrest Due to Underlying Cardiac Condition, Ventricular Fibrillation, Cardiopulmonary Arrest With Successful Resuscitation
Interventions
Initial CCL admission, Initial ICU admission
Procedure · Diagnostic Test
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 75 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
21
States / cities
Atlanta, Georgia • Indianapolis, Indiana • Ann Arbor, Michigan + 14 more
Source: ClinicalTrials.gov public record
Updated Jan 26, 2021 · Synced Jul 21, 2026, 6:56 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Gathering Evidence on Best Practices for Lay Rescuer CPR Training

NCT05908500
View directory record Official record
Conditions
Cardiac Arrest, Out-Of-Hospital
Interventions
CPR Training, CPR Manikin Type
Behavioral · Device
Lead sponsor
University of Nevada, Reno
Other
Eligibility
Not listed
Enrollment
2,100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2031
U.S. locations
1
States / cities
Reno, Nevada
Source: ClinicalTrials.gov public record
Updated Jun 3, 2025 · Synced Jul 21, 2026, 6:56 PM EDT
Not yet recruiting Phase 3 Interventional

Xenon for Neuroprotection During Post-Cardiac Arrest Syndrome in Comatose Survivors of an Out of Hospital Cardiac Arrest

NCT03176186
View directory record Official record
Conditions
Post-Cardiac Arrest Syndrome
Interventions
Xenon
Combination Product
Lead sponsor
Invero Pharma, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
1,436 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
8
States / cities
Hartford, Connecticut • Gainesville, Florida • Gulfport, Mississippi + 5 more
Source: ClinicalTrials.gov public record
Updated Apr 2, 2025 · Synced Jul 21, 2026, 6:56 PM EDT
Completed Phase 4 Interventional Results available

Continuous Chest Compressions vs AHA Standard CPR of 30:2

NCT01372748
View directory record Official record
Conditions
Out of Hospital Cardiac Arrest
Interventions
Standard CPR, Continuous chest compressions
Other
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
23,711 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
5
States / cities
Birmingham, Alabama • Pittsburgh, Pennsylvania • Dallas, Texas + 2 more
Source: ClinicalTrials.gov public record
Updated Dec 27, 2016 · Synced Jul 21, 2026, 6:56 PM EDT
Completed Not applicable Interventional Results available

ECPR for Refractory Out-Of-Hospital Cardiac Arrest

NCT03065647
View directory record Official record
Conditions
Cardiac Arrest, Heart Arrest, Sudden Cardiac Arrest, Cardiopulmonary Arrest, Death, Sudden, Cardiac, Cardiopulmonary Resuscitation, CPR, Extracorporeal Cardiopulmonary Resuscitation, Extracorporeal Membrane Oxygenation
Interventions
Expedited Transport With Mechanical CPR
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 70 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 2, 2021 · Synced Jul 21, 2026, 6:56 PM EDT
Not yet recruiting Not applicable Interventional

The Effect of SPecialty cAre on Recovery From Cardiac Arrest Trial (the SPARC Trial)

NCT07002294
View directory record Official record
Conditions
Cardiac Arrest (CA), Heart Arrest, Heart Arrest, Out-Of-Hospital
Interventions
Transfer to specialty care, Usual care
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
1,618 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2032
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced Jul 21, 2026, 6:56 PM EDT
Terminated Phase 2 Interventional Results available

Ceftriaxone to PRevent pneumOnia and inflammatTion aftEr Cardiac arresT (PROTECT)

NCT04999592
View directory record Official record
Conditions
Out-Of-Hospital Cardiac Arrest, Pneumonia
Interventions
Standard of care without prophylaxis, Antibiotic prophylaxis
Drug
Lead sponsor
David J. Gagnon
Other
Eligibility
18 Years and older
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Portland, Maine
Source: ClinicalTrials.gov public record
Updated Apr 16, 2025 · Synced Jul 21, 2026, 6:56 PM EDT
Completed Phase 3 Interventional Results available

Therapeutic Hypothermia to Improve Survival After Cardiac Arrest in Pediatric Patients-THAPCA-OH [Out of Hospital] Trial

NCT00878644
View directory record Official record
Conditions
Cardiac Arrest
Interventions
Therapeutic Hypothermia, Therapeutic Normothermia
Procedure · Other
Lead sponsor
University of Michigan
Other
Eligibility
48 Hours to 18 Years
Enrollment
295 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
33
States / cities
Birmingham, Alabama • Phoenix, Arizona • Tucson, Arizona + 29 more
Source: ClinicalTrials.gov public record
Updated Sep 28, 2017 · Synced Jul 21, 2026, 6:56 PM EDT
Completed Phase 2 Interventional

Effect of Xenon and Therapeutic Hypothermia, on the Brain and on Neurological Outcome Following Brain Ischemia in Cardiac Arrest Patients

NCT00879892
View directory record Official record
Conditions
Ischemic Brain Injury
Interventions
xenon, Hypothermia
Drug · Other
Lead sponsor
Turku University Hospital
Government
Eligibility
18 Years to 80 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 18, 2015 · Synced Jul 21, 2026, 6:56 PM EDT
Not listed Phase 1 Interventional

Phase 1 Study of HBN-1

NCT04094857
View directory record Official record
Conditions
Cardiac Arrest
Interventions
HBN-1
Drug
Lead sponsor
Hibernaid, Inc
Industry
Eligibility
40 Years to 80 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
2
States / cities
Portland, Maine • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 6, 2019 · Synced Jul 21, 2026, 6:56 PM EDT
Completed Phase 3 Interventional Results available

Amiodarone, Lidocaine or Neither for Out-Of-Hospital Cardiac Arrest Due to Ventricular Fibrillation or Tachycardia

NCT01401647
View directory record Official record
Conditions
Cardiac Arrest
Interventions
amiodarone, Lidocaine, Normal saline
Drug · Other
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
3,024 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
7
States / cities
Birmingham, Alabama • San Diego, California • Portland, Oregon + 4 more
Source: ClinicalTrials.gov public record
Updated Apr 16, 2017 · Synced Jul 21, 2026, 6:56 PM EDT
Not listed No phase listed Observational

Save Hearts in Arizona Registry and Education (SHARE) Project

NCT01999036
View directory record Official record
Conditions
Out-of-hospital Cardiac Arrest
Interventions
Not listed
Lead sponsor
University of Arizona
Other
Eligibility
Not listed
Enrollment
20,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2020
U.S. locations
1
States / cities
Multiple Locations, Arizona
Source: ClinicalTrials.gov public record
Updated May 8, 2018 · Synced Jul 21, 2026, 6:56 PM EDT
Completed Phase 2Phase 3 Interventional Results available

Induction of Mild Hypothermia Following Out-of-hospital Cardiac Arrest

NCT00391469
View directory record Official record
Conditions
Out-of-hospital Cardiac Arrest
Interventions
Rapid infusion of 2 liters of 4oC normal saline, Rapid infusion of cold normal saline
Other · Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
1,359 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Dec 1, 2014 · Synced Jul 21, 2026, 6:56 PM EDT
Completed Not applicable Interventional Results available

Circulation Improving Resuscitation Care (CIRC)

NCT00597207
View directory record Official record
Conditions
Cardiac Arrest, Cardiopulmonary Resuscitation
Interventions
AutoPulse, Manual
Device · Other
Lead sponsor
Zoll Medical Corporation
Industry
Eligibility
18 Years and older
Enrollment
4,231 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
3
States / cities
Tampa, Florida • Houston, Texas • Menasha, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 23, 2018 · Synced Jul 21, 2026, 6:56 PM EDT
Active, not recruiting No phase listed Observational

End-Tidal CO2 (ETCO2) Trends in Out-of-Hospital Cardiac Arrest

NCT07632430
View directory record Official record
Conditions
Prehospital Resuscitation, End-Tidal Carbon Dioxide, Cardiac Arrest, Out-Of-Hospital, Prehospital Emergency Medical Services
Interventions
Not listed
Lead sponsor
Office of the Medical Director for EMS in Oklahoma City and Tulsa
Other
Eligibility
18 Years and older
Enrollment
3,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Jul 21, 2026, 6:56 PM EDT
Recruiting Not applicable Interventional

Pediatric Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (P-ICECAP)

NCT05376267
View directory record Official record
Conditions
Cardiac Arrest, Out-Of-Hospital, Hypothermia, Induced, Hypoxia-Ischemia, Brain
Interventions
Therapeutic Hypothermia
Device
Lead sponsor
University of Michigan
Other
Eligibility
2 Days to 17 Years
Enrollment
900 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
50
States / cities
Birmingham, Alabama • Phoenix, Arizona • Tucson, Arizona + 43 more
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Jul 21, 2026, 6:56 PM EDT
Active, not recruiting Not applicable Interventional

The PulsePoint Study

NCT04806958
View directory record Official record
Conditions
Out-Of-Hospital Cardiac Arrest, Heart Arrest, Heart Diseases, Cardiovascular Diseases
Interventions
PulsePoint notification
Other
Lead sponsor
Dr. Steven Brooks
Other
Eligibility
Not listed
Enrollment
340 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Jul 21, 2026, 6:56 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Dose-Finding Study of Intranasal Insulin in Healthy Participants Insulin in Healthy Participants

NCT05062785
View directory record Official record
Conditions
Out-Of-Hospital Cardiac Arrest, Healthy
Interventions
Intranasal insulin
Drug
Lead sponsor
Robert Silbergleit
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 26, 2026 · Synced Jul 21, 2026, 6:56 PM EDT
Recruiting No phase listed Observational

International Device Assisted Controlled Sequential Elevation CPR Registry

NCT05588024
View directory record Official record
Conditions
Cardiac Arrest, Out-Of-Hospital
Interventions
Head Up CPR based bundle of care
Device
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
18 Years and older
Enrollment
5,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 11, 2025 · Synced Jul 21, 2026, 6:56 PM EDT
Completed Not applicable Interventional

Targeted Hypothermia Versus Targeted Normothermia After Out-of-hospital Cardiac Arrest

NCT02908308
View directory record Official record
Conditions
Out-of-hospital Cardiac Arrest
Interventions
Targeted temperature management to 33°C, Standard care with early treatment of fever
Procedure
Lead sponsor
Helsingborgs Hospital
Other
Eligibility
18 Years and older
Enrollment
1,900 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
2
States / cities
Rochester, New York • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 2, 2023 · Synced Jul 21, 2026, 6:56 PM EDT
Completed Not applicable Interventional

SmartCPR Trial: An Analysis of a Waveform-Based Automated External Defibrillation (AED) Algorithm on Survival From Out-of-Hospital Ventricular Fibrillation

NCT00535106
View directory record Official record
Conditions
Ventricular Fibrillation, Cardiac Arrest
Interventions
Automated external defibrillator (Philips FR2+ AED), SmartCPR, Delayed defibrillation
Device · Other
Lead sponsor
New York City Fire Department
Government
Eligibility
Not listed
Enrollment
900 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 18, 2009 · Synced Jul 21, 2026, 6:56 PM EDT
Completed Not applicable Interventional Results available

Pragmatic Airway Resuscitation Trial

NCT02419573
View directory record Official record
Conditions
Cardiac Arrest
Interventions
Endotracheal Intubation, Laryngeal Tube (King)
Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
3,004 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
6
States / cities
Birmingham, Alabama • Portland, Oregon • Pittsburgh, Pennsylvania + 3 more
Source: ClinicalTrials.gov public record
Updated Jan 13, 2019 · Synced Jul 21, 2026, 6:56 PM EDT
Recruiting Not applicable Interventional

First Responder Airway & Compression Rate Trial

NCT05969028
View directory record Official record
Conditions
Out-Of-Hospital Cardiac Arrest
Interventions
igel, Compression Rate
Device · Procedure
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
4,200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 12, 2024 · Synced Jul 21, 2026, 6:56 PM EDT
Active, not recruiting Not applicable Interventional

RACE-CARS - RAndomized Cluster Evaluation of Cardiac ARrest Systems

NCT04660526
View directory record Official record
Conditions
Cardiac Arrest
Interventions
Rapid cardiac arrest recognition that triggers immediate priority EMS/first responder dispatch by 911 operators, Systematic bystander resuscitation instruction by 911 operators, Comprehensive community training of lay people in CPR and AED use., Optimized first responder performance including earlier use of AEDs.
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
20,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 15, 2026 · Synced Jul 21, 2026, 6:56 PM EDT