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ClinicalTrials.gov public records Last synced Nov 6, 2026, 12:00 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 204 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Cardio-pulmonary Bypass Clear all

Conditions: Bleeding Reduction
Interventions: Acute Normovolemic Hemodilution; Procedure
Lead sponsor: Inova Health Care Services; Other
Eligibility: 18 Years to 85 Years
Enrollment: 43 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Falls Church, Virginia

Conditions: Nitric Oxide, Cardiac Surgery, Cardiopulmonary Bypass, Adult Patients Undergoing Cardiovascular Surgery With Cardiopulmonary Bypass
Interventions: Nitric Oxide Gas, Standard Care Arm; Drug
Lead sponsor: Xijing Hospital; Other
Eligibility: 18 Years and older
Enrollment: 3,650 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Acute Kidney Injury
Interventions: Aminophylline, Placebo; Drug
Lead sponsor: Stanford University; Other
Eligibility: 1 Day to 18 Years
Enrollment: 144 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Ischemic Heart Disease
Interventions: Coronary artery bypass - on-pump, Coronary artery bypass - off-pump; Procedure
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: Not listed
Enrollment: 2,203 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2008
U.S. locations: 17
States / cities: Palo Alto, California • San Francisco, California • Sepulveda, California + 14 more

Conditions: NIRS, Cardiac Surgery Associated - Acute Kidney Injury, Cardiac Surgery Requiring Cardiopulmonary Bypass, AKI - Acute Kidney Injury
Interventions: NIRS sensor placement; Device
Lead sponsor: University of Utah; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Heart Disease Congenital Complex
Interventions: Hydrocortisone, Normal Saline; Drug
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 1 Day to 28 Days
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Acute Kidney Failure
Interventions: Neseritide; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2007
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Cardiovascular Diseases, Heart Diseases, Heart Defects, Congenital
Interventions: Citrulline; Drug
Lead sponsor: Vanderbilt University; Other
Eligibility: Up to 18 Years
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2009
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Bloodloss, Surgical Procedures, Operative
Interventions: Ecallantide, Cyklokapron(R); Drug
Lead sponsor: Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA); Industry
Eligibility: 18 Years to 85 Years
Enrollment: 243 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2010
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Coronary Artery Bypass Graft Surgery, Myocardial Ischemia, Reperfusion Injury
Interventions: (MC-1) Pyridoxal 5'-phosphate; Drug
Lead sponsor: Medicure; Industry
Eligibility: 18 Years and older
Enrollment: 3,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2007
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Acute Kidney Injury, Heart; Dysfunction Postoperative, Cardiac Surgery, Children
Interventions: Not listed
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 1 Day to 4 Years
Enrollment: 107 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Congenital Heart Disease
Interventions: Tranexamic Acid, Acute Normovolemic Hemodilution; Drug · Procedure
Lead sponsor: Aymen N Naguib; Other
Eligibility: Up to 28 Days
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Children With Heart Defects
Interventions: Not listed
Lead sponsor: Emory University; Other
Eligibility: Up to 10 Years
Enrollment: 125 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2006
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Acute Kidney Injury
Interventions: Saline, Sodium Nitrite; Drug
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 19 Years to 100 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Open-heart Surgery, Cardiopulmonary Bypass
Interventions: Phenoxybenzamine; Drug
Lead sponsor: University of Arkansas; Other
Eligibility: Up to 18 Years
Enrollment: 785 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2010
U.S. locations: 1
States / cities: Little Rock, Arkansas

Conditions: Cardiac Output, Hemodynamic Monitoring
Interventions: Caretaker Device placement; Device
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Laboratory Assessment SARS-CoV-2 Antibody Levels Before and After Surgery for Patients Requiring Cardiopulmonary Bypass
Interventions: SARS-CoV-2 Antibody test; Diagnostic Test
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Pharmacokinetics, Cardiopulmonary Bypass, Children
Interventions: Not listed
Lead sponsor: Duke University; Other
Eligibility: Up to 2 Years
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Circulatory Arrest
Interventions: Not listed
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: Not listed
Enrollment: 1,250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2013
U.S. locations: 1
States / cities: New York, New York

Conditions: Coronary Artery Disease
Interventions: Coronary Artery Bypass; Procedure
Lead sponsor: Emory University; Other
Eligibility: 18 Years and older
Enrollment: 87 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2009
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Hemostasis
Interventions: Fibrinogen Concentrate (FC), Cryoprecipitate; Drug
Lead sponsor: Emory University; Other
Eligibility: 1 Day to 30 Days
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Cardio-pulmonary Bypass, Coronary Artery Bypass Graft
Interventions: pexelizumab; Drug
Lead sponsor: Alexion Pharmaceuticals, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 3,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2002
U.S. locations: 168
States / cities: Birmingham, Alabama • Mobile, Alabama • Mesa, Arizona + 120 more

Conditions: Coronary Artery Disease, Delirium
Interventions: Ropivacaine, Ketamine, Remifentanil, Dexmedetomidine, Rocuronium, Propofol, Sevoflurane, EEG monitoring; Drug · Device
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 60 Years and older
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Acute Kidney Injury
Interventions: 0.9% Normal Saline (0.9% Sodium Chloride) injection, Isolyte S injection; Drug
Lead sponsor: University of New Mexico; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Albuquerque, New Mexico

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Biomarker and Thrombogenicity Assessment in Cardiopulmonary Bypass Surgery Utilizing Acute Normovolemic Hemodilution

Nitric Oxide for Reduced Intensive Support in Cardiac Surgery With Cardiopulmonary Bypass

Aminophylline to Prevent Acute Kidney Injury in Children After Cardiac Surgery

Outcomes Following Myocardial Revascularization: On and Off Cardiopulmonary Bypass

A Comparison of Renal vs Limb NIRS for Predicting Cardiac Surgery Associated Acute Kidney Injury

Effect of Postop Steroids on Cardiovascular/Respiratory Function in Neonates Undergoing Cardiopulmonary Bypass

BNP (Nesiritide) vs. Placebo to Protect Kidney Function in Patients Undergoing Heart Bypass Surgery.

Citrulline for Children Undergoing Cardiopulmonary Bypass Surgery

Outcomes and Safety Trial Investigating Ecallantide's Effect on Reducing Surgical Blood Loss Volume in Subjects at High Risk of Bleeding Exposed to Cardio-pulmonary Bypass During Cardiac Surgery

A Safety and Efficacy Study to Confirm the Cardioprotective Effects of MC-1 in Patients Undergoing High-Risk CABG

Near Infrared Spectroscopy for the Detection of Acute Kidney Injury in Children Following Cardiac Surgery

The Role of Tranexamic Acid in Reducing Blood Transfusion Requirements After Cardiopulmonary Bypass in Neonates

Heparin Responses in Pediatric Patients Undergoing Cardiopulmonary Bypass.

Nitrite Infusion in High Risk Patients Undergoing Cardiopulmonary Bypass

Intravenous Phenoxybenzamine Use in Pediatric Patients Undergoing Open-Heart Surgery

Caretaker in the Cardiovascular Intensive Care Unit (CVICU)

Quantitative COVID-19 SARS-CoV-2 Antibody Pre and Post Cardiopulmonary Bypass

Pharmacokinetics of Dexmedetomidine in Children During Cardiopulmonary Bypass (CPB)

Aprotinin Use and Renal Outcome in Hypothermic Bypass and Circulatory Arrest for Surgical Repair of Thoracic Aorta.

SMART Trial Longitudinal Follow-Up:Off-Pump Versus On-Pump Coronary Artery Bypass Surgery

In Vivo Effects of Fibrinogen Concentrate (FC) Versus Cryoprecipitate on the Neonatal Fibrin Network Structure After Cardiopulmonary Bypass (CPB)

Effect of Pexelizumab on All-Cause Mortality and Myocardial Infarction in Patients Undergoing Coronary Artery Bypass Graft Surgery With Cardio-Pulmonary Bypass

The PATHFINDER Study: A Feasibility Trial

Fluid Chloride and AKI in Cardiopulmonary Bypass