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Showing 1–24 of 646 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Cardiovascular Disease, Obesity Clear all
Completed Phase 3 Interventional

Supplemental Calcium in Overweight People

NCT00030238
View directory record Official record
Conditions
Obesity
Interventions
Calcium supplement, Placebo
Drug
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
18 Years and older
Enrollment
540 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2007
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 21, 2019 · Synced Sep 27, 2026, 4:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Whole Body Vibration and External Load Exercise Training on Cardiovascular and Autonomic Function in Obese Individuals

NCT02679898
View directory record Official record
Conditions
Obesity
Interventions
Unloaded-Whole Body Vibration (WBVT), Loaded-Whole Body Vibration (WBVT)
Other
Lead sponsor
Florida State University
Other
Eligibility
18 Years to 25 Years · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Feb 10, 2016 · Synced Sep 27, 2026, 4:36 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Mobile Phone-based Intervention for Promoting Healthy Habits and Weight Loss

NCT02621008
View directory record Official record
Conditions
Diabetes, Hypertension, Pre-diabetes, Overweight, Obese, Weight, Adherence
Interventions
Stress Reduction& Healthy living
Other
Lead sponsor
Eco Fusion
Industry
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 31, 2015 · Synced Sep 27, 2026, 4:36 PM EDT
Completed Not applicable Interventional

The Weight-Wise Weight Loss Translation Study

NCT01141348
View directory record Official record
Conditions
Overweight, Obesity, Cardiovascular Disease
Interventions
Special Intervention, Delayed Intervention
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
40 Years to 64 Years · Female only
Enrollment
189 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
6
States / cities
Elizabeth City, North Carolina • Lexington, North Carolina • Lincolnton, North Carolina + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 9, 2010 · Synced Sep 27, 2026, 4:36 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Youth-Onset Type 2 Diabetes and Heart Disease: The Young at Heart Prospective Cohort Study

NCT06730113
View directory record Official record
Conditions
Obesity, Type 2 Diabetes
Interventions
Not listed
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
12 Years to 25 Years
Enrollment
930 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2033
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 16, 2026 · Synced Sep 27, 2026, 4:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Stand & Move at Work

NCT02566317
View directory record Official record
Conditions
Obesity, Hypertension, Diabetes
Interventions
Sit-Stand workstation, Move
Device · Behavioral
Lead sponsor
Arizona State University
Other
Eligibility
18 Years and older
Enrollment
630 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
2
States / cities
Tempe, Arizona • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 10, 2019 · Synced Sep 27, 2026, 4:36 PM EDT
Active, not recruiting No phase listed Observational

Biological Sample Repository for Gastrointestinal Disorders

NCT05874726
View directory record Official record
Conditions
Obesity, Obesity, Morbid, Obesity, Primary, Gastro-Intestinal Disorder, Overweight and Obesity, Overweight, Overweight or Obesity, Diabetes Type 2, Diabetes Mellitus, Diabetes Mellitus, Type 2, Hypertension, Hyperlipidemias, Sleep Apnea, GERD, Gastroesophageal Reflux, Musculoskeletal Pain Disorder, Cancer
Interventions
Blood Collection, Urine Collection, Tissue Sample Collection
Diagnostic Test
Lead sponsor
Pichamol Jirapinyo, MD, MPH
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 1, 2025 · Synced Sep 27, 2026, 4:36 PM EDT
Terminated Not applicable Interventional

Optimizing the Social Engagement System in Prader-Willi Syndrome: Insights From the Polyvagal Theory

NCT03101826
View directory record Official record
Conditions
Prader-Willi Syndrome
Interventions
Listening Project Protocol
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
13 Years to 25 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
Brewster, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 2, 2023 · Synced Sep 27, 2026, 4:36 PM EDT
Completed Not applicable Interventional

Improving Physical Activity Through a mHealth Intervention in Cardio-metabolic Risk Patients

NCT02551640
View directory record Official record
Conditions
Diabetes Mellitus, Type 2, Prediabetic State, Hypertension, Prehypertension, Obesity
Interventions
FeatForward App (on study smartphone)
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
2
States / cities
Charlestown, Massachusetts • Revere, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 31, 2020 · Synced Sep 27, 2026, 4:36 PM EDT
Completed Not applicable Interventional

Improving Heart Health in Appalachia

NCT01884246
View directory record Official record
Conditions
Obesity, Hypertension, Hyperlipidemia, Depression
Interventions
Self-care CVD risk reduction, Referral to primary care provider for CVD risk management
Behavioral · Other
Lead sponsor
Debra Moser
Other
Eligibility
21 Years and older
Enrollment
330 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Mar 9, 2017 · Synced Sep 27, 2026, 4:36 PM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

Peripheral Vasodilation in Obese Humans

NCT02833207
View directory record Official record
Conditions
Obesity
Interventions
Drug Trial 1 (EDD), Drug Trial 2 (ROV)
Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 40 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2021
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 10, 2022 · Synced Sep 27, 2026, 4:36 PM EDT
Completed Not applicable Interventional

Weight Management Demonstration Project: HEALTH

NCT01307280
View directory record Official record
Conditions
Weight Loss
Interventions
RCT1, RCT2, RCT3
Behavioral
Lead sponsor
RTI International
Other
Eligibility
18 Years to 64 Years
Enrollment
2,395 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
3
States / cities
Swansea, Illinois • Research Triangle Park, North Carolina • Fairborn, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 25, 2012 · Synced Sep 27, 2026, 4:36 PM EDT
Completed Not applicable Interventional

Personal Activity Intelligence (PAI) Pilot

NCT03740074
View directory record Official record
Conditions
Overweight and Obesity, Diabetes, Hypertension, Dyslipidemias, Cardiovascular Diseases
Interventions
PAI
Behavioral
Lead sponsor
Ohio University
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Athens, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 15, 2020 · Synced Sep 27, 2026, 4:36 PM EDT
Completed Phase 1 Interventional

Antibiotics, Gastric Bypass, and the Microbiome

NCT05367479
View directory record Official record
Conditions
Obesity, Morbid, Hypertension, Bariatric Surgery Candidate
Interventions
Antibiotic
Drug
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years to 70 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 9, 2022 · Synced Sep 27, 2026, 4:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of a Lifestyle Medicine Practice

NCT03739034
View directory record Official record
Conditions
Chronic Lifestyle Related Disease, Diabetes, Overweight and Obesity, Dyslipidemias, Hypertension, Cardiovascular Diseases
Interventions
Lifestyle Medicine
Behavioral
Lead sponsor
Ohio University
Other
Eligibility
18 Years and older
Enrollment
71 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Athens, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 9, 2022 · Synced Sep 27, 2026, 4:36 PM EDT
Recruiting Phase 3 Interventional

Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity

NCT07037433
View directory record Official record
Conditions
Atherosclerotic Cardiovascular Disease, Overweight, Obesity
Interventions
Maridebart Cafraglutide, Placebo
Drug
Lead sponsor
Amgen
Industry
Eligibility
45 Years to 99 Years
Enrollment
12,800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
140
States / cities
Daphne, Alabama • Fairhope, Alabama • Huntsville, Alabama + 117 more
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Sep 27, 2026, 4:36 PM EDT
Completed Phase 1 Interventional

Effects of NT-0796 in Obese Participants at Risk of Cardiovascular Disease

NCT06129409
View directory record Official record
Conditions
Cardiovascular Diseases
Interventions
NT-0796
Drug
Lead sponsor
Rezera (formerly NodThera Limited)
Industry
Eligibility
18 Years and older
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
2
States / cities
Miami, Florida • Austin, Texas
Source: ClinicalTrials.gov public record
Updated Dec 15, 2024 · Synced Sep 27, 2026, 4:36 PM EDT
Completed Phase 1Phase 2 Interventional

Fatty Liver Disease in Obese Children

NCT02117700
View directory record Official record
Conditions
Obesity, Nonalcoholic Fatty Liver Disease, Cardiovascular Disease
Interventions
N-acetyl cysteine 600 mg once/day, N-acetyl cysteine 600mg twice/day, Placebo twice/day
Dietary Supplement · Other
Lead sponsor
Nemours Children's Clinic
Other
Eligibility
7 Years to 18 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 16, 2022 · Synced Sep 27, 2026, 4:36 PM EDT
Active, not recruiting Not applicable Interventional

Remotely Delivered Resistance Training for Cardiometabolic Health Among Black Women

NCT06360536
View directory record Official record
Conditions
Overweight or Obesity, Prediabetes or Diabetes, Prehypertension (Elevated Blood Pressure) or Hypertension, Resistance Training
Interventions
Resistance Training
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
30 Years to 64 Years · Female only
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Sep 27, 2026, 4:36 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Pediatric Primary Hypertension and the Renin-Angiotensin System (PHRAS)

NCT03310684
View directory record Official record
Conditions
Pediatric Disorder, Pediatric Obesity, Primary Hypertension
Interventions
Not listed
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
5 Years to 17 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 27, 2025 · Synced Sep 27, 2026, 4:36 PM EDT
Completed Phase 2 Interventional

Effects of Worksite Wellness Interventions on Vascular Function, Insulin Sensitivity and High-Density Lipoprotein in Overweight or Obese Women

NCT00666172
View directory record Official record
Conditions
Atherosclerosis, Diabetes Mellitus, Obesity, Dyslipidemia, Hypertension
Interventions
Exercise, Weight Loss
Behavioral
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
18 Years and older · Female only
Enrollment
270 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 16, 2019 · Synced Sep 27, 2026, 4:36 PM EDT
Not yet recruiting Not applicable Interventional

Pilot Study of Endoscopic Sleeve Gastroplasty for Obese Patients With Heart Failure and Preserved Ejection Fraction

NCT07798219
View directory record Official record
Conditions
Obesity (BMI>30), Heart Failure With Preserved Ejection Fraction (HFPEF)
Interventions
Endoscopic sleeve gastroplasty (ESG)
Procedure
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
22 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Sep 27, 2026, 4:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Epigenetic Effects of a Single Bout of Exercise on Cardiovascular Risk Factors and the Metabolome

NCT05034380
View directory record Official record
Conditions
Obesity, Type 2 Diabetes, Cardiovascular Diseases, Acute Exercise
Interventions
Acute exercise
Behavioral
Lead sponsor
East Carolina University
Other
Eligibility
18 Years to 30 Years · Male only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 4, 2021 · Synced Sep 27, 2026, 4:36 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effect of Diet Composition on Weight Change and Metabolic Parameters

NCT01642849
View directory record Official record
Conditions
Obesity, Inflammation
Interventions
high protein diet, high carbohydrate diet
Dietary Supplement
Lead sponsor
University of Tennessee
Other
Eligibility
20 Years to 50 Years · Female only
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2013
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Jul 16, 2012 · Synced Sep 27, 2026, 4:36 PM EDT