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Showing 1–24 of 99 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Cartilage, Articular Clear all
Completed Phase 1 Interventional

Effects of Synvisc on Cartilage in Knee Osteoarthritis (OA)

NCT00949494
View directory record Official record
Conditions
Osteoarthritis
Interventions
Synvisc
Device
Lead sponsor
Endeavor Health
Other
Eligibility
40 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
2
States / cities
Chicago, Illinois • Evanston, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 9, 2019 · Synced Jul 22, 2026, 2:14 PM EDT
Completed Not applicable Interventional Results available

Agili-C™ Implant Performance Evaluation

NCT03299959
View directory record Official record
Conditions
Cartilage or Osteochondral Defects in the Knee, Up to Moderate Osteoarthritis
Interventions
Agili-C implant, SSOC
Device · Procedure
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
21 Years to 75 Years
Enrollment
251 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
11
States / cities
San Diego, California • New Orleans, Louisiana • Salisbury, Maryland + 7 more
Source: ClinicalTrials.gov public record
Updated Dec 4, 2025 · Synced Jul 22, 2026, 2:14 PM EDT
Active, not recruiting Not applicable Interventional

HyaloFAST Trial for Repair of Articular Cartilage in the Knee

NCT02659215
View directory record Official record
Conditions
Defect of Articular Cartilage
Interventions
Hyalofast, Microfracture
Device · Procedure
Lead sponsor
Anika Therapeutics, Inc.
Industry
Eligibility
18 Years to 60 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2026
U.S. locations
18
States / cities
Tempe, Arizona • Los Angeles, California • San Diego, California + 14 more
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Jul 22, 2026, 2:14 PM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Platelet Rich Plasma Injections In Young And Old Human Subjects

NCT06451120
View directory record Official record
Conditions
Osteoarthritis, Articular Cartilage, Musculoskeletal Disorders
Interventions
Platelet-Rich Plasma (PRP) Injections, Centrifuge, Control saline injection
Drug · Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 70 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 18, 2026 · Synced Jul 22, 2026, 2:14 PM EDT
Completed Not applicable Interventional Results available

Anterior Cruciate Ligament Reconstruction and Plyometric Exercise

NCT01851655
View directory record Official record
Conditions
Anterior Cruciate Ligament Reconstruction
Interventions
Plyometric Exercise
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
15 Years to 30 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 17, 2014 · Synced Jul 22, 2026, 2:14 PM EDT
Active, not recruiting Not applicable Interventional

Episealer® Knee System IDE Clinical Study

NCT04000659
View directory record Official record
Conditions
Degenerative Lesion of Articular Cartilage of Knee
Interventions
Episealer Knee System, Microfracture
Device · Procedure
Lead sponsor
Episurf Medical Inc.
Industry
Eligibility
30 Years to 70 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2028
U.S. locations
8
States / cities
Tempe, Arizona • La Mesa, California • New Orleans, Louisiana + 5 more
Source: ClinicalTrials.gov public record
Updated Jul 29, 2024 · Synced Jul 22, 2026, 2:14 PM EDT
Completed Phase 4 Interventional

Study of the Treatment of Articular Repair (STAR)

NCT00158613
View directory record Official record
Conditions
Articular Cartilage
Interventions
Carticel (autologous cultured chondrocyte) implantation
Biological
Lead sponsor
Vericel Corporation
Industry
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2005
U.S. locations
25
States / cities
Los Angeles, California • San Diego, California • Santa Monica, California + 22 more
Source: ClinicalTrials.gov public record
Updated May 10, 2021 · Synced Jul 22, 2026, 2:14 PM EDT
Recruiting Not applicable Interventional

Early Feasibility Study of Cartilage Defect Repair

NCT06823089
View directory record Official record
Conditions
Osteoarthritis, Hip, Femoroacetabular Impingement, Osteonecrosis, Legg-Calvé-Perthes Disease, Osteochondral Lesion, Hip Dysplasia
Interventions
ReNew Hip Implant
Device
Lead sponsor
Cytex Therapeutics, Inc.
Other
Eligibility
14 Years to 64 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2031
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Jul 22, 2026, 2:14 PM EDT
Terminated Phase 2 Interventional

Evaluation of an Acellular Osteochondral Graft for Cartilage LEsions Pilot Trial

NCT01183637
View directory record Official record
Conditions
Articular Cartilage Injury
Interventions
Kensey Nash Corp. Cartilage Repair Device, Microfracture
Device · Procedure
Lead sponsor
Kensey Nash Corporation
Industry
Eligibility
21 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
2
States / cities
Salisbury, Maryland • Kirkwood, Missouri
Source: ClinicalTrials.gov public record
Updated May 24, 2015 · Synced Jul 22, 2026, 2:14 PM EDT
Active, not recruiting Phase 3 Interventional

NOVOCART®3D for Treatment of Articular Cartilage of the Knee

NCT01957722
View directory record Official record
Conditions
Articular Cartilage of the Femoral Condyle Between 2-6cm2
Interventions
Microfracture, NOVOCART 3D
Procedure · Biological
Lead sponsor
Aesculap Biologics, LLC
Industry
Eligibility
18 Years to 65 Years
Enrollment
233 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2027
U.S. locations
30
States / cities
La Mesa, California • Los Angeles, California • Redwood City, California + 26 more
Source: ClinicalTrials.gov public record
Updated Mar 20, 2025 · Synced Jul 22, 2026, 2:14 PM EDT
Withdrawn Phase 1Phase 2 Interventional

Targeting Senescence to Reduce Osteoarthritis Pain and cartilagE Breakdown (ROPE)

NCT04770064
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
High-dose/short-duration Fisetin, Low-dose/sustained-duration Fisetin, Oral placebo capsule
Drug · Other
Lead sponsor
Austin V Stone
Other
Eligibility
35 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
2
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 28, 2022 · Synced Jul 22, 2026, 2:14 PM EDT
Active, not recruiting Phase 3 Interventional

NOVOCART 3D Treatment Following Microfracture Failure

NCT03219307
View directory record Official record
Conditions
Articular Cartilage Defect
Interventions
NOVOCART 3D
Combination Product
Lead sponsor
Aesculap Biologics, LLC
Industry
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2029
U.S. locations
3
States / cities
Chicago, Illinois • Columbus, Ohio • North Logan, Utah
Source: ClinicalTrials.gov public record
Updated Mar 20, 2025 · Synced Jul 22, 2026, 2:14 PM EDT
Not listed Not applicable Interventional

Pivotal Study to Evaluate the Safety and Efficacy of GelrinC for Treatment of Cartilage Defects

NCT03262909
View directory record Official record
Conditions
Articular Cartilage Defects in the Knee Joint
Interventions
GelrinC, Microfracture historical control arm
Device · Other
Lead sponsor
Regentis Biomaterials
Industry
Eligibility
18 Years to 50 Years
Enrollment
181 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
13
States / cities
La Mesa, California • Orange, California • Denver, Colorado + 10 more
Source: ClinicalTrials.gov public record
Updated Mar 21, 2022 · Synced Jul 22, 2026, 2:14 PM EDT
Completed Phase 2 Interventional

NeoCart Phase 2 Clinical Trial

NCT00548119
View directory record Official record
Conditions
Articular Cartilage Damage
Interventions
NeoCart, microfracture
Biological · Procedure
Lead sponsor
Histogenics Corporation
Industry
Eligibility
18 Years to 55 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2014
U.S. locations
6
States / cities
San Francisco, California • Bloomington, Minnesota • New York, New York + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 20, 2014 · Synced Jul 22, 2026, 2:14 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

MRI Markers of Cartilage Damage in Knee With Osteoarthritis

NCT00820430
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Magnetic Resonance Imaging
Other
Lead sponsor
American College of Radiology
Other
Eligibility
18 Years and older
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
5
States / cities
Hershey, Pennsylvania • Philadelphia, Pennsylvania • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 19, 2023 · Synced Jul 22, 2026, 2:14 PM EDT
Enrolling by invitation No phase listed Observational

A Post Approval Multicenter 10 Year Follow-up Observational Trial of Marketed Product - MP01 vs. Surgical Standard of Care (SSOC) Used for the Treatment of Joint Surface Lesions of the Knee

NCT06916728
View directory record Official record
Conditions
Knee Injuries, Joint Surface Knee Lesions
Interventions
Marketed Product - MP01, Surgical Standard of Care
Device · Procedure
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
21 Years to 75 Years
Enrollment
170 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
La Mesa, California
Source: ClinicalTrials.gov public record
Updated Jul 15, 2026 · Synced Jul 22, 2026, 2:14 PM EDT
Recruiting Phase 2 Interventional

Phase 2 Clinical Trial of CartiLife® in the United States

NCT04744402
View directory record Official record
Conditions
Articular Cartilage Defect, Articular Cartilage Degeneration
Interventions
Autologous Chondrocyte Implantation (CartiLife®)
Drug
Lead sponsor
Biosolution Co., Ltd.
Industry
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
5
States / cities
Irvine, California • La Mesa, California • Lafayette, Louisiana + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 27, 2023 · Synced Jul 22, 2026, 2:14 PM EDT
Completed No phase listed Observational

Longitudinal Evaluation of Hip Cartilage Degeneration: FAI

NCT02408276
View directory record Official record
Conditions
Femoroacetabular Impingement
Interventions
dGEMERIC MRI technique
Other
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
10 Years to 35 Years
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 21, 2025 · Synced Jul 22, 2026, 2:14 PM EDT
Not listed Not applicable Interventional

Safety and Effectiveness of Cartiva Implant in the Treatment of First CMC Joint Osteoarthritis Compared to LRTI (GRIP 2)

NCT03247439
View directory record Official record
Conditions
Osteoarthritis
Interventions
Cartiva
Device
Lead sponsor
Cartiva, Inc.
Industry
Eligibility
22 Years and older
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
5
States / cities
San Diego, California • Atlanta, Georgia • Indianapolis, Indiana + 2 more
Source: ClinicalTrials.gov public record
Updated Dec 2, 2020 · Synced Jul 22, 2026, 2:14 PM EDT
Active, not recruiting Not applicable Interventional

Evaluate the Safety and Effectiveness of the Polymotion Hip Resurfacing (PHR) System Compared to Total Hip Arthroplasty

NCT06792539
View directory record Official record
Conditions
Osteoarthritis of the Hip, Degenerative Joint Disease of Hip, Dysplasia; Hip
Interventions
Polymotion Hip Resurfacing (PHR) System
Device
Lead sponsor
JointMedica Inc.
Other
Eligibility
21 Years to 65 Years
Enrollment
238 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
8
States / cities
Tampa, Florida • Chicago, Illinois • Baltimore, Maryland + 5 more
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Jul 22, 2026, 2:14 PM EDT
Completed Not applicable Interventional

Changes in Quadriceps Function Following Local or Distant Interventions in Individuals With Patellofemoral Pain

NCT01434966
View directory record Official record
Conditions
Patellofemoral Pain Syndrome, Chondromalacia Patellae, Anterior Knee Pain Syndrome
Interventions
Lumbopelvic Manipulation, TENS- Spine, TENS- Knee
Other
Lead sponsor
Creighton University
Other
Eligibility
15 Years to 50 Years
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Dec 13, 2015 · Synced Jul 22, 2026, 2:14 PM EDT
Active, not recruiting Phase 1 Interventional Accepts healthy volunteers

Impact of Mesenchymal Stem Cells in Knee Osteoarthritis

NCT03477942
View directory record Official record
Conditions
Musculoskeletal Pain, Knee Osteoarthritis, Cartilage Injury, Cartilage Degeneration
Interventions
Autologous Mesenchymal Stem Cells
Biological
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 60 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2026
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 29, 2025 · Synced Jul 22, 2026, 2:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Unloader Bracing in Clinical Outcome and Cartilage Physiology Following Microfracture of Chondral Defects

NCT02016300
View directory record Official record
Conditions
Cartilage Loss, Microfracture
Interventions
Unloader Bracing, Non-Bracing
Device
Lead sponsor
Stanford University
Other
Eligibility
15 Years to 40 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2018
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated Jun 26, 2019 · Synced Jul 22, 2026, 2:14 PM EDT
Recruiting Phase 3 Interventional

Phase 3 Pivotal Trial Comparing CARTISTEM® and Surgical Comparator for Knee Cartilage Lesions and Osteoarthritis

NCT07339111
View directory record Official record
Conditions
Knee Cartilage Defects
Interventions
CARTISTEM® + Debridement, Debridement
Biological · Procedure
Lead sponsor
Medipost, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
20
States / cities
Birmingham, Alabama • Tempe, Arizona • El Cajon, California + 16 more
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Jul 22, 2026, 2:14 PM EDT