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ClinicalTrials.gov public records Last synced Oct 4, 2026, 10:24 AM EDT

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Showing 73–96 of 101 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Cartilage, Articular Clear all
Terminated No phase listed Observational Accepts healthy volunteers

ProChondrix® CR Articular Cartilage Restoration Evaluation (PACE) Registry

NCT04301258
View directory record Official record
Conditions
Cartilage Injury, Cartilage Damage
Interventions
Articular cartilage repair
Other
Lead sponsor
AlloSource
Industry
Eligibility
Not listed
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
5
States / cities
Mobile, Alabama • Wheat Ridge, Colorado • Washington D.C., District of Columbia + 2 more
Source: ClinicalTrials.gov public record
Updated Nov 21, 2025 · Synced Oct 4, 2026, 10:24 AM EDT
Completed No phase listed Observational

Quantitative MRI of Glenohumeral Cartilage & Labrum in Shoulder Instability

NCT05431114
View directory record Official record
Conditions
Instability, Joint, Shoulder Dislocation, Shoulder Injuries, Shoulder Subluxation, Anterior Shoulder Instability, Glenoid; Dislocation
Interventions
MRI
Diagnostic Test
Lead sponsor
Duke University
Other
Eligibility
18 Years to 50 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 15, 2025 · Synced Oct 4, 2026, 10:24 AM EDT
Active, not recruiting Phase 3 Interventional

NOVOCART 3D Treatment Following Microfracture Failure

NCT03219307
View directory record Official record
Conditions
Articular Cartilage Defect
Interventions
NOVOCART 3D
Combination Product
Lead sponsor
Aesculap Biologics, LLC
Industry
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2029
U.S. locations
3
States / cities
Chicago, Illinois • Columbus, Ohio • North Logan, Utah
Source: ClinicalTrials.gov public record
Updated Mar 21, 2025 · Synced Oct 4, 2026, 10:24 AM EDT
Terminated No phase listed Observational

The Knee Usual Care Evaluation Study

NCT01905358
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Not listed
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
30 Years to 80 Years
Enrollment
906 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 2, 2017 · Synced Oct 4, 2026, 10:24 AM EDT
Completed Phase 2Phase 3 Interventional

A Placebo-Controlled Study of Collagen Hydrolysate in Subjects With Knee Osteoarthritis (OA)

NCT00536302
View directory record Official record
Conditions
Knee Osteoarthritis (OA)
Interventions
Collagen Hydrolysate, Placebo
Dietary Supplement
Lead sponsor
GELITA
Industry
Eligibility
49 Years to 90 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 6, 2009 · Synced Oct 4, 2026, 10:24 AM EDT
Completed Phase 4 Interventional

Study of the Treatment of Articular Repair (STAR)

NCT00158613
View directory record Official record
Conditions
Articular Cartilage
Interventions
Carticel (autologous cultured chondrocyte) implantation
Biological
Lead sponsor
Vericel Corporation
Industry
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2005
U.S. locations
25
States / cities
Los Angeles, California • San Diego, California • Santa Monica, California + 22 more
Source: ClinicalTrials.gov public record
Updated May 11, 2021 · Synced Oct 4, 2026, 10:24 AM EDT
Active, not recruiting Phase 3 Interventional

NOVOCART®3D for Treatment of Articular Cartilage of the Knee

NCT01957722
View directory record Official record
Conditions
Articular Cartilage of the Femoral Condyle Between 2-6cm2
Interventions
Microfracture, NOVOCART 3D
Procedure · Biological
Lead sponsor
Aesculap Biologics, LLC
Industry
Eligibility
18 Years to 65 Years
Enrollment
233 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2027
U.S. locations
30
States / cities
La Mesa, California • Los Angeles, California • Redwood City, California + 26 more
Source: ClinicalTrials.gov public record
Updated Mar 21, 2025 · Synced Oct 4, 2026, 10:24 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Study of Orthotic Shoe Inserts for Controlling Osteoarthritic Knee Pain

NCT00076453
View directory record Official record
Conditions
Osteoarthritis
Interventions
Lateral wedge orthotic shoe inserts, Standard orthotic shoe inserts
Device
Lead sponsor
Rush University Medical Center
Other
Eligibility
25 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2007
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 27, 2011 · Synced Oct 4, 2026, 10:24 AM EDT
Completed No phase listed Observational

Post Market Study of DeNovo NT, Natural Tissue Graft

NCT00791245
View directory record Official record
Conditions
Cartilage Repair
Interventions
Particulated Juvenile Cartilage Allograft
Biological
Lead sponsor
Zimmer Orthobiologics, Inc.
Industry
Eligibility
18 Years to 55 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
3
States / cities
Chicago, Illinois • Indianapolis, Indiana • Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Aug 11, 2014 · Synced Oct 4, 2026, 10:24 AM EDT
Active, not recruiting Not applicable Interventional

Episealer® Knee System IDE Clinical Study

NCT04000659
View directory record Official record
Conditions
Degenerative Lesion of Articular Cartilage of Knee
Interventions
Episealer Knee System, Microfracture
Device · Procedure
Lead sponsor
Episurf Medical Inc.
Industry
Eligibility
30 Years to 70 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2028
U.S. locations
8
States / cities
Tempe, Arizona • La Mesa, California • New Orleans, Louisiana + 5 more
Source: ClinicalTrials.gov public record
Updated Jul 30, 2024 · Synced Oct 4, 2026, 10:24 AM EDT
Completed Not applicable Interventional Results available

Preventing Posttraumatic Osteoarthritis With Physical Activity Promotion

NCT04906499
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries, Exercise, Cartilage, Articular, Knee Injuries, Osteoarthritis, Osteoarthritis, Knee, Arthritis, Joint Diseases
Interventions
Physical Activity Promotion
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 35 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 29, 2024 · Synced Oct 4, 2026, 10:24 AM EDT
Terminated Phase 3 Interventional

Efficacy and Safety of Ketoprofen Topical Patch 20% in the Treatment of Pain Associated With Shoulder, Elbow or Knee Tendonitis or Bursitis

NCT00426985
View directory record Official record
Conditions
Tendonitis, Bursitis
Interventions
Ketoprofen Topical Patch 20%, Placebo
Drug · Other
Lead sponsor
Alkemira SA
Industry
Eligibility
18 Years and older
Enrollment
381 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Sep 30, 2026 · Synced Oct 4, 2026, 10:24 AM EDT
Completed Not applicable Interventional

Loaded and Unloaded Magnetic Resonance (MR) Imaging of Meniscus-Cartilage-Trabecular Bone in Osteoarthritis

NCT01919736
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Gait Retraining
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
35 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Nov 18, 2019 · Synced Oct 4, 2026, 10:24 AM EDT
Recruiting Not applicable Interventional

Impact of Bone-Marrow Aspirate Injections in Knee Arthroscopy

NCT06893302
View directory record Official record
Conditions
Chondral Lesion of the Knee, Meniscal Injuries, Cartilage Defects of the Knee, Osteoarthritis (OA) of the Knee
Interventions
Bone Marrow Aspirate (BMA), Arthroscopic Debridement Surgery, Saline
Biological · Procedure · Other
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 64 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Oct 4, 2026, 10:24 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Laser Cell Therapy for Knee Cartilage Repair

NCT04001361
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Laser Cell Therapy
Procedure
Lead sponsor
Endocellutions
Industry
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Steubenville, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 28, 2019 · Synced Oct 4, 2026, 10:24 AM EDT
Completed Not applicable Interventional Results available

Resistance Exercise and Knee Osteoarthritis Pain, Functional Impairment and Cartilage Turnover

NCT01245283
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
normal activities and clinical care, Concentric Focused Resistance Exercise, Eccentric Focused Resistance Exercise
Other
Lead sponsor
University of Florida
Other
Eligibility
60 Years to 85 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Dec 5, 2014 · Synced Oct 4, 2026, 10:24 AM EDT
Recruiting Phase 3 Interventional

Phase 3 Pivotal Trial Comparing CARTISTEM® and Surgical Comparator for Knee Cartilage Lesions and Osteoarthritis

NCT07339111
View directory record Official record
Conditions
Knee Cartilage Defects
Interventions
CARTISTEM® + Debridement, Debridement
Biological · Procedure
Lead sponsor
Medipost, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
30
States / cities
Birmingham, Alabama • Scottsdale, Arizona • Tempe, Arizona + 25 more
Source: ClinicalTrials.gov public record
Updated Sep 17, 2026 · Synced Oct 4, 2026, 10:24 AM EDT
Recruiting Not applicable Interventional

BioPoly® Partial Resurfacing Knee Implant IDE

NCT06915363
View directory record Official record
Conditions
Knee Pain Chronic, Knee Osteoarthritis, Cartilage Damage, Cartilage Defects of the Knee, Cartilage or Osteochondral Defects in the Knee, Cartilage Lesion
Interventions
BioPoly, surgical standard of care (SSOC)
Device · Procedure
Lead sponsor
BioPoly LLC
Industry
Eligibility
30 Years to 65 Years
Enrollment
152 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
4
States / cities
Fort Wayne, Indiana • Indianapolis, Indiana • Rochester, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Oct 4, 2026, 10:24 AM EDT
Completed No phase listed Observational Results available

Comparison of BioCartilage Versus Marrow Stimulating Procedure for Cartilage Defects of the Knee

NCT02203071
View directory record Official record
Conditions
Defect of Articular Cartilage
Interventions
Not listed
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 16, 2020 · Synced Oct 4, 2026, 10:24 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Evaluation of Safety and Exploratory Efficacy of CARTISTEM®, a Cell Therapy Product for Articular Cartilage Defects

NCT01733186
View directory record Official record
Conditions
Degeneration Articular Cartilage Knee
Interventions
CARTISTEM®
Biological
Lead sponsor
Medipost, Inc.
Industry
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
2
States / cities
Chicago, Illinois • Chestnut Hill, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Oct 4, 2026, 10:24 AM EDT
Terminated Not applicable Interventional

Clinical Study of Chondro-Gide® for Large Chondral Lesions in the Knee

NCT04537013
View directory record Official record
Conditions
Knee Injuries, Cartilage Injury, Cartilage Disease, Knee Discomfort
Interventions
Microfracture, Microfracture plus placement of Chondro-Gide® ACC
Procedure · Device
Lead sponsor
Geistlich Pharma AG
Industry
Eligibility
18 Years to 55 Years
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
3
States / cities
Phoenix, Arizona • Stamford, Connecticut • Johns Creek, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 13, 2026 · Synced Oct 4, 2026, 10:24 AM EDT
Completed Not applicable Interventional

Clinical Efficacy Study Comparing VisionScope Imaging (VSI) to Magnetic Resonance Imaging (MRI) in Injuries of the Knee

NCT01695720
View directory record Official record
Conditions
Meniscus Tears, Loose Bodies, Articular Osteoarthritis, Articular or Capsular Trauma
Interventions
VisionScope Imaging (VSI) Exam
Procedure
Lead sponsor
VisionScope Technologies
Industry
Eligibility
18 Years to 75 Years
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
7
States / cities
Los Angeles, California • Redwood City, California • Santa Monica, California + 4 more
Source: ClinicalTrials.gov public record
Updated May 31, 2013 · Synced Oct 4, 2026, 10:24 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Evaluation of Outcomes With Umbilical Cord Allograft for Musculoskeletal Conditions Musculoskeletal Conditions

NCT03390920
View directory record Official record
Conditions
Osteoarthritis, Tendinitis, Sports Injury, Degenerative Disc Disease, Degenerative Arthritis, Ligament Injury, Neuropathy, Pelvic Pain
Interventions
Umbilical Allograft
Other
Lead sponsor
R3 Stem Cell
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2030
U.S. locations
1
States / cities
Encino, California
Source: ClinicalTrials.gov public record
Updated Sep 17, 2021 · Synced Oct 4, 2026, 10:24 AM EDT
Completed Phase 2 Interventional Results available

Study of TG-C in Patients With Grade 3 Degenerative Joint Disease of the Knee

NCT01221441
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
TissueGene-C, Normal Saline
Biological · Drug
Lead sponsor
Kolon TissueGene, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
5
States / cities
Pinellas Park, Florida • Baltimore, Maryland • Philadelphia, Pennsylvania + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 15, 2016 · Synced Oct 4, 2026, 10:24 AM EDT