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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Cerebrospinal Fluid Clear all
Completed Phase 1 Interventional Accepts healthy volunteers

A Study to Evaluate the Pharmacodynamic Effects of Single Oral Doses of PF-06648671 on β-Amyloid (Aβ) Concentrations in Cerebrospinal Fluid (CSF)

NCT02407353
View directory record Official record
Conditions
Healthy Subjects
Interventions
PF-06648671, Placebo
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 55 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
2
States / cities
Glendale, California
Source: ClinicalTrials.gov public record
Updated Mar 21, 2016 · Synced Jun 26, 2026, 1:04 AM EDT
Completed No phase listed Observational

Neurophysiology and Anatomy of Severe Intraventricular Hemorrhage (IVH)

NCT00817310
View directory record Official record
Conditions
Intracranial Hemorrhages, Prematurity
Interventions
Not listed
Lead sponsor
Vanderbilt University
Other
Eligibility
Up to 14 Days
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 16, 2013 · Synced Jun 26, 2026, 1:04 AM EDT
Recruiting Not applicable Interventional

Investigation of the Delve Detect Cerebrospinal Fluid (CSF) Metagenomic Next-generation Sequencing (mNGS) Test When Used for the Initial Diagnostic Workup of Patients With Suspected Central Nervous System (CNS) Infection

NCT07435649
View directory record Official record
Conditions
Central Nervous System Infection
Interventions
Delve Detect CSF mNGS Test, Real-World Data
Diagnostic Test · Other
Lead sponsor
Delve Bio, Inc.
Industry
Eligibility
Not listed
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
3
States / cities
San Francisco, California • Atlanta, Georgia • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Jun 26, 2026, 1:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cerebrospinal Fluid Biomarkers in Bariatric Surgery

NCT04350892
View directory record Official record
Conditions
Obesity
Interventions
Roux-en-Y Gastric Bypass (RYGB), Sleeve Gastrectomy (SG), Very Low Calorie Diet (VLCD)
Procedure · Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 65 Years
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Jun 26, 2026, 1:04 AM EDT
Completed No phase listed Observational Results available

Assessment of CSF Shunt Flow With Thermal Measurements B

NCT05432986
View directory record Official record
Conditions
Hydrocephalus
Interventions
Thermal Anisotropy Measurement Device
Device
Lead sponsor
Rhaeos, Inc.
Industry
Eligibility
Not listed
Enrollment
141 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
10
States / cities
Oakland, California • San Francisco, California • Chicago, Illinois + 5 more
Source: ClinicalTrials.gov public record
Updated Feb 19, 2025 · Synced Jun 26, 2026, 1:04 AM EDT
Recruiting Not applicable Interventional

Examining the Feasibility of Using Pressure Gradient Regulated Automated Cerebral Spinal Fluid Drainage During External Lumbar Drain Trials

NCT07494812
View directory record Official record
Conditions
NPH (Normal Pressure Hydrocephalus)
Interventions
Intellidrop Automated CSF Drainage System
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
60 Years to 99 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Jun 26, 2026, 1:04 AM EDT
Completed Not applicable Interventional Results available

Study to Evaluate Safety & Effectiveness of Spinal Sealant

NCT00444067
View directory record Official record
Conditions
Cerebrospinal Fluid Leakage, Subdural
Interventions
Spinal Sealant, Standard of Care
Device · Other
Lead sponsor
Integra LifeSciences Corporation
Industry
Eligibility
18 Years to 75 Years
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Bedford, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 6, 2017 · Synced Jun 26, 2026, 1:04 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Pharmacokinetic and Exploratory Biomarker Study of ABT-126 in Healthy Volunteers

NCT00912431
View directory record Official record
Conditions
Healthy
Interventions
ABT-126, Placebo
Drug
Lead sponsor
Abbott
Industry
Eligibility
18 Years to 50 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2009
U.S. locations
1
States / cities
Glendale, California
Source: ClinicalTrials.gov public record
Updated Nov 1, 2010 · Synced Jun 26, 2026, 1:04 AM EDT
Not yet recruiting Not applicable Interventional

Lumbar Punctures for the Detection of ctDNA in the Cerebrospinal Fluid of Patients With Stage III and IV Non-Small Cell Lung Cancer

NCT06816979
View directory record Official record
Conditions
Lung Non-Small Cell Carcinoma, Stage III Lung Cancer AJCC v8, Stage IV Lung Cancer AJCC v8
Interventions
Biospecimen Collection, Lumbar Puncture, Magnetic Resonance Imaging
Procedure · Device
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
Not listed
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Jun 26, 2026, 1:04 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Exploratory Biomarker Study of Cerebrospinal Fluid in Healthy Volunteers

NCT01126567
View directory record Official record
Conditions
Healthy
Interventions
Sampling Rate
Other
Lead sponsor
Abbott
Industry
Eligibility
18 Years to 50 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Glendale, California
Source: ClinicalTrials.gov public record
Updated May 18, 2010 · Synced Jun 26, 2026, 1:04 AM EDT
Completed No phase listed Observational

SPINCOMS Biomarker Study

NCT04496830
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
Not listed
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
161 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 10, 2025 · Synced Jun 26, 2026, 1:04 AM EDT
Completed No phase listed Observational

Suturable DuraGen™ PMCF Study

NCT04923867
View directory record Official record
Conditions
Cerebrospinal Fluid Leak
Interventions
Suturable DuraGen™
Device
Lead sponsor
Integra LifeSciences Corporation
Industry
Eligibility
18 Years to 80 Years
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
3
States / cities
Aurora, Colorado • Jacksonville, Florida • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Apr 5, 2025 · Synced Jun 26, 2026, 1:04 AM EDT
Completed No phase listed Observational

HIV Levels in Cerebrospinal Fluid and Brain Function in Patients Receiving Anti-HIV Drugs

NCT00001103
View directory record Official record
Conditions
Cognitive Disorders, HIV Infections
Interventions
Not listed
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
Not listed
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
25
States / cities
Menlo Park, California • San Diego, California • San Francisco, California + 17 more
Source: ClinicalTrials.gov public record
Updated Jul 28, 2008 · Synced Jun 26, 2026, 1:04 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Cerebrospinal Fluid (CSF) Biomarkers Alzheimer's Disease (AD) and Non-AD Dementias

NCT01730430
View directory record Official record
Conditions
Alzheimer's Disease, Dementias
Interventions
Not listed
Lead sponsor
Duke University
Other
Eligibility
55 Years to 85 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 21, 2014 · Synced Jun 26, 2026, 1:04 AM EDT
Completed No phase listed Observational

Observational Endothelin and Markers of Cellular Apoptosis In CSF Head Injury

NCT00498498
View directory record Official record
Conditions
Cerebrovascular Trauma, Neurohormones, Cellular Apoptosis, Endothelin System
Interventions
Not listed
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 70 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
8
States / cities
Sacramento, California • Torrance, California • Miami, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Nov 15, 2011 · Synced Jun 26, 2026, 1:04 AM EDT
Completed No phase listed Observational

International Guillain-Barré Syndrome Outcome Study

NCT01582763
View directory record Official record
Conditions
Guillain-Barré Syndrome, Miller Fisher Syndrome
Interventions
Not listed
Lead sponsor
Erasmus Medical Center
Other
Eligibility
Not listed
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2024
U.S. locations
26
States / cities
Phoenix, Arizona • Orange, California • New Haven, Connecticut + 19 more
Source: ClinicalTrials.gov public record
Updated Dec 11, 2024 · Synced Jun 26, 2026, 1:04 AM EDT
Withdrawn Early Phase 1 Interventional Accepts healthy volunteers

PET Study of a2a Agonist Effects on the Ventricular CSF Clearance of [11C]Butanol

NCT04032691
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Clonidine Pill
Drug
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 19, 2021 · Synced Jun 26, 2026, 1:04 AM EDT
Completed Not applicable Interventional

Cerebrospinal Fluid Drainage (CSFD) in Acute Spinal Cord Injury

NCT02495545
View directory record Official record
Conditions
Spinal Cord Injury
Interventions
CSFD and elevation of MAP, Maintenance of MAP
Procedure
Lead sponsor
St. Joseph's Hospital and Medical Center, Phoenix
Other
Eligibility
18 Years to 75 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
3
States / cities
Birmingham, Alabama • Phoenix, Arizona • Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Nov 26, 2019 · Synced Jun 26, 2026, 1:04 AM EDT
Completed No phase listed Observational

Role of Proteomics and Metallomics in Cerebral Vasospasm Following Subarachnoid Hemorrhage

NCT01799018
View directory record Official record
Conditions
Subarachnoid Hemorrhage, Cerebral Vasospasm, Hydrocephalus
Interventions
Not listed
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
18 Years to 89 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Nov 19, 2014 · Synced Jun 26, 2026, 1:04 AM EDT
Completed Phase 4 Interventional

DepoCyt Therapy in Patients With Neoplastic Meningitis From Lymphoma or a Solid Tumor

NCT00029523
View directory record Official record
Conditions
Meningeal Neoplasms
Interventions
Intrathecal (injected into the spinal fluid) DepoCyt, Intrathecal methotrexate, Intrathecal cytarabine (also known as ara-C)
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2004
U.S. locations
21
States / cities
Phoenix, Arizona • Berkeley, California • Los Angeles, California + 18 more
Source: ClinicalTrials.gov public record
Updated Feb 27, 2007 · Synced Jun 26, 2026, 1:04 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Formative Usability Assessment of Wireless Thermal Anisotropy Devices

NCT06040697
View directory record Official record
Conditions
Hydrocephalus
Interventions
Thermal Anisotropy
Device
Lead sponsor
Rhaeos, Inc.
Industry
Eligibility
5 Years to 80 Years
Enrollment
145 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 14, 2025 · Synced Jun 26, 2026, 1:04 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

The Effect of Short-Term Statins and NSAIDs on Levels of Beta-Amyloid, a Protein Associated With Alzheimer's Disease

NCT00046358
View directory record Official record
Conditions
Alzheimer Disease
Interventions
Lovostatin, Ibuprofen
Drug
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
Not listed
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2005
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Jun 26, 2026, 1:04 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Study In Healthy Subjects To Evaluate The Changes In The Protein sAPP-Alpha In Cerebrospinal Fluid Following A Single Oral Dose Of PF-04995274

NCT01193062
View directory record Official record
Conditions
Healthy
Interventions
PF-04995274
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 55 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 2, 2018 · Synced Jun 26, 2026, 1:04 AM EDT
Completed Phase 1 Interventional

Effect of Polyunsaturated Fatty Acids on Cardiovascular and Motor Responses Under Stress

NCT00014027
View directory record Official record
Conditions
Healthy
Interventions
Docosahexaenoic acid (DHA), Eicosapentaenoic acid
Drug
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
18 Years and older
Enrollment
97 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2008
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Jun 26, 2026, 1:04 AM EDT