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ClinicalTrials.gov public records Last synced Sep 13, 2026, 10:16 PM EDT

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Showing 1–24 of 65 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Cervical Disc Degeneration Clear all
Enrolling by invitation No phase listed Observational

Cervical Interbody Implant Study

NCT04689854
View directory record Official record
Conditions
Degenerative Disc Disease, Cervical Spinal Instability
Interventions
Not listed
Lead sponsor
NuVasive
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
7
States / cities
Orange, California • Hartford, Connecticut • Somerville, Massachusetts + 4 more
Source: ClinicalTrials.gov public record
Updated Dec 21, 2025 · Synced Sep 13, 2026, 10:16 PM EDT
Completed No phase listed Observational Results available

Post Approval Study Protocol for the Two Level Simplify® Cervical Artificial Disc

NCT04980378
View directory record Official record
Conditions
Cervical Degenerative Disc Disorder
Interventions
Simplify Disc
Device
Lead sponsor
NuVasive
Industry
Eligibility
Not listed
Enrollment
291 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
18
States / cities
Orange, California • Santa Monica, California • Thornton, Colorado + 15 more
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Sep 13, 2026, 10:16 PM EDT
Active, not recruiting Not applicable Interventional

The Synergy Disc for the Treatment of 2 Level Cervical Degenerative Disc Disease Compared With Cervical Fusion Surgery

NCT05740176
View directory record Official record
Conditions
Cervical Degenerative Disc Disease
Interventions
Anterior Cervical Discectomy and Fusion
Device
Lead sponsor
Synergy Spine Solutions
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
23
States / cities
Scottsdale, Arizona • Beverly Hills, California • Los Angeles, California + 20 more
Source: ClinicalTrials.gov public record
Updated Jul 5, 2026 · Synced Sep 13, 2026, 10:16 PM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Adjacent Level Anterior Cervical Fusion: SeaSpine Shoreline Versus Removal of Previously Implanted Plate and Replating

NCT06415136
View directory record Official record
Conditions
Degenerative Disc Disease, Disc Herniation
Interventions
SeaSpine Shoreline
Device
Lead sponsor
Research Source
Network
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Southfield, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 21, 2025 · Synced Sep 13, 2026, 10:16 PM EDT
Completed Not applicable Interventional Results available

Cellentra Viable Cell Bone Matrix (VCBM) Anterior Cervical Discectomy and Fusion Outcomes Study (VCBM/MaxAn)

NCT02182843
View directory record Official record
Conditions
Cervical Disc Degenerative Disorder
Interventions
Cellentra VCBM
Biological
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
6
States / cities
Phoenix, Arizona • Fort Wayne, Indiana • Paducah, Kentucky + 3 more
Source: ClinicalTrials.gov public record
Updated Mar 14, 2019 · Synced Sep 13, 2026, 10:16 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Adjacent Segment Mechanics in Cervical Arthrodesis Patients

NCT03028402
View directory record Official record
Conditions
Intervertebral Disc Degeneration
Interventions
C5-C6 arthrodesis
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
21 Years to 60 Years
Enrollment
106 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2024
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 5, 2025 · Synced Sep 13, 2026, 10:16 PM EDT
Completed Not applicable Interventional Results available

An Assessment of P-15 Bone Putty in Anterior Cervical Fusion With Instrumentation

NCT00310440
View directory record Official record
Conditions
Intervertebral Disk Degeneration
Interventions
P-15 Synthetic osteoconductive bone substitute, Autologous bone
Device · Other
Lead sponsor
CeraPedics, Inc
Industry
Eligibility
18 Years to 70 Years
Enrollment
319 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2019
U.S. locations
10
States / cities
San Francisco, California • Thornton, Colorado • Sarasota, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Mar 11, 2020 · Synced Sep 13, 2026, 10:16 PM EDT
Completed Phase 3 Interventional Results available

Study of Safety & Effectiveness of PRESTIGE® LP Cervical Disc vs. Anterior Cervical Fusion in Cervical DDD

NCT00667459
View directory record Official record
Conditions
Cervical Degenerative Disc Disease
Interventions
PRESTIGE® LP Cervical Disc, ATLANTIS Anterior Cervical Plate
Device
Lead sponsor
Medtronic Spinal and Biologics
Industry
Eligibility
18 Years and older
Enrollment
280 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2014
U.S. locations
16
States / cities
Atlanta, Georgia • Columbus, Georgia • Coeur d'Alene, Idaho + 13 more
Source: ClinicalTrials.gov public record
Updated Jun 5, 2023 · Synced Sep 13, 2026, 10:16 PM EDT
Not yet recruiting Not applicable Interventional

Evaluation of the Safety and Effectiveness of the CORUS™ Posterior Cervical Stabilization System 3D (PCSS 3D) for the Treatment of 2-level Cervical Degenerative Disease

NCT07721493
View directory record Official record
Conditions
Degenerative Disc Disease(DDD)
Interventions
Circumferential Cervical Fusion (CCF), Anterior Cervical Discectomy and Fusion
Device · Procedure
Lead sponsor
Providence Medical Technology, Inc.
Industry
Eligibility
18 Years and older
Enrollment
225 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Paducah, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 22, 2026 · Synced Sep 13, 2026, 10:16 PM EDT
Completed Phase 2 Interventional

Safety and Preliminary Efficacy Study of NeoFuse in Subjects Undergoing Multi-Level Anterior Cervical Discectomy

NCT01097486
View directory record Official record
Conditions
Cervical Degenerative Disc Disease, Degenerative Spondylolisthesis, Spinal Stenosis
Interventions
NeoFuse, Allograft
Biological · Procedure
Lead sponsor
Mesoblast, Ltd.
Industry
Eligibility
18 Years to 70 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
8
States / cities
Sacramento, California • Santa Monica, California • Denver, Colorado + 5 more
Source: ClinicalTrials.gov public record
Updated Aug 15, 2019 · Synced Sep 13, 2026, 10:16 PM EDT
Terminated No phase listed Observational

PMCF Study to Evaluate the VERTICALE® Cervical System in Spine Surgery According to Its Intended Use.

NCT05489822
View directory record Official record
Conditions
Degenerative Disc Disease (DDD), Instabilities, Trauma, Deformity
Interventions
VERTICALE® Cervical System
Device
Lead sponsor
Silony Medical GmbH
Industry
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced Sep 13, 2026, 10:16 PM EDT
Active, not recruiting No phase listed Observational

M6-C Post Approval Study (PAS)

NCT04122248
View directory record Official record
Conditions
Cervical Degenerative Disc Disease, Cervical Radiculopathy, Cervical Spinal Cord Compression, Cervical Disc Herniation
Interventions
standard radiographic imaging, cervical total disc replacement
Other · Device
Lead sponsor
Spinal Kinetics
Industry
Eligibility
21 Years to 68 Years
Enrollment
152 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
21
States / cities
Phoenix, Arizona • Sun City West, Arizona • Beverly Hills, California + 17 more
Source: ClinicalTrials.gov public record
Updated Jul 29, 2025 · Synced Sep 13, 2026, 10:16 PM EDT
Completed Not applicable Interventional Results available

Investigation of the Simplify® Cervical Artificial Disc

NCT02667067
View directory record Official record
Conditions
Cervical Degenerative Disc Disease
Interventions
Simplify Disc, Anterior Cervical Discectomy & Fusion
Device
Lead sponsor
NuVasive
Industry
Eligibility
18 Years to 60 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
16
States / cities
La Jolla, California • Orange, California • Santa Monica, California + 13 more
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Sep 13, 2026, 10:16 PM EDT
Terminated No phase listed Observational

Cervical Interbody Fusion Device Patient Registry

NCT05114356
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
TIDAL Cervical Interbody Fusion implant
Device
Lead sponsor
Restor3D
Industry
Eligibility
18 Years to 80 Years
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Paducah, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 2, 2024 · Synced Sep 13, 2026, 10:16 PM EDT
Completed Not applicable Interventional Results available

Study of the Safety and Effectiveness of the Artificial Cervical Disc - Low Profile Device at Two Adjacent Levels

NCT00637156
View directory record Official record
Conditions
Cervical Degenerative Disc Disease, Radiculopathy, Myelopathy
Interventions
PRESTIGE LP device at two adjacent levels, Bi-level fusion with ATLANTIS Cervical Plate System
Device
Lead sponsor
Medtronic Spinal and Biologics
Industry
Eligibility
18 Years and older
Enrollment
397 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2018
U.S. locations
29
States / cities
Huntsville, Alabama • Beverly Hills, California • Colton, California + 26 more
Source: ClinicalTrials.gov public record
Updated Apr 30, 2018 · Synced Sep 13, 2026, 10:16 PM EDT
Terminated Not applicable Interventional Results available

Advent™ Cervical Disc Versus ACDF for Treatment of One Level Degenerative Disc Disease (IDE Study)

NCT00637312
View directory record Official record
Conditions
Cervical Degenerative Disc Disease
Interventions
Cervical Artificial Disc (Advent™ Cervical Disc), Hallmark™ Anterior Cervical Plate System
Device
Lead sponsor
Orthofix Inc.
Industry
Eligibility
18 Years and older
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
13
States / cities
Sacramento, California • Boulder, Colorado • Tampa, Florida + 10 more
Source: ClinicalTrials.gov public record
Updated Mar 26, 2014 · Synced Sep 13, 2026, 10:16 PM EDT
Completed No phase listed Observational

Clinical and Radiological Outcomes of Posterior Cervical Fusion with Medtronic Infinity Occipitocervical-Upper Thoracic (OCT) System

NCT04056520
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Medtronic Infinity Occipitocervical-Upper Thoracic System using the O-arm Imaging System and StealthStation Navigation system
Device
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 20, 2025 · Synced Sep 13, 2026, 10:16 PM EDT
Completed No phase listed Observational

Trinity Evolution in Anterior Cervical Disectomy and Fusion (ACDF)

NCT00951938
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Not listed
Lead sponsor
Orthofix Inc.
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
13
States / cities
Encinitas, California • Redding, California • Parker, Colorado + 10 more
Source: ClinicalTrials.gov public record
Updated Apr 7, 2014 · Synced Sep 13, 2026, 10:16 PM EDT
Completed No phase listed Observational Results available

Outcome Study of Patients Treated With Translational Cervical Plate Used to Treat Degenerative Disc Disease

NCT00443547
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Vectra-T
Device
Lead sponsor
Synthes USA HQ, Inc.
Industry
Eligibility
18 Years and older
Enrollment
231 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
13
States / cities
Carmichael, California • La Jolla, California • Marysville, California + 10 more
Source: ClinicalTrials.gov public record
Updated Jul 28, 2019 · Synced Sep 13, 2026, 10:16 PM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Treatment of One and/or Two Level Cervical Degenerative Disc Disease

NCT05812092
View directory record Official record
Conditions
Cervical Radiculopathy
Interventions
CONDUIT Interbody Cervical System with DePuy Synthes Cervical Plating System
Device
Lead sponsor
Research Source
Network
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Aug 21, 2025 · Synced Sep 13, 2026, 10:16 PM EDT
Active, not recruiting No phase listed Observational

Observational Study to Evaluate the STALIF® C FLX, STALIF® M FLX, STALIF® L FLX Cages and FORTOS-C®

NCT06876311
View directory record Official record
Conditions
Degenerative Cervical Disc Disease, Degenerative Lumbar Diseases
Interventions
Anterior Cervical Interbody Fusion, Anterior lumbar Interbody Fusion, Lateral Lumbar Interbody Fusion
Device
Lead sponsor
Silony Medical GmbH
Industry
Eligibility
21 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
San Ramon, California
Source: ClinicalTrials.gov public record
Updated Mar 13, 2025 · Synced Sep 13, 2026, 10:16 PM EDT
Terminated Not applicable Interventional

A Prospective Study of NuCel® in Cervical Spine Fusion

NCT02381067
View directory record Official record
Conditions
Spondylosis, Spinal Stenosis, Spondylolisthesis, Intervertebral Disc Disease, Intervertebral Disc Degeneration
Interventions
NuCel with Allograft Bone
Other
Lead sponsor
NuTech Medical, Inc
Industry
Eligibility
21 Years and older
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Marietta, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 17, 2020 · Synced Sep 13, 2026, 10:16 PM EDT
Completed No phase listed Observational

Osteocel® Plus in Anterior Cervical Discectomy and Fusion (ACDF)

NCT00942045
View directory record Official record
Conditions
Degenerative Disc Disease in Cervical Spine
Interventions
Biologic - Osteocel Plus
Biological
Lead sponsor
NuVasive
Industry
Eligibility
18 Years to 70 Years
Enrollment
182 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
17
States / cities
La Jolla, California • Redwood City, California • San Diego, California + 14 more
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Sep 13, 2026, 10:16 PM EDT
Recruiting No phase listed Observational

Comparison of Artificial Disc Implants in Cervical Disc Arthroplasty

NCT05701059
View directory record Official record
Conditions
Cervical Spondylosis With Myelopathy, Cervical Radiculopathy, Cervical Disc Herniation, Degenerative Disc Disease
Interventions
Cervical arthroplasty, Semi-Constrained Nuvasive Simplify, Unconstrained Biomet Zimmer Mobi-C
Procedure · Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 60 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Sep 13, 2026, 10:16 PM EDT