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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Cervical Disc Degenerative Disorder Clear all
Completed No phase listed Observational

Clinical and Radiological Outcomes of Posterior Cervical Fusion with Medtronic Infinity Occipitocervical-Upper Thoracic (OCT) System

NCT04056520
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Medtronic Infinity Occipitocervical-Upper Thoracic System using the O-arm Imaging System and StealthStation Navigation system
Device
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 20, 2025 · Synced Jul 22, 2026, 4:38 AM EDT
Terminated No phase listed Observational

PureGen: Radiographic Analysis of Fusion for ACDF

NCT01291134
View directory record Official record
Conditions
Cervical Degenerative Disc Disease
Interventions
PureGen Osteoprogenitor Cell Allograft
Biological
Lead sponsor
Alphatec Spine, Inc.
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
4
States / cities
Carlsbad, California • Middletown, Connecticut • Greensboro, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 2, 2022 · Synced Jul 22, 2026, 4:38 AM EDT
Terminated No phase listed Observational

PMCF Study to Evaluate the VERTICALE® Cervical System in Spine Surgery According to Its Intended Use.

NCT05489822
View directory record Official record
Conditions
Degenerative Disc Disease (DDD), Instabilities, Trauma, Deformity
Interventions
VERTICALE® Cervical System
Device
Lead sponsor
Silony Medical GmbH
Industry
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced Jul 22, 2026, 4:38 AM EDT
Completed No phase listed Observational Results available

Outcome Study of Patients Treated With Translational Cervical Plate Used to Treat Degenerative Disc Disease

NCT00443547
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Vectra-T
Device
Lead sponsor
Synthes USA HQ, Inc.
Industry
Eligibility
18 Years and older
Enrollment
231 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
13
States / cities
Carmichael, California • La Jolla, California • Marysville, California + 10 more
Source: ClinicalTrials.gov public record
Updated Jul 28, 2019 · Synced Jul 22, 2026, 4:38 AM EDT
Recruiting No phase listed Observational

Clinical Outcome Measure at Stryker Spine

NCT06226272
View directory record Official record
Conditions
Degenerative Disc Disease, Degenerative Scoliosis
Interventions
Spinal Fusion, Spinal Deformities Correction
Device
Lead sponsor
VB Spine, LLC
Industry
Eligibility
18 Years and older
Enrollment
5,222 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2032
U.S. locations
7
States / cities
Jacksonville, Florida • Scarborough, Maine • Southfield, Michigan + 4 more
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Jul 22, 2026, 4:38 AM EDT
Completed No phase listed Observational Results available

Post Approval Study Protocol for the Two Level Simplify® Cervical Artificial Disc

NCT04980378
View directory record Official record
Conditions
Cervical Degenerative Disc Disorder
Interventions
Simplify Disc
Device
Lead sponsor
NuVasive
Industry
Eligibility
Not listed
Enrollment
291 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
18
States / cities
Orange, California • Santa Monica, California • Thornton, Colorado + 15 more
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Jul 22, 2026, 4:38 AM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Adjacent Level Anterior Cervical Fusion: SeaSpine Shoreline Versus Removal of Previously Implanted Plate and Replating

NCT06415136
View directory record Official record
Conditions
Degenerative Disc Disease, Disc Herniation
Interventions
SeaSpine Shoreline
Device
Lead sponsor
Research Source
Network
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Southfield, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 21, 2025 · Synced Jul 22, 2026, 4:38 AM EDT
Completed Not applicable Interventional Results available

Investigation of the Simplify® Cervical Artificial Disc

NCT02667067
View directory record Official record
Conditions
Cervical Degenerative Disc Disease
Interventions
Simplify Disc, Anterior Cervical Discectomy & Fusion
Device
Lead sponsor
NuVasive
Industry
Eligibility
18 Years to 60 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
16
States / cities
La Jolla, California • Orange, California • Santa Monica, California + 13 more
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Jul 22, 2026, 4:38 AM EDT
Active, not recruiting No phase listed Observational

Observational Study to Evaluate the STALIF® C FLX, STALIF® M FLX, STALIF® L FLX Cages and FORTOS-C®

NCT06876311
View directory record Official record
Conditions
Degenerative Cervical Disc Disease, Degenerative Lumbar Diseases
Interventions
Anterior Cervical Interbody Fusion, Anterior lumbar Interbody Fusion, Lateral Lumbar Interbody Fusion
Device
Lead sponsor
Silony Medical GmbH
Industry
Eligibility
21 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
San Ramon, California
Source: ClinicalTrials.gov public record
Updated Mar 13, 2025 · Synced Jul 22, 2026, 4:38 AM EDT
Completed No phase listed Observational Results available

Patient Registry to Observe Outcomes Following Implantation of the VariLift Interbody Fusion Device

NCT01944345
View directory record Official record
Conditions
Prolapsed Lumbar Disc, Prolapsed Cervical Disc, Intervertebral Disc Degeneration, Spondylolisthesis, Grade 1, Intervertebral Disc Displacement
Interventions
Not listed
Lead sponsor
Wenzel Spine
Industry
Eligibility
18 Years to 99 Years
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
3
States / cities
Boston, Massachusetts • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated May 16, 2016 · Synced Jul 22, 2026, 4:38 AM EDT
Recruiting Not applicable Interventional

ACDF Using Structural Allograft vs. Tritanium C

NCT04388332
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Structural allograft, Tritanium C
Procedure · Device
Lead sponsor
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Other
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 13, 2025 · Synced Jul 22, 2026, 4:38 AM EDT
Active, not recruiting No phase listed Observational

M6-C Post Approval Study (PAS)

NCT04122248
View directory record Official record
Conditions
Cervical Degenerative Disc Disease, Cervical Radiculopathy, Cervical Spinal Cord Compression, Cervical Disc Herniation
Interventions
standard radiographic imaging, cervical total disc replacement
Other · Device
Lead sponsor
Spinal Kinetics
Industry
Eligibility
21 Years to 68 Years
Enrollment
152 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
21
States / cities
Phoenix, Arizona • Sun City West, Arizona • Beverly Hills, California + 17 more
Source: ClinicalTrials.gov public record
Updated Jul 29, 2025 · Synced Jul 22, 2026, 4:38 AM EDT
Completed No phase listed Observational

Post-Market, Long-Term Follow Up of Mobi-C® Cervical Disc for One and Two Level Treatment of Cervical Disc Disease

NCT03077516
View directory record Official record
Conditions
Cervical Disc Disease, Cervical Disc Degeneration
Interventions
Mobi-C
Device
Lead sponsor
LDR Spine USA
Industry
Eligibility
18 Years and older
Enrollment
216 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
8
States / cities
Laguna Hills, California • Rancho Mirage, California • Sacramento, California + 5 more
Source: ClinicalTrials.gov public record
Updated Dec 3, 2019 · Synced Jul 22, 2026, 4:38 AM EDT
Completed Phase 3 Interventional Results available

Performance of the Hedrocel(R) Cervical Fusion Device

NCT00758758
View directory record Official record
Conditions
Symptomatic Cervical Disc Disease
Interventions
Anterior Cervical Discectomy and Fusion
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years to 70 Years
Enrollment
231 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2009
U.S. locations
13
States / cities
Los Angeles, California • Clearwater, Florida • Orlando, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Aug 22, 2013 · Synced Jul 22, 2026, 4:38 AM EDT
Terminated Not applicable Interventional Results available

Advent™ Cervical Disc Versus ACDF for Treatment of One Level Degenerative Disc Disease (IDE Study)

NCT00637312
View directory record Official record
Conditions
Cervical Degenerative Disc Disease
Interventions
Cervical Artificial Disc (Advent™ Cervical Disc), Hallmark™ Anterior Cervical Plate System
Device
Lead sponsor
Orthofix Inc.
Industry
Eligibility
18 Years and older
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
13
States / cities
Sacramento, California • Boulder, Colorado • Tampa, Florida + 10 more
Source: ClinicalTrials.gov public record
Updated Mar 26, 2014 · Synced Jul 22, 2026, 4:38 AM EDT
Not yet recruiting No phase listed Observational

Assessing Safety of Cervical Spine Fusion With NMP®

NCT07245940
View directory record Official record
Conditions
Degenerative Disc Disease, Degenerative Spondylolisthesis, Spinal Stenosis Cervical
Interventions
Natural Matrix Protein (NMP) Fibers, Cervical interbody fusion
Biological · Procedure
Lead sponsor
Red Rock Regeneration Inc.
Industry
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Jasper, Alabama
Source: ClinicalTrials.gov public record
Updated Nov 23, 2025 · Synced Jul 22, 2026, 4:38 AM EDT
Enrolling by invitation No phase listed Observational

Cervical Interbody Implant Study

NCT04689854
View directory record Official record
Conditions
Degenerative Disc Disease, Cervical Spinal Instability
Interventions
Not listed
Lead sponsor
NuVasive
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
7
States / cities
Orange, California • Hartford, Connecticut • Somerville, Massachusetts + 4 more
Source: ClinicalTrials.gov public record
Updated Dec 21, 2025 · Synced Jul 22, 2026, 4:38 AM EDT
Completed Phase 4 Interventional Results available

BIO4 Clinical Case Study: Cervical Spine

NCT03077204
View directory record Official record
Conditions
Degenerative Disc Disease, Trauma (Including Fractures), Spondylolisthesis
Interventions
1 or 2-Level ACDF utilizing BIO4 with Bio AVS Cervical Allograft (with graft window)., Aviator Anterior Cervical Plating System
Biological · Device
Lead sponsor
Seton Healthcare Family
Other
Eligibility
19 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jan 13, 2022 · Synced Jul 22, 2026, 4:38 AM EDT
Active, not recruiting Not applicable Interventional

Anterior Cervical Disectomy And Fusion Using The Tritanium® C Anterior Cervical Cage For One Or Two-Levels

NCT04214535
View directory record Official record
Conditions
Cervical Disc Herniation, Cervical Disc Degeneration, Degenerative Disc Disease
Interventions
Tritanium C Anterior Cervical Cage
Device
Lead sponsor
Corewell Health East
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Royal Oak, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Jul 22, 2026, 4:38 AM EDT
Completed Not applicable Interventional Results available

Post-Approval Study Protocol for the Simplify Cervical Artificial Disc

NCT04630626
View directory record Official record
Conditions
Cervical Degenerative Disc Disorder
Interventions
Simplify Disc, ACDF
Device · Other
Lead sponsor
NuVasive
Industry
Eligibility
Not listed
Enrollment
145 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
15
States / cities
Orange, California • San Diego, California • Santa Monica, California + 12 more
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Jul 22, 2026, 4:38 AM EDT
Enrolling by invitation No phase listed Observational

Long-Term Assessment of the Safety and Performance of the NuVasive Simplify Disc at Two Levels

NCT05691231
View directory record Official record
Conditions
Cervical Disc Disease, Degenerative Disc Disease
Interventions
NuVasive Simplify Cervical Artificial Disc
Device
Lead sponsor
NuVasive
Industry
Eligibility
18 Years and older
Enrollment
158 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
2
States / cities
Charlotte, North Carolina • Plano, Texas
Source: ClinicalTrials.gov public record
Updated Dec 21, 2025 · Synced Jul 22, 2026, 4:38 AM EDT
Active, not recruiting Not applicable Interventional

Study of Posterior Cervical Stabilization System (PCSS) as Part of Circumferential Fusion to Treat Multilevel DDD

NCT04229017
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Anterior Cervical Discectomy and Fusion, Posterior Cervical Stabilization System (PCSS)
Procedure · Device
Lead sponsor
Providence Medical Technology, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
236 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
17
States / cities
Phoenix, Arizona • Encinitas, California • Los Gatos, California + 14 more
Source: ClinicalTrials.gov public record
Updated Oct 29, 2025 · Synced Jul 22, 2026, 4:38 AM EDT
Completed No phase listed Observational Results available

ViBone in Cervical and Lumbar Spine Fusion

NCT03425682
View directory record Official record
Conditions
Spondylosis, Cervical Spondylosis, Spondylolisthesis, Herniated Nucleus Pulposus, Degenerative Disc Disease
Interventions
ViBone
Other
Lead sponsor
Elutia Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
118 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
4
States / cities
San Diego, California • Danbury, Connecticut • Annapolis, Maryland + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 3, 2025 · Synced Jul 22, 2026, 4:38 AM EDT
Terminated Not applicable Interventional Results available

Clinical Outcomes Study Evaluating the Zero-P PEEK

NCT00945243
View directory record Official record
Conditions
Cervical Disc Disease
Interventions
Zero-P
Device
Lead sponsor
Synthes USA HQ, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
14
States / cities
Dothan, Alabama • Phoenix, Arizona • Newport Beach, California + 10 more
Source: ClinicalTrials.gov public record
Updated Nov 5, 2017 · Synced Jul 22, 2026, 4:38 AM EDT