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Showing 1–24 of 207 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Children With Disabilities Clear all
Recruiting No phase listed Observational

The eXtroardinarY Babies Study: Natural History of Health and Neurodevelopment in Infants and Young Children With Sex Chromosome Trisomy

NCT03396562
View directory record Official record
Conditions
Klinefelter Syndrome, Trisomy X, XYY Syndrome, XXXY and XXXXY Syndrome, Xxyy Syndrome, Xyyy Syndrome, Xxxx Syndrome, Xxxxx Syndrome, Xxxyy Syndrome, Xxyyy Syndrome, Xyyyy Syndrome, Male With Sex Chromosome Mosaicism
Interventions
Assessments of Development and Growth
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
6 Weeks to 13 Months
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2028
U.S. locations
2
States / cities
Aurora, Colorado • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 8, 2024 · Synced Jun 7, 2026, 4:24 AM EDT
Completed No phase listed Observational

Mapping the Phenotype in Adults With Phelan-McDermid Syndrome

NCT03426059
View directory record Official record
Conditions
Phelan-McDermid Syndrome, Autism Spectrum Disorder, Intellectual Disability
Interventions
No Intervention
Other
Lead sponsor
Boston Children's Hospital
Other
Eligibility
22 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
6
States / cities
Stanford, California • Chicago, Illinois • Bethesda, Maryland + 3 more
Source: ClinicalTrials.gov public record
Updated Feb 17, 2025 · Synced Jun 7, 2026, 4:24 AM EDT
Completed Phase 2 Interventional Results available

A 2-Period Crossover Study of BPN14770 in Adults Males With Fragile X Syndrome

NCT03569631
View directory record Official record
Conditions
Fragile X Syndrome, FXS, Fra(X) Syndrome
Interventions
BPN14770, Placebo
Drug
Lead sponsor
Tetra Discovery Partners
Industry
Eligibility
18 Years to 45 Years · Male only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 18, 2024 · Synced Jun 7, 2026, 4:24 AM EDT
Completed Not applicable Interventional Results available

New Skills - No Scores Research Study

NCT04254666
View directory record Official record
Conditions
Intellectual Disability
Interventions
Physical Literacy & Food Literacy Intervention.
Behavioral
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
12 Years to 16 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 12, 2023 · Synced Jun 7, 2026, 4:24 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Implementation of the Parents Taking Action in Paraguay

NCT05780138
View directory record Official record
Conditions
Depression, Autism
Interventions
Parents Taking Action
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 100 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jan 7, 2024 · Synced Jun 7, 2026, 4:24 AM EDT
Completed Not applicable Interventional

Intensive Therapy for Children With Microcephaly, Hyperkinetic Movements, or Global Developmental Delay

NCT04816175
View directory record Official record
Conditions
Microcephaly, Hyperkinesis With Developmental Delay, Global Developmental Delay
Interventions
Acquire Therapy
Behavioral
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
6 Months to 15 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 12, 2022 · Synced Jun 7, 2026, 4:24 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Culturally-Responsive Curriculum for Caregivers With Children at Autism Likelihood

NCT06314438
View directory record Official record
Conditions
Autism, Development Delay
Interventions
Family Care Project
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 85 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Kent, Washington
Source: ClinicalTrials.gov public record
Updated May 3, 2025 · Synced Jun 7, 2026, 4:24 AM EDT
Terminated Phase 3 Interventional

Memantine for the Treatment of Social Deficits in Youth With Disorders of Impaired Social Interactions

NCT03553875
View directory record Official record
Conditions
Autism, Autism Spectrum Disorder, Nonverbal Learning Disability
Interventions
Memantine Hydrochloride, Placebo
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
8 Years to 18 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Jun 7, 2026, 4:24 AM EDT
Completed Not applicable Interventional

Macronutrient Regulation of Ghrelin and Peptide YY

NCT02464514
View directory record Official record
Conditions
Obesity, Prader Willi Syndrome
Interventions
High carbohydrate meal, High fat meal
Other
Lead sponsor
Duke University
Other
Eligibility
5 Years to 17 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 9, 2015 · Synced Jun 7, 2026, 4:24 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Translational Research to Inform Interventions for Challenging Behavior

NCT04842500
View directory record Official record
Conditions
Behavior and Behavior Mechanisms
Interventions
Demand Informed Moderator Analysis
Behavioral
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years and older
Enrollment
86 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
5
States / cities
Gallatin, Tennessee • Lebanon, Tennessee • Murfreesboro, Tennessee + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 5, 2025 · Synced Jun 7, 2026, 4:24 AM EDT
Completed Not applicable Interventional

Use of an Educational Story to Prepare Children With Developmental Disabilities for Sleep Study

NCT02132273
View directory record Official record
Conditions
Developmental Disabilities, Sleep Disorders, Polysomnography, Preparation for Medical Procedure, Child
Interventions
Educational Story
Other
Lead sponsor
Jennifer Accardo
Other
Eligibility
4 Years to 17 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 26, 2016 · Synced Jun 7, 2026, 4:24 AM EDT
Enrolling by invitation Not applicable Interventional

Cognitive-Behavioral Therapy for Irritability in Children With Autism Spectrum Disorder and Intellectual Disability

NCT02914951
View directory record Official record
Conditions
Autism, Intellectual Disability
Interventions
Cognitive-Behavioral Therapy, Functional magnetic resonance imaging (fMRI)
Behavioral · Other
Lead sponsor
Yale University
Other
Eligibility
8 Years to 16 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2026
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Jun 7, 2026, 4:24 AM EDT
Completed Phase 2 Interventional Results available

AFQ056 for Language Learning in Children With FXS

NCT02920892
View directory record Official record
Conditions
Fragile X Syndrome
Interventions
AFQ056, Placebo, Language Intervention
Drug · Other
Lead sponsor
Elizabeth Berry-Kravis
Other
Eligibility
32 Months to 6 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
14
States / cities
Davis, California • Denver, Colorado • New Haven, Connecticut + 11 more
Source: ClinicalTrials.gov public record
Updated Oct 9, 2023 · Synced Jun 7, 2026, 4:24 AM EDT
Completed No phase listed Observational

Review of Diagnostic Yield of MRI Brain Results in Children Under Age 3 Years

NCT03561168
View directory record Official record
Conditions
Seizures, Development Delay, Anesthetic Neurotoxicity
Interventions
Change in plan of care based on MRI results
Diagnostic Test
Lead sponsor
Baylor College of Medicine
Other
Eligibility
Up to 1095 Days
Enrollment
561 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 18, 2018 · Synced Jun 7, 2026, 4:24 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Treatment Monitoring in Autism Spectrum Disorder (ASD) in Children

NCT05675371
View directory record Official record
Conditions
Autism Spectrum Disorder, Autism, Developmental Delay, Autism, Early Infantile, Autism, Infantile
Interventions
Assessment by Expert Clinician During Behavioral Intervention (ABA or similar), Assessment by the EarliPoint Assessment For Autism Spectrum Disorder
Behavioral · Device
Lead sponsor
EarliTec Diagnostics, Inc
Industry
Eligibility
15 Months to 84 Months
Enrollment
325 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
9
States / cities
Phoenix, Arizona • Glendale, California • San Rafael, California + 6 more
Source: ClinicalTrials.gov public record
Updated Sep 14, 2025 · Synced Jun 7, 2026, 4:24 AM EDT
Completed Phase 3 Interventional

Efficacy and Safety Study of STX209 (Arbaclofen) for the Treatment of Social Withdrawal in Children With Fragile X Syndrome

NCT01325220
View directory record Official record
Conditions
Fragile X Syndrome
Interventions
arbaclofen, Placebo
Drug
Lead sponsor
Seaside Therapeutics, Inc.
Industry
Eligibility
5 Years to 11 Years
Enrollment
172 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2011
U.S. locations
28
States / cities
Phoenix, Arizona • Long Beach, California • Sacramento, California + 24 more
Source: ClinicalTrials.gov public record
Updated Jul 30, 2013 · Synced Jun 7, 2026, 4:24 AM EDT
Recruiting Not applicable Interventional

Drumming Lessons' Influence on Children With Down Syndrome

NCT07156318
View directory record Official record
Conditions
Down Syndrome
Interventions
2 months of drumming lessons given by a professional drummer with extensive experience working with children with Down syndrome, Lessons after measurement
Behavioral
Lead sponsor
Vanderbilt University
Other
Eligibility
7 Years to 15 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Jun 7, 2026, 4:24 AM EDT
Completed Phase 2 Interventional Results available

Acamprosate in Youth With Fragile X Syndrome

NCT01300923
View directory record Official record
Conditions
Fragile X Syndrome, Autism Spectrum Disorders
Interventions
Acamprosate
Drug
Lead sponsor
Indiana University
Other
Eligibility
5 Years to 17 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 29, 2019 · Synced Jun 7, 2026, 4:24 AM EDT
Not yet recruiting Not applicable Interventional

Implementing Powered Mobility in Early Childhood Settings for Children With Cerebral Palsy

NCT07220590
View directory record Official record
Conditions
Cerebral Palsy Children, Motor Disabilities, Developmental Disability, Rehabilitation, Early Intervention, Assistive Technology
Interventions
Therapist Training on Powered Mobility Implementation, Powered Mobility Intervention for Child-Caregiver Dyads
Behavioral
Lead sponsor
Oregon Health and Science University
Other
Eligibility
1 Year and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
3
States / cities
Hillsboro, Oregon • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jan 1, 2026 · Synced Jun 7, 2026, 4:24 AM EDT
Completed Phase 4 Interventional Results available

Natural Treatments for the Management of Emotional Dysregulation in Youth With Non-verbal Learning Disability (NVLD) and/or Autism Spectrum Disorders (ASD)

NCT03757585
View directory record Official record
Conditions
Non-verbal Learning Disorder, Autism Spectrum Disorder, Autism
Interventions
Open-label Treatment with Omega-3 Fatty Acids + Inositol, Open-label Treatment with N-acetylcysteine
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
5 Years to 17 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 4, 2025 · Synced Jun 7, 2026, 4:24 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Multi-site Animal Assisted Intervention for Children With DD and Their Family Dog

NCT04799119
View directory record Official record
Conditions
Physical Activity, Social Wellbeing
Interventions
Do As I Do (DAID) dog training
Behavioral
Lead sponsor
Oregon State University
Other
Eligibility
10 Years to 17 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Corvallis, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 17, 2025 · Synced Jun 7, 2026, 4:24 AM EDT
Completed Not applicable Interventional

Response Inhibition Training for Children With Williams Syndrome

NCT02212314
View directory record Official record
Conditions
Williams Syndrome
Interventions
Response Inhibition Training
Behavioral
Lead sponsor
University of Wisconsin, Milwaukee
Other
Eligibility
10 Years to 17 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 30, 2017 · Synced Jun 7, 2026, 4:24 AM EDT
Not yet recruiting Phase 2 Interventional

Metric-Optimized Spectacle Prescriptions for Children With Down Syndrome

NCT07490444
View directory record Official record
Conditions
Refractive Error Correction, Visual Acuity
Interventions
Metric-optimized spectacles, Routine Clinical Spectacles
Device
Lead sponsor
Ohio State University
Other
Eligibility
5 Years to 12 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 23, 2026 · Synced Jun 7, 2026, 4:24 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Self-Compassion to Enhance the Well-Being of Caregivers of Children With Physical Disabilities

NCT06271824
View directory record Official record
Conditions
Stress, Caregiver Burden, Anxiety, Depressive Symptoms
Interventions
Self-Compassion Based Resilient Caregiving Course
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 10, 2024 · Synced Jun 7, 2026, 4:24 AM EDT