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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Chronic Back Pain Clear all
Completed Not applicable Interventional

Combined Interventions for Treating Depression and Chronic Back Pain

NCT00158275
View directory record Official record
Conditions
Back Pain, Depression
Interventions
Cognitive behavioral therapy, Antidepressants, Problem solving therapy
Behavioral · Drug
Lead sponsor
Kaiser Permanente
Other
Eligibility
25 Years to 74 Years
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Oct 12, 2017 · Synced Sep 20, 2026, 2:01 PM EDT
Completed Not applicable Interventional

Mindfulness and Chronic Low Back Pain

NCT03354585
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
mindfulness training, non-mindfulness training, book-listening
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
2
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Apr 28, 2024 · Synced Sep 20, 2026, 2:01 PM EDT
Completed Not applicable Interventional Results available

A Safety and Effectiveness Trial of Spinal Cord Stimulation of the Dorsal Root Ganglion for Chronic Lower Limb Pain

NCT01923285
View directory record Official record
Conditions
Chronic Lower Limb Pain
Interventions
AXIUM Neurostimulator System, Control Spinal Cord Stimulation Device
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
22 Years to 75 Years
Enrollment
152 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
22
States / cities
Phoenix, Arizona • Aptos, California • Carlsbad, California + 19 more
Source: ClinicalTrials.gov public record
Updated Nov 23, 2020 · Synced Sep 20, 2026, 2:01 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Lumbopelvic Manipulation on Neuromuscular Activity of Back & Hip Muscles in Adults With Chronic Low Back Pain

NCT01861418
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Lumbopelvic Manipulation, Sham manipulation
Other
Lead sponsor
Texas Woman's University
Other
Eligibility
20 Years to 60 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 11, 2017 · Synced Sep 20, 2026, 2:01 PM EDT
Completed Not applicable Interventional Results available

Efficacy and Cost: Benefit Ratio of 0, 1, and 2 Medial Branch Blocks for Lumbar Facet Joint Radiofrequency Denervation

NCT00484159
View directory record Official record
Conditions
Low Back Pain
Interventions
Radiofrequency denervation of medial branches, 0.5% bupivacaine, 2% lidocaine, Radiofrequency denervation
Procedure · Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
151 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 25, 2011 · Synced Sep 20, 2026, 2:01 PM EDT
Terminated Not applicable Interventional Results available

Burst Spinal Cord Stimulation (Burst-SCS) Study

NCT03718325
View directory record Official record
Conditions
Pain, Chronic, Failed Back Surgery Syndrome
Interventions
Burst-SCS, Sham SCS
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 12, 2025 · Synced Sep 20, 2026, 2:01 PM EDT
Completed Not applicable Interventional Results available

Trial on the Effect of Optically Modified Fiber Mattress Covers on Sleep Disturbances in Patients With Chronic Back Pain

NCT00969540
View directory record Official record
Conditions
Back Pain, Insomnia
Interventions
Active Mattress Cover, Placebo Mattress Cover
Device
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Dec 2, 2014 · Synced Sep 20, 2026, 2:01 PM EDT
Recruiting Not applicable Interventional

Evaluating the Auricular Point Acupressure-Self Management Program for Chronic Musculoskeletal Pain Among Rural Populations

NCT07179016
View directory record Official record
Conditions
Chronic Pain (Back / Neck), Chronic Pain Management, Chronic Knee Pain, Joint Pain
Interventions
Auricular Point Acupressure (APA) - Self Management (SM), Education Control
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 85 Years
Enrollment
693 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
3
States / cities
Columbia, South Carolina • Fort Worth, Texas • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 30, 2025 · Synced Sep 20, 2026, 2:01 PM EDT
Completed Phase 4 Interventional Results available

The BEST Trial: Biomarkers for Evaluating Spine Treatments

NCT05396014
View directory record Official record
Conditions
Chronic Low-back Pain
Interventions
Enhanced Self-Care (ESC), Acceptance and Commitment Therapy (ACT), Evidence-Based Exercise and Manual Therapy (EBEM), Duloxetine
Behavioral · Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
1,014 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
12
States / cities
Redwood City, California • San Diego, California • San Francisco, California + 9 more
Source: ClinicalTrials.gov public record
Updated Jul 22, 2025 · Synced Sep 20, 2026, 2:01 PM EDT
Withdrawn Phase 3 Interventional

Gabapentin and Chronic Post Surgical Pain

NCT03867240
View directory record Official record
Conditions
Pain, Postoperative, Scoliosis Idiopathic
Interventions
Gabapentin, Placebo
Drug · Other
Lead sponsor
Emory University
Other
Eligibility
10 Years to 18 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 7, 2021 · Synced Sep 20, 2026, 2:01 PM EDT
Completed Not applicable Interventional

Comparative Mechanisms of Psychosocial Chronic Pain Treatments

NCT02133976
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
cognitive therapy, mindfulness training, behavioral therapy, treatment as usual
Behavioral · Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 75 Years
Enrollment
521 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 20, 2024 · Synced Sep 20, 2026, 2:01 PM EDT
Completed Not applicable Interventional

Examining Effects of Aerobic Exercise on Pain Sensation

NCT03546153
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Aerobic exercise program
Behavioral
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
21 Years to 70 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Sep 26, 2019 · Synced Sep 20, 2026, 2:01 PM EDT
Completed Phase 2 Interventional Results available

Trial of Dronabinol and Vaporized Cannabis in Chronic Low Back Pain

NCT02460692
View directory record Official record
Conditions
Cannabis, Low Back Pain, Neuropathic Pain
Interventions
Placebos, dronabinol, Vaporized Cannabis 3.7% THC/5.6% CBD
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
19 Years to 70 Years
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Sep 27, 2023 · Synced Sep 20, 2026, 2:01 PM EDT
Completed Not applicable Interventional Results available

Rage Against the Pain to Address Chronic Low Back Pain Among Veterans

NCT05103475
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Rage Against the Pain (RAP), Control
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Hines, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 4, 2024 · Synced Sep 20, 2026, 2:01 PM EDT
Recruiting Not applicable Interventional

A Prospective Evaluation of Spinal Cord Induced Muscle Stimulation (MuscleSCS) for the Treatment of Chronic Low Back Pain

NCT07215104
View directory record Official record
Conditions
Chronic Low Back Pain (CLBP)
Interventions
MuscleSCS
Device
Lead sponsor
Saint Francis Hospital
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Charleston, West Virginia
Source: ClinicalTrials.gov public record
Updated Oct 9, 2025 · Synced Sep 20, 2026, 2:01 PM EDT
Completed Not applicable Interventional

Pain Neuroscience Education for Acute and Sub-Acute Low Back Pain

NCT03722394
View directory record Official record
Conditions
Low Back Pain, Pain, Chronic, Pain, Back
Interventions
Pain Neuroscience Education
Behavioral
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Oct 25, 2018 · Synced Sep 20, 2026, 2:01 PM EDT
Completed Phase 3 Interventional Results available

Buprenorphine Transdermal System (BTDS) in Subjects With Moderate to Severe Chronic Low Back Pain

NCT00490919
View directory record Official record
Conditions
Low Back Pain
Interventions
Buprenorphine transdermal system, Placebo
Drug
Lead sponsor
Purdue Pharma LP
Industry
Eligibility
18 Years and older
Enrollment
539 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
86
States / cities
Anniston, Alabama • Mobile, Alabama • Chandler, Arizona + 71 more
Source: ClinicalTrials.gov public record
Updated Sep 9, 2012 · Synced Sep 20, 2026, 2:01 PM EDT
Completed No phase listed Observational

Restoration of Disc Height Reduces Chronic Low Back Pain

NCT00828880
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
DRX9000
Device
Lead sponsor
NEMA Research, Inc.
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
McAllen, Texas
Source: ClinicalTrials.gov public record
Updated Jan 25, 2009 · Synced Sep 20, 2026, 2:01 PM EDT
Completed Not applicable Interventional

Chronic Low Back Pain and Primary Health Care

NCT01147120
View directory record Official record
Conditions
Low Back Pain
Interventions
Progressive Muscle Relaxation (PMR), Clinical Massage Therapy (CMT)
Behavioral · Procedure
Lead sponsor
William G Elder JR
Other
Eligibility
21 Years and older
Enrollment
138 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 3, 2014 · Synced Sep 20, 2026, 2:01 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Heartache and Backache- An Online Intervention Addressing Emotional and Physical Pain

NCT05513274
View directory record Official record
Conditions
Chronic Pain (Back / Neck)
Interventions
Pain Psychology Neuroscience + Written Emotional Disclosure, Pain Psychology Neuroscience + Healthy Habits Disclosure, Health Behavior Control + Written Emotional Disclosure, Health Behavior Control + Healthy Habits Disclosure
Behavioral
Lead sponsor
Wayne State University
Other
Eligibility
18 Years to 75 Years
Enrollment
107 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 15, 2025 · Synced Sep 20, 2026, 2:01 PM EDT
Active, not recruiting Phase 1Phase 2 Interventional

Safety, Tolerability, and Effectiveness of Intramuscular Injection of CELZ-201-DDT for the Treatment of Chronic Lower Back Pain

NCT06053242
View directory record Official record
Conditions
Chronic Low-back Pain, Degenerative Disc Disease
Interventions
CELZ-201-DDT, Placebo
Drug · Other
Lead sponsor
Creative Medical Technology Holdings Inc
Industry
Eligibility
18 Years to 80 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Aventura, Florida
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Sep 20, 2026, 2:01 PM EDT
Recruiting Not applicable Interventional

Feasibility of Identifying Brain Mechanisms of Qigong and Behavioral Outcomes After Qigong Practice in People With Chronic Low Back Pain

NCT04164225
View directory record Official record
Conditions
Low Back Pain
Interventions
Qigong Exercise, P.Volve Exercises
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 70 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2028
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 8, 2025 · Synced Sep 20, 2026, 2:01 PM EDT
Completed Phase 4 Interventional Results available

Spinal Cord Stimulation for Low Back Pain

NCT00205868
View directory record Official record
Conditions
Chronic Pain
Interventions
Precision Spinal Cord Stimulation System
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
304 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
30
States / cities
Cullman, Alabama • Daphne, Alabama • Huntsville, Alabama + 27 more
Source: ClinicalTrials.gov public record
Updated Jun 17, 2021 · Synced Sep 20, 2026, 2:01 PM EDT
Terminated Phase 3 Interventional Results available

Safety of BTDS in Subjects With Low Back Pain: A 52-Week Extension Phase of BUP3015

NCT01125917
View directory record Official record
Conditions
Back Pain Lower Back Chronic
Interventions
Buprenorphine transdermal patch
Drug
Lead sponsor
Purdue Pharma LP
Industry
Eligibility
18 Years and older
Enrollment
354 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
84
States / cities
Birmingham, Alabama • Haleyville, Alabama • Phoenix, Arizona + 71 more
Source: ClinicalTrials.gov public record
Updated Sep 2, 2012 · Synced Sep 20, 2026, 2:01 PM EDT