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Showing 1–24 of 102 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Chronic Diabetic Foot Ulcers Clear all
Terminated Phase 2 Interventional

Safety and Efficacy Study of MRE0094 to Treat Large, Single or Multiple, Chronic, Neuropathic, Diabetic Foot Ulcers

NCT00318214
View directory record Official record
Conditions
Foot Ulcer, Diabetic, Diabetes Complications
Interventions
MRE0094, Vehicle gel
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 85 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
19
States / cities
Phoenix, Arizona • Tucson, Arizona • Fresno, California + 16 more
Source: ClinicalTrials.gov public record
Updated May 31, 2012 · Synced Sep 18, 2026, 2:40 PM EDT
Terminated Not applicable Interventional Results available

A Prospective, Open Label, Multicenter Trial for Evaluating the Efficacy of Treating and Managing Wounds in Elderly Population in Specialized Nursing Facilities Using RD1

NCT04577183
View directory record Official record
Conditions
Diabetic Foot Ulcer, Pressure Ulcer, Venous Leg Ulcer, Trauma Injury, Skin Tear, Chronic Ulcer
Interventions
RD1 System
Device
Lead sponsor
RedDress Ltd.
Industry
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Butler, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 1, 2024 · Synced Sep 18, 2026, 2:40 PM EDT
Enrolling by invitation No phase listed Observational

Case Series of StimLabs Dehydrated Human Umbilical Cord Particulate for Acute and Chronic Wounds

NCT07414368
View directory record Official record
Conditions
Chronic Ulcers, Diabetic Foot Ulcers (DFU), DFU, Ulcer
Interventions
Corplex P is used to cover, protect, and provide a moist wound environment
Device
Lead sponsor
StimLabs
Industry
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Bridgeport, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 27, 2026 · Synced Sep 18, 2026, 2:40 PM EDT
Completed Phase 3 Interventional Results available

VA MERIT: A Comparative Efficacy Study: Treatment of Non-Healing Diabetic

NCT01450943
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
SECONDARY dressing gauze and tape, debridement, irrigation, Dermagraft, Oasis
Device · Procedure
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 85 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2018
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Sep 16, 2019 · Synced Sep 18, 2026, 2:40 PM EDT
Not listed No phase listed Observational

Negative Pressure Wound Therapy Registry

NCT02467998
View directory record Official record
Conditions
Diabetic Foot Ulcers, Venous Stasis Ulcer, Pressure Ulcer, Surgical Wound Dehiscence, Burns, Other Types of Chronic Non Healing Wounds
Interventions
NPWT
Device
Lead sponsor
U.S. Wound Registry
Other
Eligibility
Not listed
Enrollment
50,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2005
U.S. locations
1
States / cities
The Woodlands, Texas
Source: ClinicalTrials.gov public record
Updated Apr 30, 2018 · Synced Sep 18, 2026, 2:40 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Role of Tissue Oxygenation and the miR-210 Gene In Wound Healing

NCT02024243
View directory record Official record
Conditions
Non-Diabetic Patients, Wound Leg, Chronic Ulcer Leg/Foot
Interventions
Not listed
Lead sponsor
Chandan Sen
Other
Eligibility
30 Years and older
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2023
U.S. locations
3
States / cities
Indianapolis, Indiana • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 24, 2024 · Synced Sep 18, 2026, 2:40 PM EDT
Recruiting Not applicable Interventional

Prospective Case Series Evaluating the Efficacy and Safety of NeoThelium FT for Diabetic Foot Ulcers

NCT07039396
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
NeoThelium FT (HCT/P 361)
Other
Lead sponsor
NuScience Medical Biologics, LLC
Industry
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
3
States / cities
Alexandria, Louisiana • Leesville, Louisiana • Many, Louisiana
Source: ClinicalTrials.gov public record
Updated Mar 11, 2026 · Synced Sep 18, 2026, 2:40 PM EDT
Recruiting Not applicable Interventional

A Clinical Investigation to Follow the Progress of Exuding Chronic Wounds Using Mepilex® Up as the Primary Dressing.

NCT05588583
View directory record Official record
Conditions
Wounds, Wound of Skin, Wound Leg, Wound; Foot, Diabetic Foot Ulcer, Venous Leg Ulcer
Interventions
Mepilex Up
Device
Lead sponsor
Molnlycke Health Care AB
Industry
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
4
States / cities
Castro Valley, California • Los Angeles, California • Miami, Florida + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 19, 2023 · Synced Sep 18, 2026, 2:40 PM EDT
Not listed No phase listed Observational

DETEC® Esterase for Screening Wound Infection at Point of Care

NCT04614870
View directory record Official record
Conditions
Diabetic Foot Ulcer, Venous Leg Ulcer, Pressure Ulcer
Interventions
DETEC® Esterase
Diagnostic Test
Lead sponsor
Progenitec Inc.
Industry
Eligibility
21 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Arlington, Texas
Source: ClinicalTrials.gov public record
Updated Nov 17, 2023 · Synced Sep 18, 2026, 2:40 PM EDT
Terminated Not applicable Interventional

Amnio-Maxx in Patients With Diabetic Foot Ulcers Unresponsive to Standard of Care Treatment Alone

NCT06572839
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
Amnio-Maxx
Other
Lead sponsor
Capsicure, LLC
Network
Eligibility
18 Years and older
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
12
States / cities
Athens, Alabama • San Diego, California • Coral Gables, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated May 27, 2026 · Synced Sep 18, 2026, 2:40 PM EDT
Terminated Phase 3 Interventional

Efficacy and Safety Study in the Treatment of Chronic Diabetic Foot Ulcers

NCT00387101
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
Dermal - Living Skin Replacement (Dermal - LSR)
Device
Lead sponsor
ApoPharma
Industry
Eligibility
18 Years to 84 Years
Enrollment
288 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
12
States / cities
Tuscon, Arizona • Mather, California • San Diego, California + 8 more
Source: ClinicalTrials.gov public record
Updated May 1, 2008 · Synced Sep 18, 2026, 2:40 PM EDT
Completed Phase 2 Interventional

Safety and Efficacy Study of MRE0094 to Treat Chronic, Neuropathic, Diabetic Foot Ulcers

NCT00312364
View directory record Official record
Conditions
Foot Ulcer, Diabetic, Diabetes Complications
Interventions
MRE0094
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 85 Years
Enrollment
322 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
63
States / cities
Montgomery, Alabama • Bullhead City, Arizona • Phoenix, Arizona + 56 more
Source: ClinicalTrials.gov public record
Updated May 31, 2012 · Synced Sep 18, 2026, 2:40 PM EDT
Terminated Phase 3 Interventional

Multi-Center, Prospective, Randomized Controlled Trial Evaluating SkinTE® in the Treatment of Wagner 2 DFUs

NCT05372809
View directory record Official record
Conditions
Diabetic Foot
Interventions
SkinTE, Control
Biological · Other
Lead sponsor
PolarityTE
Industry
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
13
States / cities
Fresno, California • Los Angeles, California • Hollywood, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated Feb 25, 2024 · Synced Sep 18, 2026, 2:40 PM EDT
Completed Not applicable Interventional

Effect of Meso Wound Matrix in the Treatment of DFUs

NCT04182451
View directory record Official record
Conditions
Diabetic Foot Ulcers (DFUs)
Interventions
Meso Wound Matrix
Device
Lead sponsor
SerenaGroup, Inc.
Network
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
3
States / cities
Pembroke Pines, Florida • Ford City, Pennsylvania • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 25, 2023 · Synced Sep 18, 2026, 2:40 PM EDT
Recruiting Phase 4 Interventional

A Multicenter, Prospective, Controlled Modified Multi-Platform Trial Assessing the Efficacy of Human Placental Membrane Products and Standard of Care in the Management of Nonhealing Diabetic Foot Ulcers and Venous Leg Ulcers.

NCT07364630
View directory record Official record
Conditions
Diabetic Foot Ulcer, Foot Ulcer Chronic, DFU, Ulcer Foot, Venous Leg Ulcer (VLU), Venous Leg Ulcer, Venous Ulcer, Leg Ulcers, Ulcer
Interventions
Tri-Membrane Wrap™ DFU, Membrane Wrap™ DFU, Membrane Wrap-Lite™ DFU, Membrane Wrap-Hydro™ DFU, Tri-Membrane Wrap™ VLU, Membrane Wrap™ VLU, Membrane Wrap-Lite™ VLU, Membrane Wrap-Hydro™ VLU
Other
Lead sponsor
BioLab Holdings
Industry
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Philidelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 8, 2026 · Synced Sep 18, 2026, 2:40 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Clinical Investigation of Galnobax® for the Treatment of Diabetic Foot Ulcers

NCT01113515
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
Esmolol hydrochloride, Placebo gel
Drug
Lead sponsor
Novalead Pharma Private Limited
Industry
Eligibility
18 Years to 95 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated May 19, 2024 · Synced Sep 18, 2026, 2:40 PM EDT
Not listed Not applicable Interventional

Randomized Clinical Study Assessing NuShield Versus Standard of Care in Diabetic Foot Ulcers

NCT03855514
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
NuShield
Other
Lead sponsor
Organogenesis
Industry
Eligibility
18 Years to 85 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
9
States / cities
Carlsbad, California • Fresno, California • Los Angeles, California + 6 more
Source: ClinicalTrials.gov public record
Updated May 25, 2021 · Synced Sep 18, 2026, 2:40 PM EDT
Completed Not applicable Interventional

SDRM® vs. Collagen for Diabetic Foot Ulcers

NCT05883098
View directory record Official record
Conditions
Diabetic Foot, Ulcer Foot, Wound Heal
Interventions
Wound debridement, Wound closure matrix application
Procedure · Device
Lead sponsor
Polymedics Innovations Inc.
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Circleville, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 27, 2023 · Synced Sep 18, 2026, 2:40 PM EDT
Terminated Phase 3 Interventional

Evaluate the Safety and Efficacy of ON101 Cream for the Treatment of Chronic Diabetic Foot Ulcers

NCT04962139
View directory record Official record
Conditions
Chronic Diabetic Foot Ulcers
Interventions
ON101 Cream, Vehicle Cream
Drug · Other
Lead sponsor
Oneness Biotech Co., Ltd.
Industry
Eligibility
18 Years to 80 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
14
States / cities
Mesa, Arizona • Carlsbad, California • Castro Valley, California + 11 more
Source: ClinicalTrials.gov public record
Updated Mar 12, 2025 · Synced Sep 18, 2026, 2:40 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Swab Sample Collection for the Detection of Bacterial Proteases in Wounds Assay

NCT01750203
View directory record Official record
Conditions
Chronic Wounds With Different Etiologies
Interventions
Swabs
Other
Lead sponsor
Systagenix Wound Management
Industry
Eligibility
18 Years and older
Enrollment
135 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Dec 19, 2012 · Synced Sep 18, 2026, 2:40 PM EDT
Active, not recruiting No phase listed Observational

Evaluation of the Safety and Efficacy of Dehydrated Human Placenta Tissue (dHPT) for Wound Healing

NCT07375160
View directory record Official record
Conditions
Diabetic Foot Ulcer (DFU), Venous Leg Ulcer (VLU), Pressure Ulcer (PU)
Interventions
dHPT, AIC
Biological
Lead sponsor
Cellution Biologics
Industry
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Sep 18, 2026, 2:40 PM EDT
Completed Phase 3 Interventional

Evaluation of a Medical Food for Chronic Wounds

NCT00711217
View directory record Official record
Conditions
Foot Ulcer, Diabetic
Interventions
Medical Food, Drink mix calorically similar to experimental product
Other
Lead sponsor
Abbott Nutrition
Industry
Eligibility
18 Years and older
Enrollment
271 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
46
States / cities
Birmingham, Alabama • Tucson, Arizona • Brawley, California + 38 more
Source: ClinicalTrials.gov public record
Updated Nov 1, 2011 · Synced Sep 18, 2026, 2:40 PM EDT
Active, not recruiting Phase 3 Interventional

SkinTE® for the Treatment of Wagner 1 Diabetic Foot Ulcers (COVER DFUS II)

NCT06140303
View directory record Official record
Conditions
Diabetic Foot
Interventions
SkinTE, Control
Biological · Other
Lead sponsor
PolarityTE
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
23
States / cities
Mesa, Arizona • Castro Valley, California • Fresno, California + 19 more
Source: ClinicalTrials.gov public record
Updated Jul 10, 2025 · Synced Sep 18, 2026, 2:40 PM EDT
Recruiting No phase listed Observational

Evaluating the Durability of Closure for Diabetic Foot Ulcers Following a Randomized, Controlled, Modified Platform Trial.

NCT07360418
View directory record Official record
Conditions
Diabetic Foot Ulcers (DFU), Foot Ulcer Chronic, Ulcer, Diabetic Foot Ulcer
Interventions
Blue Drop Foot Scanner
Other
Lead sponsor
Applied Biologics, LLC
Industry
Eligibility
18 Years and older
Enrollment
50 participants
Timeline
2025 – 2027
U.S. locations
1
States / cities
Clinton Township, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Sep 18, 2026, 2:40 PM EDT