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ClinicalTrials.gov public records Last synced Sep 30, 2026, 3:50 PM EDT

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Showing 25–48 of 517 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Chronic Low-back Pain Clear all
Completed Phase 2 Interventional Results available

RN624 In Adult Patients With Chronic Low Back Pain

NCT00584870
View directory record Official record
Conditions
Low Back Pain
Interventions
Naproxen, Placebo, PF-04383119 (RN624)
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 90 Years
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
38
States / cities
Anniston, Alabama • Birmingham, Alabama • Chandler, Arizona + 30 more
Source: ClinicalTrials.gov public record
Updated Jul 12, 2021 · Synced Sep 30, 2026, 3:50 PM EDT
Suspended Not applicable Interventional Accepts healthy volunteers

Stanford Spine Keeper - Managing Your Low Back Pain

NCT05443503
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Mobile health applications (mHealth apps) based intervention
Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
500,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated Jan 9, 2026 · Synced Sep 30, 2026, 3:50 PM EDT
Completed Early Phase 1 Interventional Results available

Developing Brain Stimulation as a Treatment for Chronic Pain in Opiate Dependent

NCT03681769
View directory record Official record
Conditions
Chronic Pain, Opiate Dependence, Lower Back Pain
Interventions
iTBS to the left dlPFC, Sham iTBS to the left dlPFC, cTBS to the mPFC, Sham cTBS to the mPFC
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 75 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 10, 2023 · Synced Sep 30, 2026, 3:50 PM EDT
Recruiting Not applicable Interventional

Tailored Pain Guide (TPG) Study

NCT05843890
View directory record Official record
Conditions
Chronic Lower Back Pain
Interventions
Structured and tailored PainGuide, Standard PainGuide
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
550 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Sep 30, 2026, 3:50 PM EDT
Active, not recruiting Not applicable Interventional

Improving Access to Chiropractic Care in Community Health Centers

NCT06104605
View directory record Official record
Conditions
Lower Back Pain
Interventions
Institutional interventions, PCPs interventions, Patient interventions
Other
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Sep 30, 2026, 3:50 PM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Botulinum Toxin A for the Treatment of Chronic Lumbar Back Pain

NCT00404417
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Botulinum Toxin A / Placebo, Botulinum Toxin A / Botulinum Toxin A, Placebo / Botulinum Toxin A, Placebo / Placebo
Drug
Lead sponsor
Walter Reed Army Medical Center
Federal
Eligibility
18 Years to 70 Years
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Mar 2, 2010 · Synced Sep 30, 2026, 3:50 PM EDT
Terminated Phase 4 Interventional

Lidocaine Patch 5% Versus Celecoxib 200 mg in Chronic Axial Low Back Pain

NCT00904397
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Lidoderm®, Celecoxib
Drug
Lead sponsor
Endo USA Inc., a Keenova Therapeutics Company
Industry
Eligibility
18 Years and older
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2004
U.S. locations
21
States / cities
Northport, Alabama • Phoenix, Arizona • Beverly Hills, California + 18 more
Source: ClinicalTrials.gov public record
Updated Feb 15, 2010 · Synced Sep 30, 2026, 3:50 PM EDT
Completed Phase 3 Interventional

Non-Invasive Targeted Electronic Pain Control Device ("Biowave System") Versus Transcutaneous Electrical Nerve Stimulation (TENS) for the Symptomatic Treatment of Chronic Low Back Pain

NCT00277797
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Biowave Targeted Non-Invasive Electronic Pain Control Device, TENS (Transcutaneous Electrical Nerve Stimulation) device
Device
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 60 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2008
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 17, 2013 · Synced Sep 30, 2026, 3:50 PM EDT
Completed Not applicable Interventional

Adjunctive Mindfulness During Opioid Tapering for patientS With Chronic Pain (The AMOS Study)

NCT06268522
View directory record Official record
Conditions
Low Back Pain
Interventions
Mindfulness-Oriented Recovery Enhancement: (MORE) group, Psychoeducation
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
121 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Chestnut Hill, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Sep 30, 2026, 3:50 PM EDT
Completed Not applicable Interventional

Modifiable Work and Movement Solutions Low Back Pain in Seafood Workers

NCT03524378
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Ergonomic and movement modifications
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 60 Years
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
2
States / cities
Cedar Key, Florida • Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Nov 17, 2022 · Synced Sep 30, 2026, 3:50 PM EDT
Recruiting No phase listed Observational

Brain Imaging Biomarkers for Response to Spinal Cord Stimulation in Patients With Chronic Low Back Pain

NCT04658628
View directory record Official record
Conditions
Chronic Low-back Pain
Interventions
Not listed
Lead sponsor
University of California, Los Angeles
Other
Eligibility
21 Years and older
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 2, 2025 · Synced Sep 30, 2026, 3:50 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Music-based Treatments and Pain: Underlying Mechanisms and the Beneficial Effects of Music-Based Treatments

NCT05578781
View directory record Official record
Conditions
Chronic Low-back Pain
Interventions
Music Therapy, Music Medicine, Control group
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
99 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 7, 2025 · Synced Sep 30, 2026, 3:50 PM EDT
Recruiting Not applicable Interventional

Neural Mechanisms of Meditation for Opioid-Treated Chronic Low Back Pain

NCT05607381
View directory record Official record
Conditions
Low Back Pain, Opioid Use
Interventions
Meditation, Usual care
Behavioral · Other
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 65 Years
Enrollment
188 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
2
States / cities
La Jolla, California • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jul 27, 2026 · Synced Sep 30, 2026, 3:50 PM EDT
Completed Phase 4 Interventional Results available

Opioid Treatment for Chronic Low Back Pain and the Impact of Mood Symptoms

NCT01502644
View directory record Official record
Conditions
Chronic Low Back Pain, Degenerative Disc Disease, Depression, Anxiety
Interventions
Oxycodone, Morphine, Placebo
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
21 Years to 75 Years
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Chestnut Hill, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 11, 2017 · Synced Sep 30, 2026, 3:50 PM EDT
Completed Not applicable Interventional

A Trial Comparing Mechanical Diagnosis and Treatment to Manual Therapy

NCT03049644
View directory record Official record
Conditions
Chronic Lower Back Pain
Interventions
Mechanical Diagnosis and Therapy, Manual Therapy
Procedure
Lead sponsor
Canandaigua VA Medical Center
Federal
Eligibility
18 Years to 89 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Apr 7, 2022 · Synced Sep 30, 2026, 3:50 PM EDT
Terminated Phase 4 Interventional Results available

Three Way Interaction Between Gabapentin, Duloxetine, and Donepezil in Patients With Diabetic Neuropathy

NCT00619983
View directory record Official record
Conditions
Diabetic Neuropathic Pain, Chronic Low Back Pain
Interventions
donepezil, duloxetine, donepezil 2.5 mg and duloxetine 30mg, placebo, gabapentin
Drug
Lead sponsor
Wake Forest University
Other
Eligibility
18 Years to 80 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
2
States / cities
Winston-Salem, North Carolina • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 11, 2018 · Synced Sep 30, 2026, 3:50 PM EDT
Completed No phase listed Observational

Observational Cohort Study of Chronic Low Back Pain

NCT01355237
View directory record Official record
Conditions
Back Pain Lower Back Chronic
Interventions
Not listed
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
21 Years and older
Enrollment
309 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 14, 2017 · Synced Sep 30, 2026, 3:50 PM EDT
Not yet recruiting Not applicable Interventional

Differences in Mechanistic Measures (Oxytocin and Cortisol) of Therapeutic Alliance Between A Talk-Based Therapy and Soft-Tissue Mobilization in Individuals With Chronic Spinal Pain

NCT06987786
View directory record Official record
Conditions
Spine, Low Back Pain, Neck Pain
Interventions
Massage, Talk-based therapy
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 20, 2026 · Synced Sep 30, 2026, 3:50 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

High Level Pulsed Heat Versus Low Level Steady Heat in Subjects With Chronic Low Back Pain

NCT04109703
View directory record Official record
Conditions
Chronic Pain, Low Back Pain, Heat, Analgesia
Interventions
High Level Pulsed Heat delivered by Generation 5 devices from Soovu Labs Inc., Low Level (37 degrees C) delivered by the control device Generation 5 devices from Soovu Labs Inc.
Device
Lead sponsor
Soovu Labs Inc.
Industry
Eligibility
21 Years to 70 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Dec 30, 2019 · Synced Sep 30, 2026, 3:50 PM EDT
Recruiting Not applicable Interventional

Sequential and Comparative Evaluation of Pain Treatment Effectiveness Response

NCT04142177
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Pain EASE, Tailored exercise, Continued Care and Active Monitoring, Cognitive Behavioral Therapy (CBT), Spinal Manipulation Therapy (SMT), Yoga
Other · Procedure · Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
2,529 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
19
States / cities
Phoenix, Arizona • Loma Linda, California • Long Beach, California + 16 more
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Sep 30, 2026, 3:50 PM EDT
Completed Not applicable Interventional Results available

SCS as an Option for Chronic Low Back and/or Leg Pain Instead of Surgery

NCT04676022
View directory record Official record
Conditions
Chronic Pain
Interventions
WaveWriter, Conventional Medical Managament
Device · Other
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
22 Years and older
Enrollment
241 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
23
States / cities
Palm Desert, California • Santa Rosa, California • Greenwood Village, Colorado + 19 more
Source: ClinicalTrials.gov public record
Updated Mar 6, 2025 · Synced Sep 30, 2026, 3:50 PM EDT
Completed Not applicable Interventional Results available

Auricular Vagus Nerve Stimulation for Chronic Pain

NCT03959111
View directory record Official record
Conditions
Low Back Pain
Interventions
Stimulation at Location 1, Stimulation at Location 2
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 11, 2026 · Synced Sep 30, 2026, 3:50 PM EDT
Completed Not applicable Interventional

Self-Management of Chronic Low Back Pain: Targeting Patient Activation

NCT06236529
View directory record Official record
Conditions
Chronic Low-back Pain, Patient Activation
Interventions
Health Behavior Change Counseling, Self-management program
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 1, 2024 · Synced Sep 30, 2026, 3:50 PM EDT
Completed No phase listed Observational

Real-World Experience of Patients Treated for Musculoskeletal Injuries With SAM in Routine Care

NCT05254470
View directory record Official record
Conditions
Musculoskeletal Injury, Pain, Chronic, Pain, Acute, Sport Injury, Soft Tissue Injuries, Arm Injury, Back Pain, Tendon Injuries, Muscle Injury
Interventions
Continuous Ultrasound
Device
Lead sponsor
ZetrOZ, Inc.
Industry
Eligibility
18 Years and older
Enrollment
135 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Fairfield, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 24, 2022 · Synced Sep 30, 2026, 3:50 PM EDT