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Showing 1–24 of 166 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Chronic Osteoarthritis Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Vitamin D and Fish Oil for Autoimmune Disease, Inflammation and Knee Pain

NCT01351805
View directory record Official record
Conditions
Autoimmune Diseases, Systemic Inflammatory Process, Knee Pain Chronic, Osteoarthritis, Rheumatoid Arthritis
Interventions
Fish Oil, Vitamin D, placebo pill
Drug · Dietary Supplement · Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
50 Years and older
Enrollment
25,871 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 2, 2025 · Synced Sep 19, 2026, 6:24 PM EDT
Recruiting Not applicable Interventional

The PROACTIVE Study for Black Elders

NCT06512727
View directory record Official record
Conditions
Musculoskeletal Pain, Chronic Pain, Osteoarthritis, Pain, Chronic, Movement Evoked Pain
Interventions
PROACTIVE Intervention
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
50 Years to 92 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Sep 19, 2026, 6:24 PM EDT
Not yet recruiting Not applicable Interventional

Developing a Nonpharmacological Pain Intervention for Community-dwelling Older Adults With Dementia

NCT06264362
View directory record Official record
Conditions
Pain, Chronic, Dementia, Mild, Mobility Limitation, Physical Disability, Osteo Arthritis Knee, Mild Cognitive Impairment
Interventions
Tailored Physical Activity Program
Behavioral
Lead sponsor
Drexel University
Other
Eligibility
60 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 10, 2025 · Synced Sep 19, 2026, 6:24 PM EDT
Completed Phase 2 Interventional Results available

Chronic Pain Master Protocol (CPMP): A Study of LY3556050 in Participants With Osteoarthritis

NCT04627038
View directory record Official record
Conditions
Osteoarthritis
Interventions
LY3556050, Placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
40 Years and older
Enrollment
202 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
38
States / cities
Birmingham, Alabama • Chandler, Arizona • Glendale, Arizona + 32 more
Source: ClinicalTrials.gov public record
Updated Nov 1, 2023 · Synced Sep 19, 2026, 6:24 PM EDT
Completed Phase 4 Interventional Results available

Hormone Function in Men Treated for Pain With Opioids or Placebo

NCT00737737
View directory record Official record
Conditions
Chronic Pain, Osteoarthritis
Interventions
MS Contin, Placebo
Drug
Lead sponsor
National Institute of Nursing Research (NINR)
NIH
Eligibility
30 Years to 65 Years · Male only
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 28, 2015 · Synced Sep 19, 2026, 6:24 PM EDT
Active, not recruiting Not applicable Interventional

Genicular Artery Embolization Vs Observation for Symptomatic Knee Osteoarthritis

NCT04682652
View directory record Official record
Conditions
Knee Osteoarthritis, Degenerative Joint Disease of Knee
Interventions
Embozene MicroSpheres
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
40 Years to 79 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Sep 19, 2026, 6:24 PM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers

Generate and Test the Reliability of a PD Model of OXT on Pupillary Hippus as a Measure of CNS Activity

NCT04427709
View directory record Official record
Conditions
Chronic Pain, Osteoarthritis, Knee
Interventions
Oxytocin, Placebo
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 75 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Sep 19, 2026, 6:24 PM EDT
Active, not recruiting Not applicable Interventional

Maximizing Patient Goal Attainment

NCT05652270
View directory record Official record
Conditions
Knee Osteoarthritis, Knee Injuries, Knee Pain Chronic, Knee Injuries and Disorders
Interventions
Goal Attainment, Goal Development, Goal Tracking
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
21 Years and older
Enrollment
258 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Aug 30, 2026 · Synced Sep 19, 2026, 6:24 PM EDT
Completed No phase listed Observational

Study of StimRouter for Chronic Knee OA Pain

NCT05644639
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
StimRouter Neuromodulation System
Device
Lead sponsor
Bioventus LLC
Industry
Eligibility
21 Years and older
Enrollment
13 participants
Timeline
2022 – 2024
U.S. locations
1
States / cities
Livonia, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 25, 2024 · Synced Sep 19, 2026, 6:24 PM EDT
Completed Phase 2 Interventional

Safety and Tolerability of 4975 in the Treatment of Moderate to Severe Knee Pain Due to Osteoarthritis (OA)

NCT00667654
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
CNTX-4975
Drug
Lead sponsor
Centrexion Therapeutics
Industry
Eligibility
40 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2016
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 5, 2016 · Synced Sep 19, 2026, 6:24 PM EDT
Completed Not applicable Interventional

A Pilot Study to Improve Patient-Doctor Communication

NCT01606930
View directory record Official record
Conditions
Chronic Disease, Hypertension, Hyperlipidemia, Diabetes Mellitus, Osteoarthritis, COPD, Cardiovascular Disease
Interventions
Patient Primer Tool
Behavioral
Lead sponsor
Walter Reed National Military Medical Center
Federal
Eligibility
18 Years to 80 Years
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated May 27, 2012 · Synced Sep 19, 2026, 6:24 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

PatientSpot Formerly Known as ArthritisPower

NCT03840928
View directory record Official record
Conditions
Rheumatoid Arthritis, Ankylosing Spondylitis, Fibromyalgia, Gout, Crohn Disease, Juvenile Idiopathic Arthritis, Lupus Erythematosus, Myositis, Osteoarthritis, Osteoporosis, Psoriasis, Psoriatic Arthritis, Scleroderma, Dermatomyositis, Inflammatory Bowel Diseases, Polymyositis, Axial Spondyloarthritis, Diffuse Idiopathic Skeletal Hyperostosis, Polymyalgia Rheumatica, Giant Cell Arteritis, Temporal Arteritis, Wegener, Relapsing Polychondritis, Undifferentiated Connective Tissue Disease, Spinal Cord Injuries, Alzheimer Disease, Amyotrophic Lateral Sclerosis, Ataxia, Bell Palsy, Brain Tumor, Cerebral Aneurysm, Epilepsy, Guillain-Barre Syndrome, Headache, Head Injury, Hydrocephalus, Lumbar Disc Disease, Meningitis, Multiple Sclerosis, Muscular Dystrophy, Neurocutaneous Syndromes, Parkinson Disease, Stroke, Cluster Headache, Tension-Type Headache, Chronic Obstructive Pulmonary Disease, Asthma, Lung Cancer, Cystic Fibrosis, Sleep Apnea, Eczema, Alopecia, Chronic Inflammation, Unstable Angina, Heart Attack, Heart Failure, Arrythmia, Valve Heart Disease, High Blood Pressure, Congenital Heart Disease, Peripheral Arterial Disease, Diabetes, Chronic Liver Disease, Obesity
Interventions
Not listed
Lead sponsor
Global Healthy Living Foundation
Other
Eligibility
19 Years and older
Enrollment
40,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2025
U.S. locations
1
States / cities
Upper Nyack, New York
Source: ClinicalTrials.gov public record
Updated Dec 12, 2023 · Synced Sep 19, 2026, 6:24 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Chronic Pain, Couples, & Physical Activity

NCT04077164
View directory record Official record
Conditions
Chronic Pain, Fibromyalgia, Osteoarthritis, Knee, Osteoarthritis, Hip, Osteoarthritis, Ankylosing Spondylitis, Rheumatoid Arthritis, Chronic Low-back Pain, Chronic Shoulder Pain
Interventions
No intervention, observational only.
Other
Lead sponsor
Illinois Institute of Technology
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 9, 2023 · Synced Sep 19, 2026, 6:24 PM EDT
No Longer Available No phase listed Expanded access

Individual Patient Expanded Access IND of Autologous HB-adMSCS for the Treatment of Bilateral Knee Pain.

NCT04604288
View directory record Official record
Conditions
Knee Pain Chronic, Osteo Arthritis Knee
Interventions
HB-adMSC
Biological
Lead sponsor
Hope Biosciences Research Foundation
Industry
Eligibility
Not listed
U.S. locations
1
States / cities
Sugar Land, Texas
Source: ClinicalTrials.gov public record
Updated Sep 28, 2025 · Synced Sep 19, 2026, 6:24 PM EDT
Not yet recruiting Not applicable Interventional

Ketogenic Diet to Reduce Osteoarthritis Pain in MCI

NCT07417891
View directory record Official record
Conditions
Osteoarthritis (OA) of the Hip, Osteoarthritis (OA) of the Knee, Osteoarthritis (OA) of the Shoulder, Osteoarthritis, Mild Cognitive Impairment, MCI, Mild Cognitive Impairment (MCI), Dementia
Interventions
Well-formulated ketogenic diet
Other
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
55 Years to 75 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Fairway, Kansas
Source: ClinicalTrials.gov public record
Updated May 3, 2026 · Synced Sep 19, 2026, 6:24 PM EDT
Terminated Not applicable Interventional

Physical Therapy vs Remote Exercise for Knee Pain Due to Osteoarthritis (OA)

NCT06167304
View directory record Official record
Conditions
Knee Osteoarthritis, Chronic Pain
Interventions
Technology-implemented exercise therapy, Traditional Physical Therapy
Other
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Sep 19, 2026, 6:24 PM EDT
Completed Not applicable Interventional

Computer-guided Action Planning to Support Physical Activity (CAPPA) for Employees With Chronic Knee Symptoms

NCT06734052
View directory record Official record
Conditions
Osteoarthritis of Knee, Knee Pain Chronic
Interventions
CAPPA, Health education
Behavioral
Lead sponsor
Marquette University
Other
Eligibility
18 Years and older
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Sep 19, 2026, 6:24 PM EDT
Completed Phase 2 Interventional Results available

Maximizing Analgesia to Reduce Pain in Knee Osteoarthritis

NCT03098563
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Blinded study medication
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
45 Years and older
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 10, 2024 · Synced Sep 19, 2026, 6:24 PM EDT
Withdrawn Not applicable Interventional

Genicular Artery Embolization (GAE) for Osteoarthritic Knee Pain

NCT04472091
View directory record Official record
Conditions
Knee Osteoarthritis, Knee Pain Chronic, Knee Pain Swelling, Knee Arthritis, Arterial Occlusion
Interventions
Genicular artery embolization (GAE)
Device
Lead sponsor
Andrew Picel
Other
Eligibility
40 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Feb 23, 2025 · Synced Sep 19, 2026, 6:24 PM EDT
Completed Phase 2 Interventional

Study to Evaluate the Safety and Efficacy of CNTX-4975 in Subjects With Chronic, Moderate to Severe Osteoarthritis Knee Pain

NCT02558439
View directory record Official record
Conditions
Osteoarthritis
Interventions
CNTX-4975, Placebo
Drug · Other
Lead sponsor
Centrexion Therapeutics
Industry
Eligibility
45 Years to 80 Years
Enrollment
175 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
22
States / cities
Birmingham, Alabama • Tucson, Arizona • Anaheim, California + 18 more
Source: ClinicalTrials.gov public record
Updated Aug 7, 2017 · Synced Sep 19, 2026, 6:24 PM EDT
Completed Not applicable Interventional Results available

Insomnia and Osteoarthritis Study

NCT00374556
View directory record Official record
Conditions
Osteoarthritis, Insomnia
Interventions
Placebo, Eszopiclone
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 64 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2013
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 13, 2019 · Synced Sep 19, 2026, 6:24 PM EDT
Withdrawn Not applicable Interventional

OASIS: Osteoarthritis Sensitivity Integration Study

NCT01377038
View directory record Official record
Conditions
Osteoarthritis, Chronic Pain
Interventions
Phenotype assessment
Other
Lead sponsor
University of Michigan
Other
Eligibility
50 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 25, 2016 · Synced Sep 19, 2026, 6:24 PM EDT
Not yet recruiting Not applicable Interventional

Effects of Photobiomodulation on Inflammation and Chronic Pain in Knee Osteoarthritis (EPIC-KO)

NCT07079969
View directory record Official record
Conditions
Chronic Knee Pain
Interventions
Photobiomodulation therapy (PBM) device, Sham PBM device
Device
Lead sponsor
University of Florida
Other
Eligibility
50 Years to 99 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Sep 19, 2026, 6:24 PM EDT
Active, not recruiting Phase 3 Interventional

RCT, Blinded, 2-Arm Efficacy Study of IP and Placebo in Patients With Chronic Pain Related to Osteoarthritis of the Knee

NCT05318521
View directory record Official record
Conditions
Degenerative Arthritis
Interventions
Placebo, Ibuprofen modified release tablet 800 mg
Drug
Lead sponsor
Overseas Pharmaceuticals, Ltd.
Industry
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
7
States / cities
Cerritos, California • Garden Grove, California • Santa Ana, California + 4 more
Source: ClinicalTrials.gov public record
Updated Jul 26, 2026 · Synced Sep 19, 2026, 6:24 PM EDT