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ClinicalTrials.gov public records Last synced Oct 21, 2026, 7:10 AM EDT

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Showing 25–48 of 66 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Cigarette Addiction Clear all
Enrolling by invitation No phase listed Observational

Developing Evidence to Inform Regulatory Policy on Nicotine Content in E-Liquids

NCT06619964
View directory record Official record
Conditions
Nicotine Addiction
Interventions
Not listed
Lead sponsor
Rochester Institute of Technology
Other
Eligibility
21 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Oct 21, 2026, 7:10 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Neurobiology of Nicotine and Non-nicotine Components of Tobacco Addiction

NCT01056926
View directory record Official record
Conditions
Smoking
Interventions
Quit smoking, Nicotine patch, Placebo Patch
Behavioral · Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 55 Years
Enrollment
147 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 31, 2017 · Synced Oct 21, 2026, 7:10 AM EDT
Recruiting No phase listed Observational

Measuring Communal Coping in Dual-smoking Couples Making a Quit Attempt

NCT07553962
View directory record Official record
Conditions
Smoking (Tobacco) Addiction, Smoking ( Cigarette), Tobacco, Tobacco Abstinence, Quitting Smoking, Smoking Cessation
Interventions
Not listed
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated May 15, 2026 · Synced Oct 21, 2026, 7:10 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Control Systems Approach to Predicting Individualized Dynamics of Nicotine Cravings

NCT02643914
View directory record Official record
Conditions
Nicotine Addiction, Cigarette Smoking
Interventions
Nicotine, MR Compatible Nicotine Delivery Device
Drug · Device
Lead sponsor
Stony Brook University
Other
Eligibility
21 Years to 65 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Oct 21, 2026, 7:10 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

AXS-05 Phase II Trial on Smoking Behavior

NCT03471767
View directory record Official record
Conditions
Smoking Cessation, Smoking, Cigarette, Nicotine Dependence
Interventions
AXS-05, Bupropion SR
Drug
Lead sponsor
James Davis
Other
Eligibility
18 Years and older
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 19, 2022 · Synced Oct 21, 2026, 7:10 AM EDT
Recruiting Phase 2 Interventional

The CONQUER Trial - Cessation Of Nicotine, QUitting With E-cigarette Reduction

NCT07322432
View directory record Official record
Conditions
Addiction Nicotine
Interventions
VapeAway filter system
Device
Lead sponsor
VapeAway
Industry
Eligibility
21 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Oct 21, 2026, 7:10 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Abuse Liability of Reduced Nicotine Content Cigarettes in the Context of Concurrent E-Cigarette Use

NCT02870218
View directory record Official record
Conditions
Nicotine Addiction, Cigarette Smoking
Interventions
Smoking research cigarettes with e-cigarette, Nicotine discrimination thresholds
Drug
Lead sponsor
Rose Research Center, LLC
Industry
Eligibility
21 Years to 65 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
2
States / cities
Charlotte, North Carolina • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 14, 2022 · Synced Oct 21, 2026, 7:10 AM EDT
Withdrawn Phase 2 Interventional

Electronic Nicotine Delivery Systems as a Smoking Cessation Treatment

NCT02487953
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Nicotine patch, ENDS, Placebo patch, Placebo ENDS
Drug · Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 12, 2018 · Synced Oct 21, 2026, 7:10 AM EDT
Completed Not applicable Interventional

Electronic Cigarettes as a Harm Reduction Strategy Among People Living With HIV/AIDS

NCT04218708
View directory record Official record
Conditions
Nicotine Addiction
Interventions
Nicotine patch and gum, Minnesota Nicotine Withdrawal Scale (MNWS), ASSIST (the Alcohol, Smoking and Substance Involvement Screening), Counseling, NIDA Standardized Research E-cigarettes (SREC)
Other · Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 65 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 20, 2024 · Synced Oct 21, 2026, 7:10 AM EDT
Completed Not applicable Interventional

Mindfulness Training for Smoking Cessation

NCT01144689
View directory record Official record
Conditions
Cigarette Smoking, Tobacco Smoking, Nicotine Dependence, Smoking Cessation
Interventions
Mindfulness Training, Smoking Cessation Therapy
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 60 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 7, 2016 · Synced Oct 21, 2026, 7:10 AM EDT
Completed No phase listed Observational

Electronic Cigarette Use During Pregnancy

NCT03480373
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Not listed
Lead sponsor
UConn Health
Other
Eligibility
16 Years to 45 Years · Female only
Enrollment
182 participants
Timeline
2018 – 2023
U.S. locations
6
States / cities
Denver, Colorado • Farmington, Connecticut • Hartford, Connecticut + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 21, 2023 · Synced Oct 21, 2026, 7:10 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers

A Smoking Intervention Study Using Scheduled Gradual Reduction With Varenicline to Help With Cessation

NCT01772641
View directory record Official record
Conditions
Nicotine Addiction
Interventions
Scheduled Gradual Reduction + Varenicline, Scheduled Gradual Reduction + Placebo Drug, Basic Advice + Varenicline, Basic Advice + Placebo Drug
Other
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 16, 2016 · Synced Oct 21, 2026, 7:10 AM EDT
Completed Not applicable Interventional Results available

QuitFast: Evaluating Transcranial Magnetic Stimulation as a Tool to Reduce Smoking Directly Following a Quit Attempt

NCT04159571
View directory record Official record
Conditions
Smoking, Smoking Cessation, Craving, Addiction, Addiction Nicotine, Nicotine Dependence, Cigarette Smoking
Interventions
Real TBS to the vmPFC, Sham cTBS to the vmPFC
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated May 21, 2024 · Synced Oct 21, 2026, 7:10 AM EDT
Recruiting Not applicable Interventional

Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction

NCT06077240
View directory record Official record
Conditions
Smoking, Smoking Behaviors, Nicotine Dependence
Interventions
E-cigarette with 2.4% Nicotine with Menthol and Tobacco Flavors, E-cigarette with 2.4% Nicotine with Tobacco Flavor Only, E-cigarette with 5% Nicotine with Menthol and Tobacco Flavors, E-cigarette with 5% Nicotine with Tobacco Flavor Only, Tobacco Pouches with 3mg Nicotine with Menthol and Tobacco Flavors, Tobacco Pouches with 3mg Nicotine with Tobacco Flavor Only, Tobacco Pouches with 6mg Nicotine with Menthol and Tobacco Flavors, Tobacco Pouches with 6mg Nicotine with Tobacco Flavor Only
Behavioral
Lead sponsor
Yale University
Other
Eligibility
21 Years and older
Enrollment
256 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 19, 2026 · Synced Oct 21, 2026, 7:10 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

The Effects of Memantine and Bupropion on Acute, Reinforcing, and Conditioned Effects of Cigarettes - 1

NCT00136747
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Memantine, bupropion, placebo
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
21 Years to 45 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2009
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 21, 2018 · Synced Oct 21, 2026, 7:10 AM EDT
Terminated Phase 3 Interventional Results available

Varenicline and Alcohol in Inpatient Addictions Program (IAP)

NCT01169610
View directory record Official record
Conditions
Alcoholism, Nicotine Dependence
Interventions
Varenicline
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 70 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 20, 2019 · Synced Oct 21, 2026, 7:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Little Cigar and Cigarillo Warnings for Youth

NCT06413797
View directory record Official record
Conditions
Little Cigars and Cigarillos (LCC) Use
Interventions
FDA warnings + Image, FDA Warnings Text-Only, Surgeon General Text-Only Warnings
Behavioral
Lead sponsor
UNC Lineberger Comprehensive Cancer Center
Other
Eligibility
15 Years to 20 Years
Enrollment
928 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 24, 2025 · Synced Oct 21, 2026, 7:10 AM EDT
Completed Phase 1Phase 2 Interventional

The Role of Nicotine and Non-Nicotine Alkaloids in E-Cigarette Use and Dependence

NCT02590393
View directory record Official record
Conditions
Nicotine Dependence
Interventions
E-cigarettes
Combination Product
Lead sponsor
Duke University
Other
Eligibility
21 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 21, 2024 · Synced Oct 21, 2026, 7:10 AM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers

High Dose Bupropion for Smoking Cessation - Pilot Study

NCT03326128
View directory record Official record
Conditions
Smoking Cessation, Smoking, Tobacco, Smoking (Tobacco) Addiction, Cessation, Tobacco, Cigarette Smoking
Interventions
Bupropion Hydrochloride
Drug
Lead sponsor
University of Southern California
Other
Eligibility
21 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 17, 2023 · Synced Oct 21, 2026, 7:10 AM EDT
Completed Not applicable Interventional Results available

A Study to Help People Quit Smoking.

NCT01880099
View directory record Official record
Conditions
Nicotine Dependence
Interventions
placebo, Galantamine 8mg, Galantamine 16mg
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 55 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 23, 2020 · Synced Oct 21, 2026, 7:10 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

An Evaluation of the Tobacco Prevention Toolkit Healthy Futures: Alternative-to-Suspension Vaping Intervention

NCT06483412
View directory record Official record
Conditions
Tobacco Use Cessation, Addiction
Interventions
Healthy Futures: Alternative-to-Suspension Curriculum
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
14 Years to 18 Years
Enrollment
2,540 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Dec 2, 2025 · Synced Oct 21, 2026, 7:10 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Electronic Cigarettes as a Harm Reduction Strategy in Individuals With Substance Use Disorder

NCT04063267
View directory record Official record
Conditions
Cigarette Smoking, Addiction, E Cig Use
Interventions
E cigarettes, Nicotine Replacement Therapy
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 20, 2024 · Synced Oct 21, 2026, 7:10 AM EDT
Completed Early Phase 1 Interventional

Nicotine TMS EFT Smoking Pilot Study

NCT03579953
View directory record Official record
Conditions
Smoking, Nicotine Dependence, Addiction, Smoking, Cigarette
Interventions
Real cTBS, Sham cTBS
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 14, 2019 · Synced Oct 21, 2026, 7:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Addictive Potential of LCCs in Dual Users

NCT03496077
View directory record Official record
Conditions
Tobacco Use Disorder, Dual Tobacco Use, Tobacco Dependence, Smoking, Smoking, Cigar, Smoking, Cigarette, Smoking, Tobacco
Interventions
Flavored and unflavored little cigars/cigarillos (LCCs)
Other
Lead sponsor
UConn Health
Other
Eligibility
18 Years to 34 Years
Enrollment
65 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 10, 2026 · Synced Oct 21, 2026, 7:10 AM EDT