- Conditions
- Severe Clostridium Difficile Infection, Severe-Complicated/Fulminant Clostridium Difficile Infection
- Interventions
- Penn Microbiome Therapy - 001, Penn Microbiome Therapy - 002, Penn Microbiome Therapy - 003, Antibiotics
- Drug
- Lead sponsor
- University of Pennsylvania
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 15 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2020 – 2022
- U.S. locations
- 1
- States / cities
- Philadelphia, Pennsylvania
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Showing 1–24
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- Conditions
- Clostridium Difficile Infection
- Interventions
- Vancomycin Oral Capsule, Placebo Oral Capsule
- Drug
- Lead sponsor
- Medical College of Wisconsin
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 7 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2019 – 2021
- U.S. locations
- 1
- States / cities
- Milwaukee, Wisconsin
- Conditions
- Inflammatory Bowel Diseases, Clostridioides Difficile Infection
- Interventions
- Xylitol, Placebo
- Drug
- Lead sponsor
- Brigham and Women's Hospital
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 99 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2033
- U.S. locations
- 1
- States / cities
- Boston, Massachusetts
- Conditions
- Clostridium Difficile Infection (CDI)
- Interventions
- RBX2660, Placebo, Open label RBX2660 (only for confirmed CDI recurrence)
- Drug
- Lead sponsor
- Rebiotix Inc.
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 320 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2017 – 2020
- U.S. locations
- 60
- States / cities
- Athens, Alabama • Dothan, Alabama • Phoenix, Arizona + 54 more
- Conditions
- Clostridium Infections
- Interventions
- GS-CDA1/MDX-1388, normal saline
- Biological
- Lead sponsor
- MassBiologics
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 200 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2006 – 2008
- U.S. locations
- 22
- States / cities
- Los Angeles, California • Oakland, California • Newark, Delaware + 18 more
- Conditions
- Clostridium Infections
- Interventions
- Not listed
- Lead sponsor
- AstraZeneca
- Industry
- Eligibility
- 18 Years to 130 Years
- Enrollment
- 7 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2024
- U.S. locations
- 7
- States / cities
- Sacramento, California • Hamden, Connecticut • Boston, Massachusetts + 3 more
- Conditions
- Clostridioides Difficile Infection
- Interventions
- Not listed
- Lead sponsor
- Mayo Clinic
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 20 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2019 – 2020
- U.S. locations
- 1
- States / cities
- Rochester, Minnesota
- Conditions
- Clostridioides Difficile Infection
- Interventions
- SER-109
- Biological
- Lead sponsor
- Seres Therapeutics, Inc.
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 263 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2017 – 2022
- U.S. locations
- 97
- States / cities
- Dothan, Alabama • Sun City West, Arizona • Mather, California + 84 more
- Conditions
- Multidrug Resistant Organisms, Healthcare Associated Infections
- Interventions
- Quaternary ammonium, Bleach, Quaternary ammonium and UV-C light, Bleach and UV-C light
- Other
- Lead sponsor
- Duke University
- Other
- Eligibility
- Not listed
- Enrollment
- 21,395 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2012 – 2015
- U.S. locations
- 9
- States / cities
- Burlington, North Carolina • Chapel Hill, North Carolina • Durham, North Carolina + 3 more
- Conditions
- Clostridium Difficile Infection
- Interventions
- Not listed
- Lead sponsor
- Beth Israel Deaconess Medical Center
- Other
- Eligibility
- 18 Years to 75 Years
- Enrollment
- 24 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2013 – 2014
- U.S. locations
- 1
- States / cities
- Boston, Massachusetts
- Conditions
- Recurrent Clostridium Difficile Infection
- Interventions
- Lactobacillus acidophilus CL1285® and Lactobacillus casei, Placebo
- Dietary Supplement
- Lead sponsor
- Bio-K Plus International Inc.
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 140 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2010 – 2016
- U.S. locations
- 1
- States / cities
- New Hyde Park, New York
- Conditions
- Clostridium Difficile Infection
- Interventions
- Fecal Microbiota Transplant
- Drug
- Lead sponsor
- Methodist Health System
- Other
- Eligibility
- Not listed
- Enrollment
- 24 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2018 – 2022
- U.S. locations
- 1
- States / cities
- Dallas, Texas
- Conditions
- Clostridium Difficile Colitis
- Interventions
- Standard Vancomycin, Extended Vancomycin
- Drug
- Lead sponsor
- Corewell Health East
- Other
- Eligibility
- 18 Years and older
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2009 – 2010
- U.S. locations
- 1
- States / cities
- Royal Oak, Michigan
- Conditions
- Clostridium Difficile Infection
- Interventions
- Oral Vancomycin
- Drug
- Lead sponsor
- University of Nevada, Reno
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 104 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2018 – 2022
- U.S. locations
- 1
- States / cities
- Reno, Nevada
- Conditions
- Clostridium Difficile Infection
- Interventions
- Vancomycin, Placebo
- Drug · Other
- Lead sponsor
- Corewell Health East
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 1,294 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2016 – 2023
- U.S. locations
- 3
- States / cities
- Dearborn, Michigan • Royal Oak, Michigan • Troy, Michigan
- Conditions
- Clostridium Infections, Diarrhea
- Interventions
- PAR-101/OPT-80, Vancomycin
- Drug
- Lead sponsor
- Optimer Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
- Industry
- Eligibility
- 16 Years and older
- Enrollment
- 535 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2006 – 2009
- U.S. locations
- 53
- States / cities
- Gadsden, Alabama • Phoenix, Arizona • Hot Springs, Arkansas + 50 more
- Conditions
- Clostridium Difficile Infection
- Interventions
- Fecal Microbial Transplantation
- Biological
- Lead sponsor
- University of California, Irvine
- Other
- Eligibility
- 18 Years to 100 Years
- Enrollment
- 37 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2014 – 2018
- U.S. locations
- 1
- States / cities
- Orange, California
- Conditions
- Clostridium Enterocolitis, Pseudomembranous Colitis
- Interventions
- tolevamer potassium-sodium (GT267-004)
- Drug
- Lead sponsor
- Genzyme, a Sanofi Company
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 520 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2005 – 2007
- U.S. locations
- 99
- States / cities
- Phoenix, Arizona • Rogers, Arkansas • Burbank, California + 81 more
- Conditions
- Clostridium Difficile Immunisation, Diphtheria, Diphtheria Immunisation, Pertussis, Tetanus, Tetanus Immunisation
- Interventions
- Tetanus and Diphtheria Toxoids Adsorbed, Tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine adsorbed onto aluminum hydroxide
- Biological
- Lead sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
- NIH
- Eligibility
- 18 Years to 39 Years · Female only
- Enrollment
- 399 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2019 – 2020
- U.S. locations
- 1
- States / cities
- Baltimore, Maryland
- Conditions
- Gastrointestinal Hemorrhage, Clostridium Difficile Colitis
- Interventions
- Pantoprazole 40 mg IV daily and tube feed., Placebo and tube feed
- Drug · Other
- Lead sponsor
- Mohamed Saad
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 124 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2013 – 2016
- U.S. locations
- 1
- States / cities
- Louisville, Kentucky
- Conditions
- Clostridium Difficile Infection
- Interventions
- Cadazolid, Vancomycin capsule, Vancomycin solution
- Drug
- Lead sponsor
- Actelion
- Industry
- Eligibility
- Up to 18 Years
- Enrollment
- 1 participant
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2017 – 2018
- U.S. locations
- 5
- States / cities
- Idaho Falls, Idaho • Chicago, Illinois • Shreveport, Louisiana + 2 more
- Conditions
- Clostridium, Difficile, Fidaxomicin, Vancomycin
- Interventions
- Fidaxomicin, Vancomycin with Taper/Pulse, Vancomycin
- Drug
- Lead sponsor
- VA Office of Research and Development
- Federal
- Eligibility
- 18 Years and older
- Enrollment
- 308 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2016 – 2024
- U.S. locations
- 32
- States / cities
- Phoenix, Arizona • Tucson, Arizona • Little Rock, Arkansas + 28 more
- Conditions
- Clostridium Difficile, Clostridium Infections
- Interventions
- SYN-004, Placebo
- Drug
- Lead sponsor
- Theriva Biologics, Inc.
- Industry
- Eligibility
- 50 Years and older
- Enrollment
- 413 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2015 – 2016
- U.S. locations
- 6
- States / cities
- Little Rock, Arkansas • Torrance, California • DeLand, Florida + 3 more
- Conditions
- Clostridioides Difficile Infection
- Interventions
- CRS3123, Active Comparator
- Drug
- Lead sponsor
- Crestone, Inc
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 43 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2021 – 2024
- U.S. locations
- 18
- States / cities
- Fullerton, California • Lancaster, California • Mission Hills, California + 14 more