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ClinicalTrials.gov public records Last synced Oct 22, 2026, 8:41 PM EDT

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Showing 121–144 of 334 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Cognitive Changes Clear all
Completed Not applicable Interventional

7T MRI for Light Therapy in Patients With Mild Cognitive Impairment and Mild AD

NCT05596994
View directory record Official record
Conditions
Mild Cognitive Impairment, Alzheimer's Disease
Interventions
Lighting Intervention Therapy, Sham LIT
Device
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
50 Years to 85 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 29, 2025 · Synced Oct 22, 2026, 8:41 PM EDT
Not listed Not applicable Interventional

Can Lifestyle Changes Reverse Early-Stage Alzheimer's Disease

NCT04606420
View directory record Official record
Conditions
Alzheimer Disease
Interventions
Lifestyle medicine
Behavioral
Lead sponsor
Preventive Medicine Research Institute
Other
Eligibility
45 Years to 90 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
4
States / cities
San Diego, California • Sausalito, California • Boston, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 15, 2022 · Synced Oct 22, 2026, 8:41 PM EDT
Recruiting Not applicable Interventional

HOBSCOTCH-CA (HOme-Based Self-management and COgnitive Training CHanges Lives in Brain CAncer)

NCT06930846
View directory record Official record
Conditions
Brain Cancer, Brain Tumor, Brain Neoplasms, Primary Brain Tumor, Low-grade Glioma, Oligodendroglioma, Meningioma, Low Grade Astrocytoma, Cognitive Dysfunction, Memory Impairment, Memory Disorders, Memory Dysfunction
Interventions
HOBSCOTCH-CA
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Nov 21, 2025 · Synced Oct 22, 2026, 8:41 PM EDT
Completed Not applicable Interventional

Opioid and Pain Cognition

NCT04132609
View directory record Official record
Conditions
Pain
Interventions
Cognitive bias modification, Standard attentional bias
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 14, 2021 · Synced Oct 22, 2026, 8:41 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Brain Changes in Children and Adolescents With Behavioral Problems

NCT00104039
View directory record Official record
Conditions
Attention Deficit Disorder With Hyperactivity, Mental Disorders Diagnosed in Childhood, Conduct Disorder
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
8 Years to 18 Years
Enrollment
318 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2016
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 5, 2019 · Synced Oct 22, 2026, 8:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of A-GPC on Reaction Time and Cognitive Function

NCT03903250
View directory record Official record
Conditions
Cognitive Change, Reaction Time
Interventions
A-GPC, Sugar
Dietary Supplement
Lead sponsor
University of Mary Hardin-Baylor
Other
Eligibility
18 Years to 35 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Belton, Texas
Source: ClinicalTrials.gov public record
Updated Nov 12, 2020 · Synced Oct 22, 2026, 8:41 PM EDT
Active, not recruiting Not applicable Interventional

Open Pilot Trial of Adapted Cognitive Processing Therapy for Comorbid PTSD and Opioid Use Disorder

NCT06872164
View directory record Official record
Conditions
Posttraumatic Stress Disorder (PTSD), Opioid Use Disorder
Interventions
Cognitive Processing Therapy
Behavioral
Lead sponsor
The City College of New York
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Oct 22, 2026, 8:41 PM EDT
Completed Not applicable Interventional Results available

Computerized Cognitive Training in Breast Cancer Survivors

NCT05570604
View directory record Official record
Conditions
Breast Cancer, Cognitive Change, Cognitive Impairment, Quality of Life
Interventions
Sweep Seeker, Bird Safari, Jewel Diver, Master Gardener, Road Tour, Computerized Crossword Puzzles
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
21 Years and older · Female only
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Apr 24, 2025 · Synced Oct 22, 2026, 8:41 PM EDT
Completed No phase listed Observational

Changes in Brain Function in Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Who Are Receiving Chemotherapy

NCT01080521
View directory record Official record
Conditions
Cognitive Side Effects of Cancer Therapy, Malignant Ovarian Epithelial Tumor, Ovarian Brenner Tumor, Ovarian Carcinosarcoma, Ovarian Choriocarcinoma, Ovarian Clear Cell Cystadenocarcinoma, Ovarian Dysgerminoma, Ovarian Embryonal Carcinoma, Ovarian Endometrioid Adenocarcinoma, Ovarian Mixed Germ Cell Tumor, Ovarian Mucinous Cystadenocarcinoma, Ovarian Polyembryoma, Ovarian Sarcoma, Ovarian Seromucinous Carcinoma, Ovarian Serous Cystadenocarcinoma, Ovarian Teratoma, Ovarian Yolk Sac Tumor, Stage I Ovarian Cancer, Stage IA Fallopian Tube Cancer, Stage IA Ovarian Cancer, Stage IA Ovarian Germ Cell Tumor, Stage IB Fallopian Tube Cancer, Stage IB Ovarian Cancer, Stage IB Ovarian Germ Cell Tumor, Stage IC Fallopian Tube Cancer, Stage IC Ovarian Cancer, Stage IC Ovarian Germ Cell Tumor, Stage II Ovarian Cancer, Stage IIA Fallopian Tube Cancer, Stage IIA Ovarian Cancer, Stage IIA Ovarian Germ Cell Tumor, Stage IIB Fallopian Tube Cancer, Stage IIB Ovarian Cancer, Stage IIB Ovarian Germ Cell Tumor, Stage IIC Fallopian Tube Cancer, Stage IIC Ovarian Cancer, Stage IIC Ovarian Germ Cell Tumor, Stage IIIA Fallopian Tube Cancer, Stage IIIA Ovarian Cancer, Stage IIIA Ovarian Germ Cell Tumor, Stage IIIA Primary Peritoneal Cancer, Stage IIIB Fallopian Tube Cancer, Stage IIIB Ovarian Cancer, Stage IIIB Ovarian Germ Cell Tumor, Stage IIIB Primary Peritoneal Cancer, Stage IIIC Fallopian Tube Cancer, Stage IIIC Ovarian Cancer, Stage IIIC Ovarian Germ Cell Tumor, Stage IIIC Primary Peritoneal Cancer, Stage IV Fallopian Tube Cancer, Stage IV Ovarian Cancer, Stage IV Ovarian Germ Cell Tumor, Stage IV Primary Peritoneal Cancer, Undifferentiated Ovarian Carcinoma
Interventions
Cognitive Assessment, Quality-of-Life Assessment
Procedure · Other
Lead sponsor
Gynecologic Oncology Group
Network
Eligibility
18 Years and older · Female only
Enrollment
247 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2018
U.S. locations
182
States / cities
Tucson, Arizona • Little Rock, Arkansas • Burbank, California + 129 more
Source: ClinicalTrials.gov public record
Updated Apr 12, 2018 · Synced Oct 22, 2026, 8:41 PM EDT
Recruiting Not applicable Interventional

Volatility in Paranoia (VIP) Trial: An RCT of Changes in Volatility With Psychotherapy

NCT06835556
View directory record Official record
Conditions
Schizophrenia Disorders
Interventions
Cognitive Behavioral Therapy, TAU
Behavioral
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 30, 2026 · Synced Oct 22, 2026, 8:41 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Changes in Inhibition and Valuation After Eating

NCT05995496
View directory record Official record
Conditions
Bulimia Nervosa
Interventions
Fasting state, Fed state, Magnetic Resonance Imaging
Other
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Oct 22, 2026, 8:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Neural Response to Food Stimuli: fMRI Changes Following Cognitive Behavioral Therapy for Binge Eating Disorder

NCT03604172
View directory record Official record
Conditions
Binge Eating Disorder, Overweight and Obesity
Interventions
Cognitive behavioral therapy, Waitlist
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 18, 2023 · Synced Oct 22, 2026, 8:41 PM EDT
Recruiting Phase 1Phase 2 Interventional

A Study Exploring Changes in a Variety of Biomarkers Following Dosing With MT1988 in Participants at Clinical High Risk for Psychosis

NCT07226895
View directory record Official record
Conditions
Clinical High Risk for Psychosis (CHR)
Interventions
MT1988 Low Dose, MT1988 High Dose, Placebo
Drug
Lead sponsor
Monument Therapeutics Limited
Industry
Eligibility
17 Years to 30 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
15
States / cities
Irvine, California • Los Angeles, California • San Francisco, California + 10 more
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Oct 22, 2026, 8:41 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Cognitive Testing in Diverse Populations to Further the Objective and Clinical Understanding of Cognivue Study

NCT05712005
View directory record Official record
Conditions
Cognitive Change
Interventions
Not listed
Lead sponsor
Cognivue, Inc.
Industry
Eligibility
18 Years and older
Enrollment
1,437 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 3, 2023 · Synced Oct 22, 2026, 8:41 PM EDT
Not listed Not applicable Interventional

Combination of Active or Placebo Attentional Bias Modification Treatment (ABMT) to Either Cognitive Behavioral Group Therapy (CBGT) or Psychoeducational Control Intervention (PCI) for Anxiety Disorders in Children

NCT01687764
View directory record Official record
Conditions
Generalized Anxiety Disorder, Separation Anxiety Disorder, Social Anxiety Disorder
Interventions
Attentional Bias Modification Treatment (ABMT) - Active, Attentional Bias Modification Treatment - Placebo, Cognitive Behavioral Group Therapy, Psychoeducational Control Intervention
Other · Behavioral
Lead sponsor
Hospital de Clinicas de Porto Alegre
Other
Eligibility
7 Years to 11 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 19, 2012 · Synced Oct 22, 2026, 8:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Acute Effects Fortified Nutritional Supplementation on Childhood Cognition

NCT02630667
View directory record Official record
Conditions
Cognitive Ability, General, Dietary Modification
Interventions
SLOW Carbohydrate, MEDIUM Carbohydrate, FAST Carbohydrate
Other
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
9 Years to 10 Years
Enrollment
113 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2012
U.S. locations
1
States / cities
Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 8, 2016 · Synced Oct 22, 2026, 8:41 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Atlas of Retinal Imaging in Alzheimer's Study

NCT03862222
View directory record Official record
Conditions
Alzheimer Disease, Mild Cognitive Impairment, Mild Dementia, Aging, Cognitive Change
Interventions
Retinal Imaging, Pupillometry, Contrast Sensitivity, Neuropsychological Evaluation, APOE genotyping, blood draw, Gait Assessment, Actigraphy
Other · Diagnostic Test · Genetic
Lead sponsor
University of Rhode Island
Other
Eligibility
55 Years to 80 Years
Enrollment
165 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
4
States / cities
Clearwater, Florida • St. Petersburg, Florida • Kingston, Rhode Island + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 5, 2025 · Synced Oct 22, 2026, 8:41 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Normative Database and Test-Retest Reliability for BrainCheck Assessments

NCT05497427
View directory record Official record
Conditions
Cognitive Change, Cognitive Decline, Cognitive Deterioration, Neurocognitive Deficit
Interventions
BrainCheck Assessment
Device
Lead sponsor
BrainCheck, Inc.
Other
Eligibility
50 Years and older
Enrollment
1,300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
5
States / cities
Palo Alto, California • Multiple Locations, Connecticut • Austin, Texas + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 2, 2026 · Synced Oct 22, 2026, 8:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of a Complex, Partnered Martial Arts-based Intervention on Cognitive Processing.

NCT05530148
View directory record Official record
Conditions
Cognitive Change, Processing, Visual Spatial
Interventions
Martial Arts Training Group, Flexing, Toning and Balance
Behavioral
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
18 Years to 45 Years
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated May 11, 2023 · Synced Oct 22, 2026, 8:41 PM EDT
Completed Not applicable Interventional

Interpretation Bias Modification Training for Social Anxiety Disorder

NCT07753538
View directory record Official record
Conditions
Social Anxiety Disorder (SAD)
Interventions
Interpretation Bias Modification Training, Stress Management Psychoeducation
Behavioral
Lead sponsor
University of Wisconsin, Milwaukee
Other
Eligibility
18 Years to 60 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Aug 7, 2026 · Synced Oct 22, 2026, 8:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Brain Exercises for Synaptic Plasticity

NCT03058055
View directory record Official record
Conditions
Cognitive Change
Interventions
Placebo, Origami, Reading
Behavioral
Lead sponsor
University of Kentucky
Other
Eligibility
65 Years and older
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Dec 19, 2017 · Synced Oct 22, 2026, 8:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Culturally Adapted Parenting Intervention for Spanish-Speaking Parents in Improving Outcomes of Younger Acute Lymphoblastic Leukemia or Acute Myeloid Leukemia Survivors at Risk for Late Neurocognitive Effects

NCT02559557
View directory record Official record
Conditions
Cancer Survivor, Childhood Acute Lymphoblastic Leukemia in Remission, Childhood Acute Myeloid Leukemia in Remission, Cognitive Side Effects of Cancer Therapy
Interventions
Educational Intervention, Quality-of-Life Assessment, Questionnaire Administration
Other
Lead sponsor
City of Hope Medical Center
Other
Eligibility
Not listed
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Duarte, California
Source: ClinicalTrials.gov public record
Updated Oct 9, 2026 · Synced Oct 22, 2026, 8:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of Brain Activity Changes After a Behavior Change Weight Loss Intervention

NCT04522245
View directory record Official record
Conditions
Obesity, Behavior, Health, Weight Loss
Interventions
Noom Healthy Weight; mobile behavior change program for weight loss., Matched Control
Behavioral · Other
Lead sponsor
Noom Inc.
Industry
Eligibility
18 Years to 60 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Commack, New York
Source: ClinicalTrials.gov public record
Updated Jul 20, 2021 · Synced Oct 22, 2026, 8:41 PM EDT
Not listed Not applicable Interventional

Non-exercise Physical Activity Intervention

NCT04410055
View directory record Official record
Conditions
Diabete Mellitus, Aging, Cognitive Change
Interventions
Sitting, Static standing, Dynamic standing
Behavioral
Lead sponsor
Science and Research Centre Koper
Other
Eligibility
65 Years to 80 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2022
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 1, 2020 · Synced Oct 22, 2026, 8:41 PM EDT