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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Completed Phase 2 Interventional

Depressed Mood Improvement Through Nicotine Dosing 3

NCT05746273
View directory record Official record
Conditions
Depressive Disorder
Interventions
Transdermal Nicotine Patch, Transdermal Placebo Patch
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
60 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Sep 3, 2026, 5:45 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Breast Cancer Survivorship & Work-Related Cognitive Limitation

NCT02303145
View directory record Official record
Conditions
Breast Cancer
Interventions
Not listed
Lead sponsor
Tara Emrani
Other
Eligibility
18 Years to 69 Years · Female only
Enrollment
187 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Apr 30, 2015 · Synced Sep 3, 2026, 5:45 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Radicle Energy VBMTM: A Study Assessing the Impact of Health and Wellness Products on Fatigue and Related Health Outcomes

NCT07653724
View directory record Official record
Conditions
Fatigue, Cognitive Function, Global Mental Health, Sleep Disturbance
Interventions
Energy Product Placebo Control, Energy Active Product 1
Dietary Supplement
Lead sponsor
Radicle Science
Industry
Eligibility
21 Years to 105 Years
Enrollment
550 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Del Mar, California
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Sep 3, 2026, 5:45 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Study to Investigate the Safety, Tolerability and Pharmacokinetics of SUVN-G3031 in Healthy Subjects

NCT02342041
View directory record Official record
Conditions
Cognitive Disorders
Interventions
SUVN-G3031, Placebo
Drug
Lead sponsor
Suven Life Sciences Limited
Industry
Eligibility
18 Years to 45 Years · Male only
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Oct 13, 2016 · Synced Sep 3, 2026, 5:45 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Clinical Study in Healthy Volunteers to Investigate the Neurocognitive Effects of a New Antiepileptic Drug: Brivaracetam

NCT00736931
View directory record Official record
Conditions
Epilepsy
Interventions
Brivaracetam, levetiracetam, lorazepam, placebo
Drug · Other
Lead sponsor
UCB Pharma
Industry
Eligibility
18 Years to 50 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated May 27, 2012 · Synced Sep 3, 2026, 5:45 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cognitive Effects of Citicoline on Attention in Healthy Mean and Women

NCT04967157
View directory record Official record
Conditions
Healthy
Interventions
Placebo supplement, Citicoline supplement
Dietary Supplement
Lead sponsor
Kirin Holdings Company, Limited
Industry
Eligibility
35 Years to 75 Years
Enrollment
148 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Addison, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 5, 2025 · Synced Sep 3, 2026, 5:45 AM EDT
Completed Not applicable Interventional Results available

Randomized Controlled Trial of Trauma-focused CBT in Tanzania and Kenya

NCT01822366
View directory record Official record
Conditions
Childhood Traumatic Grief, Post Traumatic Stress, Post Traumatic Stress Disorder, Depressive Symptoms, Behavioral Problems, Child Overall Daily Functioning, Child and Guardian Relationship
Interventions
Trauma-focused Cognitive Behavioral Therapy
Behavioral
Lead sponsor
Duke University
Other
Eligibility
7 Years to 13 Years
Enrollment
1,280 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 4, 2021 · Synced Sep 3, 2026, 5:45 AM EDT
Completed Phase 2 Interventional

Safety and Efficacy of MEM 1003 Versus Placebo in Patients With Mild to Moderate Alzheimer's Disease

NCT00257673
View directory record Official record
Conditions
Alzheimer's Disease
Interventions
MEM 1003, Placebo for MEM 1003
Drug
Lead sponsor
Memory Pharmaceuticals
Industry
Eligibility
50 Years to 90 Years
Enrollment
183 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
57
States / cities
Northport, Alabama • Mesa, Arizona • Phoenix, Arizona + 51 more
Source: ClinicalTrials.gov public record
Updated May 5, 2008 · Synced Sep 3, 2026, 5:45 AM EDT
Recruiting Phase 3 Interventional

A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease (MINDSET 2)

NCT06976203
View directory record Official record
Conditions
Alzheimer's Disease
Interventions
KarXT, KarX-EC, Placebo
Drug · Other
Lead sponsor
Bristol-Myers Squibb
Industry
Eligibility
60 Years to 85 Years
Enrollment
586 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
30
States / cities
Fullerton, California • Irvine, California • Los Angeles, California + 27 more
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Sep 3, 2026, 5:45 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Study to Evaluate the Effects of BPN14770 on Scopolamine-induced Cognitive Impairment in Healthy Volunteers

NCT03030105
View directory record Official record
Conditions
Alzheimer Disease
Interventions
BPN14770, BPN14770 placebo, Donepezil, Donepezil placebo, Scopolamine 0.6 MG/ML, Scopolamine placebo
Drug
Lead sponsor
Tetra Discovery Partners
Industry
Eligibility
18 Years to 55 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Oct 15, 2018 · Synced Sep 3, 2026, 5:45 AM EDT
Completed Phase 2 Interventional

Huperzine A in Alzheimer's Disease

NCT00083590
View directory record Official record
Conditions
Alzheimer Disease
Interventions
Huperzine A
Drug
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
55 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
29
States / cities
Birmingham, Alabama • Phoenix, Arizona • Irvine, California + 23 more
Source: ClinicalTrials.gov public record
Updated Feb 20, 2008 · Synced Sep 3, 2026, 5:45 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Using Combined EEG and Non-invasive Brain Stimulation to Examine and Improve Reward Functioning in Opioid Use Disorder

NCT04432493
View directory record Official record
Conditions
Opioid-use Disorder
Interventions
Active repetitive transcranial magnetic stimulation (rTMS), Sham repetitive transcranial magnetic stimulation (rTMS)
Device
Lead sponsor
Rutgers University
Other
Eligibility
18 Years to 55 Years
Enrollment
81 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 7, 2024 · Synced Sep 3, 2026, 5:45 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Enhancing Cognitive Abilities With Comprehensive Training

NCT02367898
View directory record Official record
Conditions
Cognitive Abilities
Interventions
Lumosity Cognitive Training, Crossword Puzzles
Other
Lead sponsor
Lumos Labs, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
11,470 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 10, 2015 · Synced Sep 3, 2026, 5:45 AM EDT
Completed Not applicable Interventional

Neural and Behavioral Effects of Cognitive Bias Modification (CBM)

NCT04430543
View directory record Official record
Conditions
Alcohol Drinking
Interventions
Cognitive Bias Modification, Sham Training
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years to 34 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 9, 2022 · Synced Sep 3, 2026, 5:45 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Adolescent Changes in Brain and Behavior in Boys and Girls With ADHD

NCT05927506
View directory record Official record
Conditions
ADHD, Attention Deficit Hyperactivity Disorder
Interventions
Other
Behavioral
Lead sponsor
Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Other
Eligibility
12 Years to 17 Years
Enrollment
312 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 19, 2025 · Synced Sep 3, 2026, 5:45 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Postural Control During Concurrent Cognitive Tasks During Optic Flow Stimulation

NCT05117463
View directory record Official record
Conditions
Aging, Postural Balance
Interventions
Optic Flow Stimulation, Auditory Reaction Time
Other
Lead sponsor
Chia-Cheng Lin, PhD, PT, MSPT
Other
Eligibility
25 Years to 85 Years
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Greenville, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 26, 2024 · Synced Sep 3, 2026, 5:45 AM EDT
Completed Not applicable Interventional Results available

The VRIF Trial: Hypoglycemia Reduction With Automated-Insulin Delivery System

NCT03674281
View directory record Official record
Conditions
Type 1 Diabetes Mellitus, Cognitive Change
Interventions
SAP, CLC
Device
Lead sponsor
University of Virginia
Other
Eligibility
6 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 11, 2021 · Synced Sep 3, 2026, 5:45 AM EDT
Completed Phase 3 Interventional

Study of EVP-6124 (Alpha-7 nAChR) as an Adjunctive Pro-Cognitive Treatment in Schizophrenia Subjects on Chronic Stable Atypical Antipsychotic Therapy

NCT01716975
View directory record Official record
Conditions
Schizophrenia, Impaired Cognition
Interventions
EVP-6124, Placebo
Drug
Lead sponsor
FORUM Pharmaceuticals Inc
Industry
Eligibility
18 Years to 50 Years
Enrollment
767 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
49
States / cities
Phoenixville, Arizona • Little Rock, Arkansas • Cerritos, California + 46 more
Source: ClinicalTrials.gov public record
Updated May 2, 2016 · Synced Sep 3, 2026, 5:45 AM EDT
Completed Not applicable Interventional

Gambling and Brief Interventions

NCT00183599
View directory record Official record
Conditions
Gambling
Interventions
5 Minutes of Simple Advice, Motivational Enhancement Therapy (MET), Cognitive Behavioral Therapy (CBT)
Behavioral
Lead sponsor
UConn Health
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2007
U.S. locations
6
States / cities
Bridgeport, Connecticut • Farmington, Connecticut • Hartford, Connecticut + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 8, 2019 · Synced Sep 3, 2026, 5:45 AM EDT
Active, not recruiting Not applicable Interventional

Brain Stimulation for Improving Cognition in Chronic Stroke (NEPTUNE)

NCT04655963
View directory record Official record
Conditions
Chronic Stroke
Interventions
Repetitive Transcranial Magnetic Stimulation (rTMS)
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
40 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Sep 3, 2026, 5:45 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Breaking Sitting with High-intensity Interval Training for Brain Health

NCT06243016
View directory record Official record
Conditions
Aging
Interventions
High-Intensity Interval Training (HIIT) Breaks to Sitting, Light-Intensity Interval Training (LIIT) Breaks to Sitting
Behavioral
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
40 Years to 75 Years
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 6, 2025 · Synced Sep 3, 2026, 5:45 AM EDT
Completed Phase 2 Interventional Results available

Efficacy and Safety of Armodafinil as Adjunctive Therapy in Schizophrenic Adults With Cognitive Deficits

NCT00487942
View directory record Official record
Conditions
Schizophrenia
Interventions
armodafinil, placebo
Drug
Lead sponsor
Cephalon
Industry
Eligibility
18 Years to 60 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007
U.S. locations
12
States / cities
Garden Grove, California • National City, California • Paramount, California + 9 more
Source: ClinicalTrials.gov public record
Updated Jul 18, 2013 · Synced Sep 3, 2026, 5:45 AM EDT
Completed Phase 2 Interventional Results available

Effect of Insulin Sensitizer Metformin on AD Biomarkers

NCT01965756
View directory record Official record
Conditions
Alzheimer's Disease, Vascular Dementia, Dementia, Memory Impairment
Interventions
Metformin, Placebos
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
55 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 20, 2017 · Synced Sep 3, 2026, 5:45 AM EDT
Completed Phase 1Phase 2 Interventional

Mindfulness-Based Cognitive Therapy for the Treatment of Chronic Headache Pain

NCT01213056
View directory record Official record
Conditions
Headache, Pain
Interventions
Mindfulness Based Cognitive Therapy
Behavioral
Lead sponsor
University of Alabama, Tuscaloosa
Other
Eligibility
19 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Tuscaloosa, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 1, 2015 · Synced Sep 3, 2026, 5:45 AM EDT