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ClinicalTrials.gov public records Last synced Oct 30, 2026, 4:53 AM EDT

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Showing 961–984 of 4,396 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Cognitive Disorders Clear all
Completed Phase 1 Interventional Results available

Safety, Tolerability and Immunogenicity of ACI-24 Vaccine in Adults With Down Syndrome

NCT02738450
View directory record Official record
Conditions
Down Syndrome
Interventions
ACI-24 low dose, ACI-24 high dose, Placebo
Biological
Lead sponsor
AC Immune SA
Industry
Eligibility
25 Years to 45 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
4
States / cities
Phoenix, Arizona • La Jolla, California • Baltimore, Maryland + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 15, 2021 · Synced Oct 30, 2026, 4:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Enhancing Quality of Life for Older Adults With and Without Mild Cognitive Impairment (MCI) Through Social Engagement Over Video Technology

NCT05380180
View directory record Official record
Conditions
Aging, Mild Cognitive Impairment, Aging Well
Interventions
OneClick Social Engagement Intervention, OneClick Social Engagement Intervention Extension
Other
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
65 Years and older
Enrollment
99 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
2
States / cities
Champaign, Illinois • Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced Oct 30, 2026, 4:53 AM EDT
Completed Early Phase 1 Interventional Results available

Bicarbonate Administration and Cognitive Function in Midlife and Older Adults With CKD

NCT04600323
View directory record Official record
Conditions
Metabolic Acidosis, Chronic Kidney Disease, Cognitive Dysfunction
Interventions
Sodium Bicarbonate Tablets, Placebo
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
50 Years to 70 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Dec 20, 2024 · Synced Oct 30, 2026, 4:53 AM EDT
Completed Not applicable Interventional

Identifying the Neural Signature of Exercise to Advance Treatment of PD Cognitive Declines

NCT05972759
View directory record Official record
Conditions
Parkinson Disease
Interventions
Forced and voluntary exercise
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 16, 2026 · Synced Oct 30, 2026, 4:53 AM EDT
Completed Not applicable Interventional Results available

Prevention of Early Postoperative Decline

NCT02908464
View directory record Official record
Conditions
Delirium, Postoperative Cognitive Dysfunction
Interventions
Lumosity
Device
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
60 Years to 90 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 16, 2020 · Synced Oct 30, 2026, 4:53 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

The Impact of Memantine on Electroconvulsive Therapy (ECT): Will it Improve Response and Protect Against Cognitive Problems?

NCT00988663
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
memantine, Placebo
Drug
Lead sponsor
Jerrry L Lewis
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2009
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 24, 2017 · Synced Oct 30, 2026, 4:53 AM EDT
Completed Phase 1 Interventional

Cognitive Behavioral Therapy Plus Motivational Interviewing for Treatment of Obsessive-Compulsive Disorder

NCT00316316
View directory record Official record
Conditions
Obsessive-Compulsive Disorder
Interventions
Motivational interviewing plus exposure and response prevention (MI plus EX/RP), Exposure and response prevention (EX/RP)
Behavioral
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 16, 2012 · Synced Oct 30, 2026, 4:53 AM EDT
Recruiting Not applicable Interventional

Enhancing Diabetes Care by Treating Insomnia

NCT07062406
View directory record Official record
Conditions
Diabetes Type 2, Insomnia
Interventions
Cognitive Behavioral Therapy for Insomnia, Usual care for diabetes management, Usual care for treatment of insomnia
Behavioral · Other
Lead sponsor
Tulane University
Other
Eligibility
40 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Zachary, Louisiana
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Oct 30, 2026, 4:53 AM EDT
Completed Not applicable Interventional

Innovative Cognitive Impairment Case Finding and Engagement for Diverse Participation in Alzheimer's Disease Care, Treatment, And Research

NCT07016178
View directory record Official record
Conditions
Mild Cognitive Impairment (MCI), Alzheimer Disease, Alzheimer's Disease (Incl Subtypes), Dementia, Cognitive Decline
Interventions
Acceptability and Feasibility of Twistle messaging for PDM+ patients
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
65 Years and older
Enrollment
3,454 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 4, 2026 · Synced Oct 30, 2026, 4:53 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Velocardiofacial (VCFS; 22q11.2; DiGeorge) Syndrome Study

NCT00105274
View directory record Official record
Conditions
DiGeorge Syndrome, Velocardiofacial Syndrome, 22q11.2 Syndrome
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 50 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2010
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Oct 30, 2026, 4:53 AM EDT
Completed Not applicable Interventional

Accelerated Neuromodulation to Alleviate Cognitive Deficits Due to Cancer Therapy

NCT04966520
View directory record Official record
Conditions
Cancer
Interventions
Accelerated repetitive intermittent theta-burst transcranial stimulation (iTBS)
Other
Lead sponsor
Sneha Phadke
Other
Eligibility
18 Years to 99 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Feb 10, 2026 · Synced Oct 30, 2026, 4:53 AM EDT
Completed No phase listed Observational Results available

Parkinson Disease and DBS: Cognitive Effects in GBA Mutation Carriers

NCT03234478
View directory record Official record
Conditions
Parkinson, Parkinson Disease, Genetic Predisposition, GBA Gene Mutation, Cognitive Decline
Interventions
Not listed
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
30 Years to 75 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Jul 29, 2026 · Synced Oct 30, 2026, 4:53 AM EDT
Recruiting Not applicable Interventional

Cognitive Training for Emotion Regulation in Psychotic Disorders

NCT04414215
View directory record Official record
Conditions
Schizophrenia, Schizo Affective Disorder
Interventions
Emotional working memory training, Placebo working memory training
Behavioral
Lead sponsor
University of Georgia
Other
Eligibility
18 Years to 60 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2029
U.S. locations
1
States / cities
Athens, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 5, 2025 · Synced Oct 30, 2026, 4:53 AM EDT
Completed Not applicable Interventional

Brain Imaging, Cognitive Enhancement and Early Schizophrenia

NCT01561859
View directory record Official record
Conditions
Schizophrenia, Schizoaffective Disorder
Interventions
Cognitive Enhancement Therapy, Enriched Supportive Therapy
Behavioral
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years to 55 Years
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
5
States / cities
Boston, Massachusetts • Cambridge, Massachusetts • Charlestown, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 26, 2021 · Synced Oct 30, 2026, 4:53 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

The Effects of Nicotine on Cognition in Schizophrenia

NCT00383747
View directory record Official record
Conditions
Schizophrenia
Interventions
Transdermal Nicotine Patch
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 60 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 28, 2017 · Synced Oct 30, 2026, 4:53 AM EDT
Completed Not applicable Interventional Results available

Treating People With Post-Traumatic Stress Disorder With Cognitive Behavioral Therapy for Insomnia

NCT00881647
View directory record Official record
Conditions
Post-Traumatic Stress Disorder
Interventions
Cognitive Behavioral Treatment for Insomnia (CBT-I)
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 65 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 17, 2014 · Synced Oct 30, 2026, 4:53 AM EDT
Completed Phase 2 Interventional Results available

D-serine and Cognitive Remediation in Schizophrenia

NCT02156908
View directory record Official record
Conditions
Schizophrenia
Interventions
D-serine
Drug
Lead sponsor
Nathan Kline Institute for Psychiatric Research
Other
Eligibility
18 Years to 64 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Orangeburg, New York
Source: ClinicalTrials.gov public record
Updated Oct 8, 2020 · Synced Oct 30, 2026, 4:53 AM EDT
Completed Phase 1 Interventional

Desensitization and Cognitive Therapy in General Anxiety.

NCT00951340
View directory record Official record
Conditions
Generalized Anxiety Disorder
Interventions
Cognitive behavioral therapy (CBT), Emotional processing and interpersonal therapy, Listening therapy
Other · Behavioral
Lead sponsor
Penn State University
Other
Eligibility
18 Years to 65 Years
Enrollment
21 participants
Timeline
1996 – 1998
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 20, 2017 · Synced Oct 30, 2026, 4:53 AM EDT
Completed Not applicable Interventional Results available

Talk Therapy by Phone to Promote Treatment for Alcohol Problems

NCT03758274
View directory record Official record
Conditions
Alcohol Use Disorder, Alcohol Abuse
Interventions
CBT by Phone to Promote Treatment, Reading the Subject a Pamphlet on Obtaining Alcohol Use Disorder Treatment
Behavioral · Other
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Oct 4, 2023 · Synced Oct 30, 2026, 4:53 AM EDT
Terminated Phase 2 Interventional

Safety and Efficacy of OMS643762 in Subjects With Huntington's Disease

NCT02074410
View directory record Official record
Conditions
Huntington's Disease
Interventions
OMS643762, Placebo
Drug
Lead sponsor
Omeros Corporation
Industry
Eligibility
18 Years to 65 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
9
States / cities
San Diego, California • Englewood, Colorado • Gainesville, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Oct 22, 2018 · Synced Oct 30, 2026, 4:53 AM EDT
Recruiting Phase 2 Interventional

Assessment of Foralumab Safety and Modulation of Microglial Activation in Alzheimer's Disease

NCT06489548
View directory record Official record
Conditions
Dementia, Alzheimers Disease, Mild Cognitive Impairment Due to Alzheimer's Disease
Interventions
Foralumab TZLS-401 50 µg, Foralumab TZLS-401 100 µg
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
60 Years to 85 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Oct 30, 2026, 4:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Hypercapnia: Cognitive Effects and Monitoring

NCT01782625
View directory record Official record
Conditions
Hypercapnia, Exercise, Nitrogen Narcosis, Diving, Immersion
Interventions
NO exercise at depth, exercise at depth
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 50 Years · Male only
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 25, 2016 · Synced Oct 30, 2026, 4:53 AM EDT
Terminated Not applicable Interventional

Augmenting Internet-Based Cognitive Behavioral Therapy for Major Depressive Disorder With Low-Level Light Therapy

NCT02898233
View directory record Official record
Conditions
Depression
Interventions
Deprexis, Active low-level light therapy, Sham low-level light therapy
Other · Device
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 45 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jul 25, 2024 · Synced Oct 30, 2026, 4:53 AM EDT
Completed Not applicable Interventional

The Use of Rhythmic Light Therapy in Mild Cognitive Impairment

NCT07318038
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Flickering Light
Device
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
55 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Oct 30, 2026, 4:53 AM EDT