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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Completed Phase 3 Interventional

A Study of LY3298176 (Tirzepatide) For the Maintenance of Body Weight Reduction in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities

NCT06047548
View directory record Official record
Conditions
Overweight, Obesity
Interventions
Tirzepatide, Placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years and older
Enrollment
441 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
20
States / cities
Pelham, Alabama • Los Angeles, California • Santa Ana, California + 17 more
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Jul 23, 2026, 10:59 PM EDT
Not yet recruiting Phase 2 Interventional

A Study of Weekly Oral Dose of Ecnoglutide (VRB-101) for Weight Maintenance in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities

NCT07553299
View directory record Official record
Conditions
Obesity, Overweight, Weight Maintenance
Interventions
VRB-101, Placebo
Drug
Lead sponsor
Verdiva Bio Dev Limited
Industry
Eligibility
18 Years to 80 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
17
States / cities
Cullman, Alabama • Phoenix, Arizona • Tempe, Arizona + 13 more
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Jul 23, 2026, 10:59 PM EDT
Not yet recruiting Not applicable Interventional

Theoretically Informed Behavioral Intervention

NCT06580184
View directory record Official record
Conditions
HIV, CVD, Metabolic Disease
Interventions
LEARN 2 Platform
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older · Male only
Enrollment
164 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Orange, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 15, 2026 · Synced Jul 23, 2026, 10:59 PM EDT
Completed Not applicable Interventional Results available

Family-Based Treatment for Type 1 Diabetes

NCT05756361
View directory record Official record
Conditions
Diabetes Mellitus, Type 1, Obesity, Childhood, Overweight, Comorbidities and Coexisting Conditions
Interventions
Family-Based Treatment for T1D
Behavioral
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
6 Years to 17 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Jul 23, 2026, 10:59 PM EDT
Completed Not applicable Interventional

Testing an Internet-Based Intervention for Preventing Eating Disorders

NCT00934583
View directory record Official record
Conditions
Eating Disorders
Interventions
Image and Mood (IaM) program
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 25 Years · Female only
Enrollment
549 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
2
States / cities
Stanford, California • St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 16, 2020 · Synced Jul 23, 2026, 10:59 PM EDT
Recruiting Not applicable Interventional

Mindfulness-based Cognitive Therapy vs the Health Enhancement Program for Chronic Pain and Depression; The Quiet Focus Study

NCT07118722
View directory record Official record
Conditions
Chronic Pain, Depression
Interventions
Quiet Focus, Health Enhancement Program
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
50 Years to 120 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 1, 2025 · Synced Jul 23, 2026, 10:59 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Psychological Treatment of Overweight Binge Eaters

NCT01208272
View directory record Official record
Conditions
Binge Eating Disorder, Cognitive Therapy/Methods, Mental Disorders/Epidemiology, Obesity/Epidemiology, Obesity/Therapy
Interventions
Cognitive Behavioral Therapy (CBT), Interpersonal Therapy (IPT)
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 65 Years
Enrollment
162 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1994 – 1999
U.S. locations
2
States / cities
New Haaven, Connecticut • New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 22, 2010 · Synced Jul 23, 2026, 10:59 PM EDT
Completed Not applicable Interventional Results available

Mindfulness-based Cognitive Therapy for the Chronic Pain-early Cognitive Decline Co-morbidity Among Older Black Individuals in the Community; The Feeling of Being Open Pilot

NCT07210398
View directory record Official record
Conditions
Chronic Pain, Early Cognitive Decline
Interventions
Mindfulness-based cognitive therapy
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
50 Years to 120 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 28, 2026 · Synced Jul 23, 2026, 10:59 PM EDT
Completed Not applicable Interventional

Web-based vs In-person Personalized Feedback Intervention for Comorbid Substance Use and Disordered Gambling

NCT01529047
View directory record Official record
Conditions
Gambling, Alcohol Consumption, Cannabis
Interventions
Personalized Feedback Intervention
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
17 Years to 24 Years
Enrollment
361 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 26, 2023 · Synced Jul 23, 2026, 10:59 PM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

The Role of Gut Microbiome in Predicting Comorbidities and Complications in Children With Inflammatory Bowel Disease

NCT05652491
View directory record Official record
Conditions
Inflammatory Bowel Disease, Crohn's Disease, Ulcerative Colitis
Interventions
Not listed
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
Up to 20 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
2
States / cities
Bethesda, Maryland • Falls Church, Virginia
Source: ClinicalTrials.gov public record
Updated May 31, 2023 · Synced Jul 23, 2026, 10:59 PM EDT
Completed Phase 3 Interventional Results available

A Study of Tirzepatide (LY3298176) In Participants After A Lifestyle Weight Loss Program

NCT04657016
View directory record Official record
Conditions
Obesity, Overweight
Interventions
Tirzepatide, Placebo
Drug · Other
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years and older
Enrollment
579 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
45
States / cities
Huntington Park, California • Los Angeles, California • Montclair, California + 42 more
Source: ClinicalTrials.gov public record
Updated May 15, 2024 · Synced Jul 23, 2026, 10:59 PM EDT
Completed Not applicable Interventional

Comorbidity Screening and Referral by Prosthetists

NCT05410548
View directory record Official record
Conditions
Limb Ischemia, Low Back Pain, Depression, Neuropathy;Peripheral, Amputation
Interventions
Standard-of-Care, Clinical Screening
Other
Lead sponsor
University of Delaware
Other
Eligibility
18 Years to 85 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Dec 30, 2025 · Synced Jul 23, 2026, 10:59 PM EDT
Active, not recruiting Phase 2 Interventional

A Study to Assess Efficacy, Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7204239 in Combination With Tirzepatide in Participants With Obesity or Overweight With At Least One Weight-related Comorbidity

NCT06965413
View directory record Official record
Conditions
Obesity, Overweight, Overweight With One Weight Related Comorbidity
Interventions
RO7204239, RO7204239 Matching Placebo, Tirzepatide
Drug
Lead sponsor
Hoffmann-La Roche
Industry
Eligibility
18 Years and older
Enrollment
285 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
19
States / cities
Anniston, Alabama • Spring Valley, California • Clermont, Florida + 16 more
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced Jul 23, 2026, 10:59 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Preventing Tipping Points in High Comorbidity Patients: A Lifeline From Health Coaches

NCT04176510
View directory record Official record
Conditions
Comorbidity, Self-Management
Interventions
Health Coach Intervention
Behavioral
Lead sponsor
Clinical Directors Network
Network
Eligibility
18 Years and older
Enrollment
1,920 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
4
States / cities
Chicago, Illinois • Brooklyn, New York • New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 7, 2023 · Synced Jul 23, 2026, 10:59 PM EDT
Recruiting Not applicable Interventional

Human Immunodeficiency Virus (HIV) Food Insecurities

NCT04943861
View directory record Official record
Conditions
Food Insecurities, Cardiometabolic Comorbidities, HIV, PreDiabetes, Type 2 Diabetes Mellitus (T2DM)
Interventions
weCare/Secure, Usual Care
Behavioral · Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Jul 23, 2026, 10:59 PM EDT
Completed Not applicable Interventional

Treatment for Comorbid Social Anxiety and Alcohol Use Disorders.

NCT03428490
View directory record Official record
Conditions
Alcohol Use Disorder, Social Anxiety Disorder
Interventions
Fully integrated treatment, Stand-alone Intensive Outpatient Program
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 31, 2022 · Synced Jul 23, 2026, 10:59 PM EDT
Completed Phase 3 Interventional Results available

A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight With Weight Related Comorbidities

NCT05822830
View directory record Official record
Conditions
Obesity, Overweight
Interventions
Tirzepatide, Semaglutide
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years and older
Enrollment
751 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
30
States / cities
Birmingham, Alabama • Pelham, Alabama • Santa Ana, California + 24 more
Source: ClinicalTrials.gov public record
Updated Nov 25, 2025 · Synced Jul 23, 2026, 10:59 PM EDT
Recruiting Phase 3 Interventional

Efficacy and Safety of Ribupatide in Participants Living With Obesity or Overweight With Weight-Related Comorbidities Who Do Not Have Diabetes

NCT07284875
View directory record Official record
Conditions
Obesity, Overweight
Interventions
Ribupatide, Placebo
Drug
Lead sponsor
Kailera
Industry
Eligibility
18 Years and older
Enrollment
2,340 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
24
States / cities
Anniston, Alabama • Birmingham, Alabama • Cullman, Alabama + 21 more
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Jul 23, 2026, 10:59 PM EDT
Completed Phase 4 Interventional Results available

Acamprosate vs. Placebo in Bipolar Alcoholics

NCT00466661
View directory record Official record
Conditions
Alcohol Dependence, Bipolar Disorder
Interventions
Acamprosate, Placebo
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Dec 13, 2018 · Synced Jul 23, 2026, 10:59 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Drug /Cue Interactions In Alcohol-Tobacco Comorbidity

NCT00816231
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Tobacco, Alcoholic Beverage, Placebo
Behavioral · Other
Lead sponsor
H. Lee Moffitt Cancer Center and Research Institute
Other
Eligibility
21 Years to 55 Years
Enrollment
244 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2019
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Sep 5, 2019 · Synced Jul 23, 2026, 10:59 PM EDT
Terminated Not applicable Interventional Results available

Activity and Balanced Eating to Reduce Comorbidities and Symptoms of MS

NCT03808545
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
Behavioral Intervention for Physical Activity in Multiple Sclerosis (BIPAMS), BIPAMS + Diet
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 65 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Nov 17, 2022 · Synced Jul 23, 2026, 10:59 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

The Cancer Stage Shifting Initiative: Registry and Biorepository to Research and Address Health Disparities in Cancer Care

NCT07461493
View directory record Official record
Conditions
Cancer, Cancer Comorbidities
Interventions
Not listed
Lead sponsor
National Minority Quality Forum
Other
Eligibility
35 Years and older
Enrollment
100,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2039
U.S. locations
2
States / cities
Flint, Michigan • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Jul 23, 2026, 10:59 PM EDT
Completed No phase listed Observational

Composite Health Assessment Risk Model (CHARM) for Older Adults (BMT CTN 1704)

NCT03992352
View directory record Official record
Conditions
Hematologic Malignancy
Interventions
Age 60+ with planned HCT for Hematologic Malignancy
Diagnostic Test
Lead sponsor
Center for International Blood and Marrow Transplant Research
Network
Eligibility
60 Years and older
Enrollment
1,229 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
50
States / cities
Phoenix, Arizona • Duarte, California • San Francisco, California + 41 more
Source: ClinicalTrials.gov public record
Updated Feb 5, 2024 · Synced Jul 23, 2026, 10:59 PM EDT
Completed Phase 2 Interventional

A Study in Participants With Obesity or Overweight With at Least One Weight-related Comorbidity

NCT06595238
View directory record Official record
Conditions
Obesity or Overweight
Interventions
AZD6234, Placebo comparator
Drug
Lead sponsor
AstraZeneca
Industry
Eligibility
18 Years to 75 Years
Enrollment
262 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
23
States / cities
Mobile, Alabama • Phoenix, Arizona • Long Beach, California + 19 more
Source: ClinicalTrials.gov public record
Updated Jul 19, 2026 · Synced Jul 23, 2026, 10:59 PM EDT