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ClinicalTrials.gov public records Last synced Oct 8, 2026, 6:48 PM EDT

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Showing 97–120 of 201 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Complications Arthroplasty Clear all
Recruiting Phase 4 Interventional

Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplasty

NCT06083480
View directory record Official record
Conditions
Osteoarthritis, Knee, Total Knee Arthroplasty, Chronic Postsurgical Pain
Interventions
GlyNAC (combination of glycine and n-acetylcysteine), Placebo
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
50 Years and older
Enrollment
148 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 11, 2025 · Synced Oct 8, 2026, 6:48 PM EDT
Recruiting Phase 4 Interventional

Continuous Versus Single Injection Adductor Canal Blocks for Outpatient Total Knee Arthroplasty

NCT06784882
View directory record Official record
Conditions
Acute Postoperative Pain, Surgery
Interventions
continuous peripheral nerve block with OnQ pump, single injection nerve block
Device · Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jun 17, 2025 · Synced Oct 8, 2026, 6:48 PM EDT
Completed Phase 2 Interventional

Study to Evaluate Safety/Efficacy of a Single Preop Dose of AYX1 Injection to Treat Pain After Knee Replacement Surgery

NCT02807428
View directory record Official record
Conditions
Post-surgical Pain
Interventions
AYX1 Injection 660 mg/6 mL, Placebo Injection 6 mL
Drug
Lead sponsor
Adynxx, Inc.
Industry
Eligibility
40 Years and older
Enrollment
210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
9
States / cities
Birmingham, Alabama • Sheffield, Alabama • Phoenix, Arizona + 6 more
Source: ClinicalTrials.gov public record
Updated Oct 17, 2018 · Synced Oct 8, 2026, 6:48 PM EDT
Completed Early Phase 1 Interventional

Single Injection Adductor Canal Block Versus Continuous Adductor Canal Infusion for Total Knee Arthroplasty

NCT02991404
View directory record Official record
Conditions
Total Knee Arthroplasty, Pain, Postoperative, Adductor Canal Block
Interventions
Multimodal Peripheral Nerve Block Injection, Single Shot Adductor Canal Block, Initial Bolus, Continuous infusion
Procedure · Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 90 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 5, 2018 · Synced Oct 8, 2026, 6:48 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Clinical Evaluation of the Next Science SurgX Antimicrobial Wound Gel Impact on Surgical Site Complications

NCT05517278
View directory record Official record
Conditions
Total Hip Arthroplasty, Total Knee Arthroplasty
Interventions
SurgX Antimicrobial Wound Gel, Standard of Care
Other
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
3
States / cities
Manhasset, New York • New Hyde Park, New York • New York, New York
Source: ClinicalTrials.gov public record
Updated May 23, 2025 · Synced Oct 8, 2026, 6:48 PM EDT
Completed Not applicable Interventional Results available

Ultrasound-guided Fascia Iliaca Compartment Block Versus Periarticular Infiltration

NCT02658240
View directory record Official record
Conditions
Postoperative Pain
Interventions
Ropivacaine, Epinephrine
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Nov 29, 2018 · Synced Oct 8, 2026, 6:48 PM EDT
Withdrawn Not applicable Interventional

Adductor Canal Nerve Block Following Total Knee Arthroplasty

NCT01939379
View directory record Official record
Conditions
Post-op Pain
Interventions
Morphine PCA started at the end of surgery, 1 Percocet 1/325mg every 4 hours; may receive a second Percocet if needed., For the 30ml ropivacaine the intervention would be the subject can request extra pain medication which would be Percocet and/or morphine PCA.
Drug
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 99 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Apr 20, 2021 · Synced Oct 8, 2026, 6:48 PM EDT
Completed Phase 4 Interventional Results available

LIBERATE - LIposomal Bupivacaine vERsus Adjuncts in Total shouldErs

NCT03887650
View directory record Official record
Conditions
Post-operative Pain, Total Shoulder Arthroplasty, Osteoarthritis of the Shoulder, Pain Management
Interventions
Liposomal Bupivicaine 1.3%, Bupivacaine 0.5%
Drug
Lead sponsor
Hartford Hospital
Other
Eligibility
18 Years to 100 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 15, 2023 · Synced Oct 8, 2026, 6:48 PM EDT
Not listed Not applicable Interventional

A Comparative Study to Assess the Prevention of Surgical Site Infection (SSI's) in Revision Total Joint Arthroplasty Patients Treated With Single-Use Negative Pressure Wound Therapy (PICO™) or Standard Care Dressings (AQUACEL® Ag SURGICAL Dressing)

NCT02664168
View directory record Official record
Conditions
Surgical Wound Infection
Interventions
Aquacel Ag Surgical Dressing, Single-Use Negative Pressure Wound Therapy (PICO)
Device
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2016
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 12, 2018 · Synced Oct 8, 2026, 6:48 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Duloxetine RCT on Postop TKA Outcomes

NCT05086393
View directory record Official record
Conditions
Pain, Postoperative, Total Knee Arthroplasty
Interventions
Duloxetine, Placebos
Drug
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
241 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 14, 2025 · Synced Oct 8, 2026, 6:48 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Tourniquet Pressure in Primary Total Knee Arthroplasty

NCT02830087
View directory record Official record
Conditions
Tourniquets, Knee Arthroplasty, Total, Knee Replacement, Total
Interventions
Tourniquet Cuff Pressure
Procedure
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 80 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
2
States / cities
Bermuda Run, North Carolina • Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 19, 2018 · Synced Oct 8, 2026, 6:48 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Microcurrent Stimulation Reduces Post-Operative Swelling and Healing Time Following Knee Replacement Surgery

NCT02623660
View directory record Official record
Conditions
Osteoarthritis of Knee, Edema, Wounds and Injuries
Interventions
ODIN1, Standard Care, Diagnostic Device Testing
Device · Other
Lead sponsor
Bioelectric Research Corporation
Industry
Eligibility
18 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
2
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jan 12, 2016 · Synced Oct 8, 2026, 6:48 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

CMP vs Fascia Iliaca Block

NCT04426058
View directory record Official record
Conditions
Pain, Postoperative, Hip Arthroplasty
Interventions
CMP, Fascia Illica
Drug
Lead sponsor
Loyola University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 20, 2022 · Synced Oct 8, 2026, 6:48 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

A Study to Evaluate the Outcomes of Cannabinoid (CBD) Roll-on Topical Stick in Primary Total Knee Arthroplasty

NCT04585230
View directory record Official record
Conditions
Pain, Joint, Pain, Postoperative, Total Knee Arthroplasty
Interventions
CBD, Mineral Oil, Placebo
Drug
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years to 80 Years
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 19, 2020 · Synced Oct 8, 2026, 6:48 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Comparison of Negative Pressure Wound Therapy vs. Conventional Dressings for Prevention of Wound Complications After Revision THA

NCT03321799
View directory record Official record
Conditions
Infection, Drainage
Interventions
Negative Pressure Wound Therapy (NPWT), Sterile Antimicrobial Dressings
Device
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
201 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 6, 2025 · Synced Oct 8, 2026, 6:48 PM EDT
Withdrawn Phase 4 Interventional

Liposomal Bupivacaine in Total Knee Arthroplasty

NCT02426164
View directory record Official record
Conditions
Pain, Postoperative, Arthroplasty, Replacement, Knee, Osteoarthritis
Interventions
Liposomal bupivacaine, bupivacaine HCl, morphine, epinephrine, methylprednisolone
Drug
Lead sponsor
Miller Orthopedic Specialists
Other
Eligibility
18 Years to 90 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Council Bluffs, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 22, 2016 · Synced Oct 8, 2026, 6:48 PM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Comparison of Interscalene Catheter to Single Injection Interscalene Blocks for Total Shoulder Arthroplasties

NCT05868330
View directory record Official record
Conditions
Post Operative Pain, Anesthesia, Nerve Block, Shoulder Osteoarthritis
Interventions
Interscalene Catheter, Exparel Single Shot Interscalene Block
Procedure
Lead sponsor
Melinda Seering
Other
Eligibility
18 Years to 90 Years
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Nov 10, 2025 · Synced Oct 8, 2026, 6:48 PM EDT
Completed Phase 4 Interventional Results available

Optimizing Local Anesthetic Concentration for Continuous Femoral Nerve Blocks

NCT00923598
View directory record Official record
Conditions
Total Knee Arthroplasty, Knee Pain
Interventions
0.1% and 0.4% perineural ropivicaine
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 2, 2019 · Synced Oct 8, 2026, 6:48 PM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Addition of Clonidine to Ropivacaine in Adductor Canal Block

NCT03057015
View directory record Official record
Conditions
Postoperative Pain
Interventions
Clonidine, Placebo, Ropivacaine, Dexamethasone, Epinephrine
Drug
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated May 3, 2018 · Synced Oct 8, 2026, 6:48 PM EDT
Enrolling by invitation Phase 4 Interventional

Efficacy And Safety Of Tramadol And Oxycodone Versus Oxycodone Monotherapy For Pain Control After Primary Total Knee And Total Hip Arthroplasty

NCT07153003
View directory record Official record
Conditions
Post Operative Pain
Interventions
Oxycodone, Tramadol and Oxycodone
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
560 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 18, 2026 · Synced Oct 8, 2026, 6:48 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Dexamethasone in Total Knee Arthroplasty

NCT05018091
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Dexamethasone 4mg, Dexamethasone 8 Mg/mL Injectable Suspension, Dexamethasone 16mg
Drug
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
438 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
10
States / cities
Redwood City, California • San Francisco, California • Chicago, Illinois + 5 more
Source: ClinicalTrials.gov public record
Updated Aug 3, 2026 · Synced Oct 8, 2026, 6:48 PM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Effects of Oral Tranexamic Acid Following Total Knee Arthroplasty

NCT06479161
View directory record Official record
Conditions
Postoperative Pain
Interventions
Tranexamic acid
Drug
Lead sponsor
Matthew Grosso, MD
Other
Eligibility
18 Years to 89 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 13, 2024 · Synced Oct 8, 2026, 6:48 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

NSS-2-BRIDGE Study for Total Knee and Hip Arthroplasties, Bariatric, and Kidney Transplant Surgeries

NCT03834142
View directory record Official record
Conditions
Acute Pain, Arthropathy of Knee, Arthropathy of Hip, Pain, Postoperative, Kidney Transplant Donor, Bariatric Surgery Candidate
Interventions
NSS-2 Bridge
Device
Lead sponsor
Jacques E. Chelly
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
3
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 3, 2022 · Synced Oct 8, 2026, 6:48 PM EDT
Recruiting Not applicable Interventional

The Benefits Of Cryoablation In Patients Undergoing Total Knee Arthroplasty

NCT06991231
View directory record Official record
Conditions
Post-Operative Pain, Total Knee Arthroplasty
Interventions
Total knee arthroplasty (TKA), Cryoablation
Procedure · Device
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
215 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 3, 2026 · Synced Oct 8, 2026, 6:48 PM EDT