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ClinicalTrials.gov public records Last synced Sep 23, 2026, 9:13 PM EDT

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Showing 1–24 of 633 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Complications of Prematurity Clear all
Active, not recruiting Phase 3 Interventional Results available

Management of the PDA Trial

NCT03456336
View directory record Official record
Conditions
Infant, Premature, Patent Ductus Arteriosus, Infant, Newborn, Diseases, Patent Ductus Arteriosus After Premature Birth
Interventions
Active Treatment, Expectant Management
Other
Lead sponsor
NICHD Neonatal Research Network
Network
Eligibility
48 Hours to 21 Days
Enrollment
482 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
19
States / cities
Birmingham, Alabama • Palo Alto, California • San Diego, California + 15 more
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Sep 23, 2026, 9:13 PM EDT
Not listed No phase listed Observational

Vibroacoustic Study of Lung Development in Newborn Infants

NCT05827250
View directory record Official record
Conditions
Prematurity, Premature Birth, Premature Lungs, Prematurity; Extreme
Interventions
imPulse Tor
Device
Lead sponsor
Level 42 AI, Inc.
Industry
Eligibility
0 Years to 2 Years
Enrollment
200 participants
Timeline
2023 – 2025
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Apr 24, 2023 · Synced Sep 23, 2026, 9:13 PM EDT
Completed Not applicable Interventional Results available

Duration of Continuous Positive Airway Pressure and Pulmonary Function Testing in Preterm Infants

NCT02249143
View directory record Official record
Conditions
Respiratory Distress Syndrome, Bronchopulmonary Dysplasia
Interventions
CPAP and room air
Device
Lead sponsor
Oregon Health and Science University
Other
Eligibility
Up to 1 Year
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Aug 28, 2019 · Synced Sep 23, 2026, 9:13 PM EDT
Completed Phase 3 Interventional Results available

Hydrocortisone for BPD

NCT01353313
View directory record Official record
Conditions
Infant, Newborn, Infant, Small for Gestational Age, Infant, Very Low Birth Weight, Infant, Premature, Bronchopulmonary Dysplasia
Interventions
Hydrocortisone, Placebo
Drug
Lead sponsor
NICHD Neonatal Research Network
Network
Eligibility
Up to 30 Weeks
Enrollment
800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2024
U.S. locations
20
States / cities
Birmingham, Alabama • Los Angeles, California • Palo Alto, California + 16 more
Source: ClinicalTrials.gov public record
Updated Feb 26, 2025 · Synced Sep 23, 2026, 9:13 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Childhood Outcomes of Preterm Brain Abnormalities

NCT03410810
View directory record Official record
Conditions
Premature Birth, Neurodevelopmental Disorders, Brain Development Abnormality, Brain Lesion
Interventions
MRI, Neurodevelopmental/Neuropsychological Assessment
Diagnostic Test
Lead sponsor
Children's Hospital Los Angeles
Other
Eligibility
Up to 8 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 9, 2024 · Synced Sep 23, 2026, 9:13 PM EDT
Not listed Not applicable Interventional

A Study to Evaluate the Efficacy of Seattle-PAP for the Respiratory Support of Premature Infants

NCT03085329
View directory record Official record
Conditions
Premature Birth
Interventions
Seattle-PAP, Conventional bubble nasal CPAP
Device
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
Up to 30 Weeks
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 21, 2017 · Synced Sep 23, 2026, 9:13 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Decision Aid - Extreme Prematurity

NCT01713894
View directory record Official record
Conditions
Prematurity; Decision Support
Interventions
Decision Aid, Standard
Other
Lead sponsor
Christiana Care Health Services
Other
Eligibility
18 Years to 70 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Jan 11, 2018 · Synced Sep 23, 2026, 9:13 PM EDT
Completed Not applicable Interventional

Effects Of Not Measuring Gastric Residual Content On Feeding Tolerance In Premature Infants iNFANTS

NCT01965769
View directory record Official record
Conditions
Premature Infant
Interventions
No gastric residual evaluation
Other
Lead sponsor
University of Florida
Other
Eligibility
Up to 3 Days
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 17, 2013 · Synced Sep 23, 2026, 9:13 PM EDT
Completed Phase 1 Interventional Results available

Effect of Medium Chain Triglyceride Intake on Colonization of Preterm Infants With Candida

NCT03630770
View directory record Official record
Conditions
Candida Infection, Premature Infant
Interventions
Medium-Chain Triglyceride (MCT) Oil
Drug
Lead sponsor
Joseph Bliss
Other
Eligibility
Up to 6 Months
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2021
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jun 13, 2022 · Synced Sep 23, 2026, 9:13 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Patient Attitudes Toward Ultrasound Measurement of Cervical Length

NCT01482039
View directory record Official record
Conditions
Cervical Insufficiency
Interventions
Sequential ultrasound, Transvaginal ultrasound
Procedure
Lead sponsor
Intermountain Women and Children's Research
Other
Eligibility
18 Years and older · Female only
Enrollment
210 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Nov 29, 2011 · Synced Sep 23, 2026, 9:13 PM EDT
Enrolling by invitation No phase listed Observational

Preschool Outcomes of a Previous RCT - ReDiMOM (NCT04540575)

NCT07702357
View directory record Official record
Conditions
Preterm
Interventions
This is a an observational prospective cohort study of a previous interventional trial (NCT04540575)
Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
2 Years to 6 Years
Enrollment
256 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Sep 23, 2026, 9:13 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Predicting the Need for Prolonged Respiratory Support in Neonates Delivered in a Lower-Level NICU Setting

NCT07344714
View directory record Official record
Conditions
Respiratory Distress Syndrome, Newborn, Respiratory Distress Syndrome in Premature Infant, Transient Tachypnea of the Newborn, Meconium Aspiration Syndrome, Pneumonia Neonatal, Hyaline Membrane Disease, Pneumothorax, Respiratory Distress Neonatal
Interventions
Not listed
Lead sponsor
Mayo Clinic
Other
Eligibility
32 Weeks to 41 Weeks
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Sep 23, 2026, 9:13 PM EDT
Terminated Not applicable Interventional

Feasibility and Impact of Volume Targeted Ventilation in the Delivery Room

NCT03938532
View directory record Official record
Conditions
Prematurity, BPD - Bronchopulmonary Dysplasia, Respiratory Distress Syndrome, Newborn
Interventions
Volume Targeted Ventilation (VTV) using the Philips Respironics NM3 monitor, Tidal Volume Measurement using the Philips Respironics NM3 monitor
Device
Lead sponsor
Baystate Medical Center
Other
Eligibility
5 Minutes to 60 Minutes
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Springfield, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 4, 2025 · Synced Sep 23, 2026, 9:13 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Vitamin E for Extremely Preterm Infants

NCT01193270
View directory record Official record
Conditions
Infant, Newborn, Infant, Small for Gestational Age, Infant, Very Low Birth Weight, Infant, Premature, Intracranial Hemorrhages
Interventions
Vitamin E, Placebo
Drug
Lead sponsor
NICHD Neonatal Research Network
Network
Eligibility
Up to 4 Hours
Enrollment
93 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
16
States / cities
Birmingham, Alabama • Palo Alto, California • New Haven, Connecticut + 12 more
Source: ClinicalTrials.gov public record
Updated Nov 10, 2015 · Synced Sep 23, 2026, 9:13 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Antibiotics and the Prolongation of Pregnancy in Preterm Labor With an Advanced Cervical Exam

NCT00589329
View directory record Official record
Conditions
Length of Pregnancy Prolongation in Hours
Interventions
erythromycin and metronidazole (antibiotics), placebo
Drug
Lead sponsor
MetroHealth Medical Center
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2012
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 3, 2019 · Synced Sep 23, 2026, 9:13 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Electrogastrography (EGC) in Premature Infants With Feeding Intolerance

NCT00008736
View directory record Official record
Conditions
Infant, Newborn, Diseases
Interventions
metoclopramide
Drug
Lead sponsor
National Center for Research Resources (NCRR)
NIH
Eligibility
1 Minute to 1 Month
Healthy volunteers
Accepts healthy volunteers
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 23, 2005 · Synced Sep 23, 2026, 9:13 PM EDT
Completed Not applicable Interventional

Late Permissive Hypercapnia for Intubated and Ventilated Preterm Infants

NCT02799875
View directory record Official record
Conditions
Premature Neonate
Interventions
Higher permissive hypercapnia, Lower Permissive Hypercapnia
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
7 Days to 14 Days
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated May 2, 2021 · Synced Sep 23, 2026, 9:13 PM EDT
Terminated Phase 4 Interventional Results available

Curosurf and Survanta Treatment(CAST)of RDS in Very Premature Infants

NCT00767039
View directory record Official record
Conditions
Prematurity, Respiratory Distress Syndrome, Patent Ductus Arteriosus
Interventions
Survanta (beractant), Curosurf (poractant)
Drug
Lead sponsor
Alan Fujii
Other
Eligibility
Up to 8 Hours
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 2, 2011 · Synced Sep 23, 2026, 9:13 PM EDT
Completed Not applicable Interventional

Flow-synchronized Nasal IMV in Preterm Infants

NCT02085499
View directory record Official record
Conditions
Premature Infant Disease, Respiratory Insufficiency
Interventions
non-synchronized NIMV, Synchronized NIMV
Other
Lead sponsor
University of Miami
Other
Eligibility
Not listed
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated May 15, 2024 · Synced Sep 23, 2026, 9:13 PM EDT
Active, not recruiting Phase 4 Interventional Accepts healthy volunteers

Low Dose Aspirin for Preterm Preeclampsia Preventionmg/day Dose in High-risk Patients

NCT05514847
View directory record Official record
Conditions
Preeclampsia, Pregnancy Related
Interventions
Aspirin 81Mg Ec Tab, Aspirin 162Mg Ec Tab
Drug
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 14, 2025 · Synced Sep 23, 2026, 9:13 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

PREGNANT Short Cervix Trial

NCT00615550
View directory record Official record
Conditions
Preterm Delivery, Short Cervix, Short Uterine Cervical Length
Interventions
progesterone, placebo
Drug
Lead sponsor
Juniper Pharmaceuticals, Inc.
Industry
Eligibility
15 Years to 45 Years · Female only
Enrollment
465 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
27
States / cities
Mobile, Alabama • Phoenix, Arizona • Orange, California + 21 more
Source: ClinicalTrials.gov public record
Updated Mar 12, 2012 · Synced Sep 23, 2026, 9:13 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Digital vs. Speculum Exams for PPROM

NCT05773014
View directory record Official record
Conditions
PPROM
Interventions
Speculum Exams, Digital Exams
Procedure
Lead sponsor
Washington University School of Medicine
Other
Eligibility
Female only
Enrollment
86 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 4, 2026 · Synced Sep 23, 2026, 9:13 PM EDT
Completed Phase 2Phase 3 Interventional

Exosurf Neonatal and Survanta for Treatment of Respiratory Distress Syndrome

NCT01203358
View directory record Official record
Conditions
Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature, Bronchopulmonary Dysplasia
Interventions
Exosurf, Survanta
Drug
Lead sponsor
NICHD Neonatal Research Network
Network
Eligibility
Up to 6 Hours
Enrollment
617 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1991 – 1992
U.S. locations
13
States / cities
Palo Alto, California • New Haven, Connecticut • Washington D.C., District of Columbia + 10 more
Source: ClinicalTrials.gov public record
Updated Mar 21, 2019 · Synced Sep 23, 2026, 9:13 PM EDT
Completed No phase listed Observational

Impact of Treatment Induced Premature Menopause on Quality of Life

NCT00185718
View directory record Official record
Conditions
Menopause, Premature
Interventions
Not listed
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older · Female only
Enrollment
97 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2010
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Dec 16, 2012 · Synced Sep 23, 2026, 9:13 PM EDT