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ClinicalTrials.gov public records Last synced Oct 7, 2026, 1:58 AM EDT

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Showing 73–96 of 1,106 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Congenital Heart Disease Clear all
Completed Phase 3 Interventional Results available

Efficacy and Safety of Odevixibat in Patients With Alagille Syndrome

NCT04674761
View directory record Official record
Conditions
Alagille Syndrome
Interventions
Odevixibat, Placebo
Drug
Lead sponsor
Albireo
Industry
Eligibility
Not listed
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
9
States / cities
San Francisco, California • Baltimore, Maryland • Boston, Massachusetts + 5 more
Source: ClinicalTrials.gov public record
Updated Nov 2, 2023 · Synced Oct 7, 2026, 1:58 AM EDT
Terminated No phase listed Observational

NORDIC: Nitric Oxide-Derived Oxidants and Regional Endothelial and Diastolic Dysfunction in Dilated Cardiomyopathy

NCT00293137
View directory record Official record
Conditions
Chronic Systolic Heart Failure (Dilated Cardiomyopathy)
Interventions
Not listed
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 19, 2008 · Synced Oct 7, 2026, 1:58 AM EDT
Terminated Not applicable Interventional Results available

Trial of RiaSTAP Versus Cryoprecipitate to Lower Operative Transfusions

NCT02540434
View directory record Official record
Conditions
Coagulopathy
Interventions
ROTEM, Cryoprecipitate, RiaSTAP
Device · Other · Drug
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 100 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 15, 2019 · Synced Oct 7, 2026, 1:58 AM EDT
Completed No phase listed Observational

COMPASSION XT PAS - Post-approval Study of the SAPIEN XT THV in Patients With Pulmonary Valve Dysfunction

NCT02987387
View directory record Official record
Conditions
Pulmonary Valve Insufficiency, Pulmonary Valve Stenosis, Heart Defects, Congenital, Congenital Abnormalities, Cardiovascular Diseases, Heart Diseases
Interventions
SAPIEN XT THV
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
Not listed
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2025
U.S. locations
12
States / cities
Birmingham, Alabama • Aurora, Colorado • Washington D.C., District of Columbia + 9 more
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Oct 7, 2026, 1:58 AM EDT
Terminated Not applicable Interventional Results available

Timing of PDA Closure and Respiratory Outcome in Premature Infants

NCT00802685
View directory record Official record
Conditions
Patent Ductus Arteriosus
Interventions
Early ibuprofen, Late ibuprofen expectant group (placebo)
Drug · Other
Lead sponsor
University of Miami
Other
Eligibility
1 Day to 14 Days
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Feb 5, 2014 · Synced Oct 7, 2026, 1:58 AM EDT
Not listed No phase listed Observational

South Asian Arrhythmogenic Cardiomyopathy Registry

NCT04895540
View directory record Official record
Conditions
Arrhythmogenic Right Ventricular Cardiomyopathy, Arrhythmogenic Right Ventricular Dysplasia, Arrhythmogenic Ventricular Cardiomyopathy, Arrhythmogenic Cardiomyopathy, Ventricular Tachycardia, Sudden Cardiac Death
Interventions
ECG, Echocardiography, Cardiac MRI, Ambulatory ECG recording, Cardiac EP study, All study subjects will undergo sample collection for genetic testing.
Diagnostic Test · Genetic
Lead sponsor
Sheri Kashmir Institute of Medical Sciences
Other
Eligibility
Not listed
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 2, 2021 · Synced Oct 7, 2026, 1:58 AM EDT
Completed Not applicable Interventional

Umbilical Cord Blood Collection and Processing for Hypoplastic Left Heart Syndrome Patients

NCT01856049
View directory record Official record
Conditions
Hypoplastic Left Heart Syndrome (HLHS)
Interventions
Collection of umbilical cord blood
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
Female only
Enrollment
464 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2024
U.S. locations
2
States / cities
Rochester, Minnesota • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 10, 2025 · Synced Oct 7, 2026, 1:58 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pocket Echocardiography System (PES) for Detection of PDA in Neonates

NCT01790750
View directory record Official record
Conditions
Patent Ductus Arteriosus
Interventions
PES first, then FFES
Device
Lead sponsor
University of Florida
Other
Eligibility
1 Day to 90 Days
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 11, 2014 · Synced Oct 7, 2026, 1:58 AM EDT
Completed No phase listed Observational

Non-Invasive Detection of Tissue Oxygen Deprivation in Premature Infants With Patent Ductus Arteriosus.

NCT03277768
View directory record Official record
Conditions
Premature Infant, Patent Ductus Arteriosus, Hemodynamic Instability
Interventions
Resonance Raman Spectroscopy (RRS)
Device
Lead sponsor
University of Florida
Other
Eligibility
Not listed
Enrollment
55 participants
Timeline
2015 – 2018
U.S. locations
2
States / cities
Gainesville, Florida • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 10, 2019 · Synced Oct 7, 2026, 1:58 AM EDT
Terminated Phase 2 Interventional

Safety and Efficacy of P-188 NF in DMD Patients

NCT03558958
View directory record Official record
Conditions
Duchenne Muscular Dystrophy
Interventions
P-188 NF
Drug
Lead sponsor
Phrixus Pharmaceuticals, Inc.
Industry
Eligibility
12 Years to 25 Years · Male only
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 11, 2023 · Synced Oct 7, 2026, 1:58 AM EDT
Completed No phase listed Observational

Health, Fitness, and Quality of Life in Adolescent Girls With Turner Syndrome

NCT03181230
View directory record Official record
Conditions
Turner Syndrome, Turner Syndrome Mosaicism, 45, X/46, XX or XY, Turner Syndrome Mosaicism 46,X,I(X)(Q10)/45,X, Turner Syndrome Karyotype 46,X With Abnormal Sex Chromosome , Except I(Xq)
Interventions
No intervention
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
12 Years to 21 Years · Female only
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated May 3, 2021 · Synced Oct 7, 2026, 1:58 AM EDT
Not listed Not applicable Interventional

Remote Monitoring of High-Risk Patients With Chronic Cardiopulmonary Diseases

NCT04825067
View directory record Official record
Conditions
Congestive Heart Failure, Asthma, Chronic Obstructive Pulmonary Disease, Cystic Fibrosis
Interventions
Respiratory Sensor measurements
Device
Lead sponsor
Institute of Bioengineering and Bioimaging (IBB)
Government
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 29, 2022 · Synced Oct 7, 2026, 1:58 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Fetal Aortic Valvuloplasty for Evolving Hypoplastic Left Heart Syndrome

NCT06342999
View directory record Official record
Conditions
Hypoplastic Left Heart Syndrome
Interventions
Fetal Aortic Valvuloplasty Procedure, Emerge Monorail and Over-The-Wire PTCA Dilatation Catheter, Trek RX and Mini Trek RX Coronary Dilatation Catheter
Procedure · Device
Lead sponsor
Mauro H. Schenone
Other
Eligibility
Up to 45 Years · Female only
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2027 – 2036
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 1, 2026 · Synced Oct 7, 2026, 1:58 AM EDT
Completed No phase listed Observational

Platelet and Tissue cAMP: Novel Biomarkers of Milrinone Efficacy in Children

NCT02728128
View directory record Official record
Conditions
Pediatrics, Heart Failure, Congenital Heart Disease, Therapeutics
Interventions
Not listed
Lead sponsor
University of Colorado, Denver
Other
Eligibility
Up to 18 Years
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 4, 2020 · Synced Oct 7, 2026, 1:58 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Registry for Mayo Clinic Adult Congenital Heart Disease Control Population

NCT05773300
View directory record Official record
Conditions
Healthy
Interventions
Not listed
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 70 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 12, 2026 · Synced Oct 7, 2026, 1:58 AM EDT
Completed Not applicable Interventional Results available

Closure of Atrial Septal Defects With the AMPLATZER Septal Occluder - Post Approval Study

NCT00650936
View directory record Official record
Conditions
Atrial Septal Defect
Interventions
AMPLATZER Septal Occluder
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
Not listed
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2014
U.S. locations
51
States / cities
Birmingham, Alabama • Los Angeles, California • Madera, California + 44 more
Source: ClinicalTrials.gov public record
Updated Jul 9, 2019 · Synced Oct 7, 2026, 1:58 AM EDT
Completed No phase listed Observational

Impact of Serious Pediatric Illness on Parent and Sibling Health

NCT03971344
View directory record Official record
Conditions
Family Members of: Newborns Extremely Premature, Family Members of: New Pediatric Oncology Patients, Family Members of: Critical Congenital Heart Defect Patients, Family Members of: Children Severe Neurological Impairment
Interventions
Not listed
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
Not listed
Enrollment
161,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 31, 2020 · Synced Oct 7, 2026, 1:58 AM EDT
Recruiting Phase 3 Interventional

Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant

NCT06563895
View directory record Official record
Conditions
Amyloidosis, Amyloid Cardiomyopathy, Transthyretin Amyloidosis, Cardiomyopathies, Heart Diseases, Polyneuropathies
Interventions
Acoramidis, Placebo oral tablet
Drug
Lead sponsor
Eidos Therapeutics, a BridgeBio company
Industry
Eligibility
18 Years to 75 Years
Enrollment
587 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2032
U.S. locations
40
States / cities
La Jolla, California • Los Angeles, California • San Francisco, California + 31 more
Source: ClinicalTrials.gov public record
Updated Aug 4, 2026 · Synced Oct 7, 2026, 1:58 AM EDT
Completed Phase 3 Interventional Results available

Safety and Efficacy Study of Several Replagal Dosing Regimens on Cardiac Function in Adults With Fabry Disease

NCT00864851
View directory record Official record
Conditions
Fabry Disease
Interventions
Replagal
Biological
Lead sponsor
Shire
Industry
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
4
States / cities
Tucson, Arizona • Iowa City, Iowa • New York, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 9, 2021 · Synced Oct 7, 2026, 1:58 AM EDT
Completed No phase listed Observational

Neonates With Neurological Complications

NCT00366561
View directory record Official record
Conditions
Congenital Disorders
Interventions
Not listed
Lead sponsor
Children's Healthcare of Atlanta
Other
Eligibility
Up to 30 Days
Enrollment
810 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2010
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Dec 2, 2014 · Synced Oct 7, 2026, 1:58 AM EDT
Completed No phase listed Observational

Characteristics of Andersen-Tawil Syndrome

NCT00521794
View directory record Official record
Conditions
Andersen-Tawil Syndrome, Andersen Syndrome
Interventions
Not listed
Lead sponsor
University of Rochester
Other
Eligibility
10 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
4
States / cities
San Francisco, California • Kansas City, Kansas • Rochester, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 16, 2013 · Synced Oct 7, 2026, 1:58 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Respiratory Motion Analysis in Children With MRI

NCT00367354
View directory record Official record
Conditions
Congenital Disorders
Interventions
Not listed
Lead sponsor
Emory University
Other
Eligibility
Not listed
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2011
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Dec 9, 2014 · Synced Oct 7, 2026, 1:58 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Pilot Project Exploring the Impact of Whole Genome Sequencing in Healthcare

NCT01736566
View directory record Official record
Conditions
Healthy Adults (Full Study and Extension Phase), Hypertrophic Cardiomyopathy or Dilated Cardiomyopathy
Interventions
Family History + Whole Genome Sequencing, Family History Only
Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 90 Years
Enrollment
213 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 27, 2024 · Synced Oct 7, 2026, 1:58 AM EDT
Withdrawn Phase 3 Interventional

Effects of Pulmonary Vasodilation Upon VA Coupling in Fontan Patients

NCT01607983
View directory record Official record
Conditions
Congenital Heart Disease, Fontan
Interventions
inhaled nitric oxide
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
4 Years to 60 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 4, 2018 · Synced Oct 7, 2026, 1:58 AM EDT