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Showing 1–24 of 2,435 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Congestive Heart Failure (CHF) Clear all
Completed No phase listed Observational

Genetic Substudy of the Alternans Before Cardioverter Defibrillator (ABCD) Trial

NCT00583297
View directory record Official record
Conditions
Ventricular Tachycardia, Cardiovascular Diseases, Arrythmia, CVD
Interventions
Not listed
Lead sponsor
CardioDx
Industry
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 21, 2018 · Synced Sep 25, 2026, 12:37 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Study to Evaluate Breathing Muscle Training in Cardiac Rehab

NCT04984473
View directory record Official record
Conditions
Healthy, Heart Failure
Interventions
Inspiratory muscle training
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Sep 25, 2026, 12:37 AM EDT
Completed Phase 2 Interventional

At-Home Automated External Defibrillator (AED) Training Study

NCT00219674
View directory record Official record
Conditions
Myocardial Infarction, Heart Arrest, Chest Pain, Congestive Heart Failure, Angina, Unstable
Interventions
Group I: Video training, Group II: Video training + enhanced self-efficacy (SE), Group III: In-person training + enhanced SE, Group IV: In-person training + enhanced SE + support
Behavioral
Lead sponsor
Public Health - Seattle and King County
Government
Eligibility
18 Years and older
Enrollment
305 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2011
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Oct 28, 2014 · Synced Sep 25, 2026, 12:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Nutritional and Functional Changes in Heart Failure and COPD

NCT01787682
View directory record Official record
Conditions
Chronic Heart Failure, Chronic Obstructive Pulmonary Disorder
Interventions
BOOST High Protein
Dietary Supplement
Lead sponsor
Texas A&M University
Other
Eligibility
20 Years and older
Enrollment
99 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2017
U.S. locations
1
States / cities
College Station, Texas
Source: ClinicalTrials.gov public record
Updated Feb 6, 2022 · Synced Sep 25, 2026, 12:37 AM EDT
Completed No phase listed Observational

LV Dysfunction Following Pacemaker Placement

NCT03850808
View directory record Official record
Conditions
Heart Failure
Interventions
Not listed
Lead sponsor
Oregon Health and Science University
Other
Eligibility
Not listed
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Feb 24, 2019 · Synced Sep 25, 2026, 12:37 AM EDT
Completed Phase 2 Interventional

Use of Ixmyelocel-T (Formerly Catheter-based Cardiac Repair Cell [CRC]) Treatment in Patients With Heart Failure Due to Dilated Cardiomyopathy

NCT01020968
View directory record Official record
Conditions
Dilated Cardiomyopathy
Interventions
Ixmyelocel-T, Vehicle Control
Biological · Other
Lead sponsor
Vericel Corporation
Industry
Eligibility
18 Years to 86 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
3
States / cities
Minneapolis, Minnesota • Cleveland, Ohio • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated May 26, 2021 · Synced Sep 25, 2026, 12:37 AM EDT
Recruiting Phase 2 Interventional

Ertugliflozin in Chronic Heart Failure

NCT04438213
View directory record Official record
Conditions
Heart Failure
Interventions
Ertugliflozin, Metolazone, Placebo
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Oct 7, 2025 · Synced Sep 25, 2026, 12:37 AM EDT
Terminated Not applicable Interventional

Effect of Personalized Accelerated Pacing in Symptomatic Patients With Non-Obstructive Hypertrophic Cardiomyopathy

NCT06775886
View directory record Official record
Conditions
Non-obstructive Hypertrophic Cardiomyopathy, Hypertrophic Cardiomyopathy
Interventions
myPACE+ algorithm
Other
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Feb 10, 2026 · Synced Sep 25, 2026, 12:37 AM EDT
Terminated Phase 3 Interventional

COREG MR Versus TOPROL-XL On Reduction Of Microalbuminuria In Patients With Hypertension And Microalbuminuria

NCT00123903
View directory record Official record
Conditions
Heart Failure, Congestive and Microalbuminuria
Interventions
metoprolol xl, carvedilol MR, lisinopril
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 80 Years
Enrollment
1,220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
72
States / cities
Birmingham, Alabama • Mobile, Alabama • Phoenix, Arizona + 60 more
Source: ClinicalTrials.gov public record
Updated Jan 17, 2017 · Synced Sep 25, 2026, 12:37 AM EDT
Withdrawn Not applicable Interventional

e-Diary in Heart Failure

NCT03452683
View directory record Official record
Conditions
Heart Failure
Interventions
Movn Mobile App
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Concord, California
Source: ClinicalTrials.gov public record
Updated Jun 25, 2018 · Synced Sep 25, 2026, 12:37 AM EDT
Active, not recruiting Not applicable Interventional

MCNAIR Study: coMparative effeCtiveness of iN-person and teleheAlth cardIac Rehabilitation

NCT05933083
View directory record Official record
Conditions
Myocardial Infarction, Heart Failure, Systolic, Heart Valve Diseases, Angina, Stable, Coronary Artery Disease, Heart Transplant
Interventions
In-person cardiac rehabilitation, Telehealth cardiac rehabilitation
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
516 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
5
States / cities
San Francisco, California • Denver, Colorado • Baltimore, Maryland + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Sep 25, 2026, 12:37 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Feasibility Study of a Percutaneous Mitral Valve Repair System.

NCT00209339
View directory record Official record
Conditions
Mitral Valve Insufficiency, Mitral Valve Regurgitation, Mitral Valve Incompetence, Mitral Regurgitation, Mitral Insufficiency
Interventions
Percutaneous mitral valve repair (MitraClip Implant)
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2011
U.S. locations
1
States / cities
Evanston, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 6, 2018 · Synced Sep 25, 2026, 12:37 AM EDT
Recruiting Phase 2 Interventional

A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)

NCT06991257
View directory record Official record
Conditions
Heart Failure
Interventions
Placebo, Low Dose PF-07328948, Medium Dose PF-07328948, High Dose PF-07328948
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 79 Years
Enrollment
620 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
28
States / cities
Beverly Hills, California • Lake Forest, California • Santa Maria, California + 17 more
Source: ClinicalTrials.gov public record
Updated May 26, 2026 · Synced Sep 25, 2026, 12:37 AM EDT
Terminated Phase 4 Interventional Results available

Diuretic Effect of Metolazone Pre-dosing Versus Concurrent Dosing

NCT03746002
View directory record Official record
Conditions
Fluid Overload, Heart Failure Acute
Interventions
Metolazone 60 minutes prior to furosemide, Metolazone concurrently with furosemide
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 89 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 21, 2021 · Synced Sep 25, 2026, 12:37 AM EDT
Completed Not applicable Interventional Results available

REmodeling the Left Ventricle With Atrial Modulated Pacing

NCT03210402
View directory record Official record
Conditions
Heart Failure
Interventions
Elevated night pacing on, Elevated night pacing off
Device
Lead sponsor
Medtronic Cardiac Rhythm and Heart Failure
Industry
Eligibility
18 Years to 99 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
10
States / cities
Tucson, Arizona • Stockton, California • Chicago, Illinois + 7 more
Source: ClinicalTrials.gov public record
Updated Oct 7, 2024 · Synced Sep 25, 2026, 12:37 AM EDT
Terminated Not applicable Interventional Results available

Sentus QP - Extended CRT Evaluation With Quadripolar Left Ventricular Leads

NCT02290028
View directory record Official record
Conditions
Heart Failure
Interventions
Sentus QP left ventricular lead
Device
Lead sponsor
Biotronik SE & Co. KG
Industry
Eligibility
18 Years and older
Enrollment
2,226 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
75
States / cities
Fairhope, Alabama • Anchorage, Alaska • Chula Vista, California + 64 more
Source: ClinicalTrials.gov public record
Updated Mar 23, 2021 · Synced Sep 25, 2026, 12:37 AM EDT
Not yet recruiting Phase 4 Interventional

IV Iron Therapy for Older Adults With Heart Failure With Preserved Ejection Fraction and Iron Deficiency

NCT07686692
View directory record Official record
Conditions
Heart Failure With Preserved Ejection Fraction, Iron Deficiency
Interventions
Ferric derisomaltose, Placebo (normal saline)
Drug
Lead sponsor
Duke University
Other
Eligibility
65 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Sep 25, 2026, 12:37 AM EDT
Completed Phase 3 Interventional Results available

Comparison of Surgical and Medical Treatment for Congestive Heart Failure and Coronary Artery Disease

NCT00023595
View directory record Official record
Conditions
Cardiovascular Diseases, Coronary Disease, Heart Failure, Congestive, Heart Diseases
Interventions
CABG surgery plus MED, Active Medication Alone, CABG plus MED and SVR
Procedure · Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 100 Years
Enrollment
2,136 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2015
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 18, 2019 · Synced Sep 25, 2026, 12:37 AM EDT
Completed Phase 3 Interventional

Randomized, Double-Blind, Placebo Controlled Study of the Short Term Clinical Effects of Tolvaptan in Patients Hospitalized for Worsening Heart Failure With Challenging Volume Management

NCT01584557
View directory record Official record
Conditions
Heart Failure
Interventions
Tolvaptan or Samsca, placebo or sugar pill
Drug
Lead sponsor
Cardiovascular Clinical Sciences Inc
Industry
Eligibility
18 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
37
States / cities
Birmingham, Alabama • Huntsville, Alabama • Los Angeles, California + 34 more
Source: ClinicalTrials.gov public record
Updated Sep 26, 2016 · Synced Sep 25, 2026, 12:37 AM EDT
Completed Phase 2 Interventional Results available

Intensive Glycemic Control for Congestive Heart Failure Exacerbation

NCT00812253
View directory record Official record
Conditions
Congestive Heart Failure, Diabetes Mellitus
Interventions
Intravenous insulin, Subcutaneous insulin
Drug
Lead sponsor
Kathleen Dungan
Other
Eligibility
18 Years and older
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 1, 2018 · Synced Sep 25, 2026, 12:37 AM EDT
Completed Not applicable Interventional

The BOSS Study: An Acute Evaluation of Anatomical and Geometric Changes Using the Bladder on a Stick System (BOSS)

NCT03228381
View directory record Official record
Conditions
Functional Mitral Regurgitation, Heart Failure
Interventions
BOSS Device
Device
Lead sponsor
Mardil Medical
Industry
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
2
States / cities
Detroit, Michigan • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 2, 2018 · Synced Sep 25, 2026, 12:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CHF COPD Sip Feed Anabolic Response

NCT02770092
View directory record Official record
Conditions
Pulmonary Disease, Chronic Obstructive, Congestive Heart Failure
Interventions
sip feeding with stable isotope infusion
Other
Lead sponsor
Texas A&M University
Other
Eligibility
45 Years and older
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
College Station, Texas
Source: ClinicalTrials.gov public record
Updated Sep 30, 2025 · Synced Sep 25, 2026, 12:37 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Study to Evaluate the Effect of SLV320 in Addition to Chronic Furosemide Treatment on Renal Function in Subjects With Congestive Heart Failure and Impaired Renal Function

NCT00568009
View directory record Official record
Conditions
Congestive Heart Failure
Interventions
SLV320
Drug
Lead sponsor
Solvay Pharmaceuticals
Industry
Eligibility
18 Years to 85 Years
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
10
States / cities
Whittier, California • Largo, Florida • Miami, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Apr 21, 2008 · Synced Sep 25, 2026, 12:37 AM EDT
Completed Not applicable Interventional

Pragmatic Trial Of Alerts for Use of Mineralocorticoid Receptor Antagonists

NCT04903717
View directory record Official record
Conditions
Heart Failure With Reduced Ejection Fraction
Interventions
Best Practice Alert
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
1,210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 22, 2024 · Synced Sep 25, 2026, 12:37 AM EDT