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ClinicalTrials.gov public records Last synced Sep 8, 2026, 10:51 PM EDT

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Showing 1–24 of 86 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Contact Lens Wear Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Study to Evaluate the Safety and Efficacy of Kalifilcon A Daily Disposable Contact Lens

NCT04158466
View directory record Official record
Conditions
Contact Lens Wear
Interventions
Kalifilcon A Daily Disposable Contact Lenses, Biotrue ONEday Daily Disposable Contact Lenses
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years to 55 Years
Enrollment
252 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
16
States / cities
Los Angeles, California • San Francisco, California • Torrance, California + 12 more
Source: ClinicalTrials.gov public record
Updated Nov 18, 2020 · Synced Sep 8, 2026, 10:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Ocular Characteristics in Contact Lens and Spectacle Wear

NCT03913377
View directory record Official record
Conditions
Visual Acuity
Interventions
Spectacles, ACUVUE OASYS®1-Day with HydraLuxe™ Technology
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 42 Years
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
3
States / cities
Jacksonville, Florida • Longwood, Florida • New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 3, 2021 · Synced Sep 8, 2026, 10:51 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Evaluation of Corneal Epithelial Thickness Mapping

NCT01712022
View directory record Official record
Conditions
Dry Eye and Contact Lens Wear
Interventions
Not listed
Lead sponsor
Optovue
Industry
Eligibility
18 Years and older
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
3
States / cities
Palo Alto, California • San Diego, California • Latham, New York
Source: ClinicalTrials.gov public record
Updated Sep 10, 2014 · Synced Sep 8, 2026, 10:51 PM EDT
Completed No phase listed Observational

Air Optix Extended Wear Contact Lenses

NCT05886881
View directory record Official record
Conditions
Refractive Errors
Interventions
Lotrafilcon B spherical soft contact lenses, Lotrafilcon B spherical soft contact lenses with comfort additive, Lotrafilcon B toric soft contact lenses with comfort additive, Comfilcon A spherical soft contact lenses, Comfilcon A toric soft contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
505 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
4
States / cities
Orlando, Florida • Medina, Minnesota • St Louis, Missouri + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 13, 2025 · Synced Sep 8, 2026, 10:51 PM EDT
Completed Not applicable Interventional Results available

Clinical Evaluation of a Silicone Hydrogel Daily Wear Monthly Replacement Contact Lens

NCT04422990
View directory record Official record
Conditions
Refractive Errors
Interventions
Lehfilcon A contact lenses, Comfilcon A contact lenses, CLEAR CARE
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
158 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
14
States / cities
Los Angeles, California • Novato, California • Oakland, California + 10 more
Source: ClinicalTrials.gov public record
Updated Mar 28, 2022 · Synced Sep 8, 2026, 10:51 PM EDT
Completed Not applicable Interventional Results available

Clinical Assessment of a Daily Wear Monthly Replacement Soft Silicone Hydrogel Contact Lens

NCT04476784
View directory record Official record
Conditions
Myopia
Interventions
Lehfilcon A contact lenses, Comfilcon A contact lenses, CLEAR CARE
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
5
States / cities
Maitland, Florida • Bloomington, Illinois • Pittsburg, Kansas + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 25, 2021 · Synced Sep 8, 2026, 10:51 PM EDT
Completed Not applicable Interventional

A Safety and Effectiveness Study of a New Multi-Purpose Contact Lens Care Solution

NCT03537248
View directory record Official record
Conditions
Contact Lens Wear
Interventions
ASP-57, ReNu® Multiplus
Device
Lead sponsor
Asepticys LLC
Industry
Eligibility
18 Years and older
Enrollment
315 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
14
States / cities
Irvine, California • San Diego, California • Longwood, Florida + 11 more
Source: ClinicalTrials.gov public record
Updated Feb 10, 2019 · Synced Sep 8, 2026, 10:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Silicone Hydrogel Daily Wear Contact Lenses for Up to One (1) Month of Daily Wear

NCT03722784
View directory record Official record
Conditions
Myopia, Hyperopia, Astigmatism
Interventions
Invigor A (test), Invigor B (control)
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
18 Years and older
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
6
States / cities
Torrance, California • East Lansing, Michigan • St Louis, Missouri + 3 more
Source: ClinicalTrials.gov public record
Updated Sep 30, 2020 · Synced Sep 8, 2026, 10:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Silicone Hydrogel Soft Contact Lens 7-Day Extended Wear Basis

NCT02939950
View directory record Official record
Conditions
Myopia
Interventions
Bausch + Lomb Samfilcon A Soft Contact Lens, Bausch + Lomb Pure Vision Soft Contact Lens
Device
Lead sponsor
Bausch Health Americas, Inc.
Industry
Eligibility
18 Years to 40 Years
Enrollment
816 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Cicero, New York
Source: ClinicalTrials.gov public record
Updated Dec 22, 2019 · Synced Sep 8, 2026, 10:51 PM EDT
Completed Not applicable Interventional Results available

Vistakon Investigational Multi-purpose Contact Lens Care Solution.

NCT01055457
View directory record Official record
Conditions
Contact Lens Wear
Interventions
Vistakon Investigational Multi-Purpose Solution II, ReNu MultiPlus Multi-Purpose Solution
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years and older
Enrollment
315 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
14
States / cities
Mission Viejo, California • Orlando, Florida • Tallahassee, Florida + 11 more
Source: ClinicalTrials.gov public record
Updated Jun 18, 2018 · Synced Sep 8, 2026, 10:51 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Effect of Contact Lens Wear on Immune Cell Density and Morphology of the Ocular Surface

NCT01250925
View directory record Official record
Conditions
Myopia, Refractive Error
Interventions
ReNu MultiPlus® MultiPurpose Solution, OPTI-FREE® RepleniSH®, Clear Care®
Drug
Lead sponsor
Massachusetts Eye and Ear Infirmary
Other
Eligibility
18 Years and older
Enrollment
94 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
2
States / cities
Iowa City, Iowa • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 9, 2017 · Synced Sep 8, 2026, 10:51 PM EDT
Completed Not applicable Interventional Results available

Evaluation of Deposits on Contact Lenses Worn Extended Wear

NCT00725530
View directory record Official record
Conditions
Myopia
Interventions
balafilcon A contact lens (PureVision), etafilcon A contact lens (Acuvue2)
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Aug 21, 2012 · Synced Sep 8, 2026, 10:51 PM EDT
Completed Not applicable Interventional Results available

A Multi-Center Investigation of Patient Acceptability of OPTI-FREE RepleniSH® Multi-Purpose Disinfecting Solution (MPDS)

NCT00772707
View directory record Official record
Conditions
Myopia
Interventions
Multi-Purpose Disinfecting Solution (OPTI-FREE RepleniSH), Contact Lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years to 65 Years
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Sep 6, 2012 · Synced Sep 8, 2026, 10:51 PM EDT
Completed Not applicable Interventional Results available

Clinical Performance of a Silicone Hydrogel for Daily Disposable Wear

NCT03095027
View directory record Official record
Conditions
Refractive Error
Interventions
FID122819 contact lenses, Stenfilcon A contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
3
States / cities
Longwood, Florida • Maitland, Florida • Johns Creek, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 3, 2019 · Synced Sep 8, 2026, 10:51 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Limbal Stem Cell Deficiency (LSCD) Treatment With Cultivated Stem Cell (CALEC) Graft

NCT02592330
View directory record Official record
Conditions
Limbal Stem Cell Deficiency
Interventions
Biopsy to collect limbal epithelial stem cells that will be cultivated into a graft, Cultivation of Limbal epithelial cells into a graft, CALEC Transplant
Procedure · Biological
Lead sponsor
Massachusetts Eye and Ear Infirmary
Other
Eligibility
18 Years to 89 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 14, 2025 · Synced Sep 8, 2026, 10:51 PM EDT
Completed Not applicable Interventional Results available

A One-Week Crossover Dispensing Evaluation of New Daily Wear Soft Contact Lenses

NCT03306641
View directory record Official record
Conditions
Myopia
Interventions
Test Contact Lens, Nelfilcon A
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
18 Years to 55 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 21, 2020 · Synced Sep 8, 2026, 10:51 PM EDT
Completed Not applicable Interventional Results available

A 6-Hour Clinical Evaluation of New Daily-Wear Soft Contact Lenses

NCT03235089
View directory record Official record
Conditions
Myopia
Interventions
Test Lens, Control Lens
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 13, 2020 · Synced Sep 8, 2026, 10:51 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

LSH Silicone Hydrogel Soft Hydrophilic Contact Lens for Daily Wear

NCT01735045
View directory record Official record
Conditions
Myopia
Interventions
Lagado LSH (mangofilcon A) Soft (hydrophilic) Contact Lens, Benz 3GX (hioxifilcon B) Soft (hydrophilic) Contact Lens
Device
Lead sponsor
Szabocsik and Associates, Inc.
Industry
Eligibility
18 Years and older
Enrollment
76 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
5
States / cities
Huntington Beach, California • Honolulu, Hawaii • Oak Lawn, Illinois + 2 more
Source: ClinicalTrials.gov public record
Updated Nov 27, 2012 · Synced Sep 8, 2026, 10:51 PM EDT
Completed Not applicable Interventional Results available

Clinical Evaluation of Stenfilcon A Soft Contact Lens When Compared to Ocufilcon B Soft Contact Lens

NCT01354223
View directory record Official record
Conditions
Myopia
Interventions
stenfilcon A contact lens, ocufilcon B contact lens
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
4
States / cities
San Diego, California • East Lansing, Michigan • Beachwood, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 28, 2020 · Synced Sep 8, 2026, 10:51 PM EDT
Not listed Early Phase 1 Interventional Accepts healthy volunteers

Effect of Ocular Hygiene on Scleral Lens Wear

NCT03544385
View directory record Official record
Conditions
Scleral Contact Lenses
Interventions
Ringers Solution, Placebo - Concentrate
Drug
Lead sponsor
University of Houston
Other
Eligibility
18 Years to 85 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 31, 2018 · Synced Sep 8, 2026, 10:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Two Phase Clinical Study of the Impact of Contact Lenses and Solutions on Corneal Structure

NCT00804999
View directory record Official record
Conditions
Normal Contact Lens Wear
Interventions
Clear Care, ReNu, OPTI-FREE
Drug
Lead sponsor
Christine Sindt
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jan 22, 2018 · Synced Sep 8, 2026, 10:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Study Intended to Evaluate the Safety and Effectiveness of a Johnson & Johnson Vision Care Inc, (JJVCI) Contact Lens for Use on an Extended-wear Basis for up to 7 Days (6 Nights).

NCT00241280
View directory record Official record
Conditions
Myopia
Interventions
etafilcon A, galyfilcon A
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years and older
Enrollment
504 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2006
U.S. locations
25
States / cities
Costa Mesa, California • Fresno, California • Louisville, Colorado + 22 more
Source: ClinicalTrials.gov public record
Updated Mar 23, 2016 · Synced Sep 8, 2026, 10:51 PM EDT
Completed Not applicable Interventional Results available

Three Daily Wear Monthly Replacement Silicone Hydrogel Contact Lenses With Two Multi-purpose Disinfecting Solution Combinations

NCT04789382
View directory record Official record
Conditions
Refractive Errors
Interventions
LID018869+RepleniSH, LID018869+Biotrue, Biofinity+RepleniSH, PV+Biotrue
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Maitland, Florida
Source: ClinicalTrials.gov public record
Updated May 24, 2022 · Synced Sep 8, 2026, 10:51 PM EDT
Completed No phase listed Observational

Air Optix Plus HydraGlyde Multifocal Daily/Extended Wear Contact Lenses

NCT05886894
View directory record Official record
Conditions
Refractive Errors
Interventions
Lotrafilcon B multifocal soft contact lenses, Comfilcon A multifocal soft contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
40 Years and older
Enrollment
351 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
8
States / cities
San Diego, California • Jacksonville, Florida • Miami, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Aug 13, 2025 · Synced Sep 8, 2026, 10:51 PM EDT