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ClinicalTrials.gov public records Last synced Nov 9, 2026, 7:30 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 480 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Corneal Diseases Clear all

Conditions: Corneal Opacity, Keratoconus
Interventions: LALAK, IEK, Retrobulbar Block or General Anesthesia, optical coherence tomography (OCT), Topical Anesthesia, femtosecond laser; Procedure · Drug · Device
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 18 Years to 100 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Keratoconus
Interventions: Corneal tissue inlay; Procedure
Lead sponsor: Cornea and Laser Eye Institute; Other
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2025
U.S. locations: 1
States / cities: Teaneck, New Jersey

Conditions: Corneal Ulcer, Fungal Keratitis
Interventions: Intrastromal voriconazole, Natamycin; Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 70 Years
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Meibomian Gland Dysfunction (MGD)
Interventions: Vevye(Cyclosporine 0.1% Ophthalmic Solution); Drug
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years and older
Enrollment: 48 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Irregular; Contour of Cornea
Interventions: contact lens insertion solution; Device
Lead sponsor: Jennifer Fogt; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Conjunctivitis
Interventions: RPS Adeno Detector IV; Device
Lead sponsor: Rapid Pathogen Screening; Industry
Eligibility: 1 Year and older
Enrollment: 128 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 8
States / cities: Bradenton, Florida • Miami, Florida • Springfield, Missouri + 5 more

Conditions: Keratoconus
Interventions: Riboflavin Ophthalmic Solutions, UV-A Irradiation System; Drug · Device
Lead sponsor: Glaukos Corporation; Industry
Eligibility: 13 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Westerville, Ohio

Conditions: Vision Disability
Interventions: Not listed
Lead sponsor: University Hospitals Cleveland Medical Center; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2014
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Keratoconus
Interventions: riboflavin solution, placebo solution, KXL System; Drug · Device
Lead sponsor: Glaukos Corporation; Industry
Eligibility: 12 Years and older
Enrollment: 92 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 11
States / cities: Irvine, California • San Diego, California • Indianapolis, Indiana + 8 more

Conditions: Hyperopia
Interventions: MEL 80 Hyperopic LASIK Treatment; Device
Lead sponsor: Carl Zeiss Meditec, Inc.; Industry
Eligibility: 21 Years and older
Enrollment: 189 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2004 – 2008
U.S. locations: 6
States / cities: San Diego, California • Greenwood Village, Colorado • Kansas City, Missouri + 3 more

Conditions: Presbyopia, Pseudophakia
Interventions: Raindrop Near Vision Inlay; Device
Lead sponsor: ReVision Optics, Inc.; Industry
Eligibility: 50 Years and older
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 13
States / cities: Laguna Hills, California • Orange, California • Bradenton, Florida + 10 more

Conditions: Dry Eye
Interventions: nanomicellular cyclosporine 0.09%, Lifitegrast; Drug
Lead sponsor: Toyos Clinic; Other
Eligibility: 18 Years to 85 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Bilateral Cataract
Interventions: ACRYSOF® Single-Piece NATURAL Toric IOL Model SN60T9 and Model SN60T8.; Device
Lead sponsor: Alcon Research; Industry
Eligibility: 21 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2010
U.S. locations: 1
States / cities: Fort Worth, Texas

Conditions: Cystoid Macular Edema, Fuchs Dystrophy
Interventions: Optical Coherence Tomography; Diagnostic Test
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Corneal Opacity
Interventions: Mitomycin-C, Fluorometholone 1% topical ocular steroid; Drug
Lead sponsor: United States Naval Medical Center, San Diego; Federal
Eligibility: 21 Years to 65 Years
Enrollment: 300 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2023
U.S. locations: 1
States / cities: San Diego, California

Conditions: Sjogren's Syndrome, Keratoconjunctivitis Sicca
Interventions: Levocarnitine, Placebo; Drug
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 18 Years to 75 Years
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Fuchs Endothelial Dystrophy, Corneal Edema
Interventions: Descemet's stripping endothelial keratoplasty; Procedure
Lead sponsor: Cornea Research Foundation of America; Other
Eligibility: 21 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2007
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Keratoconjunctivitis Sicca
Interventions: Hydroeye, Inactive Capsule; Dietary Supplement · Other
Lead sponsor: Virginia Eye Consultants; Other
Eligibility: 40 Years and older · Female only
Enrollment: 62 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2008
U.S. locations: 2
States / cities: Houston, Texas • Norfolk, Virginia

Conditions: Keratoconus, Dry Eye, Allergy
Interventions: dexamethasone ophthalmic insert 0.4 mg, for intracanalicular use, Loteprednol Etabonate 0.38% Ophthalmic Gel/Jelly; Drug
Lead sponsor: Illinois College of Optometry; Other
Eligibility: 18 Years and older
Enrollment: 36 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Must be PRK Candidate
Interventions: Not listed
Lead sponsor: Durrie Vision; Other
Eligibility: 18 Years to 39 Years
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Overland Park, Kansas

Conditions: Cornea
Interventions: TrueTear™ intranasal neurostimulator (ITN); Device
Lead sponsor: Tufts Medical Center; Other
Eligibility: 22 Years and older
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2023
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Fuchs' Endothelial Dystrophy, Bullous Keratopathy
Interventions: Netarsudil, Placebo; Drug
Lead sponsor: Cornea Research Foundation of America; Other
Eligibility: 18 Years and older
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Dry Eye Syndromes, Keratoconjunctivitis Sicca
Interventions: KPI-121 0.25% Ophthalmic Suspension, Vehicle of KPI-121 0.25% Ophthalmic Suspension; Drug
Lead sponsor: Kala Pharmaceuticals, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 909 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 62
States / cities: Birmingham, Alabama • Chandler, Arizona • Jonesboro, Arkansas + 54 more

Conditions: Encephalitis, Herpes Simplex, Keratitis, Mouth Disease, Skin Disease
Interventions: Not listed
Lead sponsor: National Institute of Allergy and Infectious Diseases (NIAID); NIH
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1997 – 2010
U.S. locations: 1
States / cities: Bethesda, Maryland

Search by objective public record fields.

OCT-guided LALAK for KCN

Corneal Tissue Inlay for Keratoconus

Mycotic Antimicrobial Localized Injection for Treatment of Corneal Ulcers

Efficacy of Vevye Ophthalmic Solution for the Treatment of Meibomian Gland Dysfunction

Scleral Contact Lens Insertion Solution Study

A Comparison of the RPS Adeno Detector IV to Viral Cell Culture at Detecting Adenoviral Conjunctivitis

Evaluate the Safety and Feasibility of Same-Day Bilateral Epithelium-On Corneal Cross-Linking for Keratoconus

Correlation of Scheimpflug Densitometry Measurements of Corneal Haze With Disability Glare

Safety and Efficacy of Corneal Collagen Cross-Linking in Eyes With Keratoconus

Safety and Effectiveness Study of the MEL 80 Excimer Laser Using LASIK in the Treatment of Hyperopia

A Clinical Trial to Evaluate a Corneal Inlay for the Improvement of Near and Intermediate Vision in Pseudophakic Presbyopic Subjects

Clinical Efficacy of Two Topical Dry Eye Drops for Central Corneal Stain Clearing Over 90 Days

ACRYSOF® Toric NATURAL T9 Intraocular Lens (IOL)

Descemet Membrane Endothelial Keratoplasty vs. Descemet's Stripping With Endothelial Keratoplasty vs. Descemet Stripping Only

The Use of MMC During PRK and Its Effect on Postoperative Topical Steroid Requirements

Levocarnitine for Dry Eye in Sjogren's Syndrome

Study of Eye Bank Pre-cut Donor Grafts for Endothelial Keratoplasty

Efficacy and Safety Study of Nutritional Supplements for Treatments of Dry Eye

Safety and Efficacy of Intracanalicular Dexamethasone Compared to Loteprednol Etabonate in Patients With Keratoconus

A 6 Month Study to Evaluate the Safety, Analgesic Efficacy of ACUVAIL™ (Ketorolac Tromethamine Ophthalmic Solution) 0.45%, in Post-PRK Corneal Wound Healing

Intranasal Neurostimulation in Ameliorating Symptoms of Neuropathic Corneal Pain

Trial of Netarsudil for Prevention of Corticosteroid-induced Intraocular Pressure Elevation

Safety and Efficacy of KPI-121 Compared to Placebo in Subjects With Dry Eye Disease

Structure of the Herpes Simplex Virus Receptor