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ClinicalTrials.gov public records Last synced Nov 15, 2026, 2:25 PM EST

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Showing 1–24 of 46 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Corneal Ectasia Clear all

Conditions: Keratoconus, Irregular Astigmatism, Corneal Ectasia, Aberration, Corneal Wavefront, Wavefront Aberration, Corneal, Pellucid Marginal Corneal Degeneration, Keratoglobus
Interventions: Wavefront Guided Scleral Lenses, Traditional Scleral Lenses; Device
Lead sponsor: Cornea and Laser Eye Institute; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Teaneck, New Jersey

Conditions: Keratoconus
Interventions: Riboflavin-5-phosphate, Sham cross-linking; Drug
Lead sponsor: University at Buffalo; Other
Eligibility: 16 Years to 35 Years
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2011
U.S. locations: 2
States / cities: Amherst, New York • Buffalo, New York

Conditions: Keratoconus, Cornea Ectasia
Interventions: Epithelial-on Corneal Crosslinking with the PXL 330 Platinum system.; Combination Product
Lead sponsor: Arbor Center for Eye Care; Other
Eligibility: 12 Years to 60 Years
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Orland Park, Illinois

Conditions: Corneal Ectasia Disorders Including Keratoconus
Interventions: CXL; Drug
Lead sponsor: Rush Eye Associates; Other
Eligibility: 10 Years to 70 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2024
U.S. locations: 1
States / cities: Amarillo, Texas

Conditions: Progressive Keratoconus, Corneal Ectasia
Interventions: Riboflavin, Placebo; Drug
Lead sponsor: Ohio State University; Other
Eligibility: 18 Years and older
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2010
U.S. locations: 2
States / cities: Columbus, Ohio • Dublin, Ohio

Conditions: Keratoconus, Ectasia
Interventions: Riboflavin; Drug
Lead sponsor: Yaron S. Rabinowitz M.D.; Other
Eligibility: 21 Years to 65 Years
Enrollment: 600 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2021
U.S. locations: 1
States / cities: Beverly Hills, California

Conditions: Progressive Keratoconus, Corneal Ectasia
Interventions: Corneal collagen, Sham comparator; Procedure
Lead sponsor: Emory University; Other
Eligibility: 14 Years and older
Enrollment: 160 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Keratoconus, Ectasia Corneal
Interventions: Riboflavin 0.1%; Combination Product
Lead sponsor: Price Vision Group; Industry
Eligibility: 10 Years and older
Enrollment: 508 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2026
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Keratoconus
Interventions: Riboflavin drops; Drug
Lead sponsor: Nvision Laser Eye Centers; Industry
Eligibility: 12 Years and older
Enrollment: 320 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 11
States / cities: Camarillo, California • Citrus Heights, California • Fullerton, California + 8 more

Conditions: Keratoconus, Corneal Ectasia
Interventions: riboflavin ophthalmic solution; Drug
Lead sponsor: Cornea and Laser Eye Institute; Other
Eligibility: 18 Years and older
Enrollment: 170 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Teaneck, New Jersey

Conditions: Corneal Ectasia, Keratoconus, Pellucid Marginal Corneal Degeneration
Interventions: PXL-330 Platinum device for crosslinking with Peschke riboflavin solution; Combination Product
Lead sponsor: Colorado Eye Consultants/Cornea Consultants of Colorado; Industry
Eligibility: 8 Years and older
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 3
States / cities: Littleton, Colorado • Highland Park, Illinois • Brecksville, Ohio

Conditions: Keratoconus, Corneal Ectasia
Interventions: Riboflavin; Drug
Lead sponsor: Cornea and Laser Eye Institute; Other
Eligibility: 18 Years and older
Enrollment: 160 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2025
U.S. locations: 1
States / cities: Teaneck, New Jersey

Conditions: Keratoconus, Ectasia, Crosslinking, Fuchs' Endothelial Dystrophy
Interventions: Brillouin imaging; Procedure
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 20 Years to 75 Years
Enrollment: 168 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2030
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Keratoconus, Ectasia, Corneal Ectasia
Interventions: UV-X Light, Riboflavin; Device · Drug
Lead sponsor: Mercy Center for Corrective Eye Surgery; Other
Eligibility: 14 Years to 55 Years
Enrollment: 250 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: McHenry, Illinois

Conditions: Keratoconus, Corneal Ectasia
Interventions: Riboflavin 0.1% ophthalmic solution, CCL-VARIO UV lamp, CCL-VARIO at 18 mW/cm2; Drug · Device
Lead sponsor: Robert Mack, M.D.; Other
Eligibility: 18 Years to 80 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2013
U.S. locations: 1
States / cities: Hoffman Estates, Illinois

Conditions: Keratoconus, Pellucid Marginal Corneal Degeneration, Corneal Ectasia
Interventions: PXL-330 Platinum device for crosslinking with Peschke riboflavin solution; Combination Product
Lead sponsor: Goodman Eye Center; Other
Eligibility: 10 Years and older
Enrollment: 500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2029
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Keratoconus, Corneal Ectasia
Interventions: Riboflavin; Drug
Lead sponsor: Cornea and Laser Eye Institute; Other
Eligibility: 12 Years and older
Enrollment: 160 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Teaneck, New Jersey

Conditions: Keratoconus; Post-Refractive Ectasia
Interventions: Corneal Tissue Addition Keratoplasty (CTAK); Procedure
Lead sponsor: Corneagen LLC; Other
Eligibility: Not listed
Enrollment: 61 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 5
States / cities: Albuquerque, New Mexico • Fayetteville, North Carolina • Brecksville, Ohio + 2 more

Conditions: Keratoconus, Corneal Ectasia
Interventions: Riboflavin 0.1% ophthalmic solution and pulsed light, Riboflavin 0.1% ophthalmic solution and non-pulsed light; Combination Product
Lead sponsor: Price Vision Group; Industry
Eligibility: 10 Years to 90 Years
Enrollment: 500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2031
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Keratoconus, Unstable, Bacterial Keratitis, Ectasia of Cornea
Interventions: PXL-330 Platinum device for crosslinking with Peschke ribofflavin solution; Combination Product
Lead sponsor: Pacific Clear Vision Institute; Other
Eligibility: 12 Years to 45 Years
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2030
U.S. locations: 1
States / cities: Eugene, Oregon

Conditions: Keratoconus, Unstable, Ectasia Corneal, Bacterial Keratitis
Interventions: PXL 330 Platinum device/Riboflavin; Combination Product
Lead sponsor: Eye Specialists of Indiana; Other
Eligibility: 12 Years and older
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Keratoconus, Pellucid Marginal Corneal Degeneration, Corneal Degeneration, Corneal Ectasia
Interventions: PXL-330 Platinum device for crosslinking with Peschke riboflavin solution; Combination Product
Lead sponsor: Cornea Associates of Texas; Other
Eligibility: 8 Years and older
Enrollment: 249 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Keratoconus, Ectasia, Degeneration
Interventions: Not listed
Lead sponsor: Cxlusa; Industry
Eligibility: 8 Years and older
Enrollment: 2,619 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2017
U.S. locations: 5
States / cities: San Diego, California • Littleton, Colorado • Hoffman Estates, Illinois + 2 more

Conditions: Keratoconus, Corneal Ectasia
Interventions: Riboflavin/Dextran, Hypotonic Riboflavin; Drug
Lead sponsor: Cornea and Laser Eye Institute; Other
Eligibility: 18 Years and older
Enrollment: 160 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2025
U.S. locations: 1
States / cities: Teaneck, New Jersey

Search by objective public record fields.

Wavefront Guided Scleral Lenses for Keratoconus and Irregular Astigmatism

Treatment of Keratoconus Using Collagen Cross-Linking

Safety and Efficacy of Corneal Crosslinking Using the PXL-Platinum 330 for Eyes With Corneal Ectatic Conditions

The Effects of Corneal Collagen Cross-linking

Corneal Crosslinking in Keratoconus and Corneal Ectasia

Collagen Cross-Linking for Keratoconus/Ectasia With and Without Intacs

Corneal Collagen Cross-Linking for the Treatment of Progressive Keratoconus and Corneal Ectasia

Comparison of Standard vs. Accelerated Corneal Crosslinking

Study of the Safety and Effectiveness of Photochemically Induced Collagen Cross-Linking in Eyes With Keratoconus.

Accelerated Corneal Collagen Crosslinking for Keratoconus and Ectasia Using Pulse or Continuous UV-A Light

Safety and Effectiveness of the PXL-Platinum 330 System

Transepithelial Corneal Collagen Crosslinking for Keratoconus and Corneal Ectasia

A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal Ectasia

UVA-Riboflavin Crosslinking Treatment of Corneal Ectasia

Study of the Safety and Effectiveness of Collagen Cross-Linking at an Irradiance of 9 mW/cm2 and 18 mW/cm2

Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking in Eyes With Corneal Ectasia

Transepithelial (Epi-on) Corneal Collagen Crosslinking to Treat Keratoconus and Corneal Ectasia

Retrospective Study of Corneal Tissue Addition Keratoplasty for Keratoconus and Post-Refractive Ectasia

Corneal Crosslinking for Treatment of Progressive Keratoconus or Corneal Ectasia

Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking

Safety and Effectiveness of the PXL Platinum 330 System for Corneal Collagen Cross-Linking in Eyes With Corneal Thinning Position

Safety & Effectiveness of the PXL-Platinum 330 System for CXL Using Riboflavin Solution

Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas (2)

Corneal Collagen Crosslinking for Progressive Keratoconus and Ectasia Using Riboflavin/Dextran and Hypotonic Riboflavin