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ClinicalTrials.gov public records Last synced Sep 25, 2026, 5:27 AM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Critically Ill Children Clear all
Recruiting No phase listed Observational

Brain Blood Flow and Cerebral Autoregulation Monitoring in Critically Ill Children

NCT07613918
View directory record Official record
Conditions
Critical Illness, Pediatric Critical Illness, Respiratory Failure, Traumatic Brain Injury, Cardiac Arrest
Interventions
Transcranial Doppler
Device
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
1 Day to 17 Years
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Sep 25, 2026, 5:27 AM EDT
Completed Not applicable Interventional Results available

Restore Resilience in Critically Ill Children

NCT04695392
View directory record Official record
Conditions
Acute Respiratory Distress Syndrome
Interventions
R2 Bundle
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
6 Months to 17 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
2
States / cities
Baltimore, Maryland • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced Sep 25, 2026, 5:27 AM EDT
Terminated Phase 2 Interventional Results available

Catheter-Related Early Thromboprophylaxis With Enoxaparin (CRETE) Trial

NCT03003390
View directory record Official record
Conditions
Deep Venous Thrombosis
Interventions
Enoxaparin
Drug
Lead sponsor
Yale University
Other
Eligibility
Up to 17 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
6
States / cities
New Haven, Connecticut • St Louis, Missouri • New York, New York + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 12, 2020 · Synced Sep 25, 2026, 5:27 AM EDT
Recruiting Not applicable Interventional

Building Relationship, Improving Dialogue, and Growing Empathy (BRIDGE): An Intervention to Support Decision Making for Critically Ill Children

NCT07390773
View directory record Official record
Conditions
Decision Making, Neonatal Critical Illness, Pediatric Critical Illness
Interventions
BRIDGE intervention
Behavioral
Lead sponsor
Duke University
Other
Eligibility
Not listed
Enrollment
495 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
3
States / cities
San Francisco, California • Baltimore, Maryland • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 7, 2026 · Synced Sep 25, 2026, 5:27 AM EDT
Withdrawn No phase listed Observational

Clinical Pediatric Pneumonia Score in Critically Ill Children

NCT02139384
View directory record Official record
Conditions
Community Acquired Pneumonia
Interventions
Not listed
Lead sponsor
Loma Linda University
Other
Eligibility
1 Day to 21 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Apr 24, 2017 · Synced Sep 25, 2026, 5:27 AM EDT
Completed No phase listed Observational

Methionine Metabolism in Enterally Fed Pediatric Sepsis

NCT01889264
View directory record Official record
Conditions
Sepsis, Critical Illness
Interventions
Observational
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
1 Month to 19 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 21, 2017 · Synced Sep 25, 2026, 5:27 AM EDT
Completed No phase listed Observational Results available

Pilot Study Assessing Oxidative Stress in Children

NCT01052207
View directory record Official record
Conditions
Adrenal Insufficiency, Critical Illness
Interventions
Not listed
Lead sponsor
Emory University
Other
Eligibility
1 Day to 18 Years
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jun 3, 2015 · Synced Sep 25, 2026, 5:27 AM EDT
Not listed No phase listed Observational

Electronic Application of a Severe Sepsis Screening Tool and Management Bundle

NCT01724463
View directory record Official record
Conditions
Systemic Inflammatory Response Syndrome (SIRS), Sepsis, Severe Sepsis, Septic Shock
Interventions
Severe Sepsis Management Bundle
Other
Lead sponsor
University of Tennessee
Other
Eligibility
1 Month to 18 Years
Enrollment
30,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 30, 2015 · Synced Sep 25, 2026, 5:27 AM EDT
Withdrawn Not applicable Interventional

Use of NGAL for Fluid Dosing and CRRT Initiation in Pediatric and Neonatal AKI

NCT05114057
View directory record Official record
Conditions
Acute Kidney Injury, Acute Kidney Injury Due to Sepsis, Neonatal Sepsis
Interventions
Renal Angina Index (RAI)
Other
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
Up to 25 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 23, 2026 · Synced Sep 25, 2026, 5:27 AM EDT
Completed Phase 4 Interventional

Morphine PK Subgroup Analysis

NCT01322191
View directory record Official record
Conditions
Post Operative Pain
Interventions
Morphine
Drug
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
3 Years to 18 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
2
States / cities
Detroit, Michigan • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Oct 28, 2012 · Synced Sep 25, 2026, 5:27 AM EDT
Completed Phase 2 Interventional Results available

Sleep Management And Recovery After Traumatic Brain Injury in Kids: Pilot Intervention of Melatonin

NCT04932096
View directory record Official record
Conditions
Traumatic Brain Injury, Critical Illness, Sleep
Interventions
melatonin, placebo
Drug · Other
Lead sponsor
Oregon Health and Science University
Other
Eligibility
6 Years to 18 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Aug 19, 2025 · Synced Sep 25, 2026, 5:27 AM EDT
Completed No phase listed Observational

Measurement of Cardiac Output and Intravascular Volume Status in Children Using COstatus (SH)

NCT01613859
View directory record Official record
Conditions
Intensive Care
Interventions
Not listed
Lead sponsor
Transonic Systems Inc.
Industry
Eligibility
Up to 21 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated May 26, 2016 · Synced Sep 25, 2026, 5:27 AM EDT
Withdrawn No phase listed Observational

Effect of Cumulative Chloride Dose on Development of Acute Kidney Injury in Critically Ill Children

NCT02188602
View directory record Official record
Conditions
Acute Kidney Injury
Interventions
Not listed
Lead sponsor
Stanford University
Other
Eligibility
1 Month to 18 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Aug 21, 2022 · Synced Sep 25, 2026, 5:27 AM EDT
Recruiting Phase 2 Interventional

Subanesthetic Ketamine Infusions for Depressive Symptoms in Intensive Care Unit Patients

NCT07639359
View directory record Official record
Conditions
Critical Illness, Depressive Symptoms
Interventions
Ketamine (0.5 mg/kg), Normal Saline (0.9% NaCl)
Drug · Other
Lead sponsor
Hospital Italiano de Buenos Aires
Other
Eligibility
18 Years to 99 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Sep 25, 2026, 5:27 AM EDT
Recruiting No phase listed Observational

Opportunistic PK/PD Trial in Critically Ill Children (OPTIC)

NCT05055830
View directory record Official record
Conditions
Cardiac Disease, Critically Ill, Children, Adult
Interventions
The OPTIC study is collecting PK data on children prescribed understudied drugs of interest per standard of care.
Drug
Lead sponsor
Duke University
Other
Eligibility
0 Months to 20 Years
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2028
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 13, 2025 · Synced Sep 25, 2026, 5:27 AM EDT
Completed No phase listed Observational

Bleeding in Critically Ill Children With Underlying Oncologic Diagnoses

NCT04170231
View directory record Official record
Conditions
Cancer, Bleeding
Interventions
Not listed
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
28 Days to 18 Years
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 18, 2023 · Synced Sep 25, 2026, 5:27 AM EDT
Terminated Not applicable Interventional

Use of Biomarkers to Optimize Fluid Dosing,CRRT Initiation and Discontinuation in Pediatric ICU Patients With AKI

NCT01416298
View directory record Official record
Conditions
Acute Kidney Injury, Fluid Overload
Interventions
Continuous Renal Replacement Therapy
Other
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
1 Year to 25 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 19, 2018 · Synced Sep 25, 2026, 5:27 AM EDT
Recruiting Not applicable Interventional

Music Listening: A Mechanistic Trial

NCT05541029
View directory record Official record
Conditions
Critical Illness
Interventions
Live music, Recorded music, Usual care
Behavioral · Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
2 Months to 17 Years
Enrollment
171 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 19, 2026 · Synced Sep 25, 2026, 5:27 AM EDT
Completed Phase 2 Interventional Results available

Safety and Efficacy of Mupirocin in Eradicating Colonization With S. Aureus in Critically Ill Infants

NCT01827358
View directory record Official record
Conditions
Staphylococcal Infection
Interventions
Mupirocin calcium
Drug
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
Up to 24 Months
Enrollment
155 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
6
States / cities
Atlanta, Georgia • Baltimore, Maryland • Kansas City, Missouri + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 6, 2017 · Synced Sep 25, 2026, 5:27 AM EDT
Not listed No phase listed Observational

Measuring Lung Pressures in Critically Ill Children Who Are on Mechanical Ventilation

NCT02354365
View directory record Official record
Conditions
Transpulmonary Pressure, Pressure.Rate Product, Guide to Mechanical Ventilator Management, Extubation Readiness
Interventions
Transpulmonary Pressure measurement
Device
Lead sponsor
Children's Hospital Los Angeles
Other
Eligibility
1 Week to 18 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 14, 2024 · Synced Sep 25, 2026, 5:27 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Safety and Dose Escalation Study of Zinc Supplementation in Critically Ill Children

NCT01062009
View directory record Official record
Conditions
Critical Illness
Interventions
Zinc sulfate
Drug
Lead sponsor
UCSF Benioff Children's Hospital Oakland
Other
Eligibility
30 Days to 10 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
1
States / cities
Oakland, California
Source: ClinicalTrials.gov public record
Updated Aug 19, 2019 · Synced Sep 25, 2026, 5:27 AM EDT
Completed Not applicable Interventional

Sleep After Pediatric Critical Illness

NCT05879640
View directory record Official record
Conditions
Pediatric, Critical Illness, Sleep Disturbance
Interventions
Sleep education
Behavioral
Lead sponsor
Oregon Health and Science University
Other
Eligibility
6 Years to 18 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Apr 16, 2024 · Synced Sep 25, 2026, 5:27 AM EDT
Completed Phase 2Phase 3 Interventional

Lorazepam Sedation for Critically Ill Children

NCT00109395
View directory record Official record
Conditions
Critical Illness
Interventions
Lorazepam, Midazolam, Lorazepam CI
Drug
Lead sponsor
The Emmes Company, LLC
Industry
Eligibility
1 Day to 18 Years
Enrollment
179 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 19, 2023 · Synced Sep 25, 2026, 5:27 AM EDT
Withdrawn Phase 2 Interventional

Polypharmacy-related Adverse Events in Critically Ill Children

NCT03293927
View directory record Official record
Conditions
Delirium
Interventions
Fentanyl, Dexmedetomidine
Drug
Lead sponsor
Duke University
Other
Eligibility
2 Years to 17 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 17, 2019 · Synced Sep 25, 2026, 5:27 AM EDT