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Showing 1–24 of 71 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Crystal Methamphetamine Abuse Clear all
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Pilot Study of Entacapone for Methamphetamine Abuse

NCT02058966
View directory record Official record
Conditions
Methamphetamine Dependence
Interventions
Entacapone, Methamphetamine, Placebo
Drug
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 45 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Sep 11, 2019 · Synced Jul 22, 2026, 12:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Preventing Parental Opioid and/or Methamphetamine Addiction Within DHS-Involved Families: PRE-FAIR

NCT05380440
View directory record Official record
Conditions
Opioid-Related Disorders, Stimulant-Related Disorder, Child Neglect, Mental Health Impairment
Interventions
Prevention Adaptation of Families Actively Improving Relationships (PRE-FAIR), Standard Case Management and Referral
Behavioral
Lead sponsor
Chestnut Health Systems
Other
Eligibility
16 Years to 30 Years
Enrollment
241 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Jul 22, 2026, 12:02 PM EDT
Completed Not applicable Interventional Results available

The Getting Off App for Methamphetamine-Using Gay and Bisexual Men

NCT03884946
View directory record Official record
Conditions
Methamphetamine Abuse, HIV/AIDS
Interventions
Getting Off App
Other
Lead sponsor
Friends Research Institute, Inc.
Other
Eligibility
18 Years to 65 Years · Male only
Enrollment
226 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 28, 2026 · Synced Jul 22, 2026, 12:02 PM EDT
Completed Phase 2 Interventional

Behavior Change and Maintenance Intervention for HIV+ MSM Methamphetamine Users

NCT00432926
View directory record Official record
Conditions
HIV Infections, Substance Abuse, Sexually Transmitted Diseases
Interventions
EDGE counseling, no maintenance, EDGE counseling, plus maintenance, Attention control
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older · Male only
Enrollment
429 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Sep 27, 2012 · Synced Jul 22, 2026, 12:02 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Cardiovascular Effects of Prenatal Methamphetamine Exposure

NCT04616625
View directory record Official record
Conditions
Methamphetamine Abuse, Newborn Complication | Patient | Neonatalology
Interventions
Not listed
Lead sponsor
University of California, Davis
Other
Eligibility
Not listed
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
2
States / cities
Marysville, California • Sacramento, California
Source: ClinicalTrials.gov public record
Updated Oct 31, 2024 · Synced Jul 22, 2026, 12:02 PM EDT
Completed Phase 4 Interventional

Methamphetamine Abuse Treatment in Patients With AIDS - 1

NCT00000321
View directory record Official record
Conditions
Substance-Related Disorders
Interventions
Desipramine
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
Male only
Healthy volunteers
Healthy volunteers not accepted
Timeline
1996 – 2001
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Jul 22, 2026, 12:02 PM EDT
Completed No phase listed Observational

Stimulant Use and Methylation in HIV

NCT05916989
View directory record Official record
Conditions
HIV Infections, Methamphetamine-dependence, Methamphetamine Abuse
Interventions
Not listed
Lead sponsor
Florida International University
Other
Eligibility
18 Years and older · Male only
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Nov 1, 2023 · Synced Jul 22, 2026, 12:02 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Safety Assessment of Potential Interactions Between IV Methamphetamine and Osmotic-Release Methylphenidate (OROS-MPH)

NCT00603434
View directory record Official record
Conditions
Methamphetamine Dependence, Methamphetamine Abuse
Interventions
OROS-MPH
Drug
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years to 45 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Jul 22, 2026, 12:02 PM EDT
Completed Not applicable Interventional

Demonstration of a Digital Care Program for Methamphetamine Use Disorder

NCT05206175
View directory record Official record
Conditions
Methamphetamine Abuse
Interventions
Affect Treatment Program for Methamphetamine Use Disorder
Other
Lead sponsor
Affect Therapeutics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 10, 2023 · Synced Jul 22, 2026, 12:02 PM EDT
Completed Phase 2 Interventional Results available

Varenicline vs Placebo for the Treatment of Methamphetamine Dependence

NCT01011829
View directory record Official record
Conditions
Methamphetamine Dependence, Substance Abuse, Methamphetamine Abuse
Interventions
Varenicline, Placebo
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 13, 2013 · Synced Jul 22, 2026, 12:02 PM EDT
Completed Phase 2Phase 3 Interventional

Prometa Pharmacotherapy for Methamphetamine Dependence

NCT00260481
View directory record Official record
Conditions
Drug Abuse, Drug Dependence
Interventions
Prometa, Placebo
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 21, 2016 · Synced Jul 22, 2026, 12:02 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Buspirone as a Candidate Medication for Methamphetamine Abuse

NCT01843205
View directory record Official record
Conditions
Methamphetamine Dependence, Methamphetamine Abuse
Interventions
Methamphetamine, Placebo
Drug
Lead sponsor
University of Kentucky
Other
Eligibility
18 Years to 55 Years
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Feb 6, 2018 · Synced Jul 22, 2026, 12:02 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Data2Action Oregon Project: Supporting Data-driven Decision-Making for Substance Use Services, Policy, and Overdose Prevention

NCT06852170
View directory record Official record
Conditions
Substance Abuse, Decision Making, Shared, Implementation Science, Decision Making, Organizations, Substance-related Disorders, Policy
Interventions
Co-Design Sessions (CDS), Data products
Other
Lead sponsor
Chestnut Health Systems
Other
Eligibility
18 Years and older
Enrollment
341 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Mar 15, 2026 · Synced Jul 22, 2026, 12:02 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Mirtazapine to Reduce Methamphetamine Use Among MSM With High-risk HIV Behaviors

NCT00497081
View directory record Official record
Conditions
Substance Abuse, HIV Infections
Interventions
mirtazapine, placebo
Drug
Lead sponsor
San Francisco Department of Public Health
Government
Eligibility
18 Years to 60 Years · Male only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2010
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 4, 2015 · Synced Jul 22, 2026, 12:02 PM EDT
Completed Phase 3 Interventional Results available

Stimulant Abuser Groups to Engage in 12-Step

NCT00573183
View directory record Official record
Conditions
Drug Abuse
Interventions
STAGE-12, Treatment as Usual
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
471 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
10
States / cities
Jacksonville, Florida • Kaneohe, Hawaii • Columbus, Ohio + 7 more
Source: ClinicalTrials.gov public record
Updated Dec 4, 2016 · Synced Jul 22, 2026, 12:02 PM EDT
Recruiting Phase 2 Interventional

Ketamine for Methamphetamine Use Disorder

NCT06496750
View directory record Official record
Conditions
Substance Use Disorders, Substance Use, Methamphetamine Abuse
Interventions
Ketamine Hydrochloride, Midazolam Hydrochloride
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
5
States / cities
San Leandro, California • Albuquerque, New Mexico • New York, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Jul 22, 2026, 12:02 PM EDT
Completed Phase 1 Interventional

NAC as a Potential Treatment for Methamphetamine Dependence

NCT01063205
View directory record Official record
Conditions
Methamphetamine Abuse, Methamphetamine Dependence, Substance Abuse
Interventions
Placebo, N-acetylcysteine
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 55 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 26, 2012 · Synced Jul 22, 2026, 12:02 PM EDT
Terminated Phase 2 Interventional Results available

Multiple-Dose Study to Evaluate the Safety and Efficacy of IXT-m200

NCT05034874
View directory record Official record
Conditions
Methamphetamine-dependence, Methamphetamine Abuse
Interventions
IXT-m200, Placebo
Drug · Other
Lead sponsor
InterveXion Therapeutics, LLC
Industry
Eligibility
18 Years and older
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
9
States / cities
Bentonville, Arkansas • Little Rock, Arkansas • San Diego, California + 6 more
Source: ClinicalTrials.gov public record
Updated Oct 3, 2024 · Synced Jul 22, 2026, 12:02 PM EDT
Not listed Not applicable Interventional

Theta Burst TMS for Treatment of Methamphetamine Use Disorder

NCT06372288
View directory record Official record
Conditions
Methamphetamine Abuse
Interventions
Transcranial Magnetic Stimulation, Sham Transcranial Magnetic Stimulation
Device
Lead sponsor
Carilion Clinic
Other
Eligibility
18 Years to 55 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 25, 2024 · Synced Jul 22, 2026, 12:02 PM EDT
Terminated Phase 1 Interventional

Dopamine D2/D3 Receptor Upregulation by Varenicline in Methamphetamine Users

NCT03059563
View directory record Official record
Conditions
Dopamine D2/3 Receptor Availability, Cognitive Function, Methamphetamine Abuse
Interventions
Varenicline, Placebo
Drug · Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 60 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 7, 2024 · Synced Jul 22, 2026, 12:02 PM EDT
Completed Not applicable Interventional Results available

Theory-based Text Messaging to Reduce Methamphetamine Use and HIV Risks Among MSM

NCT02008526
View directory record Official record
Conditions
Methamphetamine Abuse, HIV
Interventions
Text Messages Transmitted by Peer Health Educators (TXT-PHE), Text Messages Transmitted by Automation (TXT-Auto)
Behavioral
Lead sponsor
Friends Research Institute, Inc.
Other
Eligibility
18 Years to 65 Years · Male only
Enrollment
286 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 17, 2017 · Synced Jul 22, 2026, 12:02 PM EDT
Active, not recruiting Not applicable Interventional

Contingency Management for Drug Use: Does Age Matter?

NCT05521854
View directory record Official record
Conditions
Opioid Use Disorder, Methamphetamine Abuse, Cocaine Use Disorder
Interventions
DynamiCare app (app-based contingency management), Sham control
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
175 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
2
States / cities
Chicago, Illinois • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jun 24, 2026 · Synced Jul 22, 2026, 12:02 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Study of Antibody for Methamphetamine Outpatient Therapy

NCT03336866
View directory record Official record
Conditions
Methamphetamine-dependence, Methamphetamine Abuse
Interventions
Placebo, IXT-m200
Drug
Lead sponsor
InterveXion Therapeutics, LLC
Industry
Eligibility
21 Years to 50 Years
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
2
States / cities
Anaheim, California • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Mar 9, 2022 · Synced Jul 22, 2026, 12:02 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Biobehavioral Interventions for HIV-negative, Stimulant Using Men Who Have Sex With Men

NCT01140880
View directory record Official record
Conditions
HIV Seroconversion, Stimulant Abuse
Interventions
Truvada
Drug
Lead sponsor
Friends Research Institute, Inc.
Other
Eligibility
18 Years and older · Male only
Enrollment
170 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 16, 2025 · Synced Jul 22, 2026, 12:02 PM EDT