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ClinicalTrials.gov public records Last synced Sep 13, 2026, 10:28 AM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Terminated Phase 2 Interventional Results available

IMC-A12 With Mitotane vs Mitotane Alone in Recurrent, Metastatic, or Primary ACC That Cannot Be Removed by Surgery

NCT00778817
View directory record Official record
Conditions
Recurrent Adrenocortical Carcinoma, Stage III Adrenocortical Carcinoma, Stage IV Adrenocortical Carcinoma
Interventions
IMC-A12, mitotane
Biological · Drug
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
8
States / cities
Los Angeles, California • Chicago, Illinois • Decatur, Illinois + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 28, 2014 · Synced Sep 13, 2026, 10:28 AM EDT
Completed Not applicable Interventional Results available

TRIUMPH Lumbar Artificial Disc IDE: A Pilot Study

NCT01198470
View directory record Official record
Conditions
Lumbar Degenerative Disc Disease
Interventions
TRIUMPH® Lumbar Artificial Disc
Device
Lead sponsor
Globus Medical Inc
Industry
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
1
States / cities
Savannah, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 1, 2018 · Synced Sep 13, 2026, 10:28 AM EDT
Recruiting Phase 1 Interventional

Study of Preoperative Radiation Therapy in Participants With Resectable Recurrent Abdominal Adrenocortical Carcinoma

NCT06487481
View directory record Official record
Conditions
Adrenocortical Carcinoma (ACC), Recurrent Adrenocortical Carcinoma (ACC), Recurrent Abdominal Adrenocortical Carcinoma (ACC), Carcinoma, Adrenocortical, Carcinoma, Adrenal Cortical
Interventions
Surgical resection, Preoperative RT
Procedure · Radiation
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years to 120 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2040
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Sep 13, 2026, 10:28 AM EDT
Not listed No phase listed Observational

Retrospective, Multicenter Clinical Evaluation of Health Economic Drivers and Complications for Two Lumbar Fusion Procedures

NCT02171169
View directory record Official record
Conditions
Spinal Stenosis, Spondylolisthesis, Degenerative Disc Disease (DDD)
Interventions
Not listed
Lead sponsor
Baxano Surgical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
3
States / cities
Fullerton, California • Waterford, Michigan • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 2, 2014 · Synced Sep 13, 2026, 10:28 AM EDT
Active, not recruiting Not applicable Interventional

Study of Posterior Cervical Stabilization System (PCSS) as Part of Circumferential Fusion to Treat Multilevel DDD

NCT04229017
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Anterior Cervical Discectomy and Fusion, Posterior Cervical Stabilization System (PCSS)
Procedure · Device
Lead sponsor
Providence Medical Technology, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
236 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
17
States / cities
Phoenix, Arizona • Encinitas, California • Los Gatos, California + 14 more
Source: ClinicalTrials.gov public record
Updated Oct 29, 2025 · Synced Sep 13, 2026, 10:28 AM EDT
Terminated Not applicable Interventional Results available

Clinical Outcomes of Lumbar Degenerative Disc Disease in Active-Duty U.S. Service Personnel

NCT01028300
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
ProDisc™-L Total Disc Replacement (TDR)
Device
Lead sponsor
Synthes USA HQ, Inc.
Industry
Eligibility
18 Years to 50 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 1, 2016 · Synced Sep 13, 2026, 10:28 AM EDT
Completed No phase listed Observational

An Evaluation of Interlaminar Lumbar Instrumented (ILIF™)

NCT01019057
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
ILIF
Procedure
Lead sponsor
NuVasive
Industry
Eligibility
40 Years and older
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
8
States / cities
Phoenix, Arizona • Santa Monica, California • Gainesville, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Sep 13, 2026, 10:28 AM EDT
Recruiting Phase 3 Interventional

Long-term Efficacy, Safety and Tolerability of Iptacopan in C3G or IC-MPGN

NCT03955445
View directory record Official record
Conditions
C3 Glomerulopathy, Immune-complex-membranoproliferative Glomerulonephritis
Interventions
LNP023
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
12 Years to 100 Years
Enrollment
225 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2036
U.S. locations
5
States / cities
Aurora, Colorado • Lawrenceville, Georgia • Iowa City, Iowa + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Sep 13, 2026, 10:28 AM EDT
Completed Not applicable Interventional Results available

Comparison of DISCOVER™ Artificial Cervical Disc and ACDF for Treatment of Cervical DDD (IDE Study)

NCT00432159
View directory record Official record
Conditions
Cervical Degenerative Disc Disease
Interventions
Cervical TDR, ACDF with plate
Device
Lead sponsor
DePuy Spine
Industry
Eligibility
21 Years to 70 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2016
U.S. locations
30
States / cities
Beverly Hills, California • Sacramento, California • Loveland, Colorado + 26 more
Source: ClinicalTrials.gov public record
Updated Oct 19, 2017 · Synced Sep 13, 2026, 10:28 AM EDT
Completed Phase 1 Interventional

Natural History and Results of Dual Chamber (DDD) Pacemaker Therapy of Children With Obstructive Hypertrophic Cardiomyop...

NCT00001396
View directory record Official record
Conditions
Hypertrophic Cardiomyopathy
Interventions
Paragon Pacemaker
Device
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
5 Years to 20 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1993 – 2008
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Sep 13, 2026, 10:28 AM EDT
Not listed No phase listed Observational

InterFuse® S and T for the Treatment of Scoliosis, Spondylolisthesis and Degenerative Disc Disease (DDD)

NCT02659722
View directory record Official record
Conditions
Scoliosis, Back Pain
Interventions
InterFuse
Device
Lead sponsor
Vertebral Technologies, Inc.
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Nov 1, 2016 · Synced Sep 13, 2026, 10:28 AM EDT
Completed Phase 2 Interventional Results available

A Proof-of-Concept Study of Danicopan for 6 Months of Treatment in Participants With C3 Glomerulopathy (C3G)

NCT03369236
View directory record Official record
Conditions
C3 Glomerulopathy, C3 Glomerulonephritis, Dense Deposit Disease
Interventions
Danicopan, Placebo
Drug
Lead sponsor
Alexion Pharmaceuticals, Inc.
Industry
Eligibility
17 Years to 65 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
6
States / cities
Aurora, Colorado • Lawrenceville, Georgia • Iowa City, Iowa + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 13, 2022 · Synced Sep 13, 2026, 10:28 AM EDT
Completed No phase listed Observational

Patient Outcomes Evaluation of the EBI Vuelock™ Anterior Cervical Plate System

NCT00726128
View directory record Official record
Conditions
Trauma, Tumor, Pseudarthrosis, Scoliosis, Degenerative Disc Disease
Interventions
VueLock™ Anterior Cervical Plate
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
Not listed
Enrollment
371 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2009
U.S. locations
4
States / cities
Palo Alto, California • San Diego, California • Avon, Indiana + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 23, 2020 · Synced Sep 13, 2026, 10:28 AM EDT
Completed Phase 2 Interventional

Studying the Effectiveness of Pacemaker Therapy in Children Who Have Thickened Heart Muscle

NCT00001960
View directory record Official record
Conditions
Hypertrophic Cardiomyopathy
Interventions
Pacemaker therapy
Device
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
Not listed
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2002
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Sep 13, 2026, 10:28 AM EDT
Completed Phase 3 Interventional

XL TDR® eXtreme Lateral Total Disc Replacement for the Treatment of Lumbar Degenerative Disc Disease (DDD)

NCT00927238
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
XL TDR, Lumbar fusion surgery
Device · Other
Lead sponsor
NuVasive
Industry
Eligibility
18 Years to 70 Years
Enrollment
246 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
17
States / cities
Campbell, California • Thousand Oaks, California • Durango, Colorado + 14 more
Source: ClinicalTrials.gov public record
Updated Jul 29, 2015 · Synced Sep 13, 2026, 10:28 AM EDT
Not listed No phase listed Observational

Clinical and Radiographic Outcomes of TLIF w/3D Printed Cellular Implant

NCT05023733
View directory record Official record
Conditions
Foraminal Stenosis, Degenerative Disc Disease, Lumbar Spondylolisthesis, Lumbar Spinal Stenosis
Interventions
CONDUIT™ Interbody Platform composed of the EIT (Emerging Implant Technologies) Cellular Titanium®
Device
Lead sponsor
Farhan Karim
Other
Eligibility
35 Years to 80 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 27, 2022 · Synced Sep 13, 2026, 10:28 AM EDT
Not listed Not applicable Interventional

Freedom Lumbar Disc in the Treatment of Lumbar Degenerative Disc Disease

NCT00775801
View directory record Official record
Conditions
Degenerative Disc Disease (DDD)
Interventions
FLD, Control
Device
Lead sponsor
AxioMed Spine Corporation
Industry
Eligibility
21 Years to 65 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2018
U.S. locations
12
States / cities
Los Angeles, California • San Diego, California • Loveland, Colorado + 9 more
Source: ClinicalTrials.gov public record
Updated Jan 22, 2018 · Synced Sep 13, 2026, 10:28 AM EDT
Recruiting Phase 3 Interventional

A Study to Evaluate the Effectiveness of IDCT (Intradiscal Cell Therapy) in Subjects With One Level, Symptomatic Mild to Moderate Lumbar Degenerative Disc Disease

NCT07254806
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
IDCT (rebonuputemcel), Sham (No Treatment)
Biological · Other
Lead sponsor
DiscGenics, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
28
States / cities
Birmingham, Alabama • Phoenix, Arizona • San Diego, California + 25 more
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Sep 13, 2026, 10:28 AM EDT
Enrolling by invitation No phase listed Observational

INDUCE: A Prospective 2-Year Spine Registry

NCT06971835
View directory record Official record
Conditions
Subjects Treated With NMP as Part of Their Spine Surgery, Degenerative Disc Disease (DDD)
Interventions
NMP
Device
Lead sponsor
Red Rock Regeneration Inc.
Industry
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
2
States / cities
Baton Rouge, Louisiana • Shreveport, Louisiana
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Sep 13, 2026, 10:28 AM EDT
Not listed Phase 1Phase 2 Interventional

Pilot Study to Assess Safety/Preliminary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery

NCT00798902
View directory record Official record
Conditions
Degenerative Disc Disease, Spondylolisthesis
Interventions
Prefix (AMPLEX) B2A Peptide Enhanced Ceramic Granules, Iliac crest autograft
Device · Other
Lead sponsor
BioSurface Engineering Technologies, Inc
Industry
Eligibility
18 Years to 70 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
6
States / cities
Durango, Colorado • Washington D.C., District of Columbia • Kansas City, Kansas + 3 more
Source: ClinicalTrials.gov public record
Updated Mar 8, 2012 · Synced Sep 13, 2026, 10:28 AM EDT
Terminated Phase 1 Interventional

Clinical Trial of CDX-1135 in Pediatric and Adult Patients With Dense Deposit Disease

NCT01791686
View directory record Official record
Conditions
Dense Deposit Disease, Membranoproliferative Glomerulonephritis Type II, C3 Glomerulonephritis
Interventions
CDX-1135
Drug
Lead sponsor
Celldex Therapeutics
Industry
Eligibility
4 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 6, 2014 · Synced Sep 13, 2026, 10:28 AM EDT
Terminated Phase 2 Interventional Results available

A Proof of Concept Study for a 12 Month Treatment in Patients With C3G or IC-MPGN Treated With ACH-0144471

NCT03459443
View directory record Official record
Conditions
C3 Glomerulonephritis, C3 Glomerulopathy, Immune Complex Membranoproliferative Glomerulonephritis, IC-MPGN, Dense Deposit Disease
Interventions
Danicopan
Drug
Lead sponsor
Alexion Pharmaceuticals, Inc.
Industry
Eligibility
12 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
6
States / cities
Birmingham, Alabama • Stanford, California • New Haven, Connecticut + 3 more
Source: ClinicalTrials.gov public record
Updated Aug 20, 2023 · Synced Sep 13, 2026, 10:28 AM EDT
Completed No phase listed Observational Results available

Retrospective/Prospective Data Collection on the LDR ROIC Interbody Fusion Device With VerteBRIDGE Plating

NCT02104167
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
ROIC interbody cage with VerteBRIDGE plating
Device
Lead sponsor
LDR Spine USA
Industry
Eligibility
21 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
7
States / cities
Laguna Hills, California • Munster, Indiana • Baltimore, Maryland + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 15, 2019 · Synced Sep 13, 2026, 10:28 AM EDT
Terminated Phase 2 Interventional Results available

A Phase II Study to Evaluate the Efficacy and Safety of Pembrolizumab in Combination With Mitotane in Patients With Advanced Adrenocortical Carcinoma

NCT05634577
View directory record Official record
Conditions
Adrenocortical Carcinoma
Interventions
Mitotane, Pembrolizumab
Drug
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 18, 2025 · Synced Sep 13, 2026, 10:28 AM EDT